Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Presenilin-1 (Homo sapiens (Human)) | BDBM50521243 (CHEMBL4532868) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.00590 | n/a | n/a | n/a | n/a |
Temple University School of Pharmacy Curated by ChEMBL | Assay Description Inhibition of gamma-secretase (unknown origin) assessed as decrease in amyloid beta-42 secretion by cell based AlphaLisa assay | ACS Med Chem Lett 10: 6-7 (2019) Article DOI: 10.1021/acsmedchemlett.8b00544 BindingDB Entry DOI: 10.7270/Q2JW8J8S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50521238 (CHEMBL4589937) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.00640 | n/a | n/a | n/a | n/a |
Temple University School of Pharmacy Curated by ChEMBL | Assay Description Inhibition of gamma-secretase (unknown origin) assessed as decrease in amyloid beta-42 secretion by cell based AlphaLisa assay | ACS Med Chem Lett 10: 6-7 (2019) Article DOI: 10.1021/acsmedchemlett.8b00544 BindingDB Entry DOI: 10.7270/Q2JW8J8S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50521241 (CHEMBL4456936) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.00920 | n/a | n/a | n/a | n/a |
Temple University School of Pharmacy Curated by ChEMBL | Assay Description Inhibition of gamma-secretase (unknown origin) assessed as decrease in amyloid beta-42 secretion by cell based AlphaLisa assay | ACS Med Chem Lett 10: 6-7 (2019) Article DOI: 10.1021/acsmedchemlett.8b00544 BindingDB Entry DOI: 10.7270/Q2JW8J8S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50521242 (CHEMBL4456488) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.0103 | n/a | n/a | n/a | n/a |
Temple University School of Pharmacy Curated by ChEMBL | Assay Description Inhibition of gamma-secretase (unknown origin) assessed as decrease in amyloid beta-42 secretion by cell based AlphaLisa assay | ACS Med Chem Lett 10: 6-7 (2019) Article DOI: 10.1021/acsmedchemlett.8b00544 BindingDB Entry DOI: 10.7270/Q2JW8J8S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50521239 (CHEMBL4443026) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.0114 | n/a | n/a | n/a | n/a |
Temple University School of Pharmacy Curated by ChEMBL | Assay Description Inhibition of gamma-secretase (unknown origin) assessed as decrease in amyloid beta-42 secretion by cell based AlphaLisa assay | ACS Med Chem Lett 10: 6-7 (2019) Article DOI: 10.1021/acsmedchemlett.8b00544 BindingDB Entry DOI: 10.7270/Q2JW8J8S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50521244 (CHEMBL4525398) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.0117 | n/a | n/a | n/a | n/a |
Temple University School of Pharmacy Curated by ChEMBL | Assay Description Inhibition of gamma-secretase (unknown origin) assessed as decrease in amyloid beta-42 secretion by cell based AlphaLisa assay | ACS Med Chem Lett 10: 6-7 (2019) Article DOI: 10.1021/acsmedchemlett.8b00544 BindingDB Entry DOI: 10.7270/Q2JW8J8S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50521245 (CHEMBL4547187) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.0130 | n/a | n/a | n/a | n/a |
Temple University School of Pharmacy Curated by ChEMBL | Assay Description Inhibition of gamma-secretase (unknown origin) assessed as decrease in amyloid beta-42 secretion by cell based AlphaLisa assay | ACS Med Chem Lett 10: 6-7 (2019) Article DOI: 10.1021/acsmedchemlett.8b00544 BindingDB Entry DOI: 10.7270/Q2JW8J8S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50521240 (CHEMBL4535601) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.0139 | n/a | n/a | n/a | n/a |
Temple University School of Pharmacy Curated by ChEMBL | Assay Description Inhibition of gamma-secretase (unknown origin) assessed as decrease in amyloid beta-42 secretion by cell based AlphaLisa assay | ACS Med Chem Lett 10: 6-7 (2019) Article DOI: 10.1021/acsmedchemlett.8b00544 BindingDB Entry DOI: 10.7270/Q2JW8J8S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50241259 ((2S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetam...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.114 | n/a | n/a | n/a | n/a |
Emmy Noether Research Group Curated by ChEMBL | Assay Description Reduction of human wild type PS1-induced amyloid beta40 level in CHO cells overexpressing human APP751 after 24 hrs by liquid phase electrochemilumin... | J Biol Chem 282: 24504-13 (2007) Article DOI: 10.1074/jbc.M700618200 BindingDB Entry DOI: 10.7270/Q2M0456G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50241259 ((2S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetam...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.135 | n/a | n/a | n/a | n/a |
Emmy Noether Research Group Curated by ChEMBL | Assay Description Reduction of human wild type PS1-induced amyloid beta42 level in CHO cells overexpressing human APP751 after 24 hrs by liquid phase electrochemilumin... | J Biol Chem 282: 24504-13 (2007) Article DOI: 10.1074/jbc.M700618200 BindingDB Entry DOI: 10.7270/Q2M0456G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50577524 (CHEMBL4862666) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 5 | n/a | n/a | n/a | n/a |
TBA | Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50465355 (CHEMBL4285214 | US10669276, Example 1) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 5 | n/a | n/a | n/a | n/a |
Temple University School of Pharmacy Curated by ChEMBL | Assay Description Inhibition of gamma-secretase in human H4 cells harboring APP695 K595N/M596L swedish mutant after 24 hrs by AlphaLisa assay | ACS Med Chem Lett 9: 290-291 (2018) Article DOI: 10.1021/acsmedchemlett.8b00086 BindingDB Entry DOI: 10.7270/Q25B055X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50533417 (RO 4929097 | RO-4929097 | Rg 4733 | Rg-4733 | Ro49...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 5 | n/a | n/a | n/a | n/a |
Centre Hospitalier Universitaire Vaudois (CHUV) Curated by ChEMBL | Assay Description Inhibition of gamma secretase mediated Notch1 signaling in HEK293 cells expressing truncated human Notch1 by luciferase reporter gene assay | J Med Chem 59: 7719-37 (2016) Article DOI: 10.1021/acs.jmedchem.5b01516 BindingDB Entry DOI: 10.7270/Q2M048X4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50534353 (CHEMBL4578751) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 6 | n/a | n/a | n/a | n/a |
FORUM Pharmaceuticals Curated by ChEMBL | Assay Description Modulation of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 42 residues) production | J Med Chem 59: 7389-409 (2016) Article DOI: 10.1021/acs.jmedchem.5b01960 BindingDB Entry DOI: 10.7270/Q2B56P74 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50534359 (CHEMBL4439008) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 6 | n/a | n/a | n/a | n/a |
FORUM Pharmaceuticals Curated by ChEMBL | Assay Description Modulation of gamma-secretase in human SK-N-BE(2) cells expressing human APP695 assessed as reduction in amyloid beta 42 production incubated overnig... | J Med Chem 59: 7389-409 (2016) Article DOI: 10.1021/acs.jmedchem.5b01960 BindingDB Entry DOI: 10.7270/Q2B56P74 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50534360 (CHEMBL4538043) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 6 | n/a | n/a | n/a | n/a |
FORUM Pharmaceuticals Curated by ChEMBL | Assay Description Modulation of gamma-secretase in human SH-SY5Y cells expressing human APP751 assessed as reduction in amyloid beta 42 production after 16 to 18 hrs b... | J Med Chem 59: 7389-409 (2016) Article DOI: 10.1021/acs.jmedchem.5b01960 BindingDB Entry DOI: 10.7270/Q2B56P74 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50458163 (CHEMBL4209316) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 7 | n/a | n/a | n/a | n/a |
FORUM Pharmaceuticals Curated by ChEMBL | Assay Description Modulation of gamma-secretase (unknown origin) assessed as inhibition of amyloid beta 42 production | J Med Chem 59: 7389-409 (2016) Article DOI: 10.1021/acs.jmedchem.5b01960 BindingDB Entry DOI: 10.7270/Q2B56P74 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50465354 (CHEMBL4293045 | US10669276, Example 4) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 7 | n/a | n/a | n/a | n/a |
Temple University School of Pharmacy Curated by ChEMBL | Assay Description Inhibition of gamma-secretase in human H4 cells harboring APP695 K595N/M596L swedish mutant after 24 hrs by AlphaLisa assay | ACS Med Chem Lett 9: 290-291 (2018) Article DOI: 10.1021/acsmedchemlett.8b00086 BindingDB Entry DOI: 10.7270/Q25B055X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM193081 (US9193726, 69) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 8 | n/a | n/a | n/a | n/a |
FORUM Pharmaceuticals Curated by ChEMBL | Assay Description Modulation of gamma-secretase in CHO cells expressing human APP assessed as reduction in amyloid beta (1 to 42 residues) production after 24 hrs by E... | J Med Chem 59: 7389-409 (2016) Article DOI: 10.1021/acs.jmedchem.5b01960 BindingDB Entry DOI: 10.7270/Q2B56P74 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50465362 (CHEMBL4286544) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 8 | n/a | n/a | n/a | n/a |
Temple University School of Pharmacy Curated by ChEMBL | Assay Description Inhibition of gamma-secretase in human H4 cells harboring APP695 K595N/M596L swedish mutant after 24 hrs by AlphaLisa assay | ACS Med Chem Lett 9: 290-291 (2018) Article DOI: 10.1021/acsmedchemlett.8b00086 BindingDB Entry DOI: 10.7270/Q25B055X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50465357 (CHEMBL4283902 | US10669276, Example 25) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 8 | n/a | n/a | n/a | n/a |
Temple University School of Pharmacy Curated by ChEMBL | Assay Description Inhibition of gamma-secretase in human H4 cells harboring APP695 K595N/M596L swedish mutant after 24 hrs by AlphaLisa assay | ACS Med Chem Lett 9: 290-291 (2018) Article DOI: 10.1021/acsmedchemlett.8b00086 BindingDB Entry DOI: 10.7270/Q25B055X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50577511 (CHEMBL4864477) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 8 | n/a | n/a | n/a | n/a |
TBA | Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50577522 (CHEMBL4848087) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 8 | n/a | n/a | n/a | n/a |
TBA | Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50465360 (CHEMBL4294948 | US10669276, Example 28) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 8 | n/a | n/a | n/a | n/a |
Temple University School of Pharmacy Curated by ChEMBL | Assay Description Inhibition of gamma-secretase in human H4 cells harboring APP695 K595N/M596L swedish mutant after 24 hrs by AlphaLisa assay | ACS Med Chem Lett 9: 290-291 (2018) Article DOI: 10.1021/acsmedchemlett.8b00086 BindingDB Entry DOI: 10.7270/Q25B055X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM193021 (US9193726, 9) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 9 | n/a | n/a | n/a | n/a |
FORUM Pharmaceuticals Curated by ChEMBL | Assay Description Modulation of gamma-secretase in CHO cells expressing human APP assessed as reduction in amyloid beta (1 to 42 residues) production after 24 hrs by E... | J Med Chem 59: 7389-409 (2016) Article DOI: 10.1021/acs.jmedchem.5b01960 BindingDB Entry DOI: 10.7270/Q2B56P74 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50577525 (CHEMBL4848062) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 9 | n/a | n/a | n/a | n/a |
TBA | Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50577518 (CHEMBL4855120) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a |
TBA | Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50577514 (CHEMBL4868749) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a |
TBA | Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50577508 (CHEMBL4848661) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a |
TBA | Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50577509 (CHEMBL4850647) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a |
TBA | Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50534358 (CHEMBL4435318) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a |
FORUM Pharmaceuticals Curated by ChEMBL | Assay Description Modulation of gamma-secretase in human SK-N-BE(2) cells expressing human APP695 assessed as reduction in amyloid beta 42 production incubated overnig... | J Med Chem 59: 7389-409 (2016) Article DOI: 10.1021/acs.jmedchem.5b01960 BindingDB Entry DOI: 10.7270/Q2B56P74 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50577501 (CHEMBL4851690) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a |
TBA | Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM28922 ((2S)-N-(5-chlorothiophen-2-yl)-4,4,4-trifluoro-1-h...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 12 | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1016/j.ejmech.2022.114169 BindingDB Entry DOI: 10.7270/Q2HD80PD | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50577513 (CHEMBL4865396) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 13 | n/a | n/a | n/a | n/a |
TBA | Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50465363 (CHEMBL4278310 | US10669276, Example 35) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 13 | n/a | n/a | n/a | n/a |
Temple University School of Pharmacy Curated by ChEMBL | Assay Description Inhibition of gamma-secretase in human H4 cells harboring APP695 K595N/M596L swedish mutant after 24 hrs by AlphaLisa assay | ACS Med Chem Lett 9: 290-291 (2018) Article DOI: 10.1021/acsmedchemlett.8b00086 BindingDB Entry DOI: 10.7270/Q25B055X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50577510 (CHEMBL4858970) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 13 | n/a | n/a | n/a | n/a |
TBA | Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50465077 (CHEMBL4282341) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 14 | n/a | n/a | n/a | n/a |
Temple University School of Pharmacy Curated by ChEMBL | Assay Description Inhibition of gamma-secretase (unknown origin) assessed as reduction in amyloid beta (1 to 42) production after 60 mins by cell based AlphaLisa assay | ACS Med Chem Lett 9: 165-166 (2018) Article DOI: 10.1021/acsmedchemlett.8b00043 BindingDB Entry DOI: 10.7270/Q20R9S3G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50465361 (CHEMBL4293005) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 14 | n/a | n/a | n/a | n/a |
Temple University School of Pharmacy Curated by ChEMBL | Assay Description Inhibition of gamma-secretase in human H4 cells harboring APP695 K595N/M596L swedish mutant after 24 hrs by AlphaLisa assay | ACS Med Chem Lett 9: 290-291 (2018) Article DOI: 10.1021/acsmedchemlett.8b00086 BindingDB Entry DOI: 10.7270/Q25B055X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50533417 (RO 4929097 | RO-4929097 | Rg 4733 | Rg-4733 | Ro49...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 14 | n/a | n/a | n/a | n/a |
Centre Hospitalier Universitaire Vaudois (CHUV) Curated by ChEMBL | Assay Description Inhibition of gamma secretase in HEK293 cells expressing APP695 assessed as reduction in amyloid beta (1 to 40 residues) by ELISA | J Med Chem 59: 7719-37 (2016) Article DOI: 10.1021/acs.jmedchem.5b01516 BindingDB Entry DOI: 10.7270/Q2M048X4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50534367 (CHEMBL4470238) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 14 | n/a | n/a | n/a | n/a |
FORUM Pharmaceuticals Curated by ChEMBL | Assay Description Modulation of gamma-secretase in human H4 cells expressing human APP751 assessed as reduction in amyloid beta 42 production after 16 to 18 hrs by san... | J Med Chem 59: 7389-409 (2016) Article DOI: 10.1021/acs.jmedchem.5b01960 BindingDB Entry DOI: 10.7270/Q2B56P74 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM193020 (US9193726, 8) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 14 | n/a | n/a | n/a | n/a |
FORUM Pharmaceuticals Curated by ChEMBL | Assay Description Modulation of gamma-secretase in CHO cells expressing human APP assessed as reduction in amyloid beta (1 to 42 residues) production after 24 hrs by E... | J Med Chem 59: 7389-409 (2016) Article DOI: 10.1021/acs.jmedchem.5b01960 BindingDB Entry DOI: 10.7270/Q2B56P74 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50577512 (CHEMBL4873343) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 14 | n/a | n/a | n/a | n/a |
TBA | Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50577523 (CHEMBL4869387) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 14 | n/a | n/a | n/a | n/a |
TBA | Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM28922 ((2S)-N-(5-chlorothiophen-2-yl)-4,4,4-trifluoro-1-h...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 15 | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1016/j.ejmech.2022.114169 BindingDB Entry DOI: 10.7270/Q2HD80PD | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50465358 (CHEMBL4284649 | US10669276, Example 31) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 15 | n/a | n/a | n/a | n/a |
Temple University School of Pharmacy Curated by ChEMBL | Assay Description Inhibition of gamma-secretase in human H4 cells harboring APP695 K595N/M596L swedish mutant after 24 hrs by AlphaLisa assay | ACS Med Chem Lett 9: 290-291 (2018) Article DOI: 10.1021/acsmedchemlett.8b00086 BindingDB Entry DOI: 10.7270/Q25B055X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50577521 (CHEMBL4851284) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 16 | n/a | n/a | n/a | n/a |
TBA | Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50534365 (CHEMBL4591885) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 16 | n/a | n/a | n/a | n/a |
FORUM Pharmaceuticals Curated by ChEMBL | Assay Description Modulation of gamma-secretase in human H4 cells expressing human APP751 assessed as reduction in amyloid beta 42 production after 16 to 18 hrs by san... | J Med Chem 59: 7389-409 (2016) Article DOI: 10.1021/acs.jmedchem.5b01960 BindingDB Entry DOI: 10.7270/Q2B56P74 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50534369 (E-2212 | E2212) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 17 | n/a | n/a | n/a | n/a |
FORUM Pharmaceuticals Curated by ChEMBL | Assay Description Modulation of human gamma-secretase assessed as inhibition of amyloid beta (1 to 42 residues) production by ELISA | J Med Chem 59: 7389-409 (2016) Article DOI: 10.1021/acs.jmedchem.5b01960 BindingDB Entry DOI: 10.7270/Q2B56P74 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50465076 (CHEMBL4290617) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 19 | n/a | n/a | n/a | n/a |
Temple University School of Pharmacy Curated by ChEMBL | Assay Description Inhibition of gamma-secretase (unknown origin) assessed as reduction in amyloid beta (1 to 42) production after 60 mins by cell based AlphaLisa assay | ACS Med Chem Lett 9: 165-166 (2018) Article DOI: 10.1021/acsmedchemlett.8b00043 BindingDB Entry DOI: 10.7270/Q20R9S3G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50577516 (CHEMBL4855162) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 19 | n/a | n/a | n/a | n/a |
TBA | Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR | |||||||||||
More data for this Ligand-Target Pair |
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