Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase ABL1 [T315I] (Homo sapiens (Human)) | BDBM124970 (US8765747, 2) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | US Patent | n/a | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute, Inc. US Patent | Assay Description KINOMEscan (Ambit Biosciences, San Diego, Calif.), a high-throughput method for screening small molecular agents against a large panel of human kinas... | US Patent US8765747 (2014) BindingDB Entry DOI: 10.7270/Q2VX0F6R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [T315I] (Homo sapiens (Human)) | BDBM31085 (1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluorom...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | n/a | 2.30 | n/a | n/a | n/a | 7.4 | 25 |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [T315I] (Homo sapiens (Human)) | BDBM13534 (CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB PCBioAssay | n/a | n/a | n/a | 6.30 | n/a | n/a | n/a | 7.4 | 25 |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase ABL1 [T315I] (Homo sapiens (Human)) | BDBM31096 (CHEMBL290084 | Staurosporine | cid_451705) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 27 | n/a | n/a | n/a | 7.4 | 25 |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [T315I] (Homo sapiens (Human)) | BDBM13533 (1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 42 | n/a | n/a | n/a | 7.4 | 25 |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [T315I] (Homo sapiens (Human)) | BDBM6866 (1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 68 | n/a | n/a | n/a | 7.4 | 25 |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [T315I] (Homo sapiens (Human)) | BDBM21 (CHEMBL24828 | N-(4-bromo-2-fluorophenyl)-6-methoxy...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Similars | PCBioAssay | n/a | n/a | n/a | 78 | n/a | n/a | n/a | 7.4 | 25 |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [T315I] (Homo sapiens (Human)) | BDBM4814 (CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 140 | n/a | n/a | n/a | 7.4 | 25 |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [T315I] (Homo sapiens (Human)) | BDBM16673 (4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 160 | n/a | n/a | n/a | 7.4 | 25 |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [T315I] (Homo sapiens (Human)) | BDBM5446 (CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 190 | n/a | n/a | n/a | 7.4 | 25 |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [T315I] (Homo sapiens (Human)) | BDBM31095 (5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 260 | n/a | n/a | n/a | 7.4 | 25 |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [T315I] (Homo sapiens (Human)) | BDBM31093 (4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-py...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 450 | n/a | n/a | n/a | 7.4 | 25 |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [T315I] (Homo sapiens (Human)) | BDBM4779 (CHEMBL31965 | CHEMBL545315 | CI-1033 | Canertinib ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 550 | n/a | n/a | n/a | 7.4 | 25 |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [T315I] (Homo sapiens (Human)) | BDBM13216 (BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB PCBioAssay | n/a | n/a | n/a | 590 | n/a | n/a | n/a | 7.4 | 25 |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase ABL1 [T315I] (Homo sapiens (Human)) | BDBM25118 ((3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 630 | n/a | n/a | n/a | 7.4 | 25 |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [T315I] (Homo sapiens (Human)) | BDBM31090 ((E)-N-[4-(3-chloro-4-fluoro-anilino)-3-cyano-7-eth...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 860 | n/a | n/a | n/a | 7.4 | 25 |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [T315I] (Homo sapiens (Human)) | BDBM21079 (1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 1.70E+3 | n/a | n/a | n/a | 7.4 | 25 |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [T315I] (Homo sapiens (Human)) | BDBM31088 (1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-y...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | 7.4 | 25 |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [T315I] (Homo sapiens (Human)) | BDBM26300 (2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}qu...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 2.80E+3 | n/a | n/a | n/a | 7.4 | 25 |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [T315I] (Homo sapiens (Human)) | BDBM31094 (PKC-412 | cid_24202429) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 3.20E+3 | n/a | n/a | n/a | 7.4 | 25 |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [T315I] (Homo sapiens (Human)) | BDBM26474 (5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 3.40E+3 | n/a | n/a | n/a | 7.4 | 25 |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH | |||||||||||
More data for this Ligand-Target Pair |