Found 3364 hits of ki data for polymerid = 3431 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50018051
(CHEMBL3289972)Show SMILES Fc1ccc(cc1Cl)S(=O)(=O)NCCCCN1CCN(CC1)c1noc2ccccc12 Show InChI InChI=1S/C21H24ClFN4O3S/c22-18-15-16(7-8-19(18)23)31(28,29)24-9-3-4-10-26-11-13-27(14-12-26)21-17-5-1-2-6-20(17)30-25-21/h1-2,5-8,15,24H,3-4,9-14H2 | PDB
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| 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adamed Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analy... |
J Med Chem 57: 4543-57 (2014)
Article DOI: 10.1021/jm401895u
BindingDB Entry DOI: 10.7270/Q2N29ZHX |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM555079
(US11339151, Example 55)Show SMILES CCN(CCCN1CCN(CC1)c1noc2cc(F)ccc12)S(=O)(=O)C(C)CO | PDB
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| 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Human 5-HT2A Receptor, Human 5-HT7 Receptor, and Human D2 Receptor: Binding affinity of the present compound for human 5-HT2A receptor, human 5-HT7 r... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2N019Q1 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM10755
(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2 | PDB
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| 0.130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur
Curated by ChEMBL
| Assay Description
Displacement of [3H]LSD from human 5HT7 receptor |
J Med Chem 54: 5320-34 (2011)
Article DOI: 10.1021/jm2006782
BindingDB Entry DOI: 10.7270/Q2RF5W11 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50305263
(2,8-Dimethyl-5-phenethyl-2,3,4,5-tetrahydro-1H-pyr...)Show InChI InChI=1S/C21H24N2/c1-16-8-9-20-18(14-16)19-15-22(2)12-11-21(19)23(20)13-10-17-6-4-3-5-7-17/h3-9,14H,10-13,15H2,1-2H3 | PDB
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| 0.153 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114464
BindingDB Entry DOI: 10.7270/Q2FB56XK |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50305263
(2,8-Dimethyl-5-phenethyl-2,3,4,5-tetrahydro-1H-pyr...)Show InChI InChI=1S/C21H24N2/c1-16-8-9-20-18(14-16)19-15-22(2)12-11-21(19)23(20)13-10-17-6-4-3-5-7-17/h3-9,14H,10-13,15H2,1-2H3 | PDB
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| 0.153 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Displacement of [3H]lysergic acid from 5-HT7 receptor (unknown origin) |
J Med Chem 61: 8475-8503 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01898
BindingDB Entry DOI: 10.7270/Q2V98BPM |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM10755
(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2 | PDB
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| 0.170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Newcastle
Curated by ChEMBL
| Assay Description
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation counting |
J Med Chem 60: 349-361 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01422
BindingDB Entry DOI: 10.7270/Q27M0B6T |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50590673
(CHEMBL5179460)Show SMILES Fc1ccccc1S(=O)(=O)N1CCC[C@@H]1CCCN1CCN(CC1)c1ccccn1 |r| | PDB
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TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00633
BindingDB Entry DOI: 10.7270/Q26M3BS8 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM21392
(3-(2-aminoethyl)-1H-indole-5-carboxamide | 5-CT | ...)Show InChI InChI=1S/C11H13N3O/c12-4-3-8-6-14-10-2-1-7(11(13)15)5-9(8)10/h1-2,5-6,14H,3-4,12H2,(H2,13,15) | PDB
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| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Bioscience
Curated by PDSP Ki Database
| |
Trends Pharmacol Sci 18: 104-7 (1997)
Article DOI: 10.1016/s0165-6147(97)01043-2
BindingDB Entry DOI: 10.7270/Q2BK19WB |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50018250
(CHEMBL3290016)Show SMILES Cc1c(sc2ccc(F)cc12)S(=O)(=O)NCCCCN1CCC(CC1)c1noc2cc(F)ccc12 Show InChI InChI=1S/C25H27F2N3O3S2/c1-16-21-14-18(26)5-7-23(21)34-25(16)35(31,32)28-10-2-3-11-30-12-8-17(9-13-30)24-20-6-4-19(27)15-22(20)33-29-24/h4-7,14-15,17,28H,2-3,8-13H2,1H3 | PDB
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| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adamed Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analy... |
J Med Chem 57: 4543-57 (2014)
Article DOI: 10.1021/jm401895u
BindingDB Entry DOI: 10.7270/Q2N29ZHX |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50150431
((S)-N2-(2-(4-fluorophenoxy)ethyl)-N4-(1-phenylethy...)Show InChI InChI=1S/C21H22FN3O/c1-16(17-5-3-2-4-6-17)25-19-11-12-23-21(15-19)24-13-14-26-20-9-7-18(22)8-10-20/h2-12,15-16H,13-14H2,1H3,(H2,23,24,25)/t16-/m0/s1 | PDB
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| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity against 5-Hydroxy tryptamine 7 receptor |
Bioorg Med Chem Lett 14: 4249-52 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.007
BindingDB Entry DOI: 10.7270/Q2BV7G34 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM21367
(6-{4-[2-(methylsulfanyl)phenyl]piperazin-1-yl}-N-(...)Show SMILES CSc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc23)CC1 Show InChI InChI=1S/C27H37N3OS/c1-32-26-15-7-6-14-25(26)30-20-18-29(19-21-30)17-8-2-3-16-27(31)28-24-13-9-11-22-10-4-5-12-23(22)24/h4-7,10,12,14-15,24H,2-3,8-9,11,13,16-21H2,1H3,(H,28,31) | PDB
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| 0.220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting |
Eur J Med Chem 78: 10-22 (2014)
Article DOI: 10.1016/j.ejmech.2014.03.005
BindingDB Entry DOI: 10.7270/Q2QN6899 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50590671
(CHEMBL5196234)Show SMILES Fc1ccccc1S(=O)(=O)N1CCC[C@@H]1CCCN1CCN(CC1)c1ccc(Cl)cc1 |r| | PDB
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TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00633
BindingDB Entry DOI: 10.7270/Q26M3BS8 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM21367
(6-{4-[2-(methylsulfanyl)phenyl]piperazin-1-yl}-N-(...)Show SMILES CSc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc23)CC1 Show InChI InChI=1S/C27H37N3OS/c1-32-26-15-7-6-14-25(26)30-20-18-29(19-21-30)17-8-2-3-16-27(31)28-24-13-9-11-22-10-4-5-12-23(22)24/h4-7,10,12,14-15,24H,2-3,8-9,11,13,16-21H2,1H3,(H,28,31) | PDB
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| 0.220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry |
Eur J Med Chem 85: 716-26 (2014)
Article DOI: 10.1016/j.ejmech.2014.08.023
BindingDB Entry DOI: 10.7270/Q2DZ09Z8 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM21367
(6-{4-[2-(methylsulfanyl)phenyl]piperazin-1-yl}-N-(...)Show SMILES CSc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc23)CC1 Show InChI InChI=1S/C27H37N3OS/c1-32-26-15-7-6-14-25(26)30-20-18-29(19-21-30)17-8-2-3-16-27(31)28-24-13-9-11-22-10-4-5-12-23(22)24/h4-7,10,12,14-15,24H,2-3,8-9,11,13,16-21H2,1H3,(H,28,31) | PDB
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| 0.220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50464861
(CHEMBL4291322)Show SMILES Fc1ccc2[nH]cc(CCN3CCN(CC3)c3ccccc3-c3ccccc3)c2c1 Show InChI InChI=1S/C26H26FN3/c27-22-10-11-25-24(18-22)21(19-28-25)12-13-29-14-16-30(17-15-29)26-9-5-4-8-23(26)20-6-2-1-3-7-20/h1-11,18-19,28H,12-17H2 | PDB
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| 0.260 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Pharmaceutical Industry
Curated by ChEMBL
| Assay Description
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting metho... |
Eur J Med Chem 144: 701-715 (2018)
Article DOI: 10.1016/j.ejmech.2017.12.063
BindingDB Entry DOI: 10.7270/Q26D5WP7 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50393371
(CHEMBL2159465)Show SMILES CC(C)c1ccccc1OCCN1CCC(CC1)NS(=O)(=O)c1ccc(F)cc1 Show InChI InChI=1S/C22H29FN2O3S/c1-17(2)21-5-3-4-6-22(21)28-16-15-25-13-11-19(12-14-25)24-29(26,27)20-9-7-18(23)8-10-20/h3-10,17,19,24H,11-16H2,1-2H3 | PDB
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| 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 56: 348-360 (2012)
Article DOI: 10.1016/j.ejmech.2012.07.043
BindingDB Entry DOI: 10.7270/Q28P61N6 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50150439
(CHEMBL182923 | N*2*-Phenethyl-N*4*-((S)-1-phenyl-e...)Show InChI InChI=1S/C21H23N3/c1-17(19-10-6-3-7-11-19)24-20-13-15-23-21(16-20)22-14-12-18-8-4-2-5-9-18/h2-11,13,15-17H,12,14H2,1H3,(H2,22,23,24)/t17-/m0/s1 | PDB
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| 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity against 5-Hydroxy tryptamine 7 receptor |
Bioorg Med Chem Lett 14: 4249-52 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.007
BindingDB Entry DOI: 10.7270/Q2BV7G34 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM21392
(3-(2-aminoethyl)-1H-indole-5-carboxamide | 5-CT | ...)Show InChI InChI=1S/C11H13N3O/c12-4-3-8-6-14-10-2-1-7(11(13)15)5-9(8)10/h1-2,5-6,14H,3-4,12H2,(H2,13,15) | PDB
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| 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Bari A. Moro
Curated by ChEMBL
| Assay Description
Displacement of [3H]-5-CT from human cloned 5HT7 receptor |
J Med Chem 55: 6375-80 (2012)
Article DOI: 10.1021/jm3003679
BindingDB Entry DOI: 10.7270/Q2N87BWQ |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50307501
((6S)-N,N-dipropyl-5,6,7,8-tetrahydro-1,1'-binaphth...)Show SMILES CCCN(CCC)[C@H]1CCc2c(C1)cccc2-c1cccc2ccccc12 |r| Show InChI InChI=1S/C26H31N/c1-3-17-27(18-4-2)22-15-16-24-21(19-22)11-8-14-26(24)25-13-7-10-20-9-5-6-12-23(20)25/h5-14,22H,3-4,15-19H2,1-2H3/t22-/m0/s1 | PDB
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| 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ d'Orl£ans
Curated by ChEMBL
| Assay Description
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells |
Bioorg Med Chem 18: 1958-67 (2010)
Article DOI: 10.1016/j.bmc.2010.01.035
BindingDB Entry DOI: 10.7270/Q2S182M1 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50150430
(CHEMBL183277 | N*2*-[2-(4-Fluoro-phenoxy)-ethyl]-N...)Show InChI InChI=1S/C20H21FN4O/c1-15(16-5-3-2-4-6-16)24-19-11-12-22-20(25-19)23-13-14-26-18-9-7-17(21)8-10-18/h2-12,15H,13-14H2,1H3,(H2,22,23,24,25)/t15-/m0/s1 | PDB
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| 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity against 5-Hydroxy tryptamine 7 receptor |
Bioorg Med Chem Lett 14: 4249-52 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.007
BindingDB Entry DOI: 10.7270/Q2BV7G34 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50403827
(CHEMBL414628)Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)N1CCc2ccc(I)cc12 Show InChI InChI=1S/C19H22IN3O3S/c1-26-19-5-4-16(13-18(19)22-10-7-21-8-11-22)27(24,25)23-9-6-14-2-3-15(20)12-17(14)23/h2-5,12-13,21H,6-11H2,1H3 | PDB
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| 0.316 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description
Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand (n... |
Bioorg Med Chem Lett 11: 55-8 (2001)
BindingDB Entry DOI: 10.7270/Q21R6RPV |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50590672
(CHEMBL5184712)Show SMILES Fc1ccc(cc1)S(=O)(=O)N1CCC[C@@H]1CCCN1CCN(CC1)c1ccc(Cl)cc1 |r| | PDB
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| 0.320 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00633
BindingDB Entry DOI: 10.7270/Q26M3BS8 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50098551
((R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolid...)Show SMILES CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(O)c2)CC1 |r| Show InChI InChI=1S/C18H28N2O3S/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18/h2,5-6,14-16,21H,3-4,7-13H2,1H3/t16-/m1/s1 | PDB
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| 0.339 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Institute of Science and Technology
Curated by ChEMBL
| Assay Description
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method |
J Med Chem 61: 7218-7233 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00642
BindingDB Entry DOI: 10.7270/Q2BC424N |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50098551
((R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolid...)Show SMILES CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(O)c2)CC1 |r| Show InChI InChI=1S/C18H28N2O3S/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18/h2,5-6,14-16,21H,3-4,7-13H2,1H3/t16-/m1/s1 | PDB
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| 0.339 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yonsei University
Curated by ChEMBL
| Assay Description
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method |
Eur J Med Chem 110: 302-10 (2016)
Article DOI: 10.1016/j.ejmech.2016.01.043
BindingDB Entry DOI: 10.7270/Q2SJ1NH7 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50098551
((R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolid...)Show SMILES CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(O)c2)CC1 |r| Show InChI InChI=1S/C18H28N2O3S/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18/h2,5-6,14-16,21H,3-4,7-13H2,1H3/t16-/m1/s1 | PDB
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TBA
| Assay Description
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01093
BindingDB Entry DOI: 10.7270/Q2833WTS |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50098551
((R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolid...)Show SMILES CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(O)c2)CC1 |r| Show InChI InChI=1S/C18H28N2O3S/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18/h2,5-6,14-16,21H,3-4,7-13H2,1H3/t16-/m1/s1 | PDB
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| 0.340 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yonsei University
Curated by ChEMBL
| Assay Description
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of l... |
Eur J Med Chem 123: 180-190 (2016)
Article DOI: 10.1016/j.ejmech.2016.07.029
BindingDB Entry DOI: 10.7270/Q27D2X36 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50098551
((R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolid...)Show SMILES CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(O)c2)CC1 |r| Show InChI InChI=1S/C18H28N2O3S/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18/h2,5-6,14-16,21H,3-4,7-13H2,1H3/t16-/m1/s1 | PDB
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| 0.340 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Institute of Science and Technology
Curated by ChEMBL
| Assay Description
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method |
J Med Chem 61: 7218-7233 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00642
BindingDB Entry DOI: 10.7270/Q2BC424N |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50098551
((R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolid...)Show SMILES CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(O)c2)CC1 |r| Show InChI InChI=1S/C18H28N2O3S/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18/h2,5-6,14-16,21H,3-4,7-13H2,1H3/t16-/m1/s1 | PDB
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| 0.340 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yonsei University
Curated by ChEMBL
| Assay Description
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method |
Eur J Med Chem 110: 302-10 (2016)
Article DOI: 10.1016/j.ejmech.2016.01.043
BindingDB Entry DOI: 10.7270/Q2SJ1NH7 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50098551
((R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolid...)Show SMILES CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(O)c2)CC1 |r| Show InChI InChI=1S/C18H28N2O3S/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18/h2,5-6,14-16,21H,3-4,7-13H2,1H3/t16-/m1/s1 | PDB
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| 0.340 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yonsei University
Curated by ChEMBL
| Assay Description
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method |
Bioorg Med Chem 22: 4587-96 (2014)
Article DOI: 10.1016/j.bmc.2014.07.026
BindingDB Entry DOI: 10.7270/Q22N53ZG |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50098551
((R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolid...)Show SMILES CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(O)c2)CC1 |r| Show InChI InChI=1S/C18H28N2O3S/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18/h2,5-6,14-16,21H,3-4,7-13H2,1H3/t16-/m1/s1 | PDB
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| 0.340 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01093
BindingDB Entry DOI: 10.7270/Q2833WTS |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM21392
(3-(2-aminoethyl)-1H-indole-5-carboxamide | 5-CT | ...)Show InChI InChI=1S/C11H13N3O/c12-4-3-8-6-14-10-2-1-7(11(13)15)5-9(8)10/h1-2,5-6,14H,3-4,12H2,(H2,13,15) | PDB
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Article
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| 0.350 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand bind... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112395
BindingDB Entry DOI: 10.7270/Q2MW2MW1 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50354492
(CHEMBL260994)Show SMILES Clc1ccc(cc1)N1CCN(CCCCC2C(=O)Nc3ccccc23)CC1 |w:15.15| Show InChI InChI=1S/C22H26ClN3O/c23-17-8-10-18(11-9-17)26-15-13-25(14-16-26)12-4-3-6-20-19-5-1-2-7-21(19)24-22(20)27/h1-2,5,7-11,20H,3-4,6,12-16H2,(H,24,27) | PDB
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| 0.380 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
EGIS Pharmaceuticals Plc
Curated by ChEMBL
| Assay Description
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells |
J Med Chem 51: 2522-32 (2008)
Article DOI: 10.1021/jm070279v
BindingDB Entry DOI: 10.7270/Q2QF8TQ0 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50354515
(CHEMBL261719)Show SMILES CCC1(CCCCN2CCN(CC2)c2ccc(Cl)cc2)C(=O)Nc2ccccc12 |w:2.1| Show InChI InChI=1S/C24H30ClN3O/c1-2-24(21-7-3-4-8-22(21)26-23(24)29)13-5-6-14-27-15-17-28(18-16-27)20-11-9-19(25)10-12-20/h3-4,7-12H,2,5-6,13-18H2,1H3,(H,26,29) | PDB
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| 0.380 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
EGIS Pharmaceuticals Plc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry |
J Med Chem 54: 6657-69 (2011)
Article DOI: 10.1021/jm200547z
BindingDB Entry DOI: 10.7270/Q25Q4WGZ |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM10755
(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2 | PDB
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| 0.380 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Bioscience
Curated by PDSP Ki Database
| |
Br J Pharmacol 122: 126-32 (1997)
Article DOI: 10.1038/sj.bjp.0701336
BindingDB Entry DOI: 10.7270/Q2VD6X1D |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50354515
(CHEMBL261719)Show SMILES CCC1(CCCCN2CCN(CC2)c2ccc(Cl)cc2)C(=O)Nc2ccccc12 |w:2.1| Show InChI InChI=1S/C24H30ClN3O/c1-2-24(21-7-3-4-8-22(21)26-23(24)29)13-5-6-14-27-15-17-28(18-16-27)20-11-9-19(25)10-12-20/h3-4,7-12H,2,5-6,13-18H2,1H3,(H,26,29) | PDB
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| 0.380 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
EGIS Pharmaceuticals Plc
Curated by ChEMBL
| Assay Description
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells |
J Med Chem 51: 2522-32 (2008)
Article DOI: 10.1021/jm070279v
BindingDB Entry DOI: 10.7270/Q2QF8TQ0 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM21392
(3-(2-aminoethyl)-1H-indole-5-carboxamide | 5-CT | ...)Show InChI InChI=1S/C11H13N3O/c12-4-3-8-6-14-10-2-1-7(11(13)15)5-9(8)10/h1-2,5-6,14H,3-4,12H2,(H2,13,15) | PDB
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| 0.398 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline R&D
Curated by ChEMBL
| Assay Description
Binding affinity against 5-hydroxytryptamine 7 human receptors |
J Med Chem 46: 5117-20 (2003)
Article DOI: 10.1021/jm0341204
BindingDB Entry DOI: 10.7270/Q2Q242ZQ |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM78940
(METHIOTHEPIN | MLS000859918 | Methiothepin mesylat...)Show InChI InChI=1S/C20H24N2S2/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20/h3-8,14,18H,9-13H2,1-2H3 | PDB
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| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Jagiellonian University Medical College
| Assay Description
Binding experiments were conducted in 96-well microplates in a total volume of 250 μL of buffer (50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA).... |
Chem Biol Drug Des 89: 339-352 (2017)
Article DOI: 10.1111/cbdd.12842
BindingDB Entry DOI: 10.7270/Q2PN94GQ |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)Show SMILES Cc1nc2CCCCn2c(=O)c1CCN1CCC(CC1)c1noc2cc(F)ccc12 Show InChI InChI=1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3 | PDB
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| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method |
Eur J Med Chem 145: 790-804 (2018)
Article DOI: 10.1016/j.ejmech.2018.01.002
BindingDB Entry DOI: 10.7270/Q27947BS |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50462179
(CHEMBL4245263)Show SMILES Fc1ccc2c(noc2c1)C1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2cncc3ccccc23)CC1 |r| Show InChI InChI=1S/C27H29FN4O3S/c28-21-7-8-24-25(16-21)35-30-27(24)19-9-13-31(14-10-19)15-11-22-5-3-12-32(22)36(33,34)26-18-29-17-20-4-1-2-6-23(20)26/h1-2,4,6-8,16-19,22H,3,5,9-15H2/t22-/m0/s1 | PDB
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Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method |
Eur J Med Chem 145: 790-804 (2018)
Article DOI: 10.1016/j.ejmech.2018.01.002
BindingDB Entry DOI: 10.7270/Q27947BS |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM555080
(US11339151, Example 56)Show SMILES CCN(CCCN1CCC(CC1)c1noc2cc(F)ccc12)S(=O)(=O)C(C)CO | PDB
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TBA
| Assay Description
Human 5-HT2A Receptor, Human 5-HT7 Receptor, and Human D2 Receptor: Binding affinity of the present compound for human 5-HT2A receptor, human 5-HT7 r... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2N019Q1 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM10755
(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2 | PDB
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Similars
| Article
PubMed
| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Bioscience
Curated by PDSP Ki Database
| |
Trends Pharmacol Sci 18: 104-7 (1997)
Article DOI: 10.1016/s0165-6147(97)01043-2
BindingDB Entry DOI: 10.7270/Q2BK19WB |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50354521
(CHEMBL408976)Show SMILES CCC1(CCCCN2CCN(CC2)c2cccc(Cl)c2)C(=O)Nc2ccccc12 |w:2.1| Show InChI InChI=1S/C24H30ClN3O/c1-2-24(21-10-3-4-11-22(21)26-23(24)29)12-5-6-13-27-14-16-28(17-15-27)20-9-7-8-19(25)18-20/h3-4,7-11,18H,2,5-6,12-17H2,1H3,(H,26,29) | PDB
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UniChem
Similars
| Article
PubMed
| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
EGIS Pharmaceuticals Plc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry |
J Med Chem 54: 6657-69 (2011)
Article DOI: 10.1021/jm200547z
BindingDB Entry DOI: 10.7270/Q25Q4WGZ |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50018239
(CHEMBL3290004)Show SMILES Fc1ccc2c(noc2c1)C1CCN(CCNS(=O)(=O)c2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C24H24FN3O3S/c25-20-6-8-22-23(16-20)31-27-24(22)18-9-12-28(13-10-18)14-11-26-32(29,30)21-7-5-17-3-1-2-4-19(17)15-21/h1-8,15-16,18,26H,9-14H2 | PDB
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UniChem
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| Article
PubMed
| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adamed Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analy... |
J Med Chem 57: 4543-57 (2014)
Article DOI: 10.1021/jm401895u
BindingDB Entry DOI: 10.7270/Q2N29ZHX |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50150425
(CHEMBL184607 | N*4*-(2-Phenoxy-ethyl)-N*2*-((S)-1-...)Show InChI InChI=1S/C21H23N3O/c1-17(18-8-4-2-5-9-18)24-21-16-19(12-13-23-21)22-14-15-25-20-10-6-3-7-11-20/h2-13,16-17H,14-15H2,1H3,(H2,22,23,24)/t17-/m0/s1 | PDB
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| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity against 5-Hydroxy tryptamine 7 receptor |
Bioorg Med Chem Lett 14: 4249-52 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.007
BindingDB Entry DOI: 10.7270/Q2BV7G34 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50150441
(CHEMBL181605 | N*2*-[2-(4-Fluoro-phenyl)-ethyl]-N*...)Show InChI InChI=1S/C21H22FN3/c1-16(18-5-3-2-4-6-18)25-20-12-14-24-21(15-20)23-13-11-17-7-9-19(22)10-8-17/h2-10,12,14-16H,11,13H2,1H3,(H2,23,24,25)/t16-/m0/s1 | PDB
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UniChem
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| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity against 5-Hydroxy tryptamine 7 receptor |
Bioorg Med Chem Lett 14: 4249-52 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.007
BindingDB Entry DOI: 10.7270/Q2BV7G34 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50150446
(CHEMBL181356 | N*2*-(2-Phenoxy-ethyl)-N*4*-((S)-1-...)Show InChI InChI=1S/C21H23N3O/c1-17(18-8-4-2-5-9-18)24-19-12-13-22-21(16-19)23-14-15-25-20-10-6-3-7-11-20/h2-13,16-17H,14-15H2,1H3,(H2,22,23,24)/t17-/m0/s1 | PDB
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UniChem
Similars
| Article
PubMed
| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity against 5-Hydroxy tryptamine 7 receptor |
Bioorg Med Chem Lett 14: 4249-52 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.007
BindingDB Entry DOI: 10.7270/Q2BV7G34 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50150428
(CHEMBL183423 | N*4*-[2-(4-Fluoro-phenoxy)-ethyl]-N...)Show InChI InChI=1S/C21H22FN3O/c1-16(17-5-3-2-4-6-17)25-21-15-19(11-12-24-21)23-13-14-26-20-9-7-18(22)8-10-20/h2-12,15-16H,13-14H2,1H3,(H2,23,24,25)/t16-/m0/s1 | PDB
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UniChem
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PubMed
| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity against 5-Hydroxy tryptamine 7 receptor |
Bioorg Med Chem Lett 14: 4249-52 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.007
BindingDB Entry DOI: 10.7270/Q2BV7G34 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50222900
(CHEMBL267062)Show SMILES O=C1N(CCN2CCC(CC2)c2c[nH]c3ccccc23)CCCc2ccccc12 Show InChI InChI=1S/C25H29N3O/c29-25-21-8-2-1-6-19(21)7-5-13-28(25)17-16-27-14-11-20(12-15-27)23-18-26-24-10-4-3-9-22(23)24/h1-4,6,8-10,18,20,26H,5,7,11-17H2 | PDB
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| 0.407 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor. |
Bioorg Med Chem Lett 13: 1055-8 (2003)
BindingDB Entry DOI: 10.7270/Q2X066D4 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50354521
(CHEMBL408976)Show SMILES CCC1(CCCCN2CCN(CC2)c2cccc(Cl)c2)C(=O)Nc2ccccc12 |w:2.1| Show InChI InChI=1S/C24H30ClN3O/c1-2-24(21-10-3-4-11-22(21)26-23(24)29)12-5-6-13-27-14-16-28(17-15-27)20-9-7-8-19(25)18-20/h3-4,7-11,18H,2,5-6,12-17H2,1H3,(H,26,29) | PDB
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| 0.410 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
EGIS Pharmaceuticals Plc
Curated by ChEMBL
| Assay Description
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells |
J Med Chem 51: 2522-32 (2008)
Article DOI: 10.1021/jm070279v
BindingDB Entry DOI: 10.7270/Q2QF8TQ0 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50354506
(CHEMBL260872)Show SMILES CCC1(CCCCN2CCN(CC2)c2ccc(F)cc2)C(=O)Nc2ccccc12 |w:2.2| Show InChI InChI=1S/C24H30FN3O/c1-2-24(21-7-3-4-8-22(21)26-23(24)29)13-5-6-14-27-15-17-28(18-16-27)20-11-9-19(25)10-12-20/h3-4,7-12H,2,5-6,13-18H2,1H3,(H,26,29) | PDB
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| 0.430 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
EGIS Pharmaceuticals Plc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry |
J Med Chem 54: 6657-69 (2011)
Article DOI: 10.1021/jm200547z
BindingDB Entry DOI: 10.7270/Q25Q4WGZ |
More data for this
Ligand-Target Pair | |
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