Compile Data Set for Download or QSAR

Found 25 hits of ic50 for UniProtKB: P28565   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 1D (RAT)	BDBM10755 (14C-5-hydroxy tryptamine creatinine disulfate | 2-...) Show SMILES NCCc1c[nH]c2ccc(O)cc12 Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Similars	PDB PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description Binding affinity of the compound was measured against serotonin 5-hydroxytryptamine 1D receptor				J Med Chem 37: 2509-12 (1994) BindingDB Entry DOI: 10.7270/Q2S181JQ
					More data for this Ligand-Target Pair				3D Structure (crystal)
5-hydroxytryptamine receptor 1D (RAT)	BDBM50039564 (CHEMBL83597 | [3-((R)-1-Methyl-pyrrolidin-2-ylmeth...) Show SMILES CN1CCC[C@@H]1Cc1c[nH]c2ccc(Nc3ncccc3[N+]([O-])=O)cc12 Show InChI InChI=1S/C19H21N5O2/c1-23-9-3-4-15(23)10-13-12-21-17-7-6-14(11-16(13)17)22-19-18(24(25)26)5-2-8-20-19/h2,5-8,11-12,15,21H,3-4,9-10H2,1H3,(H,20,22)/t15-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description Binding affinity of the compound was measured against serotonin 5-hydroxytryptamine 1D receptor				J Med Chem 37: 2509-12 (1994) BindingDB Entry DOI: 10.7270/Q2S181JQ
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (RAT)	BDBM50039566 ((3-Nitro-pyridin-2-yl)-(3-(R)-1-pyrrolidin-2-ylmet...) Show SMILES [O-][N+](=O)c1cccnc1Nc1ccc2[nH]cc(C[C@H]3CCCN3)c2c1 Show InChI InChI=1S/C18H19N5O2/c24-23(25)17-4-2-8-20-18(17)22-14-5-6-16-15(10-14)12(11-21-16)9-13-3-1-7-19-13/h2,4-6,8,10-11,13,19,21H,1,3,7,9H2,(H,20,22)/t13-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	6.20	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description Binding affinity of the compound was measured against serotonin 5-hydroxytryptamine 1D receptor				J Med Chem 37: 2509-12 (1994) BindingDB Entry DOI: 10.7270/Q2S181JQ
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (RAT)	BDBM50039565 (CHEMBL314213 | [3-(2-Dimethylamino-ethyl)-1H-indol...) Show SMILES CN(C)CCc1c[nH]c2ccc(Nc3ncccc3[N+]([O-])=O)cc12 Show InChI InChI=1S/C17H19N5O2/c1-21(2)9-7-12-11-19-15-6-5-13(10-14(12)15)20-17-16(22(23)24)4-3-8-18-17/h3-6,8,10-11,19H,7,9H2,1-2H3,(H,18,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description Binding affinity of the compound was measured against serotonin 5-hydroxytryptamine 1D receptor				J Med Chem 37: 2509-12 (1994) BindingDB Entry DOI: 10.7270/Q2S181JQ
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (RAT)	BDBM50039567 (CHEMBL84942 | [3-(1-Methyl-pyrrolidin-3-yl)-1H-ind...) Show SMILES CN1CCC(C1)c1c[nH]c2ccc(Nc3ncccc3[N+]([O-])=O)cc12 Show InChI InChI=1S/C18H19N5O2/c1-22-8-6-12(11-22)15-10-20-16-5-4-13(9-14(15)16)21-18-17(23(24)25)3-2-7-19-18/h2-5,7,9-10,12,20H,6,8,11H2,1H3,(H,19,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description Binding affinity of the compound was measured against serotonin 5-hydroxytryptamine 1D receptor				J Med Chem 37: 2509-12 (1994) BindingDB Entry DOI: 10.7270/Q2S181JQ
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (RAT)	BDBM79215 (CHEMBL15928 | GR 127935 | GR 127935 hydrochloride ...) Show SMILES COc1ccc(NC(=O)c2ccc(cc2)-c2ccc(cc2C)-c2noc(C)n2)cc1N1CCN(C)CC1 Show InChI InChI=1S/C29H31N5O3/c1-19-17-23(28-30-20(2)37-32-28)9-11-25(19)21-5-7-22(8-6-21)29(35)31-24-10-12-27(36-4)26(18-24)34-15-13-33(3)14-16-34/h5-12,17-18H,13-16H2,1-4H3,(H,31,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
Merck KGaA Curated by ChEMBL					Assay Description Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]-iodocyanopindolol as radio-ligand.				J Med Chem 43: 1149-57 (2000) BindingDB Entry DOI: 10.7270/Q2VD6XPX
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (RAT)	BDBM50005835 ((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...) Show SMILES CNS(=O)(=O)Cc1ccc2[nH]cc(CCN(C)C)c2c1 Show InChI InChI=1S/C14H21N3O2S/c1-15-20(18,19)10-11-4-5-14-13(8-11)12(9-16-14)6-7-17(2)3/h4-5,8-9,15-16H,6-7,10H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents	PubMed	n/a	n/a	61	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description Binding affinity of the compound was measured against serotonin 5-hydroxytryptamine 1D receptor				J Med Chem 37: 2509-12 (1994) BindingDB Entry DOI: 10.7270/Q2S181JQ
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (RAT)	BDBM50086095 (3-{1-[4-Methoxy-3-(4-methyl-piperazin-1-yl)-phenyl...) Show SMILES COc1ccc(NC(=O)N2CCC(CC2)c2c[nH]c3ccc(cc23)C(N)=O)cc1N1CCN(C)CC1 Show InChI InChI=1S/C27H34N6O3/c1-31-11-13-32(14-12-31)24-16-20(4-6-25(24)36-2)30-27(35)33-9-7-18(8-10-33)22-17-29-23-5-3-19(26(28)34)15-21(22)23/h3-6,15-18,29H,7-14H2,1-2H3,(H2,28,34)(H,30,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Merck KGaA Curated by ChEMBL					Assay Description Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]-iodocyanopindolol as radio-ligand.				J Med Chem 43: 1149-57 (2000) BindingDB Entry DOI: 10.7270/Q2VD6XPX
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (RAT)	BDBM50086097 (1-[2-(5-Fluoro-1H-indol-3-yl)-ethyl]-3-[4-methoxy-...) Show SMILES COc1ccc(NC(=O)NCCc2c[nH]c3ccc(F)cc23)cc1N1CCN(C)CC1 Show InChI InChI=1S/C23H28FN5O2/c1-28-9-11-29(12-10-28)21-14-18(4-6-22(21)31-2)27-23(30)25-8-7-16-15-26-20-5-3-17(24)13-19(16)20/h3-6,13-15,26H,7-12H2,1-2H3,(H2,25,27,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	167	n/a	n/a	n/a	n/a	n/a	n/a
Merck KGaA Curated by ChEMBL					Assay Description Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]-iodocyanopindolol as radio-ligand.				J Med Chem 43: 1149-57 (2000) BindingDB Entry DOI: 10.7270/Q2VD6XPX
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (RAT)	BDBM50086112 (4-(6-Fluoro-1H-indol-3-yl)-piperidine-1-carboxylic...) Show SMILES COc1ccc(NC(=O)N2CCC(CC2)c2c[nH]c3cc(F)ccc23)cc1N1CCN(C)CC1 Show InChI InChI=1S/C26H32FN5O2/c1-30-11-13-31(14-12-30)24-16-20(4-6-25(24)34-2)29-26(33)32-9-7-18(8-10-32)22-17-28-23-15-19(27)3-5-21(22)23/h3-6,15-18,28H,7-14H2,1-2H3,(H,29,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Merck KGaA Curated by ChEMBL					Assay Description Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]-iodocyanopindolol as radio-ligand.				J Med Chem 43: 1149-57 (2000) BindingDB Entry DOI: 10.7270/Q2VD6XPX
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (RAT)	BDBM50086102 (1-[2-(5-Hydroxy-1H-indol-3-yl)-ethyl]-3-[4-methoxy...) Show SMILES COc1ccc(NC(=O)NCCc2c[nH]c3ccc(O)cc23)cc1N1CCN(C)CC1 Show InChI InChI=1S/C23H29N5O3/c1-27-9-11-28(12-10-27)21-13-17(3-6-22(21)31-2)26-23(30)24-8-7-16-15-25-20-5-4-18(29)14-19(16)20/h3-6,13-15,25,29H,7-12H2,1-2H3,(H2,24,26,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Merck KGaA Curated by ChEMBL					Assay Description Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]-iodocyanopindolol as radio-ligand.				J Med Chem 43: 1149-57 (2000) BindingDB Entry DOI: 10.7270/Q2VD6XPX
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (RAT)	BDBM50086104 (4-[2-(1H-Indol-3-yl)-ethyl]-piperidine-1-carboxyli...) Show SMILES COc1ccc(NC(=O)N2CCC(CCc3c[nH]c4ccccc34)CC2)cc1N1CCN(C)CC1 Show InChI InChI=1S/C28H37N5O2/c1-31-15-17-32(18-16-31)26-19-23(9-10-27(26)35-2)30-28(34)33-13-11-21(12-14-33)7-8-22-20-29-25-6-4-3-5-24(22)25/h3-6,9-10,19-21,29H,7-8,11-18H2,1-2H3,(H,30,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Merck KGaA Curated by ChEMBL					Assay Description Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]-iodocyanopindolol as radio-ligand.				J Med Chem 43: 1149-57 (2000) BindingDB Entry DOI: 10.7270/Q2VD6XPX
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (RAT)	BDBM50086114 (1-{2-[4-(6-Fluoro-1H-indol-3-yl)-piperidin-1-yl]-e...) Show SMILES COc1ccc(NC(=O)NCCN2CCC(CC2)c2c[nH]c3cc(F)ccc23)cc1N1CCN(C)CC1 Show InChI InChI=1S/C28H37FN6O2/c1-33-13-15-35(16-14-33)26-18-22(4-6-27(26)37-2)32-28(36)30-9-12-34-10-7-20(8-11-34)24-19-31-25-17-21(29)3-5-23(24)25/h3-6,17-20,31H,7-16H2,1-2H3,(H2,30,32,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Merck KGaA Curated by ChEMBL					Assay Description Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]-iodocyanopindolol as radio-ligand.				J Med Chem 43: 1149-57 (2000) BindingDB Entry DOI: 10.7270/Q2VD6XPX
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (RAT)	BDBM50086110 (3-(5-Fluoro-1H-indol-3-yl)-pyrrolidine-1-carboxyli...) Show SMILES COc1ccc(NC(=O)N2CCC(C2)c2c[nH]c3ccc(F)cc23)cc1N1CCN(C)CC1 Show InChI InChI=1S/C25H30FN5O2/c1-29-9-11-30(12-10-29)23-14-19(4-6-24(23)33-2)28-25(32)31-8-7-17(16-31)21-15-27-22-5-3-18(26)13-20(21)22/h3-6,13-15,17,27H,7-12,16H2,1-2H3,(H,28,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	233	n/a	n/a	n/a	n/a	n/a	n/a
Merck KGaA Curated by ChEMBL					Assay Description Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]-iodocyanopindolol as radio-ligand.				J Med Chem 43: 1149-57 (2000) BindingDB Entry DOI: 10.7270/Q2VD6XPX
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (RAT)	BDBM50086111 (4-(1H-Indol-3-yl)-piperidine-1-carboxylic acid [4-...) Show SMILES COc1ccc(NC(=O)N2CCC(CC2)c2c[nH]c3ccccc23)cc1N1CCN(C)CC1 Show InChI InChI=1S/C26H33N5O2/c1-29-13-15-30(16-14-29)24-17-20(7-8-25(24)33-2)28-26(32)31-11-9-19(10-12-31)22-18-27-23-6-4-3-5-21(22)23/h3-8,17-19,27H,9-16H2,1-2H3,(H,28,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	233	n/a	n/a	n/a	n/a	n/a	n/a
Merck KGaA Curated by ChEMBL					Assay Description Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]-iodocyanopindolol as radio-ligand.				J Med Chem 43: 1149-57 (2000) BindingDB Entry DOI: 10.7270/Q2VD6XPX
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (RAT)	BDBM50086099 (4-(4-Fluoro-1H-indol-3-yl)-piperidine-1-carboxylic...) Show SMILES COc1ccc(NC(=O)N2CCC(CC2)c2c[nH]c3cccc(F)c23)cc1N1CCN(C)CC1 Show InChI InChI=1S/C26H32FN5O2/c1-30-12-14-31(15-13-30)23-16-19(6-7-24(23)34-2)29-26(33)32-10-8-18(9-11-32)20-17-28-22-5-3-4-21(27)25(20)22/h3-7,16-18,28H,8-15H2,1-2H3,(H,29,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Merck KGaA Curated by ChEMBL					Assay Description Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]-iodocyanopindolol as radio-ligand.				J Med Chem 43: 1149-57 (2000) BindingDB Entry DOI: 10.7270/Q2VD6XPX
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (RAT)	BDBM50086101 (4-[4-(5-Fluoro-1H-indol-3-yl)-butyl]-piperazine-1-...) Show SMILES COc1ccc(NC(=O)N2CCN(CCCCc3c[nH]c4ccc(F)cc34)CC2)cc1N1CCN(C)CC1 Show InChI InChI=1S/C29H39FN6O2/c1-33-11-15-35(16-12-33)27-20-24(7-9-28(27)38-2)32-29(37)36-17-13-34(14-18-36)10-4-3-5-22-21-31-26-8-6-23(30)19-25(22)26/h6-9,19-21,31H,3-5,10-18H2,1-2H3,(H,32,37)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	367	n/a	n/a	n/a	n/a	n/a	n/a
Merck KGaA Curated by ChEMBL					Assay Description Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]-iodocyanopindolol as radio-ligand.				J Med Chem 43: 1149-57 (2000) BindingDB Entry DOI: 10.7270/Q2VD6XPX
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (RAT)	BDBM50086100 (4-(5-Cyano-1H-indol-3-yl)-piperidine-1-carboxylic ...) Show SMILES COc1ccc(NC(=O)N2CCC(CC2)c2c[nH]c3ccc(cc23)C#N)cc1N1CCN(C)CC1 Show InChI InChI=1S/C27H32N6O2/c1-31-11-13-32(14-12-31)25-16-21(4-6-26(25)35-2)30-27(34)33-9-7-20(8-10-33)23-18-29-24-5-3-19(17-28)15-22(23)24/h3-6,15-16,18,20,29H,7-14H2,1-2H3,(H,30,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Merck KGaA Curated by ChEMBL					Assay Description Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]-iodocyanopindolol as radio-ligand.				J Med Chem 43: 1149-57 (2000) BindingDB Entry DOI: 10.7270/Q2VD6XPX
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (RAT)	BDBM50086106 (1-[3-(2-Dimethylamino-ethoxy)-4-methoxy-phenyl]-3-...) Show SMILES COc1ccc(NC(=O)NCCN2CCC(CC2)c2c[nH]c3cc(F)ccc23)cc1OCCN(C)C Show InChI InChI=1S/C27H36FN5O3/c1-32(2)14-15-36-26-17-21(5-7-25(26)35-3)31-27(34)29-10-13-33-11-8-19(9-12-33)23-18-30-24-16-20(28)4-6-22(23)24/h4-7,16-19,30H,8-15H2,1-3H3,(H2,29,31,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	433	n/a	n/a	n/a	n/a	n/a	n/a
Merck KGaA Curated by ChEMBL					Assay Description Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]-iodocyanopindolol as radio-ligand.				J Med Chem 43: 1149-57 (2000) BindingDB Entry DOI: 10.7270/Q2VD6XPX
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (RAT)	BDBM50086103 (8-Fluoro-1,3,4,5-tetrahydro-pyrido[4,3-b]indole-2-...) Show SMILES COc1ccc(NC(=O)N2CCc3[nH]c4ccc(F)cc4c3C2)cc1N1CCN(C)CC1 Show InChI InChI=1S/C24H28FN5O2/c1-28-9-11-29(12-10-28)22-14-17(4-6-23(22)32-2)26-24(31)30-8-7-21-19(15-30)18-13-16(25)3-5-20(18)27-21/h3-6,13-14,27H,7-12,15H2,1-2H3,(H,26,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	667	n/a	n/a	n/a	n/a	n/a	n/a
Merck KGaA Curated by ChEMBL					Assay Description Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]-iodocyanopindolol as radio-ligand.				J Med Chem 43: 1149-57 (2000) BindingDB Entry DOI: 10.7270/Q2VD6XPX
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (RAT)	BDBM50086115 (5-[4-(5-fluoro-1H-3-indolyl)hexahydro-1-pyridinylc...) Show SMILES CN1CCC2(COc3ccc(NC(=O)N4CCC(CC4)c4c[nH]c5ccc(F)cc45)cc23)CC1 Show InChI InChI=1S/C27H31FN4O2/c1-31-12-8-27(9-13-31)17-34-25-5-3-20(15-23(25)27)30-26(33)32-10-6-18(7-11-32)22-16-29-24-4-2-19(28)14-21(22)24/h2-5,14-16,18,29H,6-13,17H2,1H3,(H,30,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a	n/a
Merck KGaA Curated by ChEMBL					Assay Description Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]-iodocyanopindolol as radio-ligand.				J Med Chem 43: 1149-57 (2000) BindingDB Entry DOI: 10.7270/Q2VD6XPX
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (RAT)	BDBM50086117 (1-{2-[4-(6-fluoro-1H-indol-3-yl)piperidin-1yl]ethy...) Show SMILES CN1CCC2(COc3ccc(NC(=O)NCCN4CCC(CC4)c4c[nH]c5cc(F)ccc45)cc23)CC1 Show InChI InChI=1S/C29H36FN5O2/c1-34-13-8-29(9-14-34)19-37-27-5-3-22(17-25(27)29)33-28(36)31-10-15-35-11-6-20(7-12-35)24-18-32-26-16-21(30)2-4-23(24)26/h2-5,16-18,20,32H,6-15,19H2,1H3,(H2,31,33,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a	n/a
Merck KGaA Curated by ChEMBL					Assay Description Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]-iodocyanopindolol as radio-ligand.				J Med Chem 43: 1149-57 (2000) BindingDB Entry DOI: 10.7270/Q2VD6XPX
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (RAT)	BDBM50086113 (4-(5-Fluoro-1H-indol-3-yl)-piperidine-1-carboxylic...) Show SMILES COc1ccc(NC(=O)N2CCC(CC2)c2c[nH]c3ccc(F)cc23)cc1OCCN(C)C Show InChI InChI=1S/C25H31FN4O3/c1-29(2)12-13-33-24-15-19(5-7-23(24)32-3)28-25(31)30-10-8-17(9-11-30)21-16-27-22-6-4-18(26)14-20(21)22/h4-7,14-17,27H,8-13H2,1-3H3,(H,28,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck KGaA Curated by ChEMBL					Assay Description Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]-iodocyanopindolol as radio-ligand.				J Med Chem 43: 1149-57 (2000) BindingDB Entry DOI: 10.7270/Q2VD6XPX
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (RAT)	BDBM50086096 (2'-Methyl-4'-(5-methyl-[1,2,4]oxadiazol-3-yl)-biph...) Show SMILES CN1CCC2(COc3ccc(NC(=O)c4ccc(cc4)-c4ccc(cc4C)-c4noc(C)n4)cc23)CC1 Show InChI InChI=1S/C30H30N4O3/c1-19-16-23(28-31-20(2)37-33-28)8-10-25(19)21-4-6-22(7-5-21)29(35)32-24-9-11-27-26(17-24)30(18-36-27)12-14-34(3)15-13-30/h4-11,16-17H,12-15,18H2,1-3H3,(H,32,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck KGaA Curated by ChEMBL					Assay Description Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]-iodocyanopindolol as radio-ligand.				J Med Chem 43: 1149-57 (2000) BindingDB Entry DOI: 10.7270/Q2VD6XPX
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (RAT)	BDBM50151982 (5-{4-[4-(5-Cyano-1H-indol-3-yl)-butyl]-piperazin-1...) Show SMILES NC(=O)c1cc2cc(ccc2o1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1 Show InChI InChI=1S/C26H27N5O2/c27-16-18-4-6-23-22(13-18)19(17-29-23)3-1-2-8-30-9-11-31(12-10-30)21-5-7-24-20(14-21)15-25(33-24)26(28)32/h4-7,13-15,17,29H,1-3,8-12H2,(H2,28,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck KGaA Curated by ChEMBL					Assay Description Inhibition of rat hydroxytryptamine 1D receptor				J Med Chem 47: 4684-92 (2004) Article DOI: 10.1021/jm040793q BindingDB Entry DOI: 10.7270/Q2513XPS
					More data for this Ligand-Target Pair