Compile Data Set for Download or QSAR

Found 602 hits of ic50 for UniProtKB: P10721   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM472775 (US10829493, Example 1) Show SMILES CC(C)(O)Cn1cc(cn1)-c1cc2c(N)ncnn2c1 Show InChI InChI=1S/C13H16N6O/c1-13(2,20)7-18-5-10(4-16-18)9-3-11-12(14)15-8-17-19(11)6-9/h3-6,8,20H,7H2,1-2H3,(H2,14,15,17)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.300	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM472786 (US10829493, Example 12) Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(CC2(O)CC2)c1 |r| Show InChI InChI=1S/C29H31FN10O/c1-28(31,22-2-4-24(30)5-3-22)23-14-32-27(33-15-23)38-10-8-37(9-11-38)26-25-12-20(17-40(25)36-19-34-26)21-13-35-39(16-21)18-29(41)6-7-29/h2-5,12-17,19,41H,6-11,18,31H2,1H3/t28-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.300	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM472796 (US10829493, Example 22) Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@@H]1CC[C@H]1O |r| Show InChI InChI=1S/C29H31FN10O/c1-29(31,21-2-4-23(30)5-3-21)22-14-32-28(33-15-22)38-10-8-37(9-11-38)27-25-12-19(16-40(25)36-18-34-27)20-13-35-39(17-20)24-6-7-26(24)41/h2-5,12-18,24,26,41H,6-11,31H2,1H3/t24-,26-,29+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.300	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM472794 (US10829493, Example 20) Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@H]1COC[C@H]1O |r| Show InChI InChI=1S/C29H31FN10O2/c1-29(31,21-2-4-23(30)5-3-21)22-12-32-28(33-13-22)38-8-6-37(7-9-38)27-24-10-19(14-39(24)36-18-34-27)20-11-35-40(15-20)25-16-42-17-26(25)41/h2-5,10-15,18,25-26,41H,6-9,16-17,31H2,1H3/t25-,26+,29-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.300	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM472793 (US10829493, Example 19) Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@@H]1COC[C@H]1O |r| Show InChI InChI=1S/C29H31FN10O2/c1-29(31,21-2-4-23(30)5-3-21)22-12-32-28(33-13-22)38-8-6-37(7-9-38)27-24-10-19(14-39(24)36-18-34-27)20-11-35-40(15-20)25-16-42-17-26(25)41/h2-5,10-15,18,25-26,41H,6-9,16-17,31H2,1H3/t25-,26-,29+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.300	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM472792 (US10829493, Example 18) Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@H]1COC[C@@H]1O |r| Show InChI InChI=1S/C29H31FN10O2/c1-29(31,21-2-4-23(30)5-3-21)22-12-32-28(33-13-22)38-8-6-37(7-9-38)27-24-10-19(14-39(24)36-18-34-27)20-11-35-40(15-20)25-16-42-17-26(25)41/h2-5,10-15,18,25-26,41H,6-9,16-17,31H2,1H3/t25-,26-,29-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.300	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM472777 (US10829493, Example 3) Show SMILES C[C@@H](O)Cn1cc(cn1)-c1cc2c(N)ncnn2c1 |r| Show InChI InChI=1S/C12H14N6O/c1-8(19)4-17-5-10(3-15-17)9-2-11-12(13)14-7-16-18(11)6-9/h2-3,5-8,19H,4H2,1H3,(H2,13,14,16)/t8-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.300	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM472778 (US10829493, Example 4) Show SMILES Nc1ncnn2cc(cc12)-c1cnn(CCO)c1 Show InChI InChI=1S/C11H12N6O/c12-11-10-3-8(6-17(10)15-7-13-11)9-4-14-16(5-9)1-2-18/h3-7,18H,1-2H2,(H2,12,13,15)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.300	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM472779 (US10829493, Example 5) Show SMILES C[C@H](CO)n1cc(cn1)-c1cc2c(N)ncnn2c1 |r| Show InChI InChI=1S/C12H14N6O/c1-8(6-19)17-5-10(3-15-17)9-2-11-12(13)14-7-16-18(11)4-9/h2-5,7-8,19H,6H2,1H3,(H2,13,14,16)/t8-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.300	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM472780 (US10829493, Example 6) Show SMILES C[C@@H](CO)n1cc(cn1)-c1cc2c(N)ncnn2c1 |r| Show InChI InChI=1S/C12H14N6O/c1-8(6-19)17-5-10(3-15-17)9-2-11-12(13)14-7-16-18(11)4-9/h2-5,7-8,19H,6H2,1H3,(H2,13,14,16)/t8-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.300	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM472781 (US10829493, Example 7) Show SMILES Nc1ncnn2cc(cc12)-c1cnn(c1)C1COC1 Show InChI InChI=1S/C12H12N6O/c13-12-11-1-8(3-18(11)16-7-14-12)9-2-15-17(4-9)10-5-19-6-10/h1-4,7,10H,5-6H2,(H2,13,14,16)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.300	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM472782 (US10829493, Example 8) Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(CC2COC2)c1 |r| Show InChI InChI=1S/C29H31FN10O/c1-29(31,23-2-4-25(30)5-3-23)24-12-32-28(33-13-24)38-8-6-37(7-9-38)27-26-10-21(16-40(26)36-19-34-27)22-11-35-39(15-22)14-20-17-41-18-20/h2-5,10-13,15-16,19-20H,6-9,14,17-18,31H2,1H3/t29-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.300	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM472783 (US10829493, Example 9) Show SMILES C[C@H](O)Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(N)c1ccc(F)cc1 |r| Show InChI InChI=1S/C28H31FN10O/c1-19(40)15-38-16-21(12-34-38)20-11-25-26(33-18-35-39(25)17-20)36-7-9-37(10-8-36)27-31-13-23(14-32-27)28(2,30)22-3-5-24(29)6-4-22/h3-6,11-14,16-19,40H,7-10,15,30H2,1-2H3/t19-,28-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.300	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM472785 (US10829493, Example 11) Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)C1C[C@H](O)C1 |r,wU:1.0,wD:1.1,38.44,(2.18,-6.48,;3.27,-5.39,;1.78,-4.99,;4.6,-6.16,;4.6,-7.7,;5.93,-8.47,;7.27,-7.7,;8.6,-8.47,;7.27,-6.16,;5.93,-5.39,;3.27,-3.85,;1.93,-3.08,;1.93,-1.54,;3.27,-.77,;4.6,-1.54,;4.6,-3.08,;3.27,.77,;1.93,1.54,;1.93,3.08,;3.27,3.85,;4.6,3.08,;4.6,1.54,;3.27,5.39,;4.6,6.16,;4.6,7.7,;3.27,8.47,;1.93,7.7,;.47,8.18,;-.44,6.93,;.47,5.68,;1.93,6.16,;-1.98,6.93,;-2.88,8.18,;-4.35,7.7,;-4.35,6.16,;-2.88,5.68,;-5.59,5.25,;-5.83,3.73,;-7.36,3.97,;-8.6,3.07,;-7.11,5.5,)| Show InChI InChI=1S/C29H31FN10O/c1-29(31,21-2-4-23(30)5-3-21)22-14-32-28(33-15-22)38-8-6-37(7-9-38)27-26-10-19(16-40(26)36-18-34-27)20-13-35-39(17-20)24-11-25(41)12-24/h2-5,10,13-18,24-25,41H,6-9,11-12,31H2,1H3/t24?,25-,29-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.300	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM469288 (US10807985, Compound 63 | US10829493, Example 63 o...) Show SMILES CCn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(N)c1ccc(F)cc1 |r| Show InChI InChI=1S/C27H29FN10/c1-3-37-16-20(13-33-37)19-12-24-25(32-18-34-38(24)17-19)35-8-10-36(11-9-35)26-30-14-22(15-31-26)27(2,29)21-4-6-23(28)7-5-21/h4-7,12-18H,3,8-11,29H2,1-2H3/t27-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.300	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM472788 (US10829493, Example 14) Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@@H]1CCOC1 |r| Show InChI InChI=1S/C29H31FN10O/c1-29(31,22-2-4-24(30)5-3-22)23-14-32-28(33-15-23)38-9-7-37(8-10-38)27-26-12-20(16-40(26)36-19-34-27)21-13-35-39(17-21)25-6-11-41-18-25/h2-5,12-17,19,25H,6-11,18,31H2,1H3/t25-,29+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.300	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM472789 (US10829493, Example 15) Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@H]1CCOC1 |r| Show InChI InChI=1S/C29H31FN10O/c1-29(31,22-2-4-24(30)5-3-22)23-14-32-28(33-15-23)38-9-7-37(8-10-38)27-26-12-20(16-40(26)36-19-34-27)21-13-35-39(17-21)25-6-11-41-18-25/h2-5,12-17,19,25H,6-11,18,31H2,1H3/t25-,29-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.300	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM472790 (US10829493, Example 16) Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)C1CCOCC1 |r| Show InChI InChI=1S/C30H33FN10O/c1-30(32,23-2-4-25(31)5-3-23)24-16-33-29(34-17-24)39-10-8-38(9-11-39)28-27-14-21(18-41(27)37-20-35-28)22-15-36-40(19-22)26-6-12-42-13-7-26/h2-5,14-20,26H,6-13,32H2,1H3/t30-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.300	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM472784 (US10829493, Example 10) Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)C1C[C@H](O)C1 |r,wU:1.0,38.44,wD:1.1,(2.18,-6.48,;3.27,-5.39,;1.78,-4.99,;4.6,-6.16,;4.6,-7.7,;5.93,-8.47,;7.27,-7.7,;8.6,-8.47,;7.27,-6.16,;5.93,-5.39,;3.27,-3.85,;1.93,-3.08,;1.93,-1.54,;3.27,-.77,;4.6,-1.54,;4.6,-3.08,;3.27,.77,;1.93,1.54,;1.93,3.08,;3.27,3.85,;4.6,3.08,;4.6,1.54,;3.27,5.39,;4.6,6.16,;4.6,7.7,;3.27,8.47,;1.93,7.7,;.47,8.18,;-.44,6.93,;.47,5.68,;1.93,6.16,;-1.98,6.93,;-2.88,8.18,;-4.35,7.7,;-4.35,6.16,;-2.88,5.68,;-5.59,5.25,;-7.11,5.5,;-7.36,3.97,;-8.6,3.07,;-5.83,3.73,)| Show InChI InChI=1S/C29H31FN10O/c1-29(31,21-2-4-23(30)5-3-21)22-14-32-28(33-15-22)38-8-6-37(7-9-38)27-26-10-19(16-40(26)36-18-34-27)20-13-35-39(17-20)24-11-25(41)12-24/h2-5,10,13-18,24-25,41H,6-9,11-12,31H2,1H3/t24?,25-,29-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.650	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM472787 (US10829493, Example 13) Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)C1(CO)CC1 |r| Show InChI InChI=1S/C29H31FN10O/c1-28(31,22-2-4-24(30)5-3-22)23-14-32-27(33-15-23)38-10-8-37(9-11-38)26-25-12-20(16-39(25)36-19-34-26)21-13-35-40(17-21)29(18-41)6-7-29/h2-5,12-17,19,41H,6-11,18,31H2,1H3/t28-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.650	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM472791 (US10829493, Example 17) Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@@H]1COC[C@@H]1O |r| Show InChI InChI=1S/C29H31FN10O2/c1-29(31,21-2-4-23(30)5-3-21)22-12-32-28(33-13-22)38-8-6-37(7-9-38)27-24-10-19(14-39(24)36-18-34-27)20-11-35-40(15-20)25-16-42-17-26(25)41/h2-5,10-15,18,25-26,41H,6-9,16-17,31H2,1H3/t25-,26+,29+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.650	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM472795 (US10829493, Example 21) Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@H]1CC[C@@H]1O |r| Show InChI InChI=1S/C29H31FN10O/c1-29(31,21-2-4-23(30)5-3-21)22-14-32-28(33-15-22)38-10-8-37(9-11-38)27-25-12-19(16-40(25)36-18-34-27)20-13-35-39(17-20)24-6-7-26(24)41/h2-5,12-18,24,26,41H,6-11,31H2,1H3/t24-,26-,29-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.650	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM472776 (US10829493, Example 2) Show SMILES CC(C)(CO)n1cc(cn1)-c1cc2c(N)ncnn2c1 Show InChI InChI=1S/C13H16N6O/c1-13(2,7-20)19-6-10(4-16-19)9-3-11-12(14)15-8-17-18(11)5-9/h3-6,8,20H,7H2,1-2H3,(H2,14,15,17)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.650	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM175747 (US9688680, 292) Show SMILES COC(=O)N1CCC(=CC1)c1cc2c(ncnn2c1)N1CC(C1)NC(=O)Cc1ccc(Cl)cc1Cl |c:7| Show InChI InChI=1S/C24H24Cl2N6O3/c1-35-24(34)30-6-4-15(5-7-30)17-8-21-23(27-14-28-32(21)11-17)31-12-19(13-31)29-22(33)9-16-2-3-18(25)10-20(16)26/h2-4,8,10-11,14,19H,5-7,9,12-13H2,1H3,(H,29,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...				US Patent US9688680 (2017) BindingDB Entry DOI: 10.7270/Q2NV9GDQ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM175754 (US9688680, 299) Show SMILES CC[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1cnn(c1)[C@@H](C)C(C)(C)O)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C27H32ClN7O2/c1-5-23(18-6-8-22(28)9-7-18)32-26(36)21-12-33(13-21)25-24-10-19(14-35(24)31-16-29-25)20-11-30-34(15-20)17(2)27(3,4)37/h6-11,14-17,21,23,37H,5,12-13H2,1-4H3,(H,32,36)/t17-,23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...				US Patent US9688680 (2017) BindingDB Entry DOI: 10.7270/Q2NV9GDQ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM175755 (US9688680, 300) Show SMILES CC[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1cnn(c1)[C@H](C)C(C)(C)O)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C27H32ClN7O2/c1-5-23(18-6-8-22(28)9-7-18)32-26(36)21-12-33(13-21)25-24-10-19(14-35(24)31-16-29-25)20-11-30-34(15-20)17(2)27(3,4)37/h6-11,14-17,21,23,37H,5,12-13H2,1-4H3,(H,32,36)/t17-,23+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...				US Patent US9688680 (2017) BindingDB Entry DOI: 10.7270/Q2NV9GDQ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM175756 (US9688680, 301) Show SMILES CCC(=O)N1CCC(=CC1)c1cc2c(ncnn2c1)N1CC(C1)C(=O)N[C@@H](CCO)c1ccc(Cl)cc1 |r,c:7| Show InChI InChI=1S/C27H31ClN6O3/c1-2-25(36)32-10-7-18(8-11-32)20-13-24-26(29-17-30-34(24)16-20)33-14-21(15-33)27(37)31-23(9-12-35)19-3-5-22(28)6-4-19/h3-7,13,16-17,21,23,35H,2,8-12,14-15H2,1H3,(H,31,37)/t23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...				US Patent US9688680 (2017) BindingDB Entry DOI: 10.7270/Q2NV9GDQ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM175757 (US9688680, 302) Show SMILES CCOC(=O)N1CCC(=CC1)c1cc2c(ncnn2c1)N1CC(C1)C(=O)N[C@@H](CC)c1ccc(Cl)cc1 |r,c:8| Show InChI InChI=1S/C27H31ClN6O3/c1-3-23(19-5-7-22(28)8-6-19)31-26(35)21-14-33(15-21)25-24-13-20(16-34(24)30-17-29-25)18-9-11-32(12-10-18)27(36)37-4-2/h5-9,13,16-17,21,23H,3-4,10-12,14-15H2,1-2H3,(H,31,35)/t23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...				US Patent US9688680 (2017) BindingDB Entry DOI: 10.7270/Q2NV9GDQ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM175760 (US9688680, 305) Show SMILES CC[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1ccc(cc1)S(C)(=O)=O)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C26H26ClN5O3S/c1-3-23(18-4-8-21(27)9-5-18)30-26(33)20-13-31(14-20)25-24-12-19(15-32(24)29-16-28-25)17-6-10-22(11-7-17)36(2,34)35/h4-12,15-16,20,23H,3,13-14H2,1-2H3,(H,30,33)/t23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...				US Patent US9688680 (2017) BindingDB Entry DOI: 10.7270/Q2NV9GDQ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM175763 (US9688680, 308) Show SMILES CC1(CN(C1)c1ncnn2cc(cc12)-c1ccc(cc1)S(C)(=O)=O)C(=O)NCc1ccc(Cl)cc1F Show InChI InChI=1S/C25H23ClFN5O3S/c1-25(24(33)28-11-17-3-6-19(26)10-21(17)27)13-31(14-25)23-22-9-18(12-32(22)30-15-29-23)16-4-7-20(8-5-16)36(2,34)35/h3-10,12,15H,11,13-14H2,1-2H3,(H,28,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...				US Patent US9688680 (2017) BindingDB Entry DOI: 10.7270/Q2NV9GDQ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM175764 (US9688680, 309) Show SMILES CC[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)C1=CCN(CC1)S(C)(=O)=O)c1ccc(Cl)cc1 |r,t:22| Show InChI InChI=1S/C25H29ClN6O3S/c1-3-22(18-4-6-21(26)7-5-18)29-25(33)20-13-30(14-20)24-23-12-19(15-32(23)28-16-27-24)17-8-10-31(11-9-17)36(2,34)35/h4-8,12,15-16,20,22H,3,9-11,13-14H2,1-2H3,(H,29,33)/t22-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...				US Patent US9688680 (2017) BindingDB Entry DOI: 10.7270/Q2NV9GDQ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM175766 (US9688680, 311) Show SMILES CCC(=O)N1CCC(=CC1)c1cc2c(ncnn2c1)N1CC(C)(C1)C(=O)N[C@@H](CCO)c1ccc(Cl)cc1 |r,c:7| Show InChI InChI=1S/C28H33ClN6O3/c1-3-25(37)33-11-8-19(9-12-33)21-14-24-26(30-18-31-35(24)15-21)34-16-28(2,17-34)27(38)32-23(10-13-36)20-4-6-22(29)7-5-20/h4-8,14-15,18,23,36H,3,9-13,16-17H2,1-2H3,(H,32,38)/t23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...				US Patent US9688680 (2017) BindingDB Entry DOI: 10.7270/Q2NV9GDQ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM397818 (US9994552, Compound 29) Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(N)n3)c2cc1OC Show InChI InChI=1S/C25H27N7O2/c1-33-21-13-19-20(14-22(21)34-2)28-16-29-24(19)31-8-10-32(11-9-31)25-27-15-18(23(26)30-25)12-17-6-4-3-5-7-17/h3-7,13-16H,8-12H2,1-2H3,(H2,26,27,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...				J Med Chem 52: 4892-902 (2009) BindingDB Entry DOI: 10.7270/Q27M0B8Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM397824 (US9994552, Compound 35) Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(O)n3)c2cc1OC Show InChI InChI=1S/C25H26N6O3/c1-33-21-13-19-20(14-22(21)34-2)27-16-28-23(19)30-8-10-31(11-9-30)25-26-15-18(24(32)29-25)12-17-6-4-3-5-7-17/h3-7,13-16H,8-12H2,1-2H3,(H,26,29,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...				J Med Chem 52: 4892-902 (2009) BindingDB Entry DOI: 10.7270/Q27M0B8Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM397897 (US9994552, Compound 108) Show SMILES COCCOc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCCOC Show InChI InChI=1S/C29H34N6O4/c1-36-12-14-38-26-17-24-25(18-27(26)39-15-13-37-2)32-21-33-28(24)34-8-10-35(11-9-34)29-30-19-23(20-31-29)16-22-6-4-3-5-7-22/h3-7,17-21H,8-16H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...				J Med Chem 52: 4892-902 (2009) BindingDB Entry DOI: 10.7270/Q27M0B8Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM397908 (US9994552, Compound 119) Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(=O)[nH]3)c2cc1OCC1CNCCO1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...				J Med Chem 52: 4892-902 (2009) BindingDB Entry DOI: 10.7270/Q27M0B8Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM397909 (US9994552, Compound 120) Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(=O)[nH]3)c2cc1OC[C@H]1CNCCO1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...				J Med Chem 52: 4892-902 (2009) BindingDB Entry DOI: 10.7270/Q27M0B8Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM397911 (US9994552, Compound 122) Show SMILES CCOc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CCN(C)CC1 Show InChI InChI=1S/C32H39N7O2/c1-3-40-30-19-28-27(18-29(30)41-22-25-9-11-37(2)12-10-25)31(36-23-35-28)38-13-15-39(16-14-38)32-33-20-26(21-34-32)17-24-7-5-4-6-8-24/h4-8,18-21,23,25H,3,9-17,22H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...				J Med Chem 52: 4892-902 (2009) BindingDB Entry DOI: 10.7270/Q27M0B8Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM397913 (US9994552, Compound 124) Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(N)n3)c2cc1OC[C@@H]1CCCN(C)C1 |r| Show InChI InChI=1S/C31H38N8O2/c1-37-10-6-9-23(19-37)20-41-28-16-25-26(17-27(28)40-2)34-21-35-30(25)38-11-13-39(14-12-38)31-33-18-24(29(32)36-31)15-22-7-4-3-5-8-22/h3-5,7-8,16-18,21,23H,6,9-15,19-20H2,1-2H3,(H2,32,33,36)/t23-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...				J Med Chem 52: 4892-902 (2009) BindingDB Entry DOI: 10.7270/Q27M0B8Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM397914 (US9994552, Compound 125) Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(N)n3)c2cc1OCC1CCN(C)CC1 Show InChI InChI=1S/C31H38N8O2/c1-37-10-8-23(9-11-37)20-41-28-17-25-26(18-27(28)40-2)34-21-35-30(25)38-12-14-39(15-13-38)31-33-19-24(29(32)36-31)16-22-6-4-3-5-7-22/h3-7,17-19,21,23H,8-16,20H2,1-2H3,(H2,32,33,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...				J Med Chem 52: 4892-902 (2009) BindingDB Entry DOI: 10.7270/Q27M0B8Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM397916 (US9994552, Compound 127) Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(=O)[nH]3)c2cc1OCC1CCN(C)CC1 Show InChI InChI=1S/C31H37N7O3/c1-36-10-8-23(9-11-36)20-41-28-17-25-26(18-27(28)40-2)33-21-34-29(25)37-12-14-38(15-13-37)31-32-19-24(30(39)35-31)16-22-6-4-3-5-7-22/h3-7,17-19,21,23H,8-16,20H2,1-2H3,(H,32,35,39)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...				J Med Chem 52: 4892-902 (2009) BindingDB Entry DOI: 10.7270/Q27M0B8Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM397919 (US9994552, Compound 130) Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(=O)[nH]3)c2cc1OCC1CN(C)CCO1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...				J Med Chem 52: 4892-902 (2009) BindingDB Entry DOI: 10.7270/Q27M0B8Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM397920 (US9994552, Compound 131) Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1(F)CCN(C)CC1 Show InChI InChI=1S/C31H36FN7O2/c1-37-10-8-31(32,9-11-37)21-41-28-17-25-26(18-27(28)40-2)35-22-36-29(25)38-12-14-39(15-13-38)30-33-19-24(20-34-30)16-23-6-4-3-5-7-23/h3-7,17-20,22H,8-16,21H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...				J Med Chem 52: 4892-902 (2009) BindingDB Entry DOI: 10.7270/Q27M0B8Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM397923 (US9994552, Compound 134) Show SMILES COc1cc2c(ncnc2cc1OCCCN1CCN(C)CC1)N1CCN(CC1)c1ncc(Cc2ccccc2)cn1 Show InChI InChI=1S/C32H40N8O2/c1-37-10-12-38(13-11-37)9-6-18-42-30-21-28-27(20-29(30)41-2)31(36-24-35-28)39-14-16-40(17-15-39)32-33-22-26(23-34-32)19-25-7-4-3-5-8-25/h3-5,7-8,20-24H,6,9-19H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...				J Med Chem 52: 4892-902 (2009) BindingDB Entry DOI: 10.7270/Q27M0B8Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM397924 (US9994552, Compound 135) Show SMILES CCOc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(N)n3)c2cc1OCC1CCN(C)CC1 Show InChI InChI=1S/C32H40N8O2/c1-3-41-29-19-27-26(18-28(29)42-21-24-9-11-38(2)12-10-24)31(36-22-35-27)39-13-15-40(16-14-39)32-34-20-25(30(33)37-32)17-23-7-5-4-6-8-23/h4-8,18-20,22,24H,3,9-17,21H2,1-2H3,(H2,33,34,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...				J Med Chem 52: 4892-902 (2009) BindingDB Entry DOI: 10.7270/Q27M0B8Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM397927 (US9994552, Compound 138) Show SMILES CCOc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(=O)[nH]3)c2cc1OCC1CCN(C)CC1 Show InChI InChI=1S/C32H39N7O3/c1-3-41-29-19-27-26(18-28(29)42-21-24-9-11-37(2)12-10-24)30(35-22-34-27)38-13-15-39(16-14-38)32-33-20-25(31(40)36-32)17-23-7-5-4-6-8-23/h4-8,18-20,22,24H,3,9-17,21H2,1-2H3,(H,33,36,40)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...				J Med Chem 52: 4892-902 (2009) BindingDB Entry DOI: 10.7270/Q27M0B8Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM469232 (US10807985, Compound 7) Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(Cc2ccccc2)cn1 Show InChI InChI=1S/C25H25N9/c1-31-16-22(15-29-31)21-12-23-24(28-18-30-34(23)17-21)32-7-9-33(10-8-32)25-26-13-20(14-27-25)11-19-5-3-2-4-6-19/h2-6,12-18H,7-11H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...				US Patent US10807985 (2020) BindingDB Entry DOI: 10.7270/Q2F76GNN
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM469235 (US10807985, Compound 10) Show SMILES C[C@@H](c1ccccc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(C)c1 |r| Show InChI InChI=1S/C26H27N9/c1-19(20-6-4-3-5-7-20)22-13-27-26(28-14-22)34-10-8-33(9-11-34)25-24-12-21(17-35(24)31-18-29-25)23-15-30-32(2)16-23/h3-7,12-19H,8-11H2,1-2H3/t19-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...				US Patent US10807985 (2020) BindingDB Entry DOI: 10.7270/Q2F76GNN
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM469237 (US10807985, Compound 12) Show SMILES C[C@](N)(c1ccccc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cn[nH]c1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...				US Patent US10807985 (2020) BindingDB Entry DOI: 10.7270/Q2F76GNN
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM469239 (US10807985, Compound 14) Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(Cc2ccc(F)cc2)cn1 Show InChI InChI=1S/C25H24FN9/c1-32-15-21(14-30-32)20-11-23-24(29-17-31-35(23)16-20)33-6-8-34(9-7-33)25-27-12-19(13-28-25)10-18-2-4-22(26)5-3-18/h2-5,11-17H,6-10H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...				US Patent US10807985 (2020) BindingDB Entry DOI: 10.7270/Q2F76GNN
					More data for this Ligand-Target Pair

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