Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Procathepsin L [114-333,T223A] (Homo sapiens (Human)) | BDBM31992 (Dipeptidyl nitrile inhibitor, 25) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | 7.0 | 37 |
AstraZeneca | Assay Description IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates. | Bioorg Med Chem Lett 19: 4280-3 (2009) Article DOI: 10.1016/j.bmcl.2009.05.071 BindingDB Entry DOI: 10.7270/Q2TT4PBM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L [114-333,T223A] (Homo sapiens (Human)) | BDBM31993 (Dipeptidyl nitrile inhibitor, 26) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | 7.0 | 37 |
AstraZeneca | Assay Description IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates. | Bioorg Med Chem Lett 19: 4280-3 (2009) Article DOI: 10.1016/j.bmcl.2009.05.071 BindingDB Entry DOI: 10.7270/Q2TT4PBM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L [114-333,T223A] (Homo sapiens (Human)) | BDBM31984 (Dipeptidyl nitrile inhibitor, 17) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | 7.0 | 37 |
AstraZeneca | Assay Description IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates. | Bioorg Med Chem Lett 19: 4280-3 (2009) Article DOI: 10.1016/j.bmcl.2009.05.071 BindingDB Entry DOI: 10.7270/Q2TT4PBM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L [114-333,T223A] (Homo sapiens (Human)) | BDBM31980 (Dipeptidyl nitrile inhibitor, 13) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 50 | n/a | n/a | n/a | n/a | 7.0 | 37 |
AstraZeneca | Assay Description IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates. | Bioorg Med Chem Lett 19: 4280-3 (2009) Article DOI: 10.1016/j.bmcl.2009.05.071 BindingDB Entry DOI: 10.7270/Q2TT4PBM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L [114-333,T223A] (Homo sapiens (Human)) | BDBM31990 (Dipeptidyl nitrile inhibitor, 23) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 63 | n/a | n/a | n/a | n/a | 7.0 | 37 |
AstraZeneca | Assay Description IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates. | Bioorg Med Chem Lett 19: 4280-3 (2009) Article DOI: 10.1016/j.bmcl.2009.05.071 BindingDB Entry DOI: 10.7270/Q2TT4PBM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L [114-333,T223A] (Homo sapiens (Human)) | BDBM31991 (Dipeptidyl nitrile inhibitor, 24) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 79 | n/a | n/a | n/a | n/a | 7.0 | 37 |
AstraZeneca | Assay Description IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates. | Bioorg Med Chem Lett 19: 4280-3 (2009) Article DOI: 10.1016/j.bmcl.2009.05.071 BindingDB Entry DOI: 10.7270/Q2TT4PBM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L [114-333,T223A] (Homo sapiens (Human)) | BDBM31989 (Dipeptidyl nitrile inhibitor, 22) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 79 | n/a | n/a | n/a | n/a | 7.0 | 37 |
AstraZeneca | Assay Description IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates. | Bioorg Med Chem Lett 19: 4280-3 (2009) Article DOI: 10.1016/j.bmcl.2009.05.071 BindingDB Entry DOI: 10.7270/Q2TT4PBM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L [114-333,T223A] (Homo sapiens (Human)) | BDBM31977 (Dipeptidyl nitrile inhibitor, 10) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 79 | n/a | n/a | n/a | n/a | 7.0 | 37 |
AstraZeneca | Assay Description IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates. | Bioorg Med Chem Lett 19: 4280-3 (2009) Article DOI: 10.1016/j.bmcl.2009.05.071 BindingDB Entry DOI: 10.7270/Q2TT4PBM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L [114-333,T223A] (Homo sapiens (Human)) | BDBM31978 (Dipeptidyl nitrile inhibitor, 11) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 79 | n/a | n/a | n/a | n/a | 7.0 | 37 |
AstraZeneca | Assay Description IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates. | Bioorg Med Chem Lett 19: 4280-3 (2009) Article DOI: 10.1016/j.bmcl.2009.05.071 BindingDB Entry DOI: 10.7270/Q2TT4PBM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L [114-333,T223A] (Homo sapiens (Human)) | BDBM31983 (Dipeptidyl nitrile inhibitor, 16) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | 7.0 | 37 |
AstraZeneca | Assay Description IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates. | Bioorg Med Chem Lett 19: 4280-3 (2009) Article DOI: 10.1016/j.bmcl.2009.05.071 BindingDB Entry DOI: 10.7270/Q2TT4PBM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L [114-333,T223A] (Homo sapiens (Human)) | BDBM31981 (Dipeptidyl nitrile inhibitor, 14) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 251 | n/a | n/a | n/a | n/a | 7.0 | 37 |
AstraZeneca | Assay Description IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates. | Bioorg Med Chem Lett 19: 4280-3 (2009) Article DOI: 10.1016/j.bmcl.2009.05.071 BindingDB Entry DOI: 10.7270/Q2TT4PBM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L [114-333,T223A] (Homo sapiens (Human)) | BDBM31974 (Dipeptidyl nitrile inhibitor, 7) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 251 | n/a | n/a | n/a | n/a | 7.0 | 37 |
AstraZeneca | Assay Description IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates. | Bioorg Med Chem Lett 19: 4280-3 (2009) Article DOI: 10.1016/j.bmcl.2009.05.071 BindingDB Entry DOI: 10.7270/Q2TT4PBM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L [114-333,T223A] (Homo sapiens (Human)) | BDBM31975 (Dipeptidyl nitrile inhibitor, 8) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 251 | n/a | n/a | n/a | n/a | 7.0 | 37 |
AstraZeneca | Assay Description IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates. | Bioorg Med Chem Lett 19: 4280-3 (2009) Article DOI: 10.1016/j.bmcl.2009.05.071 BindingDB Entry DOI: 10.7270/Q2TT4PBM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L [114-333,T223A] (Homo sapiens (Human)) | BDBM31970 (Dipeptidyl nitrile inhibitor, 1) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 251 | n/a | n/a | n/a | n/a | 7.0 | 37 |
AstraZeneca | Assay Description IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates. | Bioorg Med Chem Lett 19: 4280-3 (2009) Article DOI: 10.1016/j.bmcl.2009.05.071 BindingDB Entry DOI: 10.7270/Q2TT4PBM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L [114-333,T223A] (Homo sapiens (Human)) | BDBM31973 (Dipeptidyl nitrile inhibitor, 6) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 316 | n/a | n/a | n/a | n/a | 7.0 | 37 |
AstraZeneca | Assay Description IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates. | Bioorg Med Chem Lett 19: 4280-3 (2009) Article DOI: 10.1016/j.bmcl.2009.05.071 BindingDB Entry DOI: 10.7270/Q2TT4PBM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L [114-333,T223A] (Homo sapiens (Human)) | BDBM31979 (Dipeptidyl nitrile inhibitor, 12) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 316 | n/a | n/a | n/a | n/a | 7.0 | 37 |
AstraZeneca | Assay Description IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates. | Bioorg Med Chem Lett 19: 4280-3 (2009) Article DOI: 10.1016/j.bmcl.2009.05.071 BindingDB Entry DOI: 10.7270/Q2TT4PBM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L [114-333,T223A] (Homo sapiens (Human)) | BDBM31988 (Dipeptidyl nitrile inhibitor, 21) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 398 | n/a | n/a | n/a | n/a | 7.0 | 37 |
AstraZeneca | Assay Description IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates. | Bioorg Med Chem Lett 19: 4280-3 (2009) Article DOI: 10.1016/j.bmcl.2009.05.071 BindingDB Entry DOI: 10.7270/Q2TT4PBM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L [114-333,T223A] (Homo sapiens (Human)) | BDBM31982 (Dipeptidyl nitrile inhibitor, 15) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 398 | n/a | n/a | n/a | n/a | 7.0 | 37 |
AstraZeneca | Assay Description IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates. | Bioorg Med Chem Lett 19: 4280-3 (2009) Article DOI: 10.1016/j.bmcl.2009.05.071 BindingDB Entry DOI: 10.7270/Q2TT4PBM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L [114-333,T223A] (Homo sapiens (Human)) | BDBM31972 (Dipeptidyl nitrile inhibitor, 5) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 501 | n/a | n/a | n/a | n/a | 7.0 | 37 |
AstraZeneca | Assay Description IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates. | Bioorg Med Chem Lett 19: 4280-3 (2009) Article DOI: 10.1016/j.bmcl.2009.05.071 BindingDB Entry DOI: 10.7270/Q2TT4PBM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L [114-333,T223A] (Homo sapiens (Human)) | BDBM31986 (Dipeptidyl nitrile inhibitor, 19) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 501 | n/a | n/a | n/a | n/a | 7.0 | 37 |
AstraZeneca | Assay Description IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates. | Bioorg Med Chem Lett 19: 4280-3 (2009) Article DOI: 10.1016/j.bmcl.2009.05.071 BindingDB Entry DOI: 10.7270/Q2TT4PBM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L [114-333,T223A] (Homo sapiens (Human)) | BDBM31987 (Dipeptidyl nitrile inhibitor, 20) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 631 | n/a | n/a | n/a | n/a | 7.0 | 37 |
AstraZeneca | Assay Description IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates. | Bioorg Med Chem Lett 19: 4280-3 (2009) Article DOI: 10.1016/j.bmcl.2009.05.071 BindingDB Entry DOI: 10.7270/Q2TT4PBM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L [114-333,T223A] (Homo sapiens (Human)) | BDBM31976 (Dipeptidyl nitrile inhibitor, 9) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 794 | n/a | n/a | n/a | n/a | 7.0 | 37 |
AstraZeneca | Assay Description IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates. | Bioorg Med Chem Lett 19: 4280-3 (2009) Article DOI: 10.1016/j.bmcl.2009.05.071 BindingDB Entry DOI: 10.7270/Q2TT4PBM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L [114-333,T223A] (Homo sapiens (Human)) | BDBM31985 (Dipeptidyl nitrile inhibitor, 18) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.26E+3 | n/a | n/a | n/a | n/a | 7.0 | 37 |
AstraZeneca | Assay Description IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates. | Bioorg Med Chem Lett 19: 4280-3 (2009) Article DOI: 10.1016/j.bmcl.2009.05.071 BindingDB Entry DOI: 10.7270/Q2TT4PBM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L [114-333,T223A] (Homo sapiens (Human)) | BDBM31971 (Dipeptidyl nitrile inhibitor, 4) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.26E+3 | n/a | n/a | n/a | n/a | 7.0 | 37 |
AstraZeneca | Assay Description IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates. | Bioorg Med Chem Lett 19: 4280-3 (2009) Article DOI: 10.1016/j.bmcl.2009.05.071 BindingDB Entry DOI: 10.7270/Q2TT4PBM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L [114-333,T223A] (Homo sapiens (Human)) | BDBM36812 (CA-074) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 5.5 | 25 |
University of California, San Francisco | Assay Description Inhibition assay using pre-treatment of recombinant cathepsin-L-like cysteine protease cruzain lacking the carboxy-terminal domain or cathepsin B fr... | Chem Biol 7: 27-38 (2000) Article DOI: 10.1016/s1074-5521(00)00061-2 BindingDB Entry DOI: 10.7270/Q24B2ZN5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L [114-333,T223A] (Homo sapiens (Human)) | BDBM36813 (CA-074b) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 5.5 | 25 |
University of California, San Francisco | Assay Description Inhibition assay using pre-treatment of recombinant cathepsin-L-like cysteine protease cruzain lacking the carboxy-terminal domain or cathepsin B fr... | Chem Biol 7: 27-38 (2000) Article DOI: 10.1016/s1074-5521(00)00061-2 BindingDB Entry DOI: 10.7270/Q24B2ZN5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L [114-333,T223A] (Homo sapiens (Human)) | BDBM36814 (MB-074) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 5.5 | 25 |
University of California, San Francisco | Assay Description Inhibition assay using pre-treatment of recombinant cathepsin-L-like cysteine protease cruzain lacking the carboxy-terminal domain or cathepsin B fr... | Chem Biol 7: 27-38 (2000) Article DOI: 10.1016/s1074-5521(00)00061-2 BindingDB Entry DOI: 10.7270/Q24B2ZN5 | |||||||||||
More data for this Ligand-Target Pair |