Compile Data Set for Download or QSAR

Found 87 hits of kd for UniProtKB: P00374   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038269 (2-Amino-8-isobutyl-5-methyl-2,8-dihydro-3H-pyrido[...) Show SMILES CC(C)CN1C=CC(C)=C2C(=O)NC(N)N=C12 |c:5,t:8,15| Show InChI InChI=1S/C12H18N4O/c1-7(2)6-16-5-4-8(3)9-10(16)14-12(13)15-11(9)17/h4-5,7,12H,6,13H2,1-3H3,(H,15,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Tested for the apparent dissociation constant for binding of compound to ternary NADPH complex with human dihydrofolate reductase using equation 4				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM66082 ((2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methy...) Show SMILES CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O Show InChI InChI=1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars	DrugBank PDB Article PubMed	n/a	n/a	n/a	0.195	n/a	n/a	n/a	n/a	n/a
Harvard University Curated by ChEMBL					Assay Description Binding affinity against Dihydrofolate reductase				J Med Chem 45: 2770-80 (2002) Article DOI: 10.1021/jm0105833 BindingDB Entry DOI: 10.7270/Q2MG7S8S
					More data for this Ligand-Target Pair				3D Structure (crystal)
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038269 (2-Amino-8-isobutyl-5-methyl-2,8-dihydro-3H-pyrido[...) Show SMILES CC(C)CN1C=CC(C)=C2C(=O)NC(N)N=C12 |c:5,t:8,15| Show InChI InChI=1S/C12H18N4O/c1-7(2)6-16-5-4-8(3)9-10(16)14-12(13)15-11(9)17/h4-5,7,12H,6,13H2,1-3H3,(H,15,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Tested for the apparent dissociation constant for binding of compound to binary NADPH complex with human dihydrofolate reductase using equation 4				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038264 (2-Amino-7-methyl-8-propyl-2,8-dihydro-3H-pyrido[2,...) Show SMILES CCCN1C(C)=CC=C2C(=O)NC(N)N=C12 |c:5,t:7,14| Show InChI InChI=1S/C11H16N4O/c1-3-6-15-7(2)4-5-8-9(15)13-11(12)14-10(8)16/h4-5,11H,3,6,12H2,1-2H3,(H,14,16)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Tested for the apparent dissociation constant for binding of compound to binary NADPH complex with human dihydrofolate reductase using equation 4				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038264 (2-Amino-7-methyl-8-propyl-2,8-dihydro-3H-pyrido[2,...) Show SMILES CCCN1C(C)=CC=C2C(=O)NC(N)N=C12 |c:5,t:7,14| Show InChI InChI=1S/C11H16N4O/c1-3-6-15-7(2)4-5-8-9(15)13-11(12)14-10(8)16/h4-5,11H,3,6,12H2,1-2H3,(H,14,16)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Tested for the apparent dissociation constant for binding of compound to ternary NADPH complex with human dihydrofolate reductase using equation 4				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038263 (2-Amino-8-propyl-2,8-dihydro-3H-pyrido[2,3-d]pyrim...) Show SMILES CCCN1C=CC=C2C(=O)NC(N)N=C12 |c:4,t:6,13| Show InChI InChI=1S/C10H14N4O/c1-2-5-14-6-3-4-7-8(14)12-10(11)13-9(7)15/h3-4,6,10H,2,5,11H2,1H3,(H,13,15)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Tested for the apparent dissociation constant for binding of compound to ternary NADPH complex with human dihydrofolate reductaseusing equation 4				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038263 (2-Amino-8-propyl-2,8-dihydro-3H-pyrido[2,3-d]pyrim...) Show SMILES CCCN1C=CC=C2C(=O)NC(N)N=C12 |c:4,t:6,13| Show InChI InChI=1S/C10H14N4O/c1-2-5-14-6-3-4-7-8(14)12-10(11)13-9(7)15/h3-4,6,10H,2,5,11H2,1H3,(H,13,15)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	20.7	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Tested for the apparent dissociation constant for binding of compound to binary NADPH complex with human dihydrofolate reductase using equation 4				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038269 (2-Amino-8-isobutyl-5-methyl-2,8-dihydro-3H-pyrido[...) Show SMILES CC(C)CN1C=CC(C)=C2C(=O)NC(N)N=C12 |c:5,t:8,15| Show InChI InChI=1S/C12H18N4O/c1-7(2)6-16-5-4-8(3)9-10(16)14-12(13)15-11(9)17/h4-5,7,12H,6,13H2,1-3H3,(H,15,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Tested for the apparent dissociation constant for binding of compound to ternary NADPH complex with human dihydrofolate reductase using equation 11				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038269 (2-Amino-8-isobutyl-5-methyl-2,8-dihydro-3H-pyrido[...) Show SMILES CC(C)CN1C=CC(C)=C2C(=O)NC(N)N=C12 |c:5,t:8,15| Show InChI InChI=1S/C12H18N4O/c1-7(2)6-16-5-4-8(3)9-10(16)14-12(13)15-11(9)17/h4-5,7,12H,6,13H2,1-3H3,(H,15,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	57	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Tested for the apparent dissociation constant for binding of compound to ternary NADPH complex with human dihydrofolate reductase using equations 15 ...				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038269 (2-Amino-8-isobutyl-5-methyl-2,8-dihydro-3H-pyrido[...) Show SMILES CC(C)CN1C=CC(C)=C2C(=O)NC(N)N=C12 |c:5,t:8,15| Show InChI InChI=1S/C12H18N4O/c1-7(2)6-16-5-4-8(3)9-10(16)14-12(13)15-11(9)17/h4-5,7,12H,6,13H2,1-3H3,(H,15,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	80	n/a	n/a	n/a	6.6	n/a
University of Sydney Curated by ChEMBL					Assay Description Apparent dissociation constant at pH 6.6 for human dihydrofolate reductase in the presence of cofactor NADPH				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50130950 (5-(4-Chloro-phenylsulfanyl)-quinazoline-2,4-diamin...) Show SMILES Nc1nc(N)c2c(Sc3ccc(Cl)cc3)cccc2n1 Show InChI InChI=1S/C14H11ClN4S/c15-8-4-6-9(7-5-8)20-11-3-1-2-10-12(11)13(16)19-14(17)18-10/h1-7H,(H4,16,17,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutical Research and Development, LLC Curated by ChEMBL					Assay Description Binding affinity to DHFR (unknown origin) by NMR analysis				J Med Chem 57: 7819-37 (2014) Article DOI: 10.1021/jm500325k BindingDB Entry DOI: 10.7270/Q2JW8GH3
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038264 (2-Amino-7-methyl-8-propyl-2,8-dihydro-3H-pyrido[2,...) Show SMILES CCCN1C(C)=CC=C2C(=O)NC(N)N=C12 |c:5,t:7,14| Show InChI InChI=1S/C11H16N4O/c1-3-6-15-7(2)4-5-8-9(15)13-11(12)14-10(8)16/h4-5,11H,3,6,12H2,1-2H3,(H,14,16)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	450	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Tested for the apparent dissociation constant for binding of compound to ternary NADPH complex with human dihydrofolate reductase using equation 11				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038267 (2-Amino-6,8-dimethyl-2,8-dihydro-3H-pyrido[2,3-d]p...) Show SMILES CN1C=C(C)C=C2C(=O)NC(N)N=C12 |t:2,5,12| Show InChI InChI=1S/C9H12N4O/c1-5-3-6-7(13(2)4-5)11-9(10)12-8(6)14/h3-4,9H,10H2,1-2H3,(H,12,14)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	500	n/a	n/a	n/a	6.6	n/a
University of Sydney Curated by ChEMBL					Assay Description Apparent dissociation constant at pH 6.6 for human dihydrofolate reductase in the presence of cofactor NADPH				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038270 (2-Amino-8-isobutyl-2,8-dihydro-3H-pyrido[2,3-d]pyr...) Show SMILES CC(C)CN1C=CC=C2C(=O)NC(N)N=C12 |c:5,t:7,14| Show InChI InChI=1S/C11H16N4O/c1-7(2)6-15-5-3-4-8-9(15)13-11(12)14-10(8)16/h3-5,7,11H,6,12H2,1-2H3,(H,14,16)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	600	n/a	n/a	n/a	6.6	n/a
University of Sydney Curated by ChEMBL					Assay Description Apparent dissociation constant at pH 6.6 for human dihydrofolate reductase in the presence of cofactor NADPH				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038272 (2-Amino-5-methyl-8-(3-methyl-butyl)-2,8-dihydro-3H...) Show SMILES CC(C)CCN1C=CC(C)=C2C(=O)NC(N)N=C12 |c:6,t:9,16| Show InChI InChI=1S/C13H20N4O/c1-8(2)4-6-17-7-5-9(3)10-11(17)15-13(14)16-12(10)18/h5,7-8,13H,4,6,14H2,1-3H3,(H,16,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	700	n/a	n/a	n/a	6.6	n/a
University of Sydney Curated by ChEMBL					Assay Description Apparent dissociation constant at pH 6.6 for human dihydrofolate reductase in the presence of cofactor NADPH				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038268 (2-Amino-8-benzyl-2,8-dihydro-3H-pyrido[2,3-d]pyrim...) Show SMILES NC1NC(=O)C2=CC=CN(Cc3ccccc3)C2=N1 |c:7,19,t:5| Show InChI InChI=1S/C14H14N4O/c15-14-16-12-11(13(19)17-14)7-4-8-18(12)9-10-5-2-1-3-6-10/h1-8,14H,9,15H2,(H,17,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	700	n/a	n/a	n/a	6.6	n/a
University of Sydney Curated by ChEMBL					Assay Description Apparent dissociation constant at pH 6.6 for human dihydrofolate reductase in the presence of cofactor NADPH				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038263 (2-Amino-8-propyl-2,8-dihydro-3H-pyrido[2,3-d]pyrim...) Show SMILES CCCN1C=CC=C2C(=O)NC(N)N=C12 |c:4,t:6,13| Show InChI InChI=1S/C10H14N4O/c1-2-5-14-6-3-4-7-8(14)12-10(11)13-9(7)15/h3-4,6,10H,2,5,11H2,1H3,(H,13,15)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	830	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Tested for the apparent dissociation constant for binding of compound to ternary NADPH complex with human dihydrofolate reductaseusing equation 11				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038264 (2-Amino-7-methyl-8-propyl-2,8-dihydro-3H-pyrido[2,...) Show SMILES CCCN1C(C)=CC=C2C(=O)NC(N)N=C12 |c:5,t:7,14| Show InChI InChI=1S/C11H16N4O/c1-3-6-15-7(2)4-5-8-9(15)13-11(12)14-10(8)16/h4-5,11H,3,6,12H2,1-2H3,(H,14,16)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Tested for the apparent dissociation constant for binding of compound to ternary NADPH complex with human dihydrofolate reductase using equations 15 ...				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038273 (2-Amino-7,8-dimethyl-2,8-dihydro-3H-pyrido[2,3-d]p...) Show SMILES CN1C(C)=CC=C2C(=O)NC(N)N=C12 |c:3,t:5,12| Show InChI InChI=1S/C9H12N4O/c1-5-3-4-6-7(13(5)2)11-9(10)12-8(6)14/h3-4,9H,10H2,1-2H3,(H,12,14)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	6.6	n/a
University of Sydney Curated by ChEMBL					Assay Description Apparent dissociation constant at pH 6.6 for Chicken dihydrofolate reductase in the presence of cofactor NADPH				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038267 (2-Amino-6,8-dimethyl-2,8-dihydro-3H-pyrido[2,3-d]p...) Show SMILES CN1C=C(C)C=C2C(=O)NC(N)N=C12 |t:2,5,12| Show InChI InChI=1S/C9H12N4O/c1-5-3-6-7(13(2)4-5)11-9(10)12-8(6)14/h3-4,9H,10H2,1-2H3,(H,12,14)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	6.6	n/a
University of Sydney Curated by ChEMBL					Assay Description Apparent dissociation constant at pH 6.6 for Chicken dihydrofolate reductase in the presence of cofactor NADPH				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038261 (2-Amino-5-methyl-8-propyl-2,8-dihydro-3H-pyrido[2,...) Show SMILES CCCN1C=CC(C)=C2C(=O)NC(N)N=C12 |c:4,t:7,14| Show InChI InChI=1S/C11H16N4O/c1-3-5-15-6-4-7(2)8-9(15)13-11(12)14-10(8)16/h4,6,11H,3,5,12H2,1-2H3,(H,14,16)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	6.6	n/a
University of Sydney Curated by ChEMBL					Assay Description Apparent dissociation constant at pH 6.6 for human dihydrofolate reductase in the presence of cofactor NADPH				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038264 (2-Amino-7-methyl-8-propyl-2,8-dihydro-3H-pyrido[2,...) Show SMILES CCCN1C(C)=CC=C2C(=O)NC(N)N=C12 |c:5,t:7,14| Show InChI InChI=1S/C11H16N4O/c1-3-6-15-7(2)4-5-8-9(15)13-11(12)14-10(8)16/h4-5,11H,3,6,12H2,1-2H3,(H,14,16)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Tested for the apparent dissociation constant for binding of compound to binary NADPH complex with human dihydrofolate reductase using equations 11 a...				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038269 (2-Amino-8-isobutyl-5-methyl-2,8-dihydro-3H-pyrido[...) Show SMILES CC(C)CN1C=CC(C)=C2C(=O)NC(N)N=C12 |c:5,t:8,15| Show InChI InChI=1S/C12H18N4O/c1-7(2)6-16-5-4-8(3)9-10(16)14-12(13)15-11(9)17/h4-5,7,12H,6,13H2,1-3H3,(H,15,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	1.60E+3	n/a	n/a	n/a	6.6	n/a
University of Sydney Curated by ChEMBL					Assay Description Apparent dissociation constant at pH 6.6 for Chicken dihydrofolate reductase in the presence of cofactor NADPH				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038268 (2-Amino-8-benzyl-2,8-dihydro-3H-pyrido[2,3-d]pyrim...) Show SMILES NC1NC(=O)C2=CC=CN(Cc3ccccc3)C2=N1 |c:7,19,t:5| Show InChI InChI=1S/C14H14N4O/c15-14-16-12-11(13(19)17-14)7-4-8-18(12)9-10-5-2-1-3-6-10/h1-8,14H,9,15H2,(H,17,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	1.70E+3	n/a	n/a	n/a	6.6	n/a
University of Sydney Curated by ChEMBL					Assay Description Apparent dissociation constant at pH 6.6 for human dihydrofolate reductase in the absence of cofactor NADPH				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038263 (2-Amino-8-propyl-2,8-dihydro-3H-pyrido[2,3-d]pyrim...) Show SMILES CCCN1C=CC=C2C(=O)NC(N)N=C12 |c:4,t:6,13| Show InChI InChI=1S/C10H14N4O/c1-2-5-14-6-3-4-7-8(14)12-10(11)13-9(7)15/h3-4,6,10H,2,5,11H2,1H3,(H,13,15)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Tested for the apparent dissociation constant for binding of compound to ternary NADPH complex with human dihydrofolate reductaseusing equations 15 a...				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038272 (2-Amino-5-methyl-8-(3-methyl-butyl)-2,8-dihydro-3H...) Show SMILES CC(C)CCN1C=CC(C)=C2C(=O)NC(N)N=C12 |c:6,t:9,16| Show InChI InChI=1S/C13H20N4O/c1-8(2)4-6-17-7-5-9(3)10-11(17)15-13(14)16-12(10)18/h5,7-8,13H,4,6,14H2,1-3H3,(H,16,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	1.80E+3	n/a	n/a	n/a	6.6	n/a
University of Sydney Curated by ChEMBL					Assay Description Apparent dissociation constant at pH 6.6 for human dihydrofolate reductase in the absence of cofactor NADPH				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038266 (2-Amino-8-isopropyl-2,8-dihydro-3H-pyrido[2,3-d]py...) Show SMILES CC(C)N1C=CC=C2C(=O)NC(N)N=C12 |c:4,t:6,13| Show InChI InChI=1S/C10H14N4O/c1-6(2)14-5-3-4-7-8(14)12-10(11)13-9(7)15/h3-6,10H,11H2,1-2H3,(H,13,15)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	1.90E+3	n/a	n/a	n/a	6.6	n/a
University of Sydney Curated by ChEMBL					Assay Description Apparent dissociation constant at pH 6.6 for human dihydrofolate reductase in the presence of cofactor NADPH				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038264 (2-Amino-7-methyl-8-propyl-2,8-dihydro-3H-pyrido[2,...) Show SMILES CCCN1C(C)=CC=C2C(=O)NC(N)N=C12 |c:5,t:7,14| Show InChI InChI=1S/C11H16N4O/c1-3-6-15-7(2)4-5-8-9(15)13-11(12)14-10(8)16/h4-5,11H,3,6,12H2,1-2H3,(H,14,16)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	2.00E+3	n/a	n/a	n/a	6.6	n/a
University of Sydney Curated by ChEMBL					Assay Description Apparent dissociation constant at pH 6.6 for human dihydrofolate reductase in the presence of cofactor NADPH				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038263 (2-Amino-8-propyl-2,8-dihydro-3H-pyrido[2,3-d]pyrim...) Show SMILES CCCN1C=CC=C2C(=O)NC(N)N=C12 |c:4,t:6,13| Show InChI InChI=1S/C10H14N4O/c1-2-5-14-6-3-4-7-8(14)12-10(11)13-9(7)15/h3-4,6,10H,2,5,11H2,1H3,(H,13,15)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Tested for the apparent dissociation constant for binding of compound to binary NADPH complex with human dihydrofolate reductase using equation 16				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038270 (2-Amino-8-isobutyl-2,8-dihydro-3H-pyrido[2,3-d]pyr...) Show SMILES CC(C)CN1C=CC=C2C(=O)NC(N)N=C12 |c:5,t:7,14| Show InChI InChI=1S/C11H16N4O/c1-7(2)6-15-5-3-4-8-9(15)13-11(12)14-10(8)16/h3-5,7,11H,6,12H2,1-2H3,(H,14,16)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	2.20E+3	n/a	n/a	n/a	6.6	n/a
University of Sydney Curated by ChEMBL					Assay Description Apparent dissociation constant at pH 6.6 for human dihydrofolate reductase in the absence of cofactor NADPH				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038269 (2-Amino-8-isobutyl-5-methyl-2,8-dihydro-3H-pyrido[...) Show SMILES CC(C)CN1C=CC(C)=C2C(=O)NC(N)N=C12 |c:5,t:8,15| Show InChI InChI=1S/C12H18N4O/c1-7(2)6-16-5-4-8(3)9-10(16)14-12(13)15-11(9)17/h4-5,7,12H,6,13H2,1-3H3,(H,15,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Tested for the apparent dissociation constant for binding of compound to binary NADPH complex with human dihydrofolate reductase using equation 16				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038270 (2-Amino-8-isobutyl-2,8-dihydro-3H-pyrido[2,3-d]pyr...) Show SMILES CC(C)CN1C=CC=C2C(=O)NC(N)N=C12 |c:5,t:7,14| Show InChI InChI=1S/C11H16N4O/c1-7(2)6-15-5-3-4-8-9(15)13-11(12)14-10(8)16/h3-5,7,11H,6,12H2,1-2H3,(H,14,16)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	2.20E+3	n/a	n/a	n/a	6.6	n/a
University of Sydney Curated by ChEMBL					Assay Description Apparent dissociation constant at pH 6.6 for Chicken dihydrofolate reductase in the presence of cofactor NADPH				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038269 (2-Amino-8-isobutyl-5-methyl-2,8-dihydro-3H-pyrido[...) Show SMILES CC(C)CN1C=CC(C)=C2C(=O)NC(N)N=C12 |c:5,t:8,15| Show InChI InChI=1S/C12H18N4O/c1-7(2)6-16-5-4-8(3)9-10(16)14-12(13)15-11(9)17/h4-5,7,12H,6,13H2,1-3H3,(H,15,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	2.40E+3	n/a	n/a	n/a	6.6	n/a
University of Sydney Curated by ChEMBL					Assay Description Apparent dissociation constant at pH 6.6 for human dihydrofolate reductase in the absence of cofactor NADPH				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038270 (2-Amino-8-isobutyl-2,8-dihydro-3H-pyrido[2,3-d]pyr...) Show SMILES CC(C)CN1C=CC=C2C(=O)NC(N)N=C12 |c:5,t:7,14| Show InChI InChI=1S/C11H16N4O/c1-7(2)6-15-5-3-4-8-9(15)13-11(12)14-10(8)16/h3-5,7,11H,6,12H2,1-2H3,(H,14,16)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	2.50E+3	n/a	n/a	n/a	6.6	n/a
University of Sydney Curated by ChEMBL					Assay Description Apparent dissociation constant at pH 6.6 for Chicken dihydrofolate reductase in the absence of cofactor NADPH				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038269 (2-Amino-8-isobutyl-5-methyl-2,8-dihydro-3H-pyrido[...) Show SMILES CC(C)CN1C=CC(C)=C2C(=O)NC(N)N=C12 |c:5,t:8,15| Show InChI InChI=1S/C12H18N4O/c1-7(2)6-16-5-4-8(3)9-10(16)14-12(13)15-11(9)17/h4-5,7,12H,6,13H2,1-3H3,(H,15,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Tested for the apparent dissociation constant for binding of compound to binary NADPH complex with human dihydrofolate reductase using equations 11 a...				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038264 (2-Amino-7-methyl-8-propyl-2,8-dihydro-3H-pyrido[2,...) Show SMILES CCCN1C(C)=CC=C2C(=O)NC(N)N=C12 |c:5,t:7,14| Show InChI InChI=1S/C11H16N4O/c1-3-6-15-7(2)4-5-8-9(15)13-11(12)14-10(8)16/h4-5,11H,3,6,12H2,1-2H3,(H,14,16)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Tested for the apparent dissociation constant for binding of compound to binary NADPH complex with human dihydrofolate reductase using equation 11				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038264 (2-Amino-7-methyl-8-propyl-2,8-dihydro-3H-pyrido[2,...) Show SMILES CCCN1C(C)=CC=C2C(=O)NC(N)N=C12 |c:5,t:7,14| Show InChI InChI=1S/C11H16N4O/c1-3-6-15-7(2)4-5-8-9(15)13-11(12)14-10(8)16/h4-5,11H,3,6,12H2,1-2H3,(H,14,16)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Tested for the apparent dissociation constant for binding of compound to binary NADPH complex with human dihydrofolate reductase using equation 16				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038273 (2-Amino-7,8-dimethyl-2,8-dihydro-3H-pyrido[2,3-d]p...) Show SMILES CN1C(C)=CC=C2C(=O)NC(N)N=C12 |c:3,t:5,12| Show InChI InChI=1S/C9H12N4O/c1-5-3-4-6-7(13(5)2)11-9(10)12-8(6)14/h3-4,9H,10H2,1-2H3,(H,12,14)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	2.90E+3	n/a	n/a	n/a	6.6	n/a
University of Sydney Curated by ChEMBL					Assay Description Apparent dissociation constant at pH 6.6 for human dihydrofolate reductase in the presence of cofactor NADPH				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038269 (2-Amino-8-isobutyl-5-methyl-2,8-dihydro-3H-pyrido[...) Show SMILES CC(C)CN1C=CC(C)=C2C(=O)NC(N)N=C12 |c:5,t:8,15| Show InChI InChI=1S/C12H18N4O/c1-7(2)6-16-5-4-8(3)9-10(16)14-12(13)15-11(9)17/h4-5,7,12H,6,13H2,1-3H3,(H,15,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Tested for the apparent dissociation constant for binding of compound to binary NADPH complex with human dihydrofolate reductase using equation 11				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038272 (2-Amino-5-methyl-8-(3-methyl-butyl)-2,8-dihydro-3H...) Show SMILES CC(C)CCN1C=CC(C)=C2C(=O)NC(N)N=C12 |c:6,t:9,16| Show InChI InChI=1S/C13H20N4O/c1-8(2)4-6-17-7-5-9(3)10-11(17)15-13(14)16-12(10)18/h5,7-8,13H,4,6,14H2,1-3H3,(H,16,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	3.30E+3	n/a	n/a	n/a	6.6	n/a
University of Sydney Curated by ChEMBL					Assay Description Apparent dissociation constant at pH 6.6 for Chicken dihydrofolate reductase in the absence of cofactor NADPH				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038264 (2-Amino-7-methyl-8-propyl-2,8-dihydro-3H-pyrido[2,...) Show SMILES CCCN1C(C)=CC=C2C(=O)NC(N)N=C12 |c:5,t:7,14| Show InChI InChI=1S/C11H16N4O/c1-3-6-15-7(2)4-5-8-9(15)13-11(12)14-10(8)16/h4-5,11H,3,6,12H2,1-2H3,(H,14,16)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	3.40E+3	n/a	n/a	n/a	6.6	n/a
University of Sydney Curated by ChEMBL					Assay Description Apparent dissociation constant at pH 6.6 for Chicken dihydrofolate reductase in the absence of cofactor NADPH				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038264 (2-Amino-7-methyl-8-propyl-2,8-dihydro-3H-pyrido[2,...) Show SMILES CCCN1C(C)=CC=C2C(=O)NC(N)N=C12 |c:5,t:7,14| Show InChI InChI=1S/C11H16N4O/c1-3-6-15-7(2)4-5-8-9(15)13-11(12)14-10(8)16/h4-5,11H,3,6,12H2,1-2H3,(H,14,16)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	3.40E+3	n/a	n/a	n/a	6.6	n/a
University of Sydney Curated by ChEMBL					Assay Description Apparent dissociation constant at pH 6.6 for human dihydrofolate reductase in the absence of cofactor NADPH				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038269 (2-Amino-8-isobutyl-5-methyl-2,8-dihydro-3H-pyrido[...) Show SMILES CC(C)CN1C=CC(C)=C2C(=O)NC(N)N=C12 |c:5,t:8,15| Show InChI InChI=1S/C12H18N4O/c1-7(2)6-16-5-4-8(3)9-10(16)14-12(13)15-11(9)17/h4-5,7,12H,6,13H2,1-3H3,(H,15,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	3.50E+3	n/a	n/a	n/a	6.6	n/a
University of Sydney Curated by ChEMBL					Assay Description Apparent dissociation constant at pH 6.6 for Chicken dihydrofolate reductase in the absence of cofactor NADPH				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038268 (2-Amino-8-benzyl-2,8-dihydro-3H-pyrido[2,3-d]pyrim...) Show SMILES NC1NC(=O)C2=CC=CN(Cc3ccccc3)C2=N1 |c:7,19,t:5| Show InChI InChI=1S/C14H14N4O/c15-14-16-12-11(13(19)17-14)7-4-8-18(12)9-10-5-2-1-3-6-10/h1-8,14H,9,15H2,(H,17,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	3.70E+3	n/a	n/a	n/a	6.6	n/a
University of Sydney Curated by ChEMBL					Assay Description Apparent dissociation constant at pH 6.6 for Chicken dihydrofolate reductase in the absence of cofactor NADPH				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038263 (2-Amino-8-propyl-2,8-dihydro-3H-pyrido[2,3-d]pyrim...) Show SMILES CCCN1C=CC=C2C(=O)NC(N)N=C12 |c:4,t:6,13| Show InChI InChI=1S/C10H14N4O/c1-2-5-14-6-3-4-7-8(14)12-10(11)13-9(7)15/h3-4,6,10H,2,5,11H2,1H3,(H,13,15)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	4.00E+3	n/a	n/a	n/a	6.6	n/a
University of Sydney Curated by ChEMBL					Assay Description Apparent dissociation constant at pH 6.6 for human dihydrofolate reductase in the presence of cofactor NADPH				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038272 (2-Amino-5-methyl-8-(3-methyl-butyl)-2,8-dihydro-3H...) Show SMILES CC(C)CCN1C=CC(C)=C2C(=O)NC(N)N=C12 |c:6,t:9,16| Show InChI InChI=1S/C13H20N4O/c1-8(2)4-6-17-7-5-9(3)10-11(17)15-13(14)16-12(10)18/h5,7-8,13H,4,6,14H2,1-3H3,(H,16,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	4.50E+3	n/a	n/a	n/a	6.6	n/a
University of Sydney Curated by ChEMBL					Assay Description Apparent dissociation constant at pH 6.6 for Chicken dihydrofolate reductase in the presence of cofactor NADPH				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038274 (2-Amino-6-methyl-8-propyl-2,8-dihydro-3H-pyrido[2,...) Show SMILES CCCN1C=C(C)C=C2C(=O)NC(N)N=C12 |t:4,7,14| Show InChI InChI=1S/C11H16N4O/c1-3-4-15-6-7(2)5-8-9(15)13-11(12)14-10(8)16/h5-6,11H,3-4,12H2,1-2H3,(H,14,16)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	4.60E+3	n/a	n/a	n/a	6.6	n/a
University of Sydney Curated by ChEMBL					Assay Description Apparent dissociation constant at pH 6.6 for human dihydrofolate reductase in the presence of cofactor NADPH				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038262 (2-Amino-5,8-dimethyl-2,8-dihydro-3H-pyrido[2,3-d]p...) Show SMILES CN1C=CC(C)=C2C(=O)NC(N)N=C12 |c:2,t:5,12| Show InChI InChI=1S/C9H12N4O/c1-5-3-4-13(2)7-6(5)8(14)12-9(10)11-7/h3-4,9H,10H2,1-2H3,(H,12,14)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	5.10E+3	n/a	n/a	n/a	6.6	n/a
University of Sydney Curated by ChEMBL					Assay Description Apparent dissociation constant at pH 6.6 for human dihydrofolate reductase in the presence of cofactor NADPH				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038261 (2-Amino-5-methyl-8-propyl-2,8-dihydro-3H-pyrido[2,...) Show SMILES CCCN1C=CC(C)=C2C(=O)NC(N)N=C12 |c:4,t:7,14| Show InChI InChI=1S/C11H16N4O/c1-3-5-15-6-4-7(2)8-9(15)13-11(12)14-10(8)16/h4,6,11H,3,5,12H2,1-2H3,(H,14,16)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	5.50E+3	n/a	n/a	n/a	6.6	n/a
University of Sydney Curated by ChEMBL					Assay Description Apparent dissociation constant at pH 6.6 for Chicken dihydrofolate reductase in the presence of cofactor NADPH				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038263 (2-Amino-8-propyl-2,8-dihydro-3H-pyrido[2,3-d]pyrim...) Show SMILES CCCN1C=CC=C2C(=O)NC(N)N=C12 |c:4,t:6,13| Show InChI InChI=1S/C10H14N4O/c1-2-5-14-6-3-4-7-8(14)12-10(11)13-9(7)15/h3-4,6,10H,2,5,11H2,1H3,(H,13,15)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	5.80E+3	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Tested for the apparent dissociation constant for binding of compound to binary NADPH complex with human dihydrofolate reductase using equations 11 a...				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair

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