BindingDB PrimarySearch

BDBM397897 US9994552, Compound 108

SMILES: COCCOc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCCOC

InChI Key: InChIKey=GWVUCXTYNJIWGK-UHFFFAOYSA-N

Data: 2 IC50 7 Kd

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 397897
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM397897 (US9994552, Compound 108) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...				J Med Chem 52: 4892-902 (2009) BindingDB Entry DOI: 10.7270/Q27M0B8Q
Duquesne University					More data for this Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V) (Homo sapiens (Human))	BDBM397897 (US9994552, Compound 108) Show SMILES Show InChI	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...				J Med Chem 52: 4892-902 (2009) BindingDB Entry DOI: 10.7270/Q27M0B8Q
Duquesne University					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM397897 (US9994552, Compound 108) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a
University of the Pacific Curated by ChEMBL					Assay Description Binding affinity to PDGFRbeta (unknown origin)				Bioorg Med Chem Lett 28: 1781-1784 (2018) Article DOI: 10.1016/j.bmcl.2018.04.030 BindingDB Entry DOI: 10.7270/Q21C20H6
University of the Pacific Curated by ChEMBL					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM397897 (US9994552, Compound 108) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a
University of the Pacific Curated by ChEMBL					Assay Description Binding affinity to KIT (unknown origin)				Bioorg Med Chem Lett 28: 1781-1784 (2018) Article DOI: 10.1016/j.bmcl.2018.04.030 BindingDB Entry DOI: 10.7270/Q21C20H6
University of the Pacific Curated by ChEMBL					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM397897 (US9994552, Compound 108) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a
University of the Pacific Curated by ChEMBL					Assay Description Binding affinity to KIT V816H mutant (unknown origin)				Bioorg Med Chem Lett 28: 1781-1784 (2018) Article DOI: 10.1016/j.bmcl.2018.04.030 BindingDB Entry DOI: 10.7270/Q21C20H6
University of the Pacific Curated by ChEMBL					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM397897 (US9994552, Compound 108) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a
University of the Pacific Curated by ChEMBL					Assay Description Binding affinity to KIT D816V mutant (unknown origin)				Bioorg Med Chem Lett 28: 1781-1784 (2018) Article DOI: 10.1016/j.bmcl.2018.04.030 BindingDB Entry DOI: 10.7270/Q21C20H6
University of the Pacific Curated by ChEMBL					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM397897 (US9994552, Compound 108) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a
University of the Pacific Curated by ChEMBL					Assay Description Binding affinity to KIT V559D mutant (unknown origin)				Bioorg Med Chem Lett 28: 1781-1784 (2018) Article DOI: 10.1016/j.bmcl.2018.04.030 BindingDB Entry DOI: 10.7270/Q21C20H6
University of the Pacific Curated by ChEMBL					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM397897 (US9994552, Compound 108) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a
University of the Pacific Curated by ChEMBL					Assay Description Binding affinity to KIT V559D/T670I mutant (unknown origin)				Bioorg Med Chem Lett 28: 1781-1784 (2018) Article DOI: 10.1016/j.bmcl.2018.04.030 BindingDB Entry DOI: 10.7270/Q21C20H6
University of the Pacific Curated by ChEMBL					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM397897 (US9994552, Compound 108) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a
University of the Pacific Curated by ChEMBL					Assay Description Binding affinity to PDGFRalpha (unknown origin)				Bioorg Med Chem Lett 28: 1781-1784 (2018) Article DOI: 10.1016/j.bmcl.2018.04.030 BindingDB Entry DOI: 10.7270/Q21C20H6
University of the Pacific Curated by ChEMBL					More data for this Ligand-Target Pair