Compile Data Set for Download or QSAR

Found 7 hits of ic50 for UniProtKB: P32305   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 1A/1B/1D/1F/2A/2B/2C/3A/3B/4/5A/5B/6/7 (Rattus norvegicus-Rattus norvegicus (rat)-RAT-Ratt...)	BDBM50025223 (CHEMBL343529) Show SMILES COc1cccc2[nH]cc(CCN)c12 Show InChI InChI=1S/C11H14N2O/c1-14-10-4-2-3-9-11(10)8(5-6-12)7-13-9/h2-4,7,13H,5-6,12H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro inhibition of Angiotensin I converting enzyme				J Med Chem 27: 41-5 (1984) BindingDB Entry DOI: 10.7270/Q2F76BJN
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Rattus norvegicus (rat))	BDBM50060429 ((R)-2-(4-Fluoro-phenyl)-2-{1-[3-(5-[1,2,4]triazol-...) Show SMILES OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(cc23)-n2cnnc2)CC1)c1ccc(F)cc1 Show InChI InChI=1S/C26H31FN6O/c27-21-5-3-19(4-6-21)26(16-34)31-22-9-12-32(13-10-22)11-1-2-20-15-28-25-8-7-23(14-24(20)25)33-17-29-30-18-33/h3-8,14-15,17-18,22,26,28,31,34H,1-2,9-13,16H2/t26-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	540	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Compound was tested for the displacement of [3H]-5-HT binding to cloned rat 5-hydroxytryptamine 7 receptor stably expressed in CHO cells				J Med Chem 42: 4981-5001 (2000) BindingDB Entry DOI: 10.7270/Q20P0Z77
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A/1B/1D/1F/2A/2B/2C/3A/3B/4/5A/5B/6/7 (Rattus norvegicus-Rattus norvegicus (rat)-RAT-Ratt...)	BDBM50028124 (2-(6-Methoxy-1H-indol-3-yl)-ethylamine | 2-(6-meth...) Show SMILES COc1ccc2c(CCN)c[nH]c2c1 Show InChI InChI=1S/C11H14N2O/c1-14-9-2-3-10-8(4-5-12)7-13-11(10)6-9/h2-3,6-7,13H,4-5,12H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	630	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro inhibition of Angiotensin I converting enzyme				J Med Chem 27: 41-5 (1984) BindingDB Entry DOI: 10.7270/Q2F76BJN
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A/1B/1D/1F/2A/2B/2C/3A/3B/4/5A/5B/6/7 (Rattus norvegicus-Rattus norvegicus (rat)-RAT-Ratt...)	BDBM50001859 ((buspirone) 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)...) Show SMILES O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 Show InChI InChI=1S/C21H31N5O2/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9H,1-4,6-7,10-17H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity at serotonin 5-HT1-type site receptor in rat cortex by displacing [3H]5-HT				J Med Chem 29: 1476-82 (1986) BindingDB Entry DOI: 10.7270/Q2319WGB
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Rattus norvegicus (rat))	BDBM50151982 (5-{4-[4-(5-Cyano-1H-indol-3-yl)-butyl]-piperazin-1...) Show SMILES NC(=O)c1cc2cc(ccc2o1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1 Show InChI InChI=1S/C26H27N5O2/c27-16-18-4-6-23-22(13-18)19(17-29-23)3-1-2-8-30-9-11-31(12-10-30)21-5-7-24-20(14-21)15-25(33-24)26(28)32/h4-7,13-15,17,29H,1-3,8-12H2,(H2,28,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck KGaA Curated by ChEMBL					Assay Description Inhibition of rat hydroxytryptamine 7 receptor				J Med Chem 47: 4684-92 (2004) Article DOI: 10.1021/jm040793q BindingDB Entry DOI: 10.7270/Q2513XPS
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Rattus norvegicus (rat))	BDBM234387 (10-(2-N,N-Dimethylaminoethoxy)-5-Thia-4-b-azainden...) Show SMILES CN(C)CCOc1c2-c3ccccc3S(=O)(=O)n2c2ccccc12 Show InChI InChI=1S/C18H18N2O3S/c1-19(2)11-12-23-18-13-7-3-5-9-15(13)20-17(18)14-8-4-6-10-16(14)24(20,21)22/h3-10H,11-12H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Suven Life Sciences Ltd					Assay Description CHO cells were transfected with an expression vector encoding rat 5-HT7 gene and CRE-Luc reporter system. Colonies were isolated and screened with 10...				J Enzyme Inhib Med Chem 26: 341-9 (2011) Article DOI: 10.3109/14756366.2010.510471 BindingDB Entry DOI: 10.7270/Q2WW7GHT
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Rattus norvegicus (rat))	BDBM234388 (3-Chloro-10-(2-N,N-Dimethylaminoethoxy)-5-Thia-4-b...) Show SMILES CN(C)CCOc1c2-c3ccccc3S(=O)(=O)n2c2cc(Cl)ccc12 Show InChI InChI=1S/C18H17ClN2O3S/c1-20(2)9-10-24-18-13-8-7-12(19)11-15(13)21-17(18)14-5-3-4-6-16(14)25(21,22)23/h3-8,11H,9-10H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Suven Life Sciences Ltd					Assay Description CHO cells were transfected with an expression vector encoding rat 5-HT7 gene and CRE-Luc reporter system. Colonies were isolated and screened with 10...				J Enzyme Inhib Med Chem 26: 341-9 (2011) Article DOI: 10.3109/14756366.2010.510471 BindingDB Entry DOI: 10.7270/Q2WW7GHT
					More data for this Ligand-Target Pair