Found 60 hits of ec50 for UniProtKB: P35347 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50153584
(CHEMBL3775924)Show SMILES CCCCC(NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](N)Cc1ccccc1)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](C)NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O |r| Show InChI InChI=1S/C161H269N49O42/c1-23-27-41-96(189-145(239)107(52-59-123(217)218)199-152(246)114(71-84(13)14)207-157(251)126(85(15)16)208-147(241)108(53-60-124(219)220)197-140(234)102(47-38-66-179-161(172)173)193-151(245)112(69-82(9)10)204-153(247)113(70-83(11)12)205-155(249)116(74-94-77-175-79-181-94)201-134(228)95(163)72-92-39-30-29-31-40-92)135(229)182-88(19)130(224)186-100(45-36-64-177-159(168)169)136(230)183-89(20)131(225)188-106(51-58-122(215)216)144(238)195-104(49-56-119(165)212)146(240)202-110(67-80(5)6)149(243)185-90(21)132(226)187-103(48-55-118(164)211)143(237)196-105-50-57-121(214)176-63-35-33-44-99(192-154(248)115(73-93-76-174-78-180-93)200-133(227)91(22)184-137(105)231)142(236)206-117(75-120(166)213)156(250)194-101(46-37-65-178-160(170)171)139(233)190-98(43-32-34-62-162)141(235)203-111(68-81(7)8)150(244)191-97(42-28-24-2)138(232)198-109(54-61-125(221)222)148(242)210-128(87(18)26-4)158(252)209-127(129(167)223)86(17)25-3/h29-31,39-40,76-91,95-117,126-128H,23-28,32-38,41-75,162-163H2,1-22H3,(H2,164,211)(H2,165,212)(H2,166,213)(H2,167,223)(H,174,180)(H,175,181)(H,176,214)(H,182,229)(H,183,230)(H,184,231)(H,185,243)(H,186,224)(H,187,226)(H,188,225)(H,189,239)(H,190,233)(H,191,244)(H,192,248)(H,193,245)(H,194,250)(H,195,238)(H,196,237)(H,197,234)(H,198,232)(H,199,246)(H,200,227)(H,201,228)(H,202,240)(H,203,235)(H,204,247)(H,205,249)(H,206,236)(H,207,251)(H,208,241)(H,209,252)(H,210,242)(H,215,216)(H,217,218)(H,219,220)(H,221,222)(H4,168,169,177)(H4,170,171,178)(H4,172,173,179)/t86-,87-,88-,89-,90-,91-,95+,96?,97?,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,126-,127-,128-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet 
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.420 | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Antagonist activity at CRF-R1 in mouse AtT-20 cells assessed as inhibition of human CRF induced cAMP accumulation after 30 mins by radioimmunoassay |
J Med Chem 59: 854-66 (2016)
Article DOI: 10.1021/acs.jmedchem.5b00926
BindingDB Entry DOI: 10.7270/Q2WQ05NH |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50153579
(CHEMBL3774395)Show SMILES CCCCCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NC(CCCC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)C(C)(C)NC(=O)[C@H](C)NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCC)C(=O)N[C@@H](CCC(O)=O)C(=O)NC(C)(C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O |r| Show InChI InChI=1S/C175H294N50O49/c1-29-33-37-56-128(231)197-123(84-133(240)241)161(266)214-119(80-91(13)14)162(267)221-136(98(22)226)166(271)218-120(81-99-47-38-36-39-48-99)158(263)215-121(82-100-85-187-86-192-100)159(264)213-117(78-89(9)10)157(262)212-116(77-88(7)8)155(260)204-106(55-46-75-191-172(185)186)147(252)207-112(62-69-131(236)237)153(258)220-134(92(15)16)165(270)217-118(79-90(11)12)156(261)208-111(61-68-130(234)235)152(257)201-101(49-34-30-2)142(247)193-94(18)138(243)198-104(53-44-73-189-170(181)182)143(248)194-95(19)139(244)200-110(60-67-129(232)233)151(256)209-113(58-65-125(178)228)163(268)224-173(23,24)167(272)196-96(20)140(245)199-108(57-64-124(177)227)150(255)206-109-59-66-127(230)188-72-43-41-52-107(219-168(273)174(25,26)223-141(246)97(21)195-144(109)249)149(254)216-122(83-126(179)229)160(265)205-105(54-45-74-190-171(183)184)146(251)202-103(51-40-42-71-176)148(253)211-115(76-87(5)6)154(259)203-102(50-35-31-3)145(250)210-114(63-70-132(238)239)164(269)225-175(27,28)169(274)222-135(137(180)242)93(17)32-4/h36,38-39,47-48,85-98,101-123,134-136,226H,29-35,37,40-46,49-84,176H2,1-28H3,(H2,177,227)(H2,178,228)(H2,179,229)(H2,180,242)(H,187,192)(H,188,230)(H,193,247)(H,194,248)(H,195,249)(H,196,272)(H,197,231)(H,198,243)(H,199,245)(H,200,244)(H,201,257)(H,202,251)(H,203,259)(H,204,260)(H,205,265)(H,206,255)(H,207,252)(H,208,261)(H,209,256)(H,210,250)(H,211,253)(H,212,262)(H,213,264)(H,214,266)(H,215,263)(H,216,254)(H,217,270)(H,218,271)(H,219,273)(H,220,258)(H,221,267)(H,222,274)(H,223,246)(H,224,268)(H,225,269)(H,232,233)(H,234,235)(H,236,237)(H,238,239)(H,240,241)(H4,181,182,189)(H4,183,184,190)(H4,185,186,191)/t93-,94-,95-,96-,97-,98+,101?,102?,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120+,121-,122-,123-,134-,135-,136-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.440 | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Antagonist activity at CRF-R1 in mouse AtT-20 cells assessed as inhibition of human CRF induced cAMP accumulation after 30 mins by radioimmunoassay |
J Med Chem 59: 854-66 (2016)
Article DOI: 10.1021/acs.jmedchem.5b00926
BindingDB Entry DOI: 10.7270/Q2WQ05NH |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50153477
(CHEMBL3775524)Show SMILES CCCCC(NC(=O)C(CCC(O)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(O)=O)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(Cc1ccccc1)NC(=O)C(NC(=O)C(CC(C)C)NC(=O)C(CC(O)=O)NC(C)=O)C(C)O)C(C)C)C(=O)NC(C)C(=O)NC(CCCNC(N)=N)C(=O)NC(C)C(=O)NC(CCC(O)=O)C(=O)NC(CCC(N)=O)C(=O)NC(C)(CC(C)C)C(=O)NC(C)C(=O)NC(CCC(N)=O)C(=O)NC1CCC(=O)NCCCCC(NC(=O)C(C)(C)NC(=O)C(C)NC1=O)C(=O)NC(CC(N)=O)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCCC)C(=O)NC(CCC(O)=O)C(=O)NC(C)(CC(C)C)C(=O)NC(C(C)CC)C(N)=O Show InChI InChI=1S/C177H298N50O49/c1-31-34-48-104(203-154(259)114(59-66-132(236)237)210-158(263)121(77-90(10)11)219-167(272)136(94(18)19)222-155(260)115(60-67-133(238)239)209-149(254)109(54-45-73-193-174(187)188)206-157(262)119(75-88(6)7)214-159(264)120(76-89(8)9)215-161(266)124(80-103-85-189-86-194-103)217-160(265)123(79-102-46-37-36-38-47-102)220-168(273)138(100(25)228)223-164(269)122(78-91(12)13)216-163(268)126(82-135(242)243)199-101(26)229)144(249)195-96(21)140(245)200-107(52-43-71-191-172(183)184)145(250)196-97(22)141(246)202-113(58-65-131(234)235)153(258)211-116(56-63-128(180)231)165(270)226-176(29,83-92(14)15)170(275)198-98(23)142(247)201-111(55-62-127(179)230)152(257)208-112-57-64-130(233)190-70-42-40-51-110(221-169(274)175(27,28)225-143(248)99(24)197-146(112)251)151(256)218-125(81-129(181)232)162(267)207-108(53-44-72-192-173(185)186)148(253)204-106(50-39-41-69-178)150(255)213-118(74-87(4)5)156(261)205-105(49-35-32-2)147(252)212-117(61-68-134(240)241)166(271)227-177(30,84-93(16)17)171(276)224-137(139(182)244)95(20)33-3/h36-38,46-47,85-100,104-126,136-138,228H,31-35,39-45,48-84,178H2,1-30H3,(H2,179,230)(H2,180,231)(H2,181,232)(H2,182,244)(H,189,194)(H,190,233)(H,195,249)(H,196,250)(H,197,251)(H,198,275)(H,199,229)(H,200,245)(H,201,247)(H,202,246)(H,203,259)(H,204,253)(H,205,261)(H,206,262)(H,207,267)(H,208,257)(H,209,254)(H,210,263)(H,211,258)(H,212,252)(H,213,255)(H,214,264)(H,215,266)(H,216,268)(H,217,265)(H,218,256)(H,219,272)(H,220,273)(H,221,274)(H,222,260)(H,223,269)(H,224,276)(H,225,248)(H,226,270)(H,227,271)(H,234,235)(H,236,237)(H,238,239)(H,240,241)(H,242,243)(H4,183,184,191)(H4,185,186,192)(H4,187,188,193)/t95?,96?,97-,98-,99-,100+,104?,105?,106-,107-,108?,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123+,124-,125-,126-,136-,137-,138-,176?,177?/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.450 | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Antagonist activity at CRF-R1 in mouse AtT-20 cells assessed as inhibition of human CRF induced cAMP accumulation after 30 mins by radioimmunoassay |
J Med Chem 59: 854-66 (2016)
Article DOI: 10.1021/acs.jmedchem.5b00926
BindingDB Entry DOI: 10.7270/Q2WQ05NH |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50153485
(CHEMBL3774939)Show SMILES CCCCC(NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)C(C)(C)NC(=O)[C@H](C)NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCC)C(=O)N[C@@H](CCC(O)=O)C(=O)NC(C)(C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O |r| Show InChI InChI=1S/C171H286N50O49/c1-29-32-46-98(197-148(253)108(57-64-126(230)231)204-152(257)115(75-86(10)11)213-161(266)130(88(14)15)216-149(254)109(58-65-127(232)233)203-143(248)103(52-43-71-187-168(181)182)200-151(256)113(73-84(6)7)208-153(258)114(74-85(8)9)209-155(260)118(78-97-81-183-82-188-97)211-154(259)117(77-96-44-35-34-36-45-96)214-162(267)132(94(21)222)217-158(263)116(76-87(12)13)210-157(262)120(80-129(236)237)193-95(22)223)138(243)189-90(17)134(239)194-101(50-41-69-185-166(177)178)139(244)190-91(18)135(240)196-107(56-63-125(228)229)147(252)205-110(54-61-122(174)225)159(264)220-169(23,24)163(268)192-92(19)136(241)195-105(53-60-121(173)224)146(251)202-106-55-62-124(227)184-68-40-38-49-104(215-164(269)170(25,26)219-137(242)93(20)191-140(106)245)145(250)212-119(79-123(175)226)156(261)201-102(51-42-70-186-167(179)180)142(247)198-100(48-37-39-67-172)144(249)207-112(72-83(4)5)150(255)199-99(47-33-30-2)141(246)206-111(59-66-128(234)235)160(265)221-171(27,28)165(270)218-131(133(176)238)89(16)31-3/h34-36,44-45,81-94,98-120,130-132,222H,29-33,37-43,46-80,172H2,1-28H3,(H2,173,224)(H2,174,225)(H2,175,226)(H2,176,238)(H,183,188)(H,184,227)(H,189,243)(H,190,244)(H,191,245)(H,192,268)(H,193,223)(H,194,239)(H,195,241)(H,196,240)(H,197,253)(H,198,247)(H,199,255)(H,200,256)(H,201,261)(H,202,251)(H,203,248)(H,204,257)(H,205,252)(H,206,246)(H,207,249)(H,208,258)(H,209,260)(H,210,262)(H,211,259)(H,212,250)(H,213,266)(H,214,267)(H,215,269)(H,216,254)(H,217,263)(H,218,270)(H,219,242)(H,220,264)(H,221,265)(H,228,229)(H,230,231)(H,232,233)(H,234,235)(H,236,237)(H4,177,178,185)(H4,179,180,186)(H4,181,182,187)/t89-,90-,91-,92-,93-,94+,98?,99?,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117+,118-,119-,120-,130-,131-,132-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Antagonist activity at CRF-R1 in mouse AtT-20 cells assessed as inhibition of human CRF induced cAMP accumulation after 30 mins by radioimmunoassay |
J Med Chem 59: 854-66 (2016)
Article DOI: 10.1021/acs.jmedchem.5b00926
BindingDB Entry DOI: 10.7270/Q2WQ05NH |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50153473
(CHEMBL3775796)Show SMILES CCCCC(NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](C)NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCC)C(=O)N[C@@H](CCC(O)=O)C(=O)NC(C)(CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O |r| Show InChI InChI=1S/C179H298N52O49/c1-29-32-46-106(207-157(263)116(57-64-135(240)241)215-161(267)123(75-91(10)11)225-171(277)139(95(18)19)227-158(264)117(58-65-136(242)243)214-152(258)112(52-43-71-196-177(189)190)211-160(266)121(73-89(6)7)220-162(268)122(74-90(8)9)221-165(271)127(79-105-85-192-87-198-105)223-163(269)125(77-103-44-35-34-36-45-103)226-172(278)141(101(25)232)228-168(274)124(76-92(12)13)222-167(273)129(81-138(246)247)203-102(26)233)147(253)199-97(21)143(249)204-110(50-41-69-194-175(185)186)148(254)200-98(22)144(250)206-115(56-63-134(238)239)156(262)216-118(54-61-131(182)235)169(275)230-178(27,82-93(14)15)173(279)202-100(24)146(252)205-113(53-60-130(181)234)155(261)213-114-55-62-133(237)193-68-40-38-49-109(210-164(270)126(78-104-84-191-86-197-104)218-145(251)99(23)201-149(114)255)154(260)224-128(80-132(183)236)166(272)212-111(51-42-70-195-176(187)188)151(257)208-108(48-37-39-67-180)153(259)219-120(72-88(4)5)159(265)209-107(47-33-30-2)150(256)217-119(59-66-137(244)245)170(276)231-179(28,83-94(16)17)174(280)229-140(142(184)248)96(20)31-3/h34-36,44-45,84-101,106-129,139-141,232H,29-33,37-43,46-83,180H2,1-28H3,(H2,181,234)(H2,182,235)(H2,183,236)(H2,184,248)(H,191,197)(H,192,198)(H,193,237)(H,199,253)(H,200,254)(H,201,255)(H,202,279)(H,203,233)(H,204,249)(H,205,252)(H,206,250)(H,207,263)(H,208,257)(H,209,265)(H,210,270)(H,211,266)(H,212,272)(H,213,261)(H,214,258)(H,215,267)(H,216,262)(H,217,256)(H,218,251)(H,219,259)(H,220,268)(H,221,271)(H,222,273)(H,223,269)(H,224,260)(H,225,277)(H,226,278)(H,227,264)(H,228,274)(H,229,280)(H,230,275)(H,231,276)(H,238,239)(H,240,241)(H,242,243)(H,244,245)(H,246,247)(H4,185,186,194)(H4,187,188,195)(H4,189,190,196)/t96-,97-,98-,99-,100-,101+,106?,107?,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125+,126-,127-,128-,129-,139-,140-,141-,178?,179?/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Antagonist activity at CRF-R1 in mouse AtT-20 cells assessed as inhibition of human CRF induced cAMP accumulation after 30 mins by radioimmunoassay |
J Med Chem 59: 854-66 (2016)
Article DOI: 10.1021/acs.jmedchem.5b00926
BindingDB Entry DOI: 10.7270/Q2WQ05NH |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50158983
(CHEMBL439883 | E G P P I S I D L S L E L L R K M I...)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C202H345N55O64S/c1-29-103(20)156(250-178(298)125(62-71-153(276)277)236-195(315)157(104(21)30-2)251-179(299)126(72-81-322-28)234-169(289)114(49-37-41-76-206)222-170(290)115(50-42-77-216-201(212)213)226-180(300)127(82-96(6)7)240-183(303)130(85-99(12)13)239-177(297)123(60-69-151(272)273)233-181(301)128(83-97(8)9)244-191(311)138(94-258)248-186(306)133(88-102(18)19)243-189(309)136(91-154(278)279)247-196(316)158(105(22)31-3)252-192(312)139(95-259)249-197(317)159(106(23)32-4)253-193(313)140-52-44-80-257(140)199(319)141-53-45-79-256(141)148(267)93-218-164(284)117-57-66-147(266)221-117)194(314)235-124(61-70-152(274)275)176(296)225-112(47-35-39-74-204)167(287)230-120(56-65-144(209)263)173(293)232-122(59-68-150(270)271)175(295)224-113(48-36-40-75-205)168(288)231-121(58-67-149(268)269)174(294)223-111(46-34-38-73-203)166(286)229-119(55-64-143(208)262)172(292)228-118(54-63-142(207)261)165(285)220-108(25)162(282)219-109(26)163(283)237-134(89-145(210)264)188(308)245-135(90-146(211)265)187(307)227-116(51-43-78-217-202(214)215)171(291)238-129(84-98(10)11)182(302)241-131(86-100(14)15)184(304)242-132(87-101(16)17)185(305)246-137(92-155(280)281)190(310)255-161(110(27)260)198(318)254-160(200(320)321)107(24)33-5/h96-141,156-161,258-260H,29-95,203-206H2,1-28H3,(H2,207,261)(H2,208,262)(H2,209,263)(H2,210,264)(H2,211,265)(H,218,284)(H,219,282)(H,220,285)(H,221,266)(H,222,290)(H,223,294)(H,224,295)(H,225,296)(H,226,300)(H,227,307)(H,228,292)(H,229,286)(H,230,287)(H,231,288)(H,232,293)(H,233,301)(H,234,289)(H,235,314)(H,236,315)(H,237,283)(H,238,291)(H,239,297)(H,240,303)(H,241,302)(H,242,304)(H,243,309)(H,244,311)(H,245,308)(H,246,305)(H,247,316)(H,248,306)(H,249,317)(H,250,298)(H,251,299)(H,252,312)(H,253,313)(H,254,318)(H,255,310)(H,268,269)(H,270,271)(H,272,273)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,320,321)(H4,212,213,216)(H4,214,215,217)/t103-,104-,105-,106-,107-,108-,109-,110+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,156-,157-,158-,159-,160-,161-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 18 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50119607
(CHEMBL440057 | E G P P I S I D L S L E L L R K M I...)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)CO)[C@@H](C)CC)[C@@H](C)O)C(C)C)[C@@H](C)CC)C(O)=O Show InChI InChI=1S/C208H343N59O64S2/c1-30-106(20)161(263-198(323)147-49-41-75-266(147)204(329)148-50-42-76-267(148)203(328)132(59-68-158(286)287)246-179(304)126(55-64-154(278)279)235-169(294)117(210)93-268)200(325)260-146(95-270)197(322)253-137(83-102(12)13)189(314)256-144(90-159(288)289)194(319)252-139(85-104(16)17)195(320)265-164(113(27)271)202(327)258-140(86-114-43-34-33-35-44-114)190(315)254-142(88-116-92-222-97-227-116)191(316)251-136(82-101(10)11)188(313)250-135(81-100(8)9)185(310)237-121(48-40-74-225-208(219)220)174(299)241-128(57-66-156(282)283)182(307)261-160(105(18)19)199(324)257-138(84-103(14)15)187(312)243-127(56-65-155(280)281)178(303)244-130(69-77-332-28)172(297)230-109(23)165(290)232-119(46-38-72-223-206(215)216)170(295)228-110(24)166(291)234-125(54-63-153(276)277)177(302)240-124(53-62-151(213)274)180(305)248-133(79-98(4)5)184(309)231-111(25)167(292)233-123(52-61-150(212)273)176(301)239-122(51-60-149(211)272)171(296)229-112(26)168(293)247-141(87-115-91-221-96-226-115)192(317)259-145(94-269)196(321)255-143(89-152(214)275)193(318)238-120(47-39-73-224-207(217)218)173(298)236-118(45-36-37-71-209)175(300)249-134(80-99(6)7)186(311)245-131(70-78-333-29)181(306)242-129(58-67-157(284)285)183(308)262-162(107(21)31-2)201(326)264-163(205(330)331)108(22)32-3/h33-35,43-44,91-92,96-113,117-148,160-164,268-271H,30-32,36-42,45-90,93-95,209-210H2,1-29H3,(H2,211,272)(H2,212,273)(H2,213,274)(H2,214,275)(H,221,226)(H,222,227)(H,228,295)(H,229,296)(H,230,297)(H,231,309)(H,232,290)(H,233,292)(H,234,291)(H,235,294)(H,236,298)(H,237,310)(H,238,318)(H,239,301)(H,240,302)(H,241,299)(H,242,306)(H,243,312)(H,244,303)(H,245,311)(H,246,304)(H,247,293)(H,248,305)(H,249,300)(H,250,313)(H,251,316)(H,252,319)(H,253,322)(H,254,315)(H,255,321)(H,256,314)(H,257,324)(H,258,327)(H,259,317)(H,260,325)(H,261,307)(H,262,308)(H,263,323)(H,264,326)(H,265,320)(H,276,277)(H,278,279)(H,280,281)(H,282,283)(H,284,285)(H,286,287)(H,288,289)(H,330,331)(H4,215,216,223)(H4,217,218,224)(H4,219,220,225)/t106-,107-,108-,109-,110-,111-,112-,113+,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,160-,161-,162-,163-,164-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 20 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50158982
(CHEMBL413414 | Sauvagine derivative)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C211H347N55O61S/c1-27-111(18)165(258-186(303)134(71-79-162(282)283)244-203(320)166(112(19)28-2)259-187(304)135(80-90-328-26)242-178(295)124(58-41-45-84-215)231-179(296)125(59-46-85-225-210(221)222)235-188(305)136(91-105(6)7)247-191(308)139(94-108(12)13)250-193(310)141(97-119-51-34-32-35-52-119)251-194(311)142(98-120-53-36-33-37-54-120)254-200(317)149-61-48-88-265(149)207(324)147(96-110(16)17)256-197(314)145(101-163(284)285)255-204(321)167(113(20)29-3)260-199(316)148(104-267)257-205(322)168(114(21)30-4)261-201(318)150-62-49-89-266(150)208(325)151-63-50-87-264(151)158(275)103-227-173(290)127-67-75-157(274)230-127)202(319)243-133(70-78-161(280)281)185(302)234-122(56-39-43-82-213)176(293)239-130(66-74-154(218)271)182(299)241-132(69-77-160(278)279)184(301)233-123(57-40-44-83-214)177(294)240-131(68-76-159(276)277)183(300)232-121(55-38-42-81-212)175(292)238-129(65-73-153(217)270)181(298)237-128(64-72-152(216)269)174(291)229-116(23)171(288)228-117(24)172(289)245-143(99-155(219)272)196(313)252-144(100-156(220)273)195(312)236-126(60-47-86-226-211(223)224)180(297)246-137(92-106(8)9)189(306)248-138(93-107(10)11)190(307)249-140(95-109(14)15)192(309)253-146(102-164(286)287)198(315)263-170(118(25)268)206(323)262-169(209(326)327)115(22)31-5/h32-37,51-54,105-118,121-151,165-170,267-268H,27-31,38-50,55-104,212-215H2,1-26H3,(H2,216,269)(H2,217,270)(H2,218,271)(H2,219,272)(H2,220,273)(H,227,290)(H,228,288)(H,229,291)(H,230,274)(H,231,296)(H,232,300)(H,233,301)(H,234,302)(H,235,305)(H,236,312)(H,237,298)(H,238,292)(H,239,293)(H,240,294)(H,241,299)(H,242,295)(H,243,319)(H,244,320)(H,245,289)(H,246,297)(H,247,308)(H,248,306)(H,249,307)(H,250,310)(H,251,311)(H,252,313)(H,253,309)(H,254,317)(H,255,321)(H,256,314)(H,257,322)(H,258,303)(H,259,304)(H,260,316)(H,261,318)(H,262,323)(H,263,315)(H,276,277)(H,278,279)(H,280,281)(H,282,283)(H,284,285)(H,286,287)(H,326,327)(H4,221,222,225)(H4,223,224,226)/t111-,112-,113-,114-,115-,116-,117-,118+,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,165-,166-,167-,168-,169-,170-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 48 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50158997
(CHEMBL267635 | Sauvagine derivative)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C205H347N57O61S/c1-29-106(20)159(254-180(299)128(63-71-156(278)279)240-197(316)160(107(21)30-2)255-181(300)129(72-82-324-28)238-172(291)118(50-37-41-76-209)227-173(292)119(51-42-77-220-204(215)216)231-182(301)130(83-99(6)7)243-185(304)133(86-102(12)13)246-188(307)136(90-114-95-219-98-223-114)247-187(306)135(88-104(16)17)250-194(313)143-53-44-80-261(143)201(320)141(89-105(18)19)252-191(310)139(93-157(280)281)251-198(317)161(108(22)31-3)256-193(312)142(97-263)253-199(318)162(109(23)32-4)257-195(314)144-54-45-81-262(144)202(321)145-55-46-79-260(145)152(271)96-222-167(286)121-59-67-151(270)226-121)196(315)239-127(62-70-155(276)277)179(298)230-116(48-35-39-74-207)170(289)235-124(58-66-148(212)267)176(295)237-126(61-69-154(274)275)178(297)229-117(49-36-40-75-208)171(290)236-125(60-68-153(272)273)177(296)228-115(47-34-38-73-206)169(288)234-123(57-65-147(211)266)175(294)233-122(56-64-146(210)265)168(287)225-111(25)165(284)224-112(26)166(285)241-137(91-149(213)268)190(309)248-138(92-150(214)269)189(308)232-120(52-43-78-221-205(217)218)174(293)242-131(84-100(8)9)183(302)244-132(85-101(10)11)184(303)245-134(87-103(14)15)186(305)249-140(94-158(282)283)192(311)259-164(113(27)264)200(319)258-163(203(322)323)110(24)33-5/h95,98-113,115-145,159-164,263-264H,29-94,96-97,206-209H2,1-28H3,(H2,210,265)(H2,211,266)(H2,212,267)(H2,213,268)(H2,214,269)(H,219,223)(H,222,286)(H,224,284)(H,225,287)(H,226,270)(H,227,292)(H,228,296)(H,229,297)(H,230,298)(H,231,301)(H,232,308)(H,233,294)(H,234,288)(H,235,289)(H,236,290)(H,237,295)(H,238,291)(H,239,315)(H,240,316)(H,241,285)(H,242,293)(H,243,304)(H,244,302)(H,245,303)(H,246,307)(H,247,306)(H,248,309)(H,249,305)(H,250,313)(H,251,317)(H,252,310)(H,253,318)(H,254,299)(H,255,300)(H,256,312)(H,257,314)(H,258,319)(H,259,311)(H,272,273)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,282,283)(H,322,323)(H4,215,216,220)(H4,217,218,221)/t106-,107-,108-,109-,110-,111-,112-,113+,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,159-,160-,161-,162-,163-,164-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 52 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50158985
(CHEMBL411590 | Sauvagine derivative)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C217H350N56O61S/c1-27-113(18)171(208(326)250-139(70-78-167(287)288)191(309)241-128(54-37-41-82-219)182(300)246-136(66-74-160(224)278)188(306)248-138(69-77-166(285)286)190(308)240-129(55-38-42-83-220)183(301)247-137(68-76-165(283)284)189(307)239-127(53-36-40-81-218)181(299)245-135(65-73-159(223)277)187(305)244-134(64-72-158(222)276)180(298)236-118(23)177(295)235-119(24)178(296)252-149(100-161(225)279)202(320)259-150(101-162(226)280)201(319)243-132(58-45-86-232-217(229)230)186(304)253-143(92-108(8)9)195(313)254-144(93-109(10)11)196(314)255-145(94-110(12)13)197(315)260-152(103-170(293)294)204(322)270-176(120(25)275)212(330)269-175(215(333)334)117(22)31-5)265-192(310)140(71-79-168(289)290)251-209(327)172(114(19)28-2)266-193(311)141(80-90-335-26)249-184(302)130(56-39-43-84-221)238-185(303)131(57-44-85-231-216(227)228)242-194(312)142(91-107(6)7)256-199(317)147(98-121-62-63-122-49-32-33-50-123(122)97-121)257-200(318)148(99-124-104-233-126-52-35-34-51-125(124)126)258-198(316)146(95-111(14)15)261-206(324)155-59-46-88-272(155)213(331)153(96-112(16)17)263-203(321)151(102-169(291)292)262-210(328)173(115(20)29-3)267-205(323)154(106-274)264-211(329)174(116(21)30-4)268-207(325)156-60-47-89-273(156)214(332)157-61-48-87-271(157)164(282)105-234-179(297)133-67-75-163(281)237-133/h32-35,49-52,62-63,97,104,107-120,127-157,171-176,233,274-275H,27-31,36-48,53-61,64-96,98-103,105-106,218-221H2,1-26H3,(H2,222,276)(H2,223,277)(H2,224,278)(H2,225,279)(H2,226,280)(H,234,297)(H,235,295)(H,236,298)(H,237,281)(H,238,303)(H,239,307)(H,240,308)(H,241,309)(H,242,312)(H,243,319)(H,244,305)(H,245,299)(H,246,300)(H,247,301)(H,248,306)(H,249,302)(H,250,326)(H,251,327)(H,252,296)(H,253,304)(H,254,313)(H,255,314)(H,256,317)(H,257,318)(H,258,316)(H,259,320)(H,260,315)(H,261,324)(H,262,328)(H,263,321)(H,264,329)(H,265,310)(H,266,311)(H,267,323)(H,268,325)(H,269,330)(H,270,322)(H,283,284)(H,285,286)(H,287,288)(H,289,290)(H,291,292)(H,293,294)(H,333,334)(H4,227,228,231)(H4,229,230,232)/t113-,114-,115-,116-,117-,118-,119-,120+,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,152-,153-,154-,155-,156-,157-,171-,172-,173-,174-,175-,176-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 63 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50158952
(CHEMBL438948 | Sauvagine derivative)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C211H347N55O62S/c1-27-110(18)165(258-186(304)134(70-78-162(283)284)244-203(321)166(111(19)28-2)259-187(305)135(79-89-329-26)242-178(296)124(53-38-42-83-215)231-179(297)125(54-43-84-225-210(221)222)235-188(306)136(90-104(6)7)247-191(309)139(93-107(12)13)250-193(311)141(96-118-48-33-32-34-49-118)251-194(312)142(97-119-59-61-120(269)62-60-119)254-200(318)149-56-45-87-265(149)207(325)147(95-109(16)17)256-197(315)145(100-163(285)286)255-204(322)167(112(20)29-3)260-199(317)148(103-267)257-205(323)168(113(21)30-4)261-201(319)150-57-46-88-266(150)208(326)151-58-47-86-264(151)158(276)102-227-173(291)127-66-74-157(275)230-127)202(320)243-133(69-77-161(281)282)185(303)234-122(51-36-40-81-213)176(294)239-130(65-73-154(218)272)182(300)241-132(68-76-160(279)280)184(302)233-123(52-37-41-82-214)177(295)240-131(67-75-159(277)278)183(301)232-121(50-35-39-80-212)175(293)238-129(64-72-153(217)271)181(299)237-128(63-71-152(216)270)174(292)229-115(23)171(289)228-116(24)172(290)245-143(98-155(219)273)196(314)252-144(99-156(220)274)195(313)236-126(55-44-85-226-211(223)224)180(298)246-137(91-105(8)9)189(307)248-138(92-106(10)11)190(308)249-140(94-108(14)15)192(310)253-146(101-164(287)288)198(316)263-170(117(25)268)206(324)262-169(209(327)328)114(22)31-5/h32-34,48-49,59-62,104-117,121-151,165-170,267-269H,27-31,35-47,50-58,63-103,212-215H2,1-26H3,(H2,216,270)(H2,217,271)(H2,218,272)(H2,219,273)(H2,220,274)(H,227,291)(H,228,289)(H,229,292)(H,230,275)(H,231,297)(H,232,301)(H,233,302)(H,234,303)(H,235,306)(H,236,313)(H,237,299)(H,238,293)(H,239,294)(H,240,295)(H,241,300)(H,242,296)(H,243,320)(H,244,321)(H,245,290)(H,246,298)(H,247,309)(H,248,307)(H,249,308)(H,250,311)(H,251,312)(H,252,314)(H,253,310)(H,254,318)(H,255,322)(H,256,315)(H,257,323)(H,258,304)(H,259,305)(H,260,317)(H,261,319)(H,262,324)(H,263,316)(H,277,278)(H,279,280)(H,281,282)(H,283,284)(H,285,286)(H,287,288)(H,327,328)(H4,221,222,225)(H4,223,224,226)/t110-,111-,112-,113-,114-,115-,116-,117+,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,165-,166-,167-,168-,169-,170-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 64 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50158953
(CHEMBL438928 | Sauvagine derivative)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C208H345N57O62S/c1-27-107(18)162(257-183(303)131(65-73-159(282)283)243-200(320)163(108(19)28-2)258-184(304)132(74-84-328-26)241-175(295)121(48-35-39-78-212)230-176(296)122(49-40-79-223-207(218)219)234-185(305)133(85-101(6)7)246-188(308)136(88-104(12)13)249-191(311)139(92-116-97-222-100-226-116)250-190(310)138(91-115-54-56-117(268)57-55-115)253-197(317)146-51-42-82-264(146)204(324)144(90-106(16)17)255-194(314)142(95-160(284)285)254-201(321)164(109(20)29-3)259-196(316)145(99-266)256-202(322)165(110(21)30-4)260-198(318)147-52-43-83-265(147)205(325)148-53-44-81-263(148)155(275)98-225-170(290)124-61-69-154(274)229-124)199(319)242-130(64-72-158(280)281)182(302)233-119(46-33-37-76-210)173(293)238-127(60-68-151(215)271)179(299)240-129(63-71-157(278)279)181(301)232-120(47-34-38-77-211)174(294)239-128(62-70-156(276)277)180(300)231-118(45-32-36-75-209)172(292)237-126(59-67-150(214)270)178(298)236-125(58-66-149(213)269)171(291)228-112(23)168(288)227-113(24)169(289)244-140(93-152(216)272)193(313)251-141(94-153(217)273)192(312)235-123(50-41-80-224-208(220)221)177(297)245-134(86-102(8)9)186(306)247-135(87-103(10)11)187(307)248-137(89-105(14)15)189(309)252-143(96-161(286)287)195(315)262-167(114(25)267)203(323)261-166(206(326)327)111(22)31-5/h54-57,97,100-114,118-148,162-167,266-268H,27-53,58-96,98-99,209-212H2,1-26H3,(H2,213,269)(H2,214,270)(H2,215,271)(H2,216,272)(H2,217,273)(H,222,226)(H,225,290)(H,227,288)(H,228,291)(H,229,274)(H,230,296)(H,231,300)(H,232,301)(H,233,302)(H,234,305)(H,235,312)(H,236,298)(H,237,292)(H,238,293)(H,239,294)(H,240,299)(H,241,295)(H,242,319)(H,243,320)(H,244,289)(H,245,297)(H,246,308)(H,247,306)(H,248,307)(H,249,311)(H,250,310)(H,251,313)(H,252,309)(H,253,317)(H,254,321)(H,255,314)(H,256,322)(H,257,303)(H,258,304)(H,259,316)(H,260,318)(H,261,323)(H,262,315)(H,276,277)(H,278,279)(H,280,281)(H,282,283)(H,284,285)(H,286,287)(H,326,327)(H4,218,219,223)(H4,220,221,224)/t107-,108-,109-,110-,111-,112-,113-,114+,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,162-,163-,164-,165-,166-,167-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 65 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50159001
(CHEMBL412026 | Sauvagine derivative)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C208H349N55O62S/c1-29-108(20)162(255-183(301)131(67-75-159(280)281)241-200(318)163(109(21)30-2)256-184(302)132(76-86-326-28)239-175(293)121(50-37-41-80-212)228-176(294)122(51-42-81-222-207(218)219)232-185(303)133(87-101(6)7)244-188(306)136(90-104(12)13)247-191(309)139(94-116-56-58-117(266)59-57-116)248-190(308)138(92-106(16)17)251-197(315)146-53-44-84-262(146)204(322)144(93-107(18)19)253-194(312)142(97-160(282)283)252-201(319)164(110(22)31-3)257-196(314)145(100-264)254-202(320)165(111(23)32-4)258-198(316)147-54-45-85-263(147)205(323)148-55-46-83-261(148)155(273)99-224-170(288)124-63-71-154(272)227-124)199(317)240-130(66-74-158(278)279)182(300)231-119(48-35-39-78-210)173(291)236-127(62-70-151(215)269)179(297)238-129(65-73-157(276)277)181(299)230-120(49-36-40-79-211)174(292)237-128(64-72-156(274)275)180(298)229-118(47-34-38-77-209)172(290)235-126(61-69-150(214)268)178(296)234-125(60-68-149(213)267)171(289)226-113(25)168(286)225-114(26)169(287)242-140(95-152(216)270)193(311)249-141(96-153(217)271)192(310)233-123(52-43-82-223-208(220)221)177(295)243-134(88-102(8)9)186(304)245-135(89-103(10)11)187(305)246-137(91-105(14)15)189(307)250-143(98-161(284)285)195(313)260-167(115(27)265)203(321)259-166(206(324)325)112(24)33-5/h56-59,101-115,118-148,162-167,264-266H,29-55,60-100,209-212H2,1-28H3,(H2,213,267)(H2,214,268)(H2,215,269)(H2,216,270)(H2,217,271)(H,224,288)(H,225,286)(H,226,289)(H,227,272)(H,228,294)(H,229,298)(H,230,299)(H,231,300)(H,232,303)(H,233,310)(H,234,296)(H,235,290)(H,236,291)(H,237,292)(H,238,297)(H,239,293)(H,240,317)(H,241,318)(H,242,287)(H,243,295)(H,244,306)(H,245,304)(H,246,305)(H,247,309)(H,248,308)(H,249,311)(H,250,307)(H,251,315)(H,252,319)(H,253,312)(H,254,320)(H,255,301)(H,256,302)(H,257,314)(H,258,316)(H,259,321)(H,260,313)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,282,283)(H,284,285)(H,324,325)(H4,218,219,222)(H4,220,221,223)/t108-,109-,110-,111-,112-,113-,114-,115+,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,162-,163-,164-,165-,166-,167-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 68 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50158977
(CHEMBL438939 | Sauvagine derivative)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C208H349N55O62S/c1-29-108(20)162(255-183(301)131(67-75-159(280)281)241-200(318)163(109(21)30-2)256-184(302)132(76-86-326-28)239-175(293)121(50-37-41-80-212)228-176(294)122(51-42-81-222-207(218)219)232-185(303)133(87-101(6)7)244-187(305)135(89-103(10)11)246-189(307)137(91-105(14)15)248-191(309)139(94-116-56-58-117(266)59-57-116)251-197(315)146-53-44-84-262(146)204(322)144(93-107(18)19)253-194(312)142(97-160(282)283)252-201(319)164(110(22)31-3)257-196(314)145(100-264)254-202(320)165(111(23)32-4)258-198(316)147-54-45-85-263(147)205(323)148-55-46-83-261(148)155(273)99-224-170(288)124-63-71-154(272)227-124)199(317)240-130(66-74-158(278)279)182(300)231-119(48-35-39-78-210)173(291)236-127(62-70-151(215)269)179(297)238-129(65-73-157(276)277)181(299)230-120(49-36-40-79-211)174(292)237-128(64-72-156(274)275)180(298)229-118(47-34-38-77-209)172(290)235-126(61-69-150(214)268)178(296)234-125(60-68-149(213)267)171(289)226-113(25)168(286)225-114(26)169(287)242-140(95-152(216)270)193(311)249-141(96-153(217)271)192(310)233-123(52-43-82-223-208(220)221)177(295)243-134(88-102(8)9)186(304)245-136(90-104(12)13)188(306)247-138(92-106(16)17)190(308)250-143(98-161(284)285)195(313)260-167(115(27)265)203(321)259-166(206(324)325)112(24)33-5/h56-59,101-115,118-148,162-167,264-266H,29-55,60-100,209-212H2,1-28H3,(H2,213,267)(H2,214,268)(H2,215,269)(H2,216,270)(H2,217,271)(H,224,288)(H,225,286)(H,226,289)(H,227,272)(H,228,294)(H,229,298)(H,230,299)(H,231,300)(H,232,303)(H,233,310)(H,234,296)(H,235,290)(H,236,291)(H,237,292)(H,238,297)(H,239,293)(H,240,317)(H,241,318)(H,242,287)(H,243,295)(H,244,305)(H,245,304)(H,246,307)(H,247,306)(H,248,309)(H,249,311)(H,250,308)(H,251,315)(H,252,319)(H,253,312)(H,254,320)(H,255,301)(H,256,302)(H,257,314)(H,258,316)(H,259,321)(H,260,313)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,282,283)(H,284,285)(H,324,325)(H4,218,219,222)(H4,220,221,223)/t108-,109-,110-,111-,112-,113-,114-,115+,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,162-,163-,164-,165-,166-,167-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 76 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50158978
(CHEMBL428824 | Sauvagine derivative)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C215H349N55O61S/c1-27-113(18)169(262-190(307)138(73-81-166(286)287)248-207(324)170(114(19)28-2)263-191(308)139(82-92-332-26)246-182(299)128(60-40-44-86-219)235-183(300)129(61-46-87-229-214(225)226)239-192(309)140(93-107(6)7)251-195(312)143(96-110(12)13)254-198(315)146(100-123-55-45-54-122-53-35-36-56-124(122)123)255-197(314)145(99-121-51-33-32-34-52-121)258-204(321)153-63-48-90-269(153)211(328)151(98-112(16)17)260-201(318)149(103-167(288)289)259-208(325)171(115(20)29-3)264-203(320)152(106-271)261-209(326)172(116(21)30-4)265-205(322)154-64-49-91-270(154)212(329)155-65-50-89-268(155)162(279)105-231-177(294)131-69-77-161(278)234-131)206(323)247-137(72-80-165(284)285)189(306)238-126(58-38-42-84-217)180(297)243-134(68-76-158(222)275)186(303)245-136(71-79-164(282)283)188(305)237-127(59-39-43-85-218)181(298)244-135(70-78-163(280)281)187(304)236-125(57-37-41-83-216)179(296)242-133(67-75-157(221)274)185(302)241-132(66-74-156(220)273)178(295)233-118(23)175(292)232-119(24)176(293)249-147(101-159(223)276)200(317)256-148(102-160(224)277)199(316)240-130(62-47-88-230-215(227)228)184(301)250-141(94-108(8)9)193(310)252-142(95-109(10)11)194(311)253-144(97-111(14)15)196(313)257-150(104-168(290)291)202(319)267-174(120(25)272)210(327)266-173(213(330)331)117(22)31-5/h32-36,45,51-56,107-120,125-155,169-174,271-272H,27-31,37-44,46-50,57-106,216-219H2,1-26H3,(H2,220,273)(H2,221,274)(H2,222,275)(H2,223,276)(H2,224,277)(H,231,294)(H,232,292)(H,233,295)(H,234,278)(H,235,300)(H,236,304)(H,237,305)(H,238,306)(H,239,309)(H,240,316)(H,241,302)(H,242,296)(H,243,297)(H,244,298)(H,245,303)(H,246,299)(H,247,323)(H,248,324)(H,249,293)(H,250,301)(H,251,312)(H,252,310)(H,253,311)(H,254,315)(H,255,314)(H,256,317)(H,257,313)(H,258,321)(H,259,325)(H,260,318)(H,261,326)(H,262,307)(H,263,308)(H,264,320)(H,265,322)(H,266,327)(H,267,319)(H,280,281)(H,282,283)(H,284,285)(H,286,287)(H,288,289)(H,290,291)(H,330,331)(H4,225,226,229)(H4,227,228,230)/t113-,114-,115-,116-,117-,118-,119-,120+,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,152-,153-,154-,155-,169-,170-,171-,172-,173-,174-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 78 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50158994
(CHEMBL436912 | Sauvagine derivative)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C208H345N57O61S/c1-27-108(18)162(257-183(302)131(66-74-159(281)282)243-200(319)163(109(19)28-2)258-184(303)132(75-85-327-26)241-175(294)121(53-38-42-79-212)230-176(295)122(54-43-80-223-207(218)219)234-185(304)133(86-102(6)7)246-188(307)136(89-105(12)13)249-190(309)138(92-116-48-33-32-34-49-116)250-191(310)139(93-117-98-222-101-226-117)253-197(316)146-56-45-83-264(146)204(323)144(91-107(16)17)255-194(313)142(96-160(283)284)254-201(320)164(110(20)29-3)259-196(315)145(100-266)256-202(321)165(111(21)30-4)260-198(317)147-57-46-84-265(147)205(324)148-58-47-82-263(148)155(274)99-225-170(289)124-62-70-154(273)229-124)199(318)242-130(65-73-158(279)280)182(301)233-119(51-36-40-77-210)173(292)238-127(61-69-151(215)270)179(298)240-129(64-72-157(277)278)181(300)232-120(52-37-41-78-211)174(293)239-128(63-71-156(275)276)180(299)231-118(50-35-39-76-209)172(291)237-126(60-68-150(214)269)178(297)236-125(59-67-149(213)268)171(290)228-113(23)168(287)227-114(24)169(288)244-140(94-152(216)271)193(312)251-141(95-153(217)272)192(311)235-123(55-44-81-224-208(220)221)177(296)245-134(87-103(8)9)186(305)247-135(88-104(10)11)187(306)248-137(90-106(14)15)189(308)252-143(97-161(285)286)195(314)262-167(115(25)267)203(322)261-166(206(325)326)112(22)31-5/h32-34,48-49,98,101-115,118-148,162-167,266-267H,27-31,35-47,50-97,99-100,209-212H2,1-26H3,(H2,213,268)(H2,214,269)(H2,215,270)(H2,216,271)(H2,217,272)(H,222,226)(H,225,289)(H,227,287)(H,228,290)(H,229,273)(H,230,295)(H,231,299)(H,232,300)(H,233,301)(H,234,304)(H,235,311)(H,236,297)(H,237,291)(H,238,292)(H,239,293)(H,240,298)(H,241,294)(H,242,318)(H,243,319)(H,244,288)(H,245,296)(H,246,307)(H,247,305)(H,248,306)(H,249,309)(H,250,310)(H,251,312)(H,252,308)(H,253,316)(H,254,320)(H,255,313)(H,256,321)(H,257,302)(H,258,303)(H,259,315)(H,260,317)(H,261,322)(H,262,314)(H,275,276)(H,277,278)(H,279,280)(H,281,282)(H,283,284)(H,285,286)(H,325,326)(H4,218,219,223)(H4,220,221,224)/t108-,109-,110-,111-,112-,113-,114-,115+,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,162-,163-,164-,165-,166-,167-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 81 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50158999
(CHEMBL436914 | Sauvagine derivative)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C207H347N55O61S/c1-29-108(20)161(254-182(299)130(68-76-157(278)279)240-199(316)162(109(21)30-2)255-183(300)131(77-87-324-28)238-174(291)120(55-40-44-81-211)227-175(292)121(56-45-82-221-206(217)218)231-184(301)132(88-101(6)7)243-188(305)136(92-105(14)15)249-197(314)160(107(18)19)253-192(309)137(94-116-50-35-34-36-51-116)248-195(312)144-58-47-85-261(144)203(320)142(93-106(16)17)251-191(308)140(97-158(280)281)250-200(317)163(110(22)31-3)256-194(311)143(100-263)252-201(318)164(111(23)32-4)257-196(313)145-59-48-86-262(145)204(321)146-60-49-84-260(146)153(271)99-223-169(286)123-64-72-152(270)226-123)198(315)239-129(67-75-156(276)277)181(298)230-118(53-38-42-79-209)172(289)235-126(63-71-149(214)267)178(295)237-128(66-74-155(274)275)180(297)229-119(54-39-43-80-210)173(290)236-127(65-73-154(272)273)179(296)228-117(52-37-41-78-208)171(288)234-125(62-70-148(213)266)177(294)233-124(61-69-147(212)265)170(287)225-113(25)167(284)224-114(26)168(285)241-138(95-150(215)268)190(307)246-139(96-151(216)269)189(306)232-122(57-46-83-222-207(219)220)176(293)242-133(89-102(8)9)185(302)244-134(90-103(10)11)186(303)245-135(91-104(12)13)187(304)247-141(98-159(282)283)193(310)259-166(115(27)264)202(319)258-165(205(322)323)112(24)33-5/h34-36,50-51,101-115,117-146,160-166,263-264H,29-33,37-49,52-100,208-211H2,1-28H3,(H2,212,265)(H2,213,266)(H2,214,267)(H2,215,268)(H2,216,269)(H,223,286)(H,224,284)(H,225,287)(H,226,270)(H,227,292)(H,228,296)(H,229,297)(H,230,298)(H,231,301)(H,232,306)(H,233,294)(H,234,288)(H,235,289)(H,236,290)(H,237,295)(H,238,291)(H,239,315)(H,240,316)(H,241,285)(H,242,293)(H,243,305)(H,244,302)(H,245,303)(H,246,307)(H,247,304)(H,248,312)(H,249,314)(H,250,317)(H,251,308)(H,252,318)(H,253,309)(H,254,299)(H,255,300)(H,256,311)(H,257,313)(H,258,319)(H,259,310)(H,272,273)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,282,283)(H,322,323)(H4,217,218,221)(H4,219,220,222)/t108-,109-,110-,111-,112-,113-,114-,115+,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,160-,161-,162-,163-,164-,165-,166-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 85 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50159000
(CHEMBL430078 | Sauvagine derivative)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C213H348N56O61S/c1-27-111(18)167(261-188(306)136(70-78-164(285)286)247-205(323)168(112(19)28-2)262-189(307)137(79-89-331-26)245-180(298)126(57-40-44-83-217)234-181(299)127(58-45-84-227-212(223)224)238-190(308)138(90-105(6)7)250-193(311)141(93-108(12)13)253-196(314)144(97-120-102-229-122-53-36-35-52-121(120)122)254-195(313)143(96-119-50-33-32-34-51-119)257-202(320)151-60-47-87-268(151)209(327)149(95-110(16)17)259-199(317)147(100-165(287)288)258-206(324)169(113(20)29-3)263-201(319)150(104-270)260-207(325)170(114(21)30-4)264-203(321)152-61-48-88-269(152)210(328)153-62-49-86-267(153)160(278)103-230-175(293)129-66-74-159(277)233-129)204(322)246-135(69-77-163(283)284)187(305)237-124(55-38-42-81-215)178(296)242-132(65-73-156(220)274)184(302)244-134(68-76-162(281)282)186(304)236-125(56-39-43-82-216)179(297)243-133(67-75-161(279)280)185(303)235-123(54-37-41-80-214)177(295)241-131(64-72-155(219)273)183(301)240-130(63-71-154(218)272)176(294)232-116(23)173(291)231-117(24)174(292)248-145(98-157(221)275)198(316)255-146(99-158(222)276)197(315)239-128(59-46-85-228-213(225)226)182(300)249-139(91-106(8)9)191(309)251-140(92-107(10)11)192(310)252-142(94-109(14)15)194(312)256-148(101-166(289)290)200(318)266-172(118(25)271)208(326)265-171(211(329)330)115(22)31-5/h32-36,50-53,102,105-118,123-153,167-172,229,270-271H,27-31,37-49,54-101,103-104,214-217H2,1-26H3,(H2,218,272)(H2,219,273)(H2,220,274)(H2,221,275)(H2,222,276)(H,230,293)(H,231,291)(H,232,294)(H,233,277)(H,234,299)(H,235,303)(H,236,304)(H,237,305)(H,238,308)(H,239,315)(H,240,301)(H,241,295)(H,242,296)(H,243,297)(H,244,302)(H,245,298)(H,246,322)(H,247,323)(H,248,292)(H,249,300)(H,250,311)(H,251,309)(H,252,310)(H,253,314)(H,254,313)(H,255,316)(H,256,312)(H,257,320)(H,258,324)(H,259,317)(H,260,325)(H,261,306)(H,262,307)(H,263,319)(H,264,321)(H,265,326)(H,266,318)(H,279,280)(H,281,282)(H,283,284)(H,285,286)(H,287,288)(H,289,290)(H,329,330)(H4,223,224,227)(H4,225,226,228)/t111-,112-,113-,114-,115-,116-,117-,118+,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,152-,153-,167-,168-,169-,170-,171-,172-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 95 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50158998
(CHEMBL414711 | Sauvagine derivative)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C204H347N55O63S/c1-29-105(20)158(251-180(299)127(64-73-155(277)278)238-196(315)159(106(21)30-2)252-181(300)128(74-84-323-28)236-171(290)116(50-37-41-78-208)224-172(291)117(51-42-79-218-203(214)215)228-182(301)129(85-98(6)7)242-185(304)131(87-100(10)11)241-179(298)125(62-71-153(273)274)235-183(302)134(90-103(16)17)247-193(312)141-53-44-82-258(141)200(319)139(91-104(18)19)249-190(309)137(94-156(279)280)248-197(316)160(107(22)31-3)253-192(311)140(97-260)250-198(317)161(108(23)32-4)254-194(313)142-54-45-83-259(142)201(320)143-55-46-81-257(143)150(268)96-220-166(285)119-59-68-149(267)223-119)195(314)237-126(63-72-154(275)276)178(297)227-114(48-35-39-76-206)169(288)232-122(58-67-146(211)264)175(294)234-124(61-70-152(271)272)177(296)226-115(49-36-40-77-207)170(289)233-123(60-69-151(269)270)176(295)225-113(47-34-38-75-205)168(287)231-121(57-66-145(210)263)174(293)230-120(56-65-144(209)262)167(286)222-110(25)164(283)221-111(26)165(284)239-135(92-147(212)265)189(308)245-136(93-148(213)266)188(307)229-118(52-43-80-219-204(216)217)173(292)240-130(86-99(8)9)184(303)243-132(88-101(12)13)186(305)244-133(89-102(14)15)187(306)246-138(95-157(281)282)191(310)256-163(112(27)261)199(318)255-162(202(321)322)109(24)33-5/h98-143,158-163,260-261H,29-97,205-208H2,1-28H3,(H2,209,262)(H2,210,263)(H2,211,264)(H2,212,265)(H2,213,266)(H,220,285)(H,221,283)(H,222,286)(H,223,267)(H,224,291)(H,225,295)(H,226,296)(H,227,297)(H,228,301)(H,229,307)(H,230,293)(H,231,287)(H,232,288)(H,233,289)(H,234,294)(H,235,302)(H,236,290)(H,237,314)(H,238,315)(H,239,284)(H,240,292)(H,241,298)(H,242,304)(H,243,303)(H,244,305)(H,245,308)(H,246,306)(H,247,312)(H,248,316)(H,249,309)(H,250,317)(H,251,299)(H,252,300)(H,253,311)(H,254,313)(H,255,318)(H,256,310)(H,269,270)(H,271,272)(H,273,274)(H,275,276)(H,277,278)(H,279,280)(H,281,282)(H,321,322)(H4,214,215,218)(H4,216,217,219)/t105-,106-,107-,108-,109-,110-,111-,112+,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,158-,159-,160-,161-,162-,163-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 96 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50158980
(CHEMBL410347 | Sauvagine derivative)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C210H350N56O61S/c1-29-109(20)164(258-185(303)133(67-75-161(282)283)244-202(320)165(110(21)30-2)259-186(304)134(76-86-328-28)242-177(295)123(54-39-43-80-214)231-178(296)124(55-44-81-224-209(220)221)235-187(305)135(87-102(6)7)247-190(308)138(90-105(12)13)250-193(311)141(94-117-99-226-119-50-35-34-49-118(117)119)251-192(310)140(92-107(16)17)254-199(317)148-57-46-84-265(148)206(324)146(93-108(18)19)256-196(314)144(97-162(284)285)255-203(321)166(111(22)31-3)260-198(316)147(101-267)257-204(322)167(112(23)32-4)261-200(318)149-58-47-85-266(149)207(325)150-59-48-83-264(150)157(275)100-227-172(290)126-63-71-156(274)230-126)201(319)243-132(66-74-160(280)281)184(302)234-121(52-37-41-78-212)175(293)239-129(62-70-153(217)271)181(299)241-131(65-73-159(278)279)183(301)233-122(53-38-42-79-213)176(294)240-130(64-72-158(276)277)182(300)232-120(51-36-40-77-211)174(292)238-128(61-69-152(216)270)180(298)237-127(60-68-151(215)269)173(291)229-114(25)170(288)228-115(26)171(289)245-142(95-154(218)272)195(313)252-143(96-155(219)273)194(312)236-125(56-45-82-225-210(222)223)179(297)246-136(88-103(8)9)188(306)248-137(89-104(10)11)189(307)249-139(91-106(14)15)191(309)253-145(98-163(286)287)197(315)263-169(116(27)268)205(323)262-168(208(326)327)113(24)33-5/h34-35,49-50,99,102-116,120-150,164-169,226,267-268H,29-33,36-48,51-98,100-101,211-214H2,1-28H3,(H2,215,269)(H2,216,270)(H2,217,271)(H2,218,272)(H2,219,273)(H,227,290)(H,228,288)(H,229,291)(H,230,274)(H,231,296)(H,232,300)(H,233,301)(H,234,302)(H,235,305)(H,236,312)(H,237,298)(H,238,292)(H,239,293)(H,240,294)(H,241,299)(H,242,295)(H,243,319)(H,244,320)(H,245,289)(H,246,297)(H,247,308)(H,248,306)(H,249,307)(H,250,311)(H,251,310)(H,252,313)(H,253,309)(H,254,317)(H,255,321)(H,256,314)(H,257,322)(H,258,303)(H,259,304)(H,260,316)(H,261,318)(H,262,323)(H,263,315)(H,276,277)(H,278,279)(H,280,281)(H,282,283)(H,284,285)(H,286,287)(H,326,327)(H4,220,221,224)(H4,222,223,225)/t109-,110-,111-,112-,113-,114-,115-,116+,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,164-,165-,166-,167-,168-,169-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 98 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50158995
(CHEMBL264275 | Sauvagine derivative)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C207H347N55O62S/c1-29-107(20)161(254-182(300)130(67-75-157(279)280)240-199(317)162(108(21)30-2)255-183(301)131(76-86-325-28)238-174(292)120(50-37-41-80-211)227-175(293)121(51-42-81-221-206(217)218)231-184(302)132(87-100(6)7)243-188(306)136(91-104(14)15)249-197(315)160(106(18)19)253-192(310)137(93-115-56-58-116(265)59-57-115)248-195(313)144-53-44-84-261(144)203(321)142(92-105(16)17)251-191(309)140(96-158(281)282)250-200(318)163(109(22)31-3)256-194(312)143(99-263)252-201(319)164(110(23)32-4)257-196(314)145-54-45-85-262(145)204(322)146-55-46-83-260(146)153(272)98-223-169(287)123-63-71-152(271)226-123)198(316)239-129(66-74-156(277)278)181(299)230-118(48-35-39-78-209)172(290)235-126(62-70-149(214)268)178(296)237-128(65-73-155(275)276)180(298)229-119(49-36-40-79-210)173(291)236-127(64-72-154(273)274)179(297)228-117(47-34-38-77-208)171(289)234-125(61-69-148(213)267)177(295)233-124(60-68-147(212)266)170(288)225-112(25)167(285)224-113(26)168(286)241-138(94-150(215)269)190(308)246-139(95-151(216)270)189(307)232-122(52-43-82-222-207(219)220)176(294)242-133(88-101(8)9)185(303)244-134(89-102(10)11)186(304)245-135(90-103(12)13)187(305)247-141(97-159(283)284)193(311)259-166(114(27)264)202(320)258-165(205(323)324)111(24)33-5/h56-59,100-114,117-146,160-166,263-265H,29-55,60-99,208-211H2,1-28H3,(H2,212,266)(H2,213,267)(H2,214,268)(H2,215,269)(H2,216,270)(H,223,287)(H,224,285)(H,225,288)(H,226,271)(H,227,293)(H,228,297)(H,229,298)(H,230,299)(H,231,302)(H,232,307)(H,233,295)(H,234,289)(H,235,290)(H,236,291)(H,237,296)(H,238,292)(H,239,316)(H,240,317)(H,241,286)(H,242,294)(H,243,306)(H,244,303)(H,245,304)(H,246,308)(H,247,305)(H,248,313)(H,249,315)(H,250,318)(H,251,309)(H,252,319)(H,253,310)(H,254,300)(H,255,301)(H,256,312)(H,257,314)(H,258,320)(H,259,311)(H,273,274)(H,275,276)(H,277,278)(H,279,280)(H,281,282)(H,283,284)(H,323,324)(H4,217,218,221)(H4,219,220,222)/t107-,108-,109-,110-,111-,112-,113-,114+,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,160-,161-,162-,163-,164-,165-,166-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 100 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50159002
(CHEMBL429970 | Human urocortin 2)Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(O)=O Show InChI InChI=1S/C183H323N57O52/c1-38-91(25)133(188)170(283)232-134(88(19)20)172(285)227-120(76-87(17)18)166(279)231-123(80-241)168(281)225-118(74-85(13)14)164(277)226-122(78-132(253)254)167(280)233-135(89(21)22)177(290)240-69-47-53-124(240)169(282)237-137(92(26)39-2)171(284)204-79-129(248)212-114(70-81(5)6)161(274)223-116(72-83(9)10)162(275)221-111(56-61-127(186)246)158(271)236-139(94(28)41-4)174(287)229-119(75-86(15)16)165(278)224-117(73-84(11)12)163(276)222-113(58-63-131(251)252)155(268)219-109(54-59-125(184)244)151(264)208-98(32)145(258)214-105(49-43-65-200-180(191)192)150(263)207-97(31)144(257)213-104(48-42-64-199-179(189)190)149(262)206-95(29)142(255)205-96(30)143(256)215-106(50-44-66-201-181(193)194)153(266)220-112(57-62-130(249)250)154(267)218-110(55-60-126(185)245)152(265)209-101(35)148(261)238-141(103(37)243)176(289)239-140(102(36)242)175(288)230-121(77-128(187)247)160(273)211-100(34)147(260)217-108(52-46-68-203-183(197)198)157(270)235-138(93(27)40-3)173(286)228-115(71-82(7)8)159(272)210-99(33)146(259)216-107(51-45-67-202-182(195)196)156(269)234-136(90(23)24)178(291)292/h81-124,133-141,241-243H,38-80,188H2,1-37H3,(H2,184,244)(H2,185,245)(H2,186,246)(H2,187,247)(H,204,284)(H,205,255)(H,206,262)(H,207,263)(H,208,264)(H,209,265)(H,210,272)(H,211,273)(H,212,248)(H,213,257)(H,214,258)(H,215,256)(H,216,259)(H,217,260)(H,218,267)(H,219,268)(H,220,266)(H,221,275)(H,222,276)(H,223,274)(H,224,278)(H,225,281)(H,226,277)(H,227,285)(H,228,286)(H,229,287)(H,230,288)(H,231,279)(H,232,283)(H,233,280)(H,234,269)(H,235,270)(H,236,271)(H,237,282)(H,238,261)(H,239,289)(H,249,250)(H,251,252)(H,253,254)(H,291,292)(H4,189,190,199)(H4,191,192,200)(H4,193,194,201)(H4,195,196,202)(H4,197,198,203)/t91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102+,103+,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,133-,134-,135-,136-,137-,138-,139-,140-,141-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >100 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50158961
(CHEMBL263862 | Sauvagine derivative)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C208H349N55O61S/c1-29-109(20)162(255-183(300)131(68-76-159(279)280)241-200(317)163(110(21)30-2)256-184(301)132(77-87-325-28)239-175(292)121(55-40-44-81-212)228-176(293)122(56-45-82-222-207(218)219)232-185(302)133(88-102(6)7)244-188(305)136(91-105(12)13)247-191(308)139(95-117-50-35-34-36-51-117)248-190(307)138(93-107(16)17)251-197(314)146-58-47-85-262(146)204(321)144(94-108(18)19)253-194(311)142(98-160(281)282)252-201(318)164(111(22)31-3)257-196(313)145(101-264)254-202(319)165(112(23)32-4)258-198(315)147-59-48-86-263(147)205(322)148-60-49-84-261(148)155(272)100-224-170(287)124-64-72-154(271)227-124)199(316)240-130(67-75-158(277)278)182(299)231-119(53-38-42-79-210)173(290)236-127(63-71-151(215)268)179(296)238-129(66-74-157(275)276)181(298)230-120(54-39-43-80-211)174(291)237-128(65-73-156(273)274)180(297)229-118(52-37-41-78-209)172(289)235-126(62-70-150(214)267)178(295)234-125(61-69-149(213)266)171(288)226-114(25)168(285)225-115(26)169(286)242-140(96-152(216)269)193(310)249-141(97-153(217)270)192(309)233-123(57-46-83-223-208(220)221)177(294)243-134(89-103(8)9)186(303)245-135(90-104(10)11)187(304)246-137(92-106(14)15)189(306)250-143(99-161(283)284)195(312)260-167(116(27)265)203(320)259-166(206(323)324)113(24)33-5/h34-36,50-51,102-116,118-148,162-167,264-265H,29-33,37-49,52-101,209-212H2,1-28H3,(H2,213,266)(H2,214,267)(H2,215,268)(H2,216,269)(H2,217,270)(H,224,287)(H,225,285)(H,226,288)(H,227,271)(H,228,293)(H,229,297)(H,230,298)(H,231,299)(H,232,302)(H,233,309)(H,234,295)(H,235,289)(H,236,290)(H,237,291)(H,238,296)(H,239,292)(H,240,316)(H,241,317)(H,242,286)(H,243,294)(H,244,305)(H,245,303)(H,246,304)(H,247,308)(H,248,307)(H,249,310)(H,250,306)(H,251,314)(H,252,318)(H,253,311)(H,254,319)(H,255,300)(H,256,301)(H,257,313)(H,258,315)(H,259,320)(H,260,312)(H,273,274)(H,275,276)(H,277,278)(H,279,280)(H,281,282)(H,283,284)(H,323,324)(H4,218,219,222)(H4,220,221,223)/t109-,110-,111-,112-,113-,114-,115-,116+,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,162-,163-,164-,165-,166-,167-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 103 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50158954
(CHEMBL442112 | Sauvagine derivative)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C211H347N55O63S/c1-27-109(18)165(258-186(305)134(69-77-162(284)285)244-203(322)166(110(19)28-2)259-187(306)135(78-88-330-26)242-178(297)124(48-35-39-82-215)231-179(298)125(49-40-83-225-210(221)222)235-188(307)136(89-103(6)7)247-191(310)139(92-106(12)13)250-193(312)141(95-117-54-58-119(269)59-55-117)251-194(313)142(96-118-56-60-120(270)61-57-118)254-200(319)149-51-42-86-265(149)207(326)147(94-108(16)17)256-197(316)145(99-163(286)287)255-204(323)167(111(20)29-3)260-199(318)148(102-267)257-205(324)168(112(21)30-4)261-201(320)150-52-43-87-266(150)208(327)151-53-44-85-264(151)158(277)101-227-173(292)127-65-73-157(276)230-127)202(321)243-133(68-76-161(282)283)185(304)234-122(46-33-37-80-213)176(295)239-130(64-72-154(218)273)182(301)241-132(67-75-160(280)281)184(303)233-123(47-34-38-81-214)177(296)240-131(66-74-159(278)279)183(302)232-121(45-32-36-79-212)175(294)238-129(63-71-153(217)272)181(300)237-128(62-70-152(216)271)174(293)229-114(23)171(290)228-115(24)172(291)245-143(97-155(219)274)196(315)252-144(98-156(220)275)195(314)236-126(50-41-84-226-211(223)224)180(299)246-137(90-104(8)9)189(308)248-138(91-105(10)11)190(309)249-140(93-107(14)15)192(311)253-146(100-164(288)289)198(317)263-170(116(25)268)206(325)262-169(209(328)329)113(22)31-5/h54-61,103-116,121-151,165-170,267-270H,27-53,62-102,212-215H2,1-26H3,(H2,216,271)(H2,217,272)(H2,218,273)(H2,219,274)(H2,220,275)(H,227,292)(H,228,290)(H,229,293)(H,230,276)(H,231,298)(H,232,302)(H,233,303)(H,234,304)(H,235,307)(H,236,314)(H,237,300)(H,238,294)(H,239,295)(H,240,296)(H,241,301)(H,242,297)(H,243,321)(H,244,322)(H,245,291)(H,246,299)(H,247,310)(H,248,308)(H,249,309)(H,250,312)(H,251,313)(H,252,315)(H,253,311)(H,254,319)(H,255,323)(H,256,316)(H,257,324)(H,258,305)(H,259,306)(H,260,318)(H,261,320)(H,262,325)(H,263,317)(H,278,279)(H,280,281)(H,282,283)(H,284,285)(H,286,287)(H,288,289)(H,328,329)(H4,221,222,225)(H4,223,224,226)/t109-,110-,111-,112-,113-,114-,115-,116+,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,165-,166-,167-,168-,169-,170-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 103 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50158971
(CHEMBL427923 | Sauvagine derivative)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C205H351N55O61S/c1-31-106(21)158(251-180(297)128(66-74-155(276)277)238-196(313)159(107(22)32-2)252-181(298)129(75-85-322-30)236-172(289)118(53-40-44-79-209)225-173(290)119(54-45-80-219-204(215)216)229-182(299)130(86-99(7)8)241-186(303)134(90-103(15)16)247-197(314)160(108(23)33-3)253-190(307)135(91-104(17)18)246-193(310)142-56-47-83-259(142)201(318)140(92-105(19)20)249-189(306)138(95-156(278)279)248-198(315)161(109(24)34-4)254-192(309)141(98-261)250-199(316)162(110(25)35-5)255-194(311)143-57-48-84-260(143)202(319)144-58-49-82-258(144)151(269)97-221-167(284)121-62-70-150(268)224-121)195(312)237-127(65-73-154(274)275)179(296)228-116(51-38-42-77-207)170(287)233-124(61-69-147(212)265)176(293)235-126(64-72-153(272)273)178(295)227-117(52-39-43-78-208)171(288)234-125(63-71-152(270)271)177(294)226-115(50-37-41-76-206)169(286)232-123(60-68-146(211)264)175(292)231-122(59-67-145(210)263)168(285)223-112(27)165(282)222-113(28)166(283)239-136(93-148(213)266)188(305)244-137(94-149(214)267)187(304)230-120(55-46-81-220-205(217)218)174(291)240-131(87-100(9)10)183(300)242-132(88-101(11)12)184(301)243-133(89-102(13)14)185(302)245-139(96-157(280)281)191(308)257-164(114(29)262)200(317)256-163(203(320)321)111(26)36-6/h99-144,158-164,261-262H,31-98,206-209H2,1-30H3,(H2,210,263)(H2,211,264)(H2,212,265)(H2,213,266)(H2,214,267)(H,221,284)(H,222,282)(H,223,285)(H,224,268)(H,225,290)(H,226,294)(H,227,295)(H,228,296)(H,229,299)(H,230,304)(H,231,292)(H,232,286)(H,233,287)(H,234,288)(H,235,293)(H,236,289)(H,237,312)(H,238,313)(H,239,283)(H,240,291)(H,241,303)(H,242,300)(H,243,301)(H,244,305)(H,245,302)(H,246,310)(H,247,314)(H,248,315)(H,249,306)(H,250,316)(H,251,297)(H,252,298)(H,253,307)(H,254,309)(H,255,311)(H,256,317)(H,257,308)(H,270,271)(H,272,273)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,320,321)(H4,215,216,219)(H4,217,218,220)/t106-,107-,108-,109-,110-,111-,112-,113-,114+,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,158-,159-,160-,161-,162-,163-,164-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 106 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50158979
(CHEMBL427811 | Sauvagine derivative)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C215H349N55O62S/c1-27-112(18)169(262-190(308)138(72-80-166(287)288)248-207(325)170(113(19)28-2)263-191(309)139(81-91-333-26)246-182(300)128(55-37-41-85-219)235-183(301)129(56-43-86-229-214(225)226)239-192(310)140(92-106(6)7)251-195(313)143(95-109(12)13)254-198(316)146(99-122-50-42-49-121-48-32-33-51-124(121)122)255-197(315)145(98-120-61-63-123(273)64-62-120)258-204(322)153-58-45-89-269(153)211(329)151(97-111(16)17)260-201(319)149(102-167(289)290)259-208(326)171(114(20)29-3)264-203(321)152(105-271)261-209(327)172(115(21)30-4)265-205(323)154-59-46-90-270(154)212(330)155-60-47-88-268(155)162(280)104-231-177(295)131-68-76-161(279)234-131)206(324)247-137(71-79-165(285)286)189(307)238-126(53-35-39-83-217)180(298)243-134(67-75-158(222)276)186(304)245-136(70-78-164(283)284)188(306)237-127(54-36-40-84-218)181(299)244-135(69-77-163(281)282)187(305)236-125(52-34-38-82-216)179(297)242-133(66-74-157(221)275)185(303)241-132(65-73-156(220)274)178(296)233-117(23)175(293)232-118(24)176(294)249-147(100-159(223)277)200(318)256-148(101-160(224)278)199(317)240-130(57-44-87-230-215(227)228)184(302)250-141(93-107(8)9)193(311)252-142(94-108(10)11)194(312)253-144(96-110(14)15)196(314)257-150(103-168(291)292)202(320)267-174(119(25)272)210(328)266-173(213(331)332)116(22)31-5/h32-33,42,48-51,61-64,106-119,125-155,169-174,271-273H,27-31,34-41,43-47,52-60,65-105,216-219H2,1-26H3,(H2,220,274)(H2,221,275)(H2,222,276)(H2,223,277)(H2,224,278)(H,231,295)(H,232,293)(H,233,296)(H,234,279)(H,235,301)(H,236,305)(H,237,306)(H,238,307)(H,239,310)(H,240,317)(H,241,303)(H,242,297)(H,243,298)(H,244,299)(H,245,304)(H,246,300)(H,247,324)(H,248,325)(H,249,294)(H,250,302)(H,251,313)(H,252,311)(H,253,312)(H,254,316)(H,255,315)(H,256,318)(H,257,314)(H,258,322)(H,259,326)(H,260,319)(H,261,327)(H,262,308)(H,263,309)(H,264,321)(H,265,323)(H,266,328)(H,267,320)(H,281,282)(H,283,284)(H,285,286)(H,287,288)(H,289,290)(H,291,292)(H,331,332)(H4,225,226,229)(H4,227,228,230)/t112-,113-,114-,115-,116-,117-,118-,119+,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,152-,153-,154-,155-,169-,170-,171-,172-,173-,174-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 108 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50158965
(CHEMBL437089 | Sauvagine derivative)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C207H346N56O62S/c1-27-107(18)161(255-183(302)130(67-76-158(280)281)242-199(318)162(108(19)28-2)256-184(303)131(77-87-326-26)240-174(293)119(53-38-42-81-211)228-175(294)120(54-43-82-222-206(218)219)232-185(304)132(88-101(6)7)246-187(306)134(90-103(10)11)245-182(301)126(62-71-150(215)269)239-190(309)137(94-115-48-33-32-34-49-115)251-196(315)144-56-45-85-262(144)203(322)142(93-106(16)17)253-193(312)140(97-159(282)283)252-200(319)163(109(20)29-3)257-195(314)143(100-264)254-201(320)164(110(21)30-4)258-197(316)145-57-46-86-263(145)204(323)146-58-47-84-261(146)154(273)99-224-169(288)122-63-72-153(272)227-122)198(317)241-129(66-75-157(278)279)181(300)231-117(51-36-40-79-209)172(291)236-125(61-70-149(214)268)178(297)238-128(65-74-156(276)277)180(299)230-118(52-37-41-80-210)173(292)237-127(64-73-155(274)275)179(298)229-116(50-35-39-78-208)171(290)235-124(60-69-148(213)267)177(296)234-123(59-68-147(212)266)170(289)226-112(23)167(286)225-113(24)168(287)243-138(95-151(216)270)192(311)249-139(96-152(217)271)191(310)233-121(55-44-83-223-207(220)221)176(295)244-133(89-102(8)9)186(305)247-135(91-104(12)13)188(307)248-136(92-105(14)15)189(308)250-141(98-160(284)285)194(313)260-166(114(25)265)202(321)259-165(205(324)325)111(22)31-5/h32-34,48-49,101-114,116-146,161-166,264-265H,27-31,35-47,50-100,208-211H2,1-26H3,(H2,212,266)(H2,213,267)(H2,214,268)(H2,215,269)(H2,216,270)(H2,217,271)(H,224,288)(H,225,286)(H,226,289)(H,227,272)(H,228,294)(H,229,298)(H,230,299)(H,231,300)(H,232,304)(H,233,310)(H,234,296)(H,235,290)(H,236,291)(H,237,292)(H,238,297)(H,239,309)(H,240,293)(H,241,317)(H,242,318)(H,243,287)(H,244,295)(H,245,301)(H,246,306)(H,247,305)(H,248,307)(H,249,311)(H,250,308)(H,251,315)(H,252,319)(H,253,312)(H,254,320)(H,255,302)(H,256,303)(H,257,314)(H,258,316)(H,259,321)(H,260,313)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,282,283)(H,284,285)(H,324,325)(H4,218,219,222)(H4,220,221,223)/t107-,108-,109-,110-,111-,112-,113-,114+,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,161-,162-,163-,164-,165-,166-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 112 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50158973
(CHEMBL438391 | Sauvagine derivative)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C212H347N57O61S/c1-27-110(18)166(261-187(306)135(68-76-163(285)286)247-204(323)167(111(19)28-2)262-188(307)136(77-87-331-26)245-179(298)125(55-37-41-81-216)234-180(299)126(56-43-82-227-211(222)223)238-189(308)137(88-104(6)7)250-192(311)140(91-107(12)13)253-194(313)142(94-119-50-42-49-118-48-32-33-51-121(118)119)254-195(314)143(95-120-100-226-103-230-120)257-201(320)150-58-45-85-268(150)208(327)148(93-109(16)17)259-198(317)146(98-164(287)288)258-205(324)168(112(20)29-3)263-200(319)149(102-270)260-206(325)169(113(21)30-4)264-202(321)151-59-46-86-269(151)209(328)152-60-47-84-267(152)159(278)101-229-174(293)128-64-72-158(277)233-128)203(322)246-134(67-75-162(283)284)186(305)237-123(53-35-39-79-214)177(296)242-131(63-71-155(219)274)183(302)244-133(66-74-161(281)282)185(304)236-124(54-36-40-80-215)178(297)243-132(65-73-160(279)280)184(303)235-122(52-34-38-78-213)176(295)241-130(62-70-154(218)273)182(301)240-129(61-69-153(217)272)175(294)232-115(23)172(291)231-116(24)173(292)248-144(96-156(220)275)197(316)255-145(97-157(221)276)196(315)239-127(57-44-83-228-212(224)225)181(300)249-138(89-105(8)9)190(309)251-139(90-106(10)11)191(310)252-141(92-108(14)15)193(312)256-147(99-165(289)290)199(318)266-171(117(25)271)207(326)265-170(210(329)330)114(22)31-5/h32-33,42,48-51,100,103-117,122-152,166-171,270-271H,27-31,34-41,43-47,52-99,101-102,213-216H2,1-26H3,(H2,217,272)(H2,218,273)(H2,219,274)(H2,220,275)(H2,221,276)(H,226,230)(H,229,293)(H,231,291)(H,232,294)(H,233,277)(H,234,299)(H,235,303)(H,236,304)(H,237,305)(H,238,308)(H,239,315)(H,240,301)(H,241,295)(H,242,296)(H,243,297)(H,244,302)(H,245,298)(H,246,322)(H,247,323)(H,248,292)(H,249,300)(H,250,311)(H,251,309)(H,252,310)(H,253,313)(H,254,314)(H,255,316)(H,256,312)(H,257,320)(H,258,324)(H,259,317)(H,260,325)(H,261,306)(H,262,307)(H,263,319)(H,264,321)(H,265,326)(H,266,318)(H,279,280)(H,281,282)(H,283,284)(H,285,286)(H,287,288)(H,289,290)(H,329,330)(H4,222,223,227)(H4,224,225,228)/t110-,111-,112-,113-,114-,115-,116-,117+,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,152-,166-,167-,168-,169-,170-,171-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 116 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50158967
(CHEMBL414130 | Sauvagine derivative)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C205H351N55O61S/c1-31-107(22)159(252-180(297)128(65-73-156(276)277)238-197(314)160(108(23)32-2)253-181(298)129(74-84-322-30)236-172(289)118(52-39-43-78-209)225-173(290)119(53-44-79-219-204(215)216)229-182(299)130(85-99(6)7)241-184(301)132(87-101(10)11)243-186(303)134(89-103(14)15)245-188(305)136(91-105(18)19)248-194(311)143-55-46-82-259(143)201(318)141(92-106(20)21)250-191(308)139(95-157(278)279)249-198(315)161(109(24)33-3)254-193(310)142(98-261)251-199(316)162(110(25)34-4)255-195(312)144-56-47-83-260(144)202(319)145-57-48-81-258(145)152(269)97-221-167(284)121-61-69-151(268)224-121)196(313)237-127(64-72-155(274)275)179(296)228-116(50-37-41-76-207)170(287)233-124(60-68-148(212)265)176(293)235-126(63-71-154(272)273)178(295)227-117(51-38-42-77-208)171(288)234-125(62-70-153(270)271)177(294)226-115(49-36-40-75-206)169(286)232-123(59-67-147(211)264)175(292)231-122(58-66-146(210)263)168(285)223-112(27)165(282)222-113(28)166(283)239-137(93-149(213)266)190(307)246-138(94-150(214)267)189(306)230-120(54-45-80-220-205(217)218)174(291)240-131(86-100(8)9)183(300)242-133(88-102(12)13)185(302)244-135(90-104(16)17)187(304)247-140(96-158(280)281)192(309)257-164(114(29)262)200(317)256-163(203(320)321)111(26)35-5/h99-145,159-164,261-262H,31-98,206-209H2,1-30H3,(H2,210,263)(H2,211,264)(H2,212,265)(H2,213,266)(H2,214,267)(H,221,284)(H,222,282)(H,223,285)(H,224,268)(H,225,290)(H,226,294)(H,227,295)(H,228,296)(H,229,299)(H,230,306)(H,231,292)(H,232,286)(H,233,287)(H,234,288)(H,235,293)(H,236,289)(H,237,313)(H,238,314)(H,239,283)(H,240,291)(H,241,301)(H,242,300)(H,243,303)(H,244,302)(H,245,305)(H,246,307)(H,247,304)(H,248,311)(H,249,315)(H,250,308)(H,251,316)(H,252,297)(H,253,298)(H,254,310)(H,255,312)(H,256,317)(H,257,309)(H,270,271)(H,272,273)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,320,321)(H4,215,216,219)(H4,217,218,220)/t107-,108-,109-,110-,111-,112-,113-,114+,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,159-,160-,161-,162-,163-,164-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 163 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50158963
(CHEMBL438220 | Sauvagine derivative)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C213H348N56O62S/c1-27-110(18)167(261-188(307)136(69-77-164(286)287)247-205(324)168(111(19)28-2)262-189(308)137(78-88-332-26)245-180(299)126(52-37-41-82-217)234-181(300)127(53-42-83-227-212(223)224)238-190(309)138(89-104(6)7)250-193(312)141(92-107(12)13)253-196(315)144(96-119-101-229-122-48-33-32-47-121(119)122)254-195(314)143(95-118-58-60-120(272)61-59-118)257-202(321)151-55-44-86-268(151)209(328)149(94-109(16)17)259-199(318)147(99-165(288)289)258-206(325)169(112(20)29-3)263-201(320)150(103-270)260-207(326)170(113(21)30-4)264-203(322)152-56-45-87-269(152)210(329)153-57-46-85-267(153)160(279)102-230-175(294)129-65-73-159(278)233-129)204(323)246-135(68-76-163(284)285)187(306)237-124(50-35-39-80-215)178(297)242-132(64-72-156(220)275)184(303)244-134(67-75-162(282)283)186(305)236-125(51-36-40-81-216)179(298)243-133(66-74-161(280)281)185(304)235-123(49-34-38-79-214)177(296)241-131(63-71-155(219)274)183(302)240-130(62-70-154(218)273)176(295)232-115(23)173(292)231-116(24)174(293)248-145(97-157(221)276)198(317)255-146(98-158(222)277)197(316)239-128(54-43-84-228-213(225)226)182(301)249-139(90-105(8)9)191(310)251-140(91-106(10)11)192(311)252-142(93-108(14)15)194(313)256-148(100-166(290)291)200(319)266-172(117(25)271)208(327)265-171(211(330)331)114(22)31-5/h32-33,47-48,58-61,101,104-117,123-153,167-172,229,270-272H,27-31,34-46,49-57,62-100,102-103,214-217H2,1-26H3,(H2,218,273)(H2,219,274)(H2,220,275)(H2,221,276)(H2,222,277)(H,230,294)(H,231,292)(H,232,295)(H,233,278)(H,234,300)(H,235,304)(H,236,305)(H,237,306)(H,238,309)(H,239,316)(H,240,302)(H,241,296)(H,242,297)(H,243,298)(H,244,303)(H,245,299)(H,246,323)(H,247,324)(H,248,293)(H,249,301)(H,250,312)(H,251,310)(H,252,311)(H,253,315)(H,254,314)(H,255,317)(H,256,313)(H,257,321)(H,258,325)(H,259,318)(H,260,326)(H,261,307)(H,262,308)(H,263,320)(H,264,322)(H,265,327)(H,266,319)(H,280,281)(H,282,283)(H,284,285)(H,286,287)(H,288,289)(H,290,291)(H,330,331)(H4,223,224,227)(H4,225,226,228)/t110-,111-,112-,113-,114-,115-,116-,117+,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,152-,153-,167-,168-,169-,170-,171-,172-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 188 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50158986
(CHEMBL410568 | Sauvagine derivative)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C206H345N55O63S/c1-28-105(18)159(252-181(300)129(66-74-156(279)280)239-197(316)160(106(19)29-2)253-182(301)130(75-85-325-27)237-173(292)119(49-36-40-79-210)226-174(293)120(50-41-80-220-205(216)217)230-183(302)131(86-99(6)7)242-187(306)135(90-103(14)15)248-200(319)164(112(25)263)257-191(310)136(92-114-55-57-115(265)58-56-114)247-194(313)143-52-43-83-260(143)202(321)141(91-104(16)17)250-190(309)139(95-157(281)282)249-198(317)161(107(20)30-3)254-193(312)142(98-262)251-199(318)162(108(21)31-4)255-195(314)144-53-44-84-261(144)203(322)145-54-45-82-259(145)152(272)97-222-168(287)122-62-70-151(271)225-122)196(315)238-128(65-73-155(277)278)180(299)229-117(47-34-38-77-208)171(290)234-125(61-69-148(213)268)177(296)236-127(64-72-154(275)276)179(298)228-118(48-35-39-78-209)172(291)235-126(63-71-153(273)274)178(297)227-116(46-33-37-76-207)170(289)233-124(60-68-147(212)267)176(295)232-123(59-67-146(211)266)169(288)224-110(23)166(285)223-111(24)167(286)240-137(93-149(214)269)189(308)245-138(94-150(215)270)188(307)231-121(51-42-81-221-206(218)219)175(294)241-132(87-100(8)9)184(303)243-133(88-101(10)11)185(304)244-134(89-102(12)13)186(305)246-140(96-158(283)284)192(311)258-165(113(26)264)201(320)256-163(204(323)324)109(22)32-5/h55-58,99-113,116-145,159-165,262-265H,28-54,59-98,207-210H2,1-27H3,(H2,211,266)(H2,212,267)(H2,213,268)(H2,214,269)(H2,215,270)(H,222,287)(H,223,285)(H,224,288)(H,225,271)(H,226,293)(H,227,297)(H,228,298)(H,229,299)(H,230,302)(H,231,307)(H,232,295)(H,233,289)(H,234,290)(H,235,291)(H,236,296)(H,237,292)(H,238,315)(H,239,316)(H,240,286)(H,241,294)(H,242,306)(H,243,303)(H,244,304)(H,245,308)(H,246,305)(H,247,313)(H,248,319)(H,249,317)(H,250,309)(H,251,318)(H,252,300)(H,253,301)(H,254,312)(H,255,314)(H,256,320)(H,257,310)(H,258,311)(H,273,274)(H,275,276)(H,277,278)(H,279,280)(H,281,282)(H,283,284)(H,323,324)(H4,216,217,220)(H4,218,219,221)/t105-,106-,107-,108-,109-,110-,111-,112+,113+,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,159-,160-,161-,162-,163-,164-,165-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 189 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50158964
(CHEMBL428127 | Sauvagine derivative)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C206H344N56O63S/c1-27-105(18)160(254-181(301)128(65-73-157(280)281)240-198(318)161(106(19)28-2)255-182(302)129(74-84-326-26)238-173(293)118(48-35-39-78-210)227-174(294)119(49-40-79-221-205(217)218)231-183(303)130(85-99(6)7)243-186(306)133(88-102(12)13)246-188(308)135(91-113-54-56-114(265)57-55-113)247-191(311)138(94-151(216)271)250-195(315)143-51-42-82-261(143)202(322)141(90-104(16)17)252-192(312)139(95-158(282)283)251-199(319)162(107(20)29-3)256-194(314)142(98-263)253-200(320)163(108(21)30-4)257-196(316)144-52-43-83-262(144)203(323)145-53-44-81-260(145)153(273)97-223-168(288)121-61-69-152(272)226-121)197(317)239-127(64-72-156(278)279)180(300)230-116(46-33-37-76-208)171(291)235-124(60-68-148(213)268)177(297)237-126(63-71-155(276)277)179(299)229-117(47-34-38-77-209)172(292)236-125(62-70-154(274)275)178(298)228-115(45-32-36-75-207)170(290)234-123(59-67-147(212)267)176(296)233-122(58-66-146(211)266)169(289)225-110(23)166(286)224-111(24)167(287)241-136(92-149(214)269)190(310)248-137(93-150(215)270)189(309)232-120(50-41-80-222-206(219)220)175(295)242-131(86-100(8)9)184(304)244-132(87-101(10)11)185(305)245-134(89-103(14)15)187(307)249-140(96-159(284)285)193(313)259-165(112(25)264)201(321)258-164(204(324)325)109(22)31-5/h54-57,99-112,115-145,160-165,263-265H,27-53,58-98,207-210H2,1-26H3,(H2,211,266)(H2,212,267)(H2,213,268)(H2,214,269)(H2,215,270)(H2,216,271)(H,223,288)(H,224,286)(H,225,289)(H,226,272)(H,227,294)(H,228,298)(H,229,299)(H,230,300)(H,231,303)(H,232,309)(H,233,296)(H,234,290)(H,235,291)(H,236,292)(H,237,297)(H,238,293)(H,239,317)(H,240,318)(H,241,287)(H,242,295)(H,243,306)(H,244,304)(H,245,305)(H,246,308)(H,247,311)(H,248,310)(H,249,307)(H,250,315)(H,251,319)(H,252,312)(H,253,320)(H,254,301)(H,255,302)(H,256,314)(H,257,316)(H,258,321)(H,259,313)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,282,283)(H,284,285)(H,324,325)(H4,217,218,221)(H4,219,220,222)/t105-,106-,107-,108-,109-,110-,111-,112+,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,160-,161-,162-,163-,164-,165-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 221 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50158992
(CHEMBL415130 | Sauvagine derivative)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C207H346N56O62S/c1-27-107(18)161(255-183(302)130(67-76-158(280)281)242-199(318)162(108(19)28-2)256-184(303)131(77-87-326-26)239-174(293)119(53-38-42-81-211)228-175(294)120(54-43-82-222-206(218)219)232-185(304)132(88-101(6)7)245-188(307)135(91-104(12)13)248-190(309)137(94-115-48-33-32-34-49-115)249-182(301)126(62-71-150(215)269)240-196(315)144-56-45-85-262(144)203(322)142(93-106(16)17)253-193(312)140(97-159(282)283)252-200(319)163(109(20)29-3)257-195(314)143(100-264)254-201(320)164(110(21)30-4)258-197(316)145-57-46-86-263(145)204(323)146-58-47-84-261(146)154(273)99-224-169(288)122-63-72-153(272)227-122)198(317)241-129(66-75-157(278)279)181(300)231-117(51-36-40-79-209)172(291)236-125(61-70-149(214)268)178(297)238-128(65-74-156(276)277)180(299)230-118(52-37-41-80-210)173(292)237-127(64-73-155(274)275)179(298)229-116(50-35-39-78-208)171(290)235-124(60-69-148(213)267)177(296)234-123(59-68-147(212)266)170(289)226-112(23)167(286)225-113(24)168(287)243-138(95-151(216)270)192(311)250-139(96-152(217)271)191(310)233-121(55-44-83-223-207(220)221)176(295)244-133(89-102(8)9)186(305)246-134(90-103(10)11)187(306)247-136(92-105(14)15)189(308)251-141(98-160(284)285)194(313)260-166(114(25)265)202(321)259-165(205(324)325)111(22)31-5/h32-34,48-49,101-114,116-146,161-166,264-265H,27-31,35-47,50-100,208-211H2,1-26H3,(H2,212,266)(H2,213,267)(H2,214,268)(H2,215,269)(H2,216,270)(H2,217,271)(H,224,288)(H,225,286)(H,226,289)(H,227,272)(H,228,294)(H,229,298)(H,230,299)(H,231,300)(H,232,304)(H,233,310)(H,234,296)(H,235,290)(H,236,291)(H,237,292)(H,238,297)(H,239,293)(H,240,315)(H,241,317)(H,242,318)(H,243,287)(H,244,295)(H,245,307)(H,246,305)(H,247,306)(H,248,309)(H,249,301)(H,250,311)(H,251,308)(H,252,319)(H,253,312)(H,254,320)(H,255,302)(H,256,303)(H,257,314)(H,258,316)(H,259,321)(H,260,313)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,282,283)(H,284,285)(H,324,325)(H4,218,219,222)(H4,220,221,223)/t107-,108-,109-,110-,111-,112-,113-,114+,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,161-,162-,163-,164-,165-,166-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 237 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50158990
(CHEMBL438601 | Sauvagine derivative)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C204H349N55O61S/c1-31-106(22)158(251-179(296)127(65-73-154(275)276)237-196(313)159(107(23)32-2)252-180(297)128(74-84-321-30)235-171(288)117(52-39-43-78-208)224-172(289)118(53-44-79-218-203(214)215)228-181(298)129(85-98(6)7)240-185(302)133(89-102(14)15)246-194(311)157(105(20)21)250-189(306)134(90-103(16)17)245-192(309)141-55-46-82-258(141)200(317)139(91-104(18)19)248-188(305)137(94-155(277)278)247-197(314)160(108(24)33-3)253-191(308)140(97-260)249-198(315)161(109(25)34-4)254-193(310)142-56-47-83-259(142)201(318)143-57-48-81-257(143)150(268)96-220-166(283)120-61-69-149(267)223-120)195(312)236-126(64-72-153(273)274)178(295)227-115(50-37-41-76-206)169(286)232-123(60-68-146(211)264)175(292)234-125(63-71-152(271)272)177(294)226-116(51-38-42-77-207)170(287)233-124(62-70-151(269)270)176(293)225-114(49-36-40-75-205)168(285)231-122(59-67-145(210)263)174(291)230-121(58-66-144(209)262)167(284)222-111(27)164(281)221-112(28)165(282)238-135(92-147(212)265)187(304)243-136(93-148(213)266)186(303)229-119(54-45-80-219-204(216)217)173(290)239-130(86-99(8)9)182(299)241-131(87-100(10)11)183(300)242-132(88-101(12)13)184(301)244-138(95-156(279)280)190(307)256-163(113(29)261)199(316)255-162(202(319)320)110(26)35-5/h98-143,157-163,260-261H,31-97,205-208H2,1-30H3,(H2,209,262)(H2,210,263)(H2,211,264)(H2,212,265)(H2,213,266)(H,220,283)(H,221,281)(H,222,284)(H,223,267)(H,224,289)(H,225,293)(H,226,294)(H,227,295)(H,228,298)(H,229,303)(H,230,291)(H,231,285)(H,232,286)(H,233,287)(H,234,292)(H,235,288)(H,236,312)(H,237,313)(H,238,282)(H,239,290)(H,240,302)(H,241,299)(H,242,300)(H,243,304)(H,244,301)(H,245,309)(H,246,311)(H,247,314)(H,248,305)(H,249,315)(H,250,306)(H,251,296)(H,252,297)(H,253,308)(H,254,310)(H,255,316)(H,256,307)(H,269,270)(H,271,272)(H,273,274)(H,275,276)(H,277,278)(H,279,280)(H,319,320)(H4,214,215,218)(H4,216,217,219)/t106-,107-,108-,109-,110-,111-,112-,113+,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,157-,158-,159-,160-,161-,162-,163-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 266 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50158988
(CHEMBL412296 | Sauvagine derivative)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C201H343N55O61S/c1-29-104(20)156(248-178(295)125(63-71-153(273)274)236-193(310)157(105(21)30-2)249-179(296)126(72-82-318-28)234-170(287)115(50-37-41-76-205)223-171(288)116(51-42-77-215-200(211)212)227-181(298)129(85-99(10)11)239-180(297)128(84-98(8)9)222-148(265)94-217-165(282)127(83-97(6)7)244-190(307)139-53-44-80-255(139)197(314)137(89-103(18)19)246-187(304)135(92-154(275)276)245-194(311)158(106(22)31-3)250-189(306)138(96-257)247-195(312)159(107(23)32-4)251-191(308)140-54-45-81-256(140)198(315)141-55-46-79-254(141)149(266)95-218-164(281)118-59-67-147(264)221-118)192(309)235-124(62-70-152(271)272)177(294)226-113(48-35-39-74-203)168(285)231-121(58-66-144(208)261)174(291)233-123(61-69-151(269)270)176(293)225-114(49-36-40-75-204)169(286)232-122(60-68-150(267)268)175(292)224-112(47-34-38-73-202)167(284)230-120(57-65-143(207)260)173(290)229-119(56-64-142(206)259)166(283)220-109(25)162(279)219-110(26)163(280)237-133(90-145(209)262)186(303)242-134(91-146(210)263)185(302)228-117(52-43-78-216-201(213)214)172(289)238-130(86-100(12)13)182(299)240-131(87-101(14)15)183(300)241-132(88-102(16)17)184(301)243-136(93-155(277)278)188(305)253-161(111(27)258)196(313)252-160(199(316)317)108(24)33-5/h97-141,156-161,257-258H,29-96,202-205H2,1-28H3,(H2,206,259)(H2,207,260)(H2,208,261)(H2,209,262)(H2,210,263)(H,217,282)(H,218,281)(H,219,279)(H,220,283)(H,221,264)(H,222,265)(H,223,288)(H,224,292)(H,225,293)(H,226,294)(H,227,298)(H,228,302)(H,229,290)(H,230,284)(H,231,285)(H,232,286)(H,233,291)(H,234,287)(H,235,309)(H,236,310)(H,237,280)(H,238,289)(H,239,297)(H,240,299)(H,241,300)(H,242,303)(H,243,301)(H,244,307)(H,245,311)(H,246,304)(H,247,312)(H,248,295)(H,249,296)(H,250,306)(H,251,308)(H,252,313)(H,253,305)(H,267,268)(H,269,270)(H,271,272)(H,273,274)(H,275,276)(H,277,278)(H,316,317)(H4,211,212,215)(H4,213,214,216)/t104-,105-,106-,107-,108-,109-,110-,111+,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,156-,157-,158-,159-,160-,161-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 312 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50158966
(CHEMBL429403 | Sauvagine derivative)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C207H346N56O63S/c1-27-106(18)161(255-183(303)130(66-75-158(281)282)242-199(319)162(107(19)28-2)256-184(304)131(76-86-327-26)239-174(294)119(48-35-39-80-211)228-175(295)120(49-40-81-222-206(218)219)232-185(305)132(87-100(6)7)245-188(308)135(90-103(12)13)248-190(310)137(93-114-54-56-115(266)57-55-114)249-182(302)126(61-70-150(215)270)240-196(316)144-51-42-84-262(144)203(323)142(92-105(16)17)253-193(313)140(96-159(283)284)252-200(320)163(108(20)29-3)257-195(315)143(99-264)254-201(321)164(109(21)30-4)258-197(317)145-52-43-85-263(145)204(324)146-53-44-83-261(146)154(274)98-224-169(289)122-62-71-153(273)227-122)198(318)241-129(65-74-157(279)280)181(301)231-117(46-33-37-78-209)172(292)236-125(60-69-149(214)269)178(298)238-128(64-73-156(277)278)180(300)230-118(47-34-38-79-210)173(293)237-127(63-72-155(275)276)179(299)229-116(45-32-36-77-208)171(291)235-124(59-68-148(213)268)177(297)234-123(58-67-147(212)267)170(290)226-111(23)167(287)225-112(24)168(288)243-138(94-151(216)271)192(312)250-139(95-152(217)272)191(311)233-121(50-41-82-223-207(220)221)176(296)244-133(88-101(8)9)186(306)246-134(89-102(10)11)187(307)247-136(91-104(14)15)189(309)251-141(97-160(285)286)194(314)260-166(113(25)265)202(322)259-165(205(325)326)110(22)31-5/h54-57,100-113,116-146,161-166,264-266H,27-53,58-99,208-211H2,1-26H3,(H2,212,267)(H2,213,268)(H2,214,269)(H2,215,270)(H2,216,271)(H2,217,272)(H,224,289)(H,225,287)(H,226,290)(H,227,273)(H,228,295)(H,229,299)(H,230,300)(H,231,301)(H,232,305)(H,233,311)(H,234,297)(H,235,291)(H,236,292)(H,237,293)(H,238,298)(H,239,294)(H,240,316)(H,241,318)(H,242,319)(H,243,288)(H,244,296)(H,245,308)(H,246,306)(H,247,307)(H,248,310)(H,249,302)(H,250,312)(H,251,309)(H,252,320)(H,253,313)(H,254,321)(H,255,303)(H,256,304)(H,257,315)(H,258,317)(H,259,322)(H,260,314)(H,275,276)(H,277,278)(H,279,280)(H,281,282)(H,283,284)(H,285,286)(H,325,326)(H4,218,219,222)(H4,220,221,223)/t106-,107-,108-,109-,110-,111-,112-,113+,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,161-,162-,163-,164-,165-,166-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 325 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50158968
(CHEMBL427611 | Sauvagine derivative)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C211H348N56O62S/c1-27-109(18)165(259-187(306)134(69-78-162(284)285)246-203(322)166(110(19)28-2)260-188(307)135(79-89-330-26)243-178(297)123(55-37-41-83-215)232-179(298)124(56-43-84-226-210(222)223)236-189(308)136(90-103(6)7)249-192(311)139(93-106(12)13)252-194(313)141(96-118-50-42-49-117-48-32-33-51-119(117)118)253-186(305)130(64-73-154(219)273)244-200(319)148-58-45-87-266(148)207(326)146(95-108(16)17)257-197(316)144(99-163(286)287)256-204(323)167(111(20)29-3)261-199(318)147(102-268)258-205(324)168(112(21)30-4)262-201(320)149-59-46-88-267(149)208(327)150-60-47-86-265(150)158(277)101-228-173(292)126-65-74-157(276)231-126)202(321)245-133(68-77-161(282)283)185(304)235-121(53-35-39-81-213)176(295)240-129(63-72-153(218)272)182(301)242-132(67-76-160(280)281)184(303)234-122(54-36-40-82-214)177(296)241-131(66-75-159(278)279)183(302)233-120(52-34-38-80-212)175(294)239-128(62-71-152(217)271)181(300)238-127(61-70-151(216)270)174(293)230-114(23)171(290)229-115(24)172(291)247-142(97-155(220)274)196(315)254-143(98-156(221)275)195(314)237-125(57-44-85-227-211(224)225)180(299)248-137(91-104(8)9)190(309)250-138(92-105(10)11)191(310)251-140(94-107(14)15)193(312)255-145(100-164(288)289)198(317)264-170(116(25)269)206(325)263-169(209(328)329)113(22)31-5/h32-33,42,48-51,103-116,120-150,165-170,268-269H,27-31,34-41,43-47,52-102,212-215H2,1-26H3,(H2,216,270)(H2,217,271)(H2,218,272)(H2,219,273)(H2,220,274)(H2,221,275)(H,228,292)(H,229,290)(H,230,293)(H,231,276)(H,232,298)(H,233,302)(H,234,303)(H,235,304)(H,236,308)(H,237,314)(H,238,300)(H,239,294)(H,240,295)(H,241,296)(H,242,301)(H,243,297)(H,244,319)(H,245,321)(H,246,322)(H,247,291)(H,248,299)(H,249,311)(H,250,309)(H,251,310)(H,252,313)(H,253,305)(H,254,315)(H,255,312)(H,256,323)(H,257,316)(H,258,324)(H,259,306)(H,260,307)(H,261,318)(H,262,320)(H,263,325)(H,264,317)(H,278,279)(H,280,281)(H,282,283)(H,284,285)(H,286,287)(H,288,289)(H,328,329)(H4,222,223,226)(H4,224,225,227)/t109-,110-,111-,112-,113-,114-,115-,116+,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,165-,166-,167-,168-,169-,170-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 367 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50158974
(CHEMBL428809 | Sauvagine derivative)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C205H343N55O61S/c1-28-106(18)159(252-181(298)129(67-75-156(276)277)239-197(314)160(107(19)29-2)253-182(299)130(76-86-322-27)237-173(290)119(54-39-43-80-209)226-174(291)120(55-44-81-219-204(215)216)230-183(300)131(87-100(6)7)243-186(303)134(90-103(12)13)246-188(305)136(93-115-49-34-33-35-50-115)240-167(284)113(25)224-194(311)143-57-46-84-259(143)201(318)141(92-105(16)17)250-191(308)139(96-157(278)279)249-198(315)161(108(20)30-3)254-193(310)142(99-261)251-199(316)162(109(21)31-4)255-195(312)144-58-47-85-260(144)202(319)145-59-48-83-258(145)152(269)98-221-168(285)122-63-71-151(268)225-122)196(313)238-128(66-74-155(274)275)180(297)229-117(52-37-41-78-207)171(288)234-125(62-70-148(212)265)177(294)236-127(65-73-154(272)273)179(296)228-118(53-38-42-79-208)172(289)235-126(64-72-153(270)271)178(295)227-116(51-36-40-77-206)170(287)233-124(61-69-147(211)264)176(293)232-123(60-68-146(210)263)169(286)223-111(23)165(282)222-112(24)166(283)241-137(94-149(213)266)190(307)247-138(95-150(214)267)189(306)231-121(56-45-82-220-205(217)218)175(292)242-132(88-101(8)9)184(301)244-133(89-102(10)11)185(302)245-135(91-104(14)15)187(304)248-140(97-158(280)281)192(309)257-164(114(26)262)200(317)256-163(203(320)321)110(22)32-5/h33-35,49-50,100-114,116-145,159-164,261-262H,28-32,36-48,51-99,206-209H2,1-27H3,(H2,210,263)(H2,211,264)(H2,212,265)(H2,213,266)(H2,214,267)(H,221,285)(H,222,282)(H,223,286)(H,224,311)(H,225,268)(H,226,291)(H,227,295)(H,228,296)(H,229,297)(H,230,300)(H,231,306)(H,232,293)(H,233,287)(H,234,288)(H,235,289)(H,236,294)(H,237,290)(H,238,313)(H,239,314)(H,240,284)(H,241,283)(H,242,292)(H,243,303)(H,244,301)(H,245,302)(H,246,305)(H,247,307)(H,248,304)(H,249,315)(H,250,308)(H,251,316)(H,252,298)(H,253,299)(H,254,310)(H,255,312)(H,256,317)(H,257,309)(H,270,271)(H,272,273)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,320,321)(H4,215,216,219)(H4,217,218,220)/t106-,107-,108-,109-,110-,111-,112-,113-,114+,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,159-,160-,161-,162-,163-,164-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 385 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50158972
(CHEMBL268549 | Sauvagine derivative)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C207H346N56O63S/c1-27-106(18)161(255-183(303)130(66-75-158(281)282)242-199(319)162(107(19)28-2)256-184(304)131(76-86-327-26)240-174(294)119(48-35-39-80-211)228-175(295)120(49-40-81-222-206(218)219)232-185(305)132(87-100(6)7)246-187(307)134(89-102(10)11)245-182(302)126(61-70-150(215)270)239-190(310)137(93-114-54-56-115(266)57-55-114)251-196(316)144-51-42-84-262(144)203(323)142(92-105(16)17)253-193(313)140(96-159(283)284)252-200(320)163(108(20)29-3)257-195(315)143(99-264)254-201(321)164(109(21)30-4)258-197(317)145-52-43-85-263(145)204(324)146-53-44-83-261(146)154(274)98-224-169(289)122-62-71-153(273)227-122)198(318)241-129(65-74-157(279)280)181(301)231-117(46-33-37-78-209)172(292)236-125(60-69-149(214)269)178(298)238-128(64-73-156(277)278)180(300)230-118(47-34-38-79-210)173(293)237-127(63-72-155(275)276)179(299)229-116(45-32-36-77-208)171(291)235-124(59-68-148(213)268)177(297)234-123(58-67-147(212)267)170(290)226-111(23)167(287)225-112(24)168(288)243-138(94-151(216)271)192(312)249-139(95-152(217)272)191(311)233-121(50-41-82-223-207(220)221)176(296)244-133(88-101(8)9)186(306)247-135(90-103(12)13)188(308)248-136(91-104(14)15)189(309)250-141(97-160(285)286)194(314)260-166(113(25)265)202(322)259-165(205(325)326)110(22)31-5/h54-57,100-113,116-146,161-166,264-266H,27-53,58-99,208-211H2,1-26H3,(H2,212,267)(H2,213,268)(H2,214,269)(H2,215,270)(H2,216,271)(H2,217,272)(H,224,289)(H,225,287)(H,226,290)(H,227,273)(H,228,295)(H,229,299)(H,230,300)(H,231,301)(H,232,305)(H,233,311)(H,234,297)(H,235,291)(H,236,292)(H,237,293)(H,238,298)(H,239,310)(H,240,294)(H,241,318)(H,242,319)(H,243,288)(H,244,296)(H,245,302)(H,246,307)(H,247,306)(H,248,308)(H,249,312)(H,250,309)(H,251,316)(H,252,320)(H,253,313)(H,254,321)(H,255,303)(H,256,304)(H,257,315)(H,258,317)(H,259,322)(H,260,314)(H,275,276)(H,277,278)(H,279,280)(H,281,282)(H,283,284)(H,285,286)(H,325,326)(H4,218,219,222)(H4,220,221,223)/t106-,107-,108-,109-,110-,111-,112-,113+,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,161-,162-,163-,164-,165-,166-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 404 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50158960
(CHEMBL428296 | Sauvagine derivative)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C210H346N58O61S/c1-27-108(18)164(260-185(305)133(65-73-161(284)285)246-202(322)165(109(19)28-2)261-186(306)134(74-84-330-26)244-177(297)123(52-37-41-78-214)233-178(298)124(53-42-79-225-209(220)221)237-187(307)135(85-102(6)7)249-190(310)138(88-105(12)13)252-192(312)140(91-116-97-227-119-48-33-32-47-118(116)119)253-193(313)141(92-117-98-224-101-229-117)256-199(319)148-55-44-82-267(148)206(326)146(90-107(16)17)258-196(316)144(95-162(286)287)257-203(323)166(110(20)29-3)262-198(318)147(100-269)259-204(324)167(111(21)30-4)263-200(320)149-56-45-83-268(149)207(327)150-57-46-81-266(150)157(277)99-228-172(292)126-61-69-156(276)232-126)201(321)245-132(64-72-160(282)283)184(304)236-121(50-35-39-76-212)175(295)241-129(60-68-153(217)273)181(301)243-131(63-71-159(280)281)183(303)235-122(51-36-40-77-213)176(296)242-130(62-70-158(278)279)182(302)234-120(49-34-38-75-211)174(294)240-128(59-67-152(216)272)180(300)239-127(58-66-151(215)271)173(293)231-113(23)170(290)230-114(24)171(291)247-142(93-154(218)274)195(315)254-143(94-155(219)275)194(314)238-125(54-43-80-226-210(222)223)179(299)248-136(86-103(8)9)188(308)250-137(87-104(10)11)189(309)251-139(89-106(14)15)191(311)255-145(96-163(288)289)197(317)265-169(115(25)270)205(325)264-168(208(328)329)112(22)31-5/h32-33,47-48,97-98,101-115,120-150,164-169,227,269-270H,27-31,34-46,49-96,99-100,211-214H2,1-26H3,(H2,215,271)(H2,216,272)(H2,217,273)(H2,218,274)(H2,219,275)(H,224,229)(H,228,292)(H,230,290)(H,231,293)(H,232,276)(H,233,298)(H,234,302)(H,235,303)(H,236,304)(H,237,307)(H,238,314)(H,239,300)(H,240,294)(H,241,295)(H,242,296)(H,243,301)(H,244,297)(H,245,321)(H,246,322)(H,247,291)(H,248,299)(H,249,310)(H,250,308)(H,251,309)(H,252,312)(H,253,313)(H,254,315)(H,255,311)(H,256,319)(H,257,323)(H,258,316)(H,259,324)(H,260,305)(H,261,306)(H,262,318)(H,263,320)(H,264,325)(H,265,317)(H,278,279)(H,280,281)(H,282,283)(H,284,285)(H,286,287)(H,288,289)(H,328,329)(H4,220,221,225)(H4,222,223,226)/t108-,109-,110-,111-,112-,113-,114-,115+,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,164-,165-,166-,167-,168-,169-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 408 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50158956
(CHEMBL409748 | Sauvagine derivative)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C204H348N56O62S/c1-29-105(20)158(252-180(299)127(64-73-155(277)278)239-196(315)159(106(21)30-2)253-181(300)128(74-84-323-28)237-171(290)116(50-37-41-78-208)225-172(291)117(51-42-79-219-203(215)216)229-182(301)129(85-98(6)7)243-185(304)131(87-100(10)11)242-179(298)123(59-68-147(212)266)236-183(302)134(90-103(16)17)248-193(312)141-53-44-82-259(141)200(319)139(91-104(18)19)250-190(309)137(94-156(279)280)249-197(316)160(107(22)31-3)254-192(311)140(97-261)251-198(317)161(108(23)32-4)255-194(313)142-54-45-83-260(142)201(320)143-55-46-81-258(143)151(270)96-221-166(285)119-60-69-150(269)224-119)195(314)238-126(63-72-154(275)276)178(297)228-114(48-35-39-76-206)169(288)233-122(58-67-146(211)265)175(294)235-125(62-71-153(273)274)177(296)227-115(49-36-40-77-207)170(289)234-124(61-70-152(271)272)176(295)226-113(47-34-38-75-205)168(287)232-121(57-66-145(210)264)174(293)231-120(56-65-144(209)263)167(286)223-110(25)164(283)222-111(26)165(284)240-135(92-148(213)267)189(308)246-136(93-149(214)268)188(307)230-118(52-43-80-220-204(217)218)173(292)241-130(86-99(8)9)184(303)244-132(88-101(12)13)186(305)245-133(89-102(14)15)187(306)247-138(95-157(281)282)191(310)257-163(112(27)262)199(318)256-162(202(321)322)109(24)33-5/h98-143,158-163,261-262H,29-97,205-208H2,1-28H3,(H2,209,263)(H2,210,264)(H2,211,265)(H2,212,266)(H2,213,267)(H2,214,268)(H,221,285)(H,222,283)(H,223,286)(H,224,269)(H,225,291)(H,226,295)(H,227,296)(H,228,297)(H,229,301)(H,230,307)(H,231,293)(H,232,287)(H,233,288)(H,234,289)(H,235,294)(H,236,302)(H,237,290)(H,238,314)(H,239,315)(H,240,284)(H,241,292)(H,242,298)(H,243,304)(H,244,303)(H,245,305)(H,246,308)(H,247,306)(H,248,312)(H,249,316)(H,250,309)(H,251,317)(H,252,299)(H,253,300)(H,254,311)(H,255,313)(H,256,318)(H,257,310)(H,271,272)(H,273,274)(H,275,276)(H,277,278)(H,279,280)(H,281,282)(H,321,322)(H4,215,216,219)(H4,217,218,220)/t105-,106-,107-,108-,109-,110-,111-,112+,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,158-,159-,160-,161-,162-,163-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 423 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50158984
(CHEMBL427792 | Sauvagine derivative)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C204H344N58O62S/c1-27-104(18)158(254-180(301)127(62-71-155(279)280)241-196(317)159(105(19)28-2)255-181(302)128(72-82-325-26)239-171(292)116(48-35-39-76-208)227-172(293)117(49-40-77-220-203(215)216)231-182(303)129(83-98(6)7)245-184(305)131(85-100(10)11)244-179(300)123(57-66-147(212)268)238-187(308)134(89-112-94-219-97-223-112)250-193(314)141-51-42-80-261(141)200(321)139(88-103(16)17)252-190(311)137(92-156(281)282)251-197(318)160(106(20)29-3)256-192(313)140(96-263)253-198(319)161(107(21)30-4)257-194(315)142-52-43-81-262(142)201(322)143-53-44-79-260(143)151(272)95-222-166(287)119-58-67-150(271)226-119)195(316)240-126(61-70-154(277)278)178(299)230-114(46-33-37-74-206)169(290)235-122(56-65-146(211)267)175(296)237-125(60-69-153(275)276)177(298)229-115(47-34-38-75-207)170(291)236-124(59-68-152(273)274)176(297)228-113(45-32-36-73-205)168(289)234-121(55-64-145(210)266)174(295)233-120(54-63-144(209)265)167(288)225-109(23)164(285)224-110(24)165(286)242-135(90-148(213)269)189(310)248-136(91-149(214)270)188(309)232-118(50-41-78-221-204(217)218)173(294)243-130(84-99(8)9)183(304)246-132(86-101(12)13)185(306)247-133(87-102(14)15)186(307)249-138(93-157(283)284)191(312)259-163(111(25)264)199(320)258-162(202(323)324)108(22)31-5/h94,97-111,113-143,158-163,263-264H,27-93,95-96,205-208H2,1-26H3,(H2,209,265)(H2,210,266)(H2,211,267)(H2,212,268)(H2,213,269)(H2,214,270)(H,219,223)(H,222,287)(H,224,285)(H,225,288)(H,226,271)(H,227,293)(H,228,297)(H,229,298)(H,230,299)(H,231,303)(H,232,309)(H,233,295)(H,234,289)(H,235,290)(H,236,291)(H,237,296)(H,238,308)(H,239,292)(H,240,316)(H,241,317)(H,242,286)(H,243,294)(H,244,300)(H,245,305)(H,246,304)(H,247,306)(H,248,310)(H,249,307)(H,250,314)(H,251,318)(H,252,311)(H,253,319)(H,254,301)(H,255,302)(H,256,313)(H,257,315)(H,258,320)(H,259,312)(H,273,274)(H,275,276)(H,277,278)(H,279,280)(H,281,282)(H,283,284)(H,323,324)(H4,215,216,220)(H4,217,218,221)/t104-,105-,106-,107-,108-,109-,110-,111+,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,158-,159-,160-,161-,162-,163-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 445 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50158996
(CHEMBL438760 | Sauvagine derivative)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C204H348N56O62S/c1-29-105(20)158(252-180(299)127(64-73-155(277)278)239-196(315)159(106(21)30-2)253-181(300)128(74-84-323-28)236-171(290)116(50-37-41-78-208)225-172(291)117(51-42-79-219-203(215)216)229-182(301)129(85-98(6)7)243-185(304)132(88-101(12)13)245-184(303)131(87-100(10)11)242-179(298)123(59-68-147(212)266)237-193(312)141-53-44-82-259(141)200(319)139(91-104(18)19)250-190(309)137(94-156(279)280)249-197(316)160(107(22)31-3)254-192(311)140(97-261)251-198(317)161(108(23)32-4)255-194(313)142-54-45-83-260(142)201(320)143-55-46-81-258(143)151(270)96-221-166(285)119-60-69-150(269)224-119)195(314)238-126(63-72-154(275)276)178(297)228-114(48-35-39-76-206)169(288)233-122(58-67-146(211)265)175(294)235-125(62-71-153(273)274)177(296)227-115(49-36-40-77-207)170(289)234-124(61-70-152(271)272)176(295)226-113(47-34-38-75-205)168(287)232-121(57-66-145(210)264)174(293)231-120(56-65-144(209)263)167(286)223-110(25)164(283)222-111(26)165(284)240-135(92-148(213)267)189(308)247-136(93-149(214)268)188(307)230-118(52-43-80-220-204(217)218)173(292)241-130(86-99(8)9)183(302)244-133(89-102(14)15)186(305)246-134(90-103(16)17)187(306)248-138(95-157(281)282)191(310)257-163(112(27)262)199(318)256-162(202(321)322)109(24)33-5/h98-143,158-163,261-262H,29-97,205-208H2,1-28H3,(H2,209,263)(H2,210,264)(H2,211,265)(H2,212,266)(H2,213,267)(H2,214,268)(H,221,285)(H,222,283)(H,223,286)(H,224,269)(H,225,291)(H,226,295)(H,227,296)(H,228,297)(H,229,301)(H,230,307)(H,231,293)(H,232,287)(H,233,288)(H,234,289)(H,235,294)(H,236,290)(H,237,312)(H,238,314)(H,239,315)(H,240,284)(H,241,292)(H,242,298)(H,243,304)(H,244,302)(H,245,303)(H,246,305)(H,247,308)(H,248,306)(H,249,316)(H,250,309)(H,251,317)(H,252,299)(H,253,300)(H,254,311)(H,255,313)(H,256,318)(H,257,310)(H,271,272)(H,273,274)(H,275,276)(H,277,278)(H,279,280)(H,281,282)(H,321,322)(H4,215,216,219)(H4,217,218,220)/t105-,106-,107-,108-,109-,110-,111-,112+,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,158-,159-,160-,161-,162-,163-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 447 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50158981
(CHEMBL429547 | Sauvagine derivative)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C210H350N56O61S/c1-29-108(19)163(257-185(303)133(68-76-160(282)283)244-201(319)164(109(20)30-2)258-186(304)134(77-87-328-28)242-177(295)123(55-40-44-81-214)231-178(296)124(56-45-82-224-209(220)221)235-187(305)135(88-102(7)8)247-190(308)138(91-105(13)14)250-192(310)140(94-117-99-226-119-51-36-35-50-118(117)119)253-203(321)166(111(22)32-4)260-198(316)147-58-47-85-265(147)206(324)145(93-107(17)18)255-195(313)143(97-161(284)285)254-202(320)165(110(21)31-3)259-197(315)146(101-267)256-204(322)167(112(23)33-5)261-199(317)148-59-48-86-266(148)207(325)149-60-49-84-264(149)156(275)100-227-172(290)126-64-72-155(274)230-126)200(318)243-132(67-75-159(280)281)184(302)234-121(53-38-42-79-212)175(293)239-129(63-71-152(217)271)181(299)241-131(66-74-158(278)279)183(301)233-122(54-39-43-80-213)176(294)240-130(65-73-157(276)277)182(300)232-120(52-37-41-78-211)174(292)238-128(62-70-151(216)270)180(298)237-127(61-69-150(215)269)173(291)229-114(25)170(288)228-115(26)171(289)245-141(95-153(218)272)194(312)251-142(96-154(219)273)193(311)236-125(57-46-83-225-210(222)223)179(297)246-136(89-103(9)10)188(306)248-137(90-104(11)12)189(307)249-139(92-106(15)16)191(309)252-144(98-162(286)287)196(314)263-169(116(27)268)205(323)262-168(208(326)327)113(24)34-6/h35-36,50-51,99,102-116,120-149,163-169,226,267-268H,29-34,37-49,52-98,100-101,211-214H2,1-28H3,(H2,215,269)(H2,216,270)(H2,217,271)(H2,218,272)(H2,219,273)(H,227,290)(H,228,288)(H,229,291)(H,230,274)(H,231,296)(H,232,300)(H,233,301)(H,234,302)(H,235,305)(H,236,311)(H,237,298)(H,238,292)(H,239,293)(H,240,294)(H,241,299)(H,242,295)(H,243,318)(H,244,319)(H,245,289)(H,246,297)(H,247,308)(H,248,306)(H,249,307)(H,250,310)(H,251,312)(H,252,309)(H,253,321)(H,254,320)(H,255,313)(H,256,322)(H,257,303)(H,258,304)(H,259,315)(H,260,316)(H,261,317)(H,262,323)(H,263,314)(H,276,277)(H,278,279)(H,280,281)(H,282,283)(H,284,285)(H,286,287)(H,326,327)(H4,220,221,224)(H4,222,223,225)/t108-,109-,110-,111-,112-,113-,114-,115-,116+,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,163-,164-,165-,166-,167-,168-,169-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 562 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50158975
(CHEMBL410814 | Sauvagine derivative)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C209H345N55O61S/c1-28-108(18)163(256-185(302)133(69-77-160(280)281)243-201(318)164(109(19)29-2)257-186(303)134(78-88-326-27)241-177(294)123(56-38-42-82-213)230-178(295)124(57-44-83-223-208(219)220)234-187(304)135(89-102(6)7)247-190(307)138(92-105(12)13)250-192(309)140(95-118-51-43-50-117-49-33-34-52-119(117)118)244-171(288)115(25)228-198(315)147-59-46-86-263(147)205(322)145(94-107(16)17)254-195(312)143(98-161(282)283)253-202(319)165(110(20)30-3)258-197(314)146(101-265)255-203(320)166(111(21)31-4)259-199(316)148-60-47-87-264(148)206(323)149-61-48-85-262(149)156(273)100-225-172(289)126-65-73-155(272)229-126)200(317)242-132(68-76-159(278)279)184(301)233-121(54-36-40-80-211)175(292)238-129(64-72-152(216)269)181(298)240-131(67-75-158(276)277)183(300)232-122(55-37-41-81-212)176(293)239-130(66-74-157(274)275)182(299)231-120(53-35-39-79-210)174(291)237-128(63-71-151(215)268)180(297)236-127(62-70-150(214)267)173(290)227-113(23)169(286)226-114(24)170(287)245-141(96-153(217)270)194(311)251-142(97-154(218)271)193(310)235-125(58-45-84-224-209(221)222)179(296)246-136(90-103(8)9)188(305)248-137(91-104(10)11)189(306)249-139(93-106(14)15)191(308)252-144(99-162(284)285)196(313)261-168(116(26)266)204(321)260-167(207(324)325)112(22)32-5/h33-34,43,49-52,102-116,120-149,163-168,265-266H,28-32,35-42,44-48,53-101,210-213H2,1-27H3,(H2,214,267)(H2,215,268)(H2,216,269)(H2,217,270)(H2,218,271)(H,225,289)(H,226,286)(H,227,290)(H,228,315)(H,229,272)(H,230,295)(H,231,299)(H,232,300)(H,233,301)(H,234,304)(H,235,310)(H,236,297)(H,237,291)(H,238,292)(H,239,293)(H,240,298)(H,241,294)(H,242,317)(H,243,318)(H,244,288)(H,245,287)(H,246,296)(H,247,307)(H,248,305)(H,249,306)(H,250,309)(H,251,311)(H,252,308)(H,253,319)(H,254,312)(H,255,320)(H,256,302)(H,257,303)(H,258,314)(H,259,316)(H,260,321)(H,261,313)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,282,283)(H,284,285)(H,324,325)(H4,219,220,223)(H4,221,222,224)/t108-,109-,110-,111-,112-,113-,114-,115-,116+,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,163-,164-,165-,166-,167-,168-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 582 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50158959
(CHEMBL429719 | Sauvagine derivative)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C205H343N55O62S/c1-28-105(18)159(252-181(299)129(66-74-156(277)278)239-197(315)160(106(19)29-2)253-182(300)130(75-85-323-27)237-173(291)119(49-36-40-79-209)226-174(292)120(50-41-80-219-204(215)216)230-183(301)131(86-99(6)7)243-186(304)134(89-102(12)13)246-188(306)136(92-114-55-57-115(263)58-56-114)240-167(285)112(25)224-194(312)143-52-43-83-259(143)201(319)141(91-104(16)17)250-191(309)139(95-157(279)280)249-198(316)161(107(20)30-3)254-193(311)142(98-261)251-199(317)162(108(21)31-4)255-195(313)144-53-44-84-260(144)202(320)145-54-45-82-258(145)152(270)97-221-168(286)122-62-70-151(269)225-122)196(314)238-128(65-73-155(275)276)180(298)229-117(47-34-38-77-207)171(289)234-125(61-69-148(212)266)177(295)236-127(64-72-154(273)274)179(297)228-118(48-35-39-78-208)172(290)235-126(63-71-153(271)272)178(296)227-116(46-33-37-76-206)170(288)233-124(60-68-147(211)265)176(294)232-123(59-67-146(210)264)169(287)223-110(23)165(283)222-111(24)166(284)241-137(93-149(213)267)190(308)247-138(94-150(214)268)189(307)231-121(51-42-81-220-205(217)218)175(293)242-132(87-100(8)9)184(302)244-133(88-101(10)11)185(303)245-135(90-103(14)15)187(305)248-140(96-158(281)282)192(310)257-164(113(26)262)200(318)256-163(203(321)322)109(22)32-5/h55-58,99-113,116-145,159-164,261-263H,28-54,59-98,206-209H2,1-27H3,(H2,210,264)(H2,211,265)(H2,212,266)(H2,213,267)(H2,214,268)(H,221,286)(H,222,283)(H,223,287)(H,224,312)(H,225,269)(H,226,292)(H,227,296)(H,228,297)(H,229,298)(H,230,301)(H,231,307)(H,232,294)(H,233,288)(H,234,289)(H,235,290)(H,236,295)(H,237,291)(H,238,314)(H,239,315)(H,240,285)(H,241,284)(H,242,293)(H,243,304)(H,244,302)(H,245,303)(H,246,306)(H,247,308)(H,248,305)(H,249,316)(H,250,309)(H,251,317)(H,252,299)(H,253,300)(H,254,311)(H,255,313)(H,256,318)(H,257,310)(H,271,272)(H,273,274)(H,275,276)(H,277,278)(H,279,280)(H,281,282)(H,321,322)(H4,215,216,219)(H4,217,218,220)/t105-,106-,107-,108-,109-,110-,111-,112-,113+,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,159-,160-,161-,162-,163-,164-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 606 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50158991
(CHEMBL438210 | Sauvagine derivative)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C212H351N55O61S/c1-29-110(19)165(258-187(304)135(71-79-162(283)284)245-203(320)166(111(20)30-2)259-188(305)136(80-90-329-28)243-179(296)125(58-40-44-84-216)232-180(297)126(59-46-85-226-211(222)223)236-189(306)137(91-104(7)8)248-192(309)140(94-107(13)14)251-194(311)142(97-120-53-45-52-119-51-35-36-54-121(119)120)254-205(322)168(113(22)32-4)261-200(317)149-61-48-88-266(149)208(325)147(96-109(17)18)256-197(314)145(100-163(285)286)255-204(321)167(112(21)31-3)260-199(316)148(103-268)257-206(323)169(114(23)33-5)262-201(318)150-62-49-89-267(150)209(326)151-63-50-87-265(151)158(276)102-228-174(291)128-67-75-157(275)231-128)202(319)244-134(70-78-161(281)282)186(303)235-123(56-38-42-82-214)177(294)240-131(66-74-154(219)272)183(300)242-133(69-77-160(279)280)185(302)234-124(57-39-43-83-215)178(295)241-132(68-76-159(277)278)184(301)233-122(55-37-41-81-213)176(293)239-130(65-73-153(218)271)182(299)238-129(64-72-152(217)270)175(292)230-116(25)172(289)229-117(26)173(290)246-143(98-155(220)273)196(313)252-144(99-156(221)274)195(312)237-127(60-47-86-227-212(224)225)181(298)247-138(92-105(9)10)190(307)249-139(93-106(11)12)191(308)250-141(95-108(15)16)193(310)253-146(101-164(287)288)198(315)264-171(118(27)269)207(324)263-170(210(327)328)115(24)34-6/h35-36,45,51-54,104-118,122-151,165-171,268-269H,29-34,37-44,46-50,55-103,213-216H2,1-28H3,(H2,217,270)(H2,218,271)(H2,219,272)(H2,220,273)(H2,221,274)(H,228,291)(H,229,289)(H,230,292)(H,231,275)(H,232,297)(H,233,301)(H,234,302)(H,235,303)(H,236,306)(H,237,312)(H,238,299)(H,239,293)(H,240,294)(H,241,295)(H,242,300)(H,243,296)(H,244,319)(H,245,320)(H,246,290)(H,247,298)(H,248,309)(H,249,307)(H,250,308)(H,251,311)(H,252,313)(H,253,310)(H,254,322)(H,255,321)(H,256,314)(H,257,323)(H,258,304)(H,259,305)(H,260,316)(H,261,317)(H,262,318)(H,263,324)(H,264,315)(H,277,278)(H,279,280)(H,281,282)(H,283,284)(H,285,286)(H,287,288)(H,327,328)(H4,222,223,226)(H4,224,225,227)/t110-,111-,112-,113-,114-,115-,116-,117-,118+,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,165-,166-,167-,168-,169-,170-,171-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 608 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50158993
(CHEMBL437289 | Sauvagine derivative)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C204H348N56O62S/c1-29-104(19)157(251-180(299)127(65-74-154(277)278)239-195(314)158(105(20)30-2)253-181(300)128(75-85-323-28)236-171(290)116(51-38-42-79-208)225-172(291)117(52-43-80-219-203(215)216)229-182(301)129(86-98(7)8)242-186(305)133(90-102(15)16)247-196(315)159(106(21)31-3)252-179(298)123(60-69-146(212)266)237-192(311)140-54-45-83-259(140)200(319)138(91-103(17)18)249-189(308)136(94-155(279)280)248-197(316)160(107(22)32-4)254-191(310)139(97-261)250-198(317)161(108(23)33-5)255-193(312)141-55-46-84-260(141)201(320)142-56-47-82-258(142)150(270)96-221-166(285)119-61-70-149(269)224-119)194(313)238-126(64-73-153(275)276)178(297)228-114(49-36-40-77-206)169(288)233-122(59-68-145(211)265)175(294)235-125(63-72-152(273)274)177(296)227-115(50-37-41-78-207)170(289)234-124(62-71-151(271)272)176(295)226-113(48-35-39-76-205)168(287)232-121(58-67-144(210)264)174(293)231-120(57-66-143(209)263)167(286)223-110(25)164(283)222-111(26)165(284)240-134(92-147(213)267)188(307)245-135(93-148(214)268)187(306)230-118(53-44-81-220-204(217)218)173(292)241-130(87-99(9)10)183(302)243-131(88-100(11)12)184(303)244-132(89-101(13)14)185(304)246-137(95-156(281)282)190(309)257-163(112(27)262)199(318)256-162(202(321)322)109(24)34-6/h98-142,157-163,261-262H,29-97,205-208H2,1-28H3,(H2,209,263)(H2,210,264)(H2,211,265)(H2,212,266)(H2,213,267)(H2,214,268)(H,221,285)(H,222,283)(H,223,286)(H,224,269)(H,225,291)(H,226,295)(H,227,296)(H,228,297)(H,229,301)(H,230,306)(H,231,293)(H,232,287)(H,233,288)(H,234,289)(H,235,294)(H,236,290)(H,237,311)(H,238,313)(H,239,314)(H,240,284)(H,241,292)(H,242,305)(H,243,302)(H,244,303)(H,245,307)(H,246,304)(H,247,315)(H,248,316)(H,249,308)(H,250,317)(H,251,299)(H,252,298)(H,253,300)(H,254,310)(H,255,312)(H,256,318)(H,257,309)(H,271,272)(H,273,274)(H,275,276)(H,277,278)(H,279,280)(H,281,282)(H,321,322)(H4,215,216,219)(H4,217,218,220)/t104-,105-,106-,107-,108-,109-,110-,111-,112+,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,157-,158-,159-,160-,161-,162-,163-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 707 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50158958
(CHEMBL439102 | Sauvagine derivative)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C208H349N55O61S/c1-29-108(19)161(254-183(300)131(69-77-158(279)280)241-199(316)162(109(20)30-2)255-184(301)132(78-88-325-28)239-175(292)121(56-41-45-82-212)228-176(293)122(57-46-83-222-207(218)219)232-185(302)133(89-102(7)8)244-188(305)136(92-105(13)14)247-190(307)138(95-117-51-36-35-37-52-117)250-201(318)164(111(22)32-4)257-196(313)145-59-48-86-262(145)204(321)143(94-107(17)18)252-193(310)141(98-159(281)282)251-200(317)163(110(21)31-3)256-195(312)144(101-264)253-202(319)165(112(23)33-5)258-197(314)146-60-49-87-263(146)205(322)147-61-50-85-261(147)154(272)100-224-170(287)124-65-73-153(271)227-124)198(315)240-130(68-76-157(277)278)182(299)231-119(54-39-43-80-210)173(290)236-127(64-72-150(215)268)179(296)238-129(67-75-156(275)276)181(298)230-120(55-40-44-81-211)174(291)237-128(66-74-155(273)274)180(297)229-118(53-38-42-79-209)172(289)235-126(63-71-149(214)267)178(295)234-125(62-70-148(213)266)171(288)226-114(25)168(285)225-115(26)169(286)242-139(96-151(216)269)192(309)248-140(97-152(217)270)191(308)233-123(58-47-84-223-208(220)221)177(294)243-134(90-103(9)10)186(303)245-135(91-104(11)12)187(304)246-137(93-106(15)16)189(306)249-142(99-160(283)284)194(311)260-167(116(27)265)203(320)259-166(206(323)324)113(24)34-6/h35-37,51-52,102-116,118-147,161-167,264-265H,29-34,38-50,53-101,209-212H2,1-28H3,(H2,213,266)(H2,214,267)(H2,215,268)(H2,216,269)(H2,217,270)(H,224,287)(H,225,285)(H,226,288)(H,227,271)(H,228,293)(H,229,297)(H,230,298)(H,231,299)(H,232,302)(H,233,308)(H,234,295)(H,235,289)(H,236,290)(H,237,291)(H,238,296)(H,239,292)(H,240,315)(H,241,316)(H,242,286)(H,243,294)(H,244,305)(H,245,303)(H,246,304)(H,247,307)(H,248,309)(H,249,306)(H,250,318)(H,251,317)(H,252,310)(H,253,319)(H,254,300)(H,255,301)(H,256,312)(H,257,313)(H,258,314)(H,259,320)(H,260,311)(H,273,274)(H,275,276)(H,277,278)(H,279,280)(H,281,282)(H,283,284)(H,323,324)(H4,218,219,222)(H4,220,221,223)/t108-,109-,110-,111-,112-,113-,114-,115-,116+,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,161-,162-,163-,164-,165-,166-,167-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 756 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(MOUSE) | BDBM50159004
(CHEMBL441929 | Sauvagine derivative)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C206H345N55O62S/c1-28-106(18)159(252-181(299)129(67-75-156(278)279)239-197(315)160(107(19)29-2)253-182(300)130(76-86-324-27)237-173(291)119(54-39-43-80-210)226-174(292)120(55-44-81-220-205(216)217)230-183(301)131(87-100(6)7)242-186(304)134(90-103(12)13)245-188(306)136(93-115-49-34-33-35-50-115)248-200(318)164(113(25)263)258-195(313)143-57-46-84-260(143)202(320)141(92-105(16)17)250-191(309)139(96-157(280)281)249-198(316)161(108(20)30-3)254-193(311)142(99-262)251-199(317)162(109(21)31-4)255-194(312)144-58-47-85-261(144)203(321)145-59-48-83-259(145)152(271)98-222-168(286)122-63-71-151(270)225-122)196(314)238-128(66-74-155(276)277)180(298)229-117(52-37-41-78-208)171(289)234-125(62-70-148(213)267)177(295)236-127(65-73-154(274)275)179(297)228-118(53-38-42-79-209)172(290)235-126(64-72-153(272)273)178(296)227-116(51-36-40-77-207)170(288)233-124(61-69-147(212)266)176(294)232-123(60-68-146(211)265)169(287)224-111(23)166(284)223-112(24)167(285)240-137(94-149(214)268)190(308)246-138(95-150(215)269)189(307)231-121(56-45-82-221-206(218)219)175(293)241-132(88-101(8)9)184(302)243-133(89-102(10)11)185(303)244-135(91-104(14)15)187(305)247-140(97-158(282)283)192(310)257-165(114(26)264)201(319)256-163(204(322)323)110(22)32-5/h33-35,49-50,100-114,116-145,159-165,262-264H,28-32,36-48,51-99,207-210H2,1-27H3,(H2,211,265)(H2,212,266)(H2,213,267)(H2,214,268)(H2,215,269)(H,222,286)(H,223,284)(H,224,287)(H,225,270)(H,226,292)(H,227,296)(H,228,297)(H,229,298)(H,230,301)(H,231,307)(H,232,294)(H,233,288)(H,234,289)(H,235,290)(H,236,295)(H,237,291)(H,238,314)(H,239,315)(H,240,285)(H,241,293)(H,242,304)(H,243,302)(H,244,303)(H,245,306)(H,246,308)(H,247,305)(H,248,318)(H,249,316)(H,250,309)(H,251,317)(H,252,299)(H,253,300)(H,254,311)(H,255,312)(H,256,319)(H,257,310)(H,258,313)(H,272,273)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,282,283)(H,322,323)(H4,216,217,220)(H4,218,219,221)/t106-,107-,108-,109-,110-,111-,112-,113+,114+,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,159-,160-,161-,162-,163-,164-,165-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 944 | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor |
J Med Chem 48: 262-5 (2005)
Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5 |
More data for this
Ligand-Target Pair | |
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