Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DNA gyrase subunit A/B (Bacillus subtilis) | BDBM21689 (1-cyclopropyl-6,8-difluoro-7-(3-methylpiperazin-1-...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5.60E+3 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Microbiotix | Assay Description The 50% inhibitory concentration (IC50) is defined as the concentration of compound that inhibits the decatenation of kinetoplast DNA by 50%. | Antimicrob Agents Chemother 51: 119-27 (2007) Article DOI: 10.1128/AAC.01311-05 BindingDB Entry DOI: 10.7270/Q2988599 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA gyrase subunit A/B (Bacillus subtilis) | BDBM21690 (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank Article PubMed | n/a | n/a | 6.30E+3 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Microbiotix | Assay Description The 50% inhibitory concentration (IC50) is defined as the concentration of compound that inhibits the decatenation of kinetoplast DNA by 50%. | Antimicrob Agents Chemother 51: 119-27 (2007) Article DOI: 10.1128/AAC.01311-05 BindingDB Entry DOI: 10.7270/Q2988599 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA gyrase subunit A/B (Bacillus subtilis) | BDBM21688 (1-cyclopropyl-7-[4-(4-{4-[(3-ethyl-4-methylphenyl)...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.10E+4 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Microbiotix | Assay Description The 50% inhibitory concentration (IC50) is defined as the concentration of compound that inhibits the decatenation of kinetoplast DNA by 50%. | Antimicrob Agents Chemother 51: 119-27 (2007) Article DOI: 10.1128/AAC.01311-05 BindingDB Entry DOI: 10.7270/Q2988599 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA gyrase subunit A/B (Bacillus subtilis) | BDBM21691 (1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridi...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.49E+5 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Microbiotix | Assay Description The 50% inhibitory concentration (IC50) is defined as the concentration of compound that inhibits the decatenation of kinetoplast DNA by 50%. | Antimicrob Agents Chemother 51: 119-27 (2007) Article DOI: 10.1128/AAC.01311-05 BindingDB Entry DOI: 10.7270/Q2988599 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA gyrase subunit A/B (Bacillus subtilis) | BDBM21686 (3-(4-hydroxybutyl)-6-(3-ethyl-4-methylanilino)urac...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >5.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Microbiotix | Assay Description The 50% inhibitory concentration (IC50) is defined as the concentration of compound that inhibits the decatenation of kinetoplast DNA by 50%. | Antimicrob Agents Chemother 51: 119-27 (2007) Article DOI: 10.1128/AAC.01311-05 BindingDB Entry DOI: 10.7270/Q2988599 | |||||||||||
More data for this Ligand-Target Pair |