BDBM50028124 2-(6-Methoxy-1H-indol-3-yl)-ethylamine::2-(6-methoxy-1H-indol-3-yl)ethanamine::6-MeOT::CHEMBL337825

SMILES: COc1ccc2c(CCN)c[nH]c2c1

InChI Key: InChIKey=VOCGEKMEZOPDFP-UHFFFAOYSA-N

Data: 2 KI  2 IC50  4 EC50

PDB links: 2 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50028124   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
HTR7 (GUINEA PIG)	BDBM50028124 (2-(6-Methoxy-1H-indol-3-yl)-ethylamine | 2-(6-meth...) Show SMILES COc1ccc2c(CCN)c[nH]c2c1 Show InChI InChI=1S/C11H14N2O/c1-14-9-2-3-10-8(4-5-12)7-13-11(10)6-9/h2-3,6-7,13H,4-5,12H2,1H3	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	36.3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Discovery Research Curated by PDSP Ki Database									Br J Pharmacol 115: 107-16 (1995) Article DOI: 10.1111/j.1476-5381.1995.tb16327.x BindingDB Entry DOI: 10.7270/Q2610XTR
					More data for this Ligand-Target Pair
HTR7 (GUINEA PIG)	BDBM50028124 (2-(6-Methoxy-1H-indol-3-yl)-ethylamine | 2-(6-meth...) Show SMILES COc1ccc2c(CCN)c[nH]c2c1 Show InChI InChI=1S/C11H14N2O/c1-14-9-2-3-10-8(4-5-12)7-13-11(10)6-9/h2-3,6-7,13H,4-5,12H2,1H3	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	363	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Discovery Research Curated by PDSP Ki Database									Br J Pharmacol 115: 107-16 (1995) Article DOI: 10.1111/j.1476-5381.1995.tb16327.x BindingDB Entry DOI: 10.7270/Q2610XTR
					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM50028124 (2-(6-Methoxy-1H-indol-3-yl)-ethylamine | 2-(6-meth...) Show SMILES COc1ccc2c(CCN)c[nH]c2c1 Show InChI InChI=1S/C11H14N2O/c1-14-9-2-3-10-8(4-5-12)7-13-11(10)6-9/h2-3,6-7,13H,4-5,12H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	113	n/a	n/a	n/a	n/a
Research Triangle Institute Curated by ChEMBL					Assay Description Induction of DAT-mediated dopamine release in rat brain synaptosomes by [3H]DA release assay				Bioorg Med Chem Lett 24: 4754-8 (2014) Article DOI: 10.1016/j.bmcl.2014.07.062 BindingDB Entry DOI: 10.7270/Q2416ZNK
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50028124 (2-(6-Methoxy-1H-indol-3-yl)-ethylamine | 2-(6-meth...) Show SMILES COc1ccc2c(CCN)c[nH]c2c1 Show InChI InChI=1S/C11H14N2O/c1-14-9-2-3-10-8(4-5-12)7-13-11(10)6-9/h2-3,6-7,13H,4-5,12H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	2.44E+3	n/a	n/a	n/a	n/a
Research Triangle Institute Curated by ChEMBL					Assay Description Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay				Bioorg Med Chem Lett 24: 4754-8 (2014) Article DOI: 10.1016/j.bmcl.2014.07.062 BindingDB Entry DOI: 10.7270/Q2416ZNK
					More data for this Ligand-Target Pair
Serotonin (5-HT) receptor (Rattus norvegicus-Rattus norvegicus (rat)-RAT-Ratt...)	BDBM50028124 (2-(6-Methoxy-1H-indol-3-yl)-ethylamine | 2-(6-meth...) Show SMILES COc1ccc2c(CCN)c[nH]c2c1 Show InChI InChI=1S/C11H14N2O/c1-14-9-2-3-10-8(4-5-12)7-13-11(10)6-9/h2-3,6-7,13H,4-5,12H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	630	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro inhibition of Angiotensin I converting enzyme				J Med Chem 27: 41-5 (1984) BindingDB Entry DOI: 10.7270/Q2F76BJN
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily B member 2 (Homo sapiens (Human))	BDBM50028124 (2-(6-Methoxy-1H-indol-3-yl)-ethylamine | 2-(6-meth...) Show SMILES COc1ccc2c(CCN)c[nH]c2c1 Show InChI InChI=1S/C11H14N2O/c1-14-9-2-3-10-8(4-5-12)7-13-11(10)6-9/h2-3,6-7,13H,4-5,12H2,1H3	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.91E+12	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of voltage-gated potassium channel				J Med Chem 50: 83-93 (2007) Article DOI: 10.1021/jm060414o BindingDB Entry DOI: 10.7270/Q20R9S5C
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM50028124 (2-(6-Methoxy-1H-indol-3-yl)-ethylamine | 2-(6-meth...) Show SMILES COc1ccc2c(CCN)c[nH]c2c1 Show InChI InChI=1S/C11H14N2O/c1-14-9-2-3-10-8(4-5-12)7-13-11(10)6-9/h2-3,6-7,13H,4-5,12H2,1H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	54	n/a	n/a	n/a	n/a
Research Triangle Institute Curated by ChEMBL					Assay Description Induction of 5-HTT-mediated 5-HT release in rat brain synaptosomes by [3H]5-HT release assay				Bioorg Med Chem Lett 24: 4754-8 (2014) Article DOI: 10.1016/j.bmcl.2014.07.062 BindingDB Entry DOI: 10.7270/Q2416ZNK
					More data for this Ligand-Target Pair
Norepinephrine Monoamine transporters (Rattus norvegicus)	BDBM50028124 (2-(6-Methoxy-1H-indol-3-yl)-ethylamine | 2-(6-meth...) Show SMILES COc1ccc2c(CCN)c[nH]c2c1 Show InChI InChI=1S/C11H14N2O/c1-14-9-2-3-10-8(4-5-12)7-13-11(10)6-9/h2-3,6-7,13H,4-5,12H2,1H3	Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	465	n/a	n/a	n/a	n/a
Research Triangle Institute Curated by ChEMBL					Assay Description Induction of NET-mediated norepinephrine release in rat brain synaptosomes by [3H]NE release assay				Bioorg Med Chem Lett 24: 4754-8 (2014) Article DOI: 10.1016/j.bmcl.2014.07.062 BindingDB Entry DOI: 10.7270/Q2416ZNK
					More data for this Ligand-Target Pair