Compile Data Set for Download or QSAR

Found 22 hits of ec50 for UniProtKB: P25102   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H2 receptor (RAT)	BDBM50000348 (CHEMBL3228794) Show SMILES CC(C)Cc1ccc2ccc(=O)n(CCN(C)C)c2n1 Show InChI InChI=1S/C16H23N3O/c1-12(2)11-14-7-5-13-6-8-15(20)19(16(13)17-14)10-9-18(3)4/h5-8,12H,9-11H2,1-4H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	590	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at histamine H2 receptor in Charles River rat assessed as inhibition of histamine-mediated electrically stimulated uterine contra...				J Med Chem 22: 301-6 (1979) BindingDB Entry DOI: 10.7270/Q25140QF
					More data for this Ligand-Target Pair
Histamine H2 receptor (RAT)	BDBM50000382 (CHEBI:6896 | METIAMIDE | SK&F-92058) Show SMILES C\N=C(/S)NCCSCc1[nH]cnc1C Show InChI InChI=1S/C9H16N4S2/c1-7-8(13-6-12-7)5-15-4-3-11-9(14)10-2/h6H,3-5H2,1-2H3,(H,12,13)(H2,10,11,14)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at histamine H2 receptor in Charles River rat assessed as inhibition of histamine-mediated electrically stimulated uterine contra...				J Med Chem 22: 301-6 (1979) BindingDB Entry DOI: 10.7270/Q25140QF
					More data for this Ligand-Target Pair
Histamine H2 receptor (RAT)	BDBM50000385 (CHEMBL3228793) Show SMILES CC(C)c1ccc2ccc(=O)n(CCN(C)C)c2n1 Show InChI InChI=1S/C15H21N3O/c1-11(2)13-7-5-12-6-8-14(19)18(15(12)16-13)10-9-17(3)4/h5-8,11H,9-10H2,1-4H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at histamine H2 receptor in Charles River rat assessed as inhibition of histamine-mediated electrically stimulated uterine contra...				J Med Chem 22: 301-6 (1979) BindingDB Entry DOI: 10.7270/Q25140QF
					More data for this Ligand-Target Pair
Histamine H2 receptor (RAT)	BDBM50000391 (CHEMBL3228792) Show SMILES CCc1ccc2ccc(=O)n(CCN(C)C)c2n1 Show InChI InChI=1S/C14H19N3O/c1-4-12-7-5-11-6-8-13(18)17(14(11)15-12)10-9-16(2)3/h5-8H,4,9-10H2,1-3H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at histamine H2 receptor in Charles River rat assessed as inhibition of histamine-mediated electrically stimulated uterine contra...				J Med Chem 22: 301-6 (1979) BindingDB Entry DOI: 10.7270/Q25140QF
					More data for this Ligand-Target Pair
Histamine H2 receptor (RAT)	BDBM50000408 (CHEMBL3228806) Show SMILES CCN(CC)CCn1c2nc(C)cc(C)c2ccc1=O Show InChI InChI=1S/C16H23N3O/c1-5-18(6-2)9-10-19-15(20)8-7-14-12(3)11-13(4)17-16(14)19/h7-8,11H,5-6,9-10H2,1-4H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at histamine H2 receptor in Charles River rat assessed as inhibition of histamine-mediated electrically stimulated uterine contra...				J Med Chem 22: 301-6 (1979) BindingDB Entry DOI: 10.7270/Q25140QF
					More data for this Ligand-Target Pair
Histamine H2 receptor (RAT)	BDBM50000405 (CHEMBL3228819 | CHEMBL92526) Show SMILES CN(C)CCN1CCCc2c(C)cc(C)nc12 Show InChI InChI=1S/C14H23N3/c1-11-10-12(2)15-14-13(11)6-5-7-17(14)9-8-16(3)4/h10H,5-9H2,1-4H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	4.30E+3	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at histamine H2 receptor in Charles River rat assessed as inhibition of histamine-mediated electrically stimulated uterine contra...				J Med Chem 22: 301-6 (1979) BindingDB Entry DOI: 10.7270/Q25140QF
					More data for this Ligand-Target Pair
Histamine H2 receptor (RAT)	BDBM50000411 (CHEMBL3228809) Show SMILES CC(C)N(CCn1c2nc(C)cc(C)c2ccc1=O)C(C)C Show InChI InChI=1S/C18H27N3O/c1-12(2)20(13(3)4)9-10-21-17(22)8-7-16-14(5)11-15(6)19-18(16)21/h7-8,11-13H,9-10H2,1-6H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	4.60E+3	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at histamine H2 receptor in Charles River rat assessed as inhibition of histamine-mediated electrically stimulated uterine contra...				J Med Chem 22: 301-6 (1979) BindingDB Entry DOI: 10.7270/Q25140QF
					More data for this Ligand-Target Pair
Histamine H2 receptor (RAT)	BDBM50000443 (CHEMBL280584 | CHEMBL3228799) Show SMILES CN(C)CCn1c2nc(cc(C)c2ccc1=O)C(F)(F)F Show InChI InChI=1S/C14H16F3N3O/c1-9-8-11(14(15,16)17)18-13-10(9)4-5-12(21)20(13)7-6-19(2)3/h4-5,8H,6-7H2,1-3H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	5.30E+3	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at histamine H2 receptor in Charles River rat assessed as inhibition of histamine-mediated electrically stimulated uterine contra...				J Med Chem 22: 301-6 (1979) BindingDB Entry DOI: 10.7270/Q25140QF
					More data for this Ligand-Target Pair
Histamine H2 receptor (RAT)	BDBM50000444 (CHEMBL282206 | CHEMBL3228808) Show SMILES CCCCN(CCCC)CCn1c2nc(C)cc(C)c2ccc1=O Show InChI InChI=1S/C20H31N3O/c1-5-7-11-22(12-8-6-2)13-14-23-19(24)10-9-18-16(3)15-17(4)21-20(18)23/h9-10,15H,5-8,11-14H2,1-4H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at histamine H2 receptor in Charles River rat assessed as inhibition of histamine-mediated electrically stimulated uterine contra...				J Med Chem 22: 301-6 (1979) BindingDB Entry DOI: 10.7270/Q25140QF
					More data for this Ligand-Target Pair
Histamine H2 receptor (RAT)	BDBM50000952 (CHEMBL3228791) Show SMILES CN(C)CCn1c2nc(C)ccc2ccc1=O Show InChI InChI=1S/C13H17N3O/c1-10-4-5-11-6-7-12(17)16(13(11)14-10)9-8-15(2)3/h4-7H,8-9H2,1-3H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	9.50E+3	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at histamine H2 receptor in Charles River rat assessed as inhibition of histamine-mediated electrically stimulated uterine contra...				J Med Chem 22: 301-6 (1979) BindingDB Entry DOI: 10.7270/Q25140QF
					More data for this Ligand-Target Pair
Histamine H2 receptor (RAT)	BDBM50000953 (CHEMBL3228807) Show SMILES Cc1cc(C)c2ccc(=O)n(CCN3CCCCC3)c2n1 Show InChI InChI=1S/C17H23N3O/c1-13-12-14(2)18-17-15(13)6-7-16(21)20(17)11-10-19-8-4-3-5-9-19/h6-7,12H,3-5,8-11H2,1-2H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at histamine H2 receptor in Charles River rat assessed as inhibition of histamine-mediated electrically stimulated uterine contra...				J Med Chem 22: 301-6 (1979) BindingDB Entry DOI: 10.7270/Q25140QF
					More data for this Ligand-Target Pair
Histamine H2 receptor (RAT)	BDBM50000954 (CHEMBL3228820) Show SMILES CN(C)CCn1c2nc(C)cc(C)c2ccc1=S Show InChI InChI=1S/C14H19N3S/c1-10-9-11(2)15-14-12(10)5-6-13(18)17(14)8-7-16(3)4/h5-6,9H,7-8H2,1-4H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at histamine H2 receptor in Charles River rat assessed as inhibition of histamine-mediated electrically stimulated uterine contra...				J Med Chem 22: 301-6 (1979) BindingDB Entry DOI: 10.7270/Q25140QF
					More data for this Ligand-Target Pair
Histamine H2 receptor (RAT)	BDBM50000955 (CHEMBL3228795) Show SMILES CN(C)CCn1c2nc(C)cc(C)c2ccc1=O Show InChI InChI=1S/C14H19N3O/c1-10-9-11(2)15-14-12(10)5-6-13(18)17(14)8-7-16(3)4/h5-6,9H,7-8H2,1-4H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at histamine H2 receptor in Charles River rat assessed as inhibition of histamine-mediated electrically stimulated uterine contra...				J Med Chem 22: 301-6 (1979) BindingDB Entry DOI: 10.7270/Q25140QF
					More data for this Ligand-Target Pair
Histamine H2 receptor (RAT)	BDBM50000956 (CHEMBL3228818) Show SMILES CN(C)CCN1C(=O)CCc2c(C)cc(C)nc12 Show InChI InChI=1S/C14H21N3O/c1-10-9-11(2)15-14-12(10)5-6-13(18)17(14)8-7-16(3)4/h9H,5-8H2,1-4H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	1.90E+4	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at histamine H2 receptor in Charles River rat assessed as inhibition of histamine-mediated electrically stimulated uterine contra...				J Med Chem 22: 301-6 (1979) BindingDB Entry DOI: 10.7270/Q25140QF
					More data for this Ligand-Target Pair
Histamine H2 receptor (RAT)	BDBM50000957 (CHEMBL3228796) Show SMILES CCc1cc(CC)c2ccc(=O)n(CCN(C)C)c2n1 Show InChI InChI=1S/C16H23N3O/c1-5-12-11-13(6-2)17-16-14(12)7-8-15(20)19(16)10-9-18(3)4/h7-8,11H,5-6,9-10H2,1-4H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	1.90E+4	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at histamine H2 receptor in Charles River rat assessed as inhibition of histamine-mediated electrically stimulated uterine contra...				J Med Chem 22: 301-6 (1979) BindingDB Entry DOI: 10.7270/Q25140QF
					More data for this Ligand-Target Pair
Histamine H2 receptor (RAT)	BDBM50000958 (CHEMBL3228800) Show SMILES COc1cc(C)c2ccc(=O)n(CCN(C)C)c2n1 Show InChI InChI=1S/C14H19N3O2/c1-10-9-12(19-4)15-14-11(10)5-6-13(18)17(14)8-7-16(2)3/h5-6,9H,7-8H2,1-4H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	2.70E+4	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at histamine H2 receptor in Charles River rat assessed as inhibition of histamine-mediated electrically stimulated uterine contra...				J Med Chem 22: 301-6 (1979) BindingDB Entry DOI: 10.7270/Q25140QF
					More data for this Ligand-Target Pair
Histamine H2 receptor (RAT)	BDBM50000959 (CHEMBL3228801) Show SMILES CN(C)CCn1c2nc(Cl)cc(C)c2ccc1=O Show InChI InChI=1S/C13H16ClN3O/c1-9-8-11(14)15-13-10(9)4-5-12(18)17(13)7-6-16(2)3/h4-5,8H,6-7H2,1-3H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	3.50E+4	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at histamine H2 receptor in Charles River rat assessed as inhibition of histamine-mediated electrically stimulated uterine contra...				J Med Chem 22: 301-6 (1979) BindingDB Entry DOI: 10.7270/Q25140QF
					More data for this Ligand-Target Pair
Histamine H2 receptor (RAT)	BDBM50000960 (CHEMBL3228814) Show SMILES CN(C)C(C)(C)Cn1c2nc(C)cc(C)c2ccc1=O Show InChI InChI=1S/C16H23N3O/c1-11-9-12(2)17-15-13(11)7-8-14(20)19(15)10-16(3,4)18(5)6/h7-9H,10H2,1-6H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	3.70E+4	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at histamine H2 receptor in Charles River rat assessed as inhibition of histamine-mediated electrically stimulated uterine contra...				J Med Chem 22: 301-6 (1979) BindingDB Entry DOI: 10.7270/Q25140QF
					More data for this Ligand-Target Pair
Histamine H2 receptor (RAT)	BDBM50000961 (CHEMBL3228802) Show SMILES CN(C)CCn1c2nc(C)c(C)c(C)c2ccc1=O Show InChI InChI=1S/C15H21N3O/c1-10-11(2)13-6-7-14(19)18(9-8-17(4)5)15(13)16-12(10)3/h6-7H,8-9H2,1-5H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at histamine H2 receptor in Charles River rat assessed as inhibition of histamine-mediated electrically stimulated uterine contra...				J Med Chem 22: 301-6 (1979) BindingDB Entry DOI: 10.7270/Q25140QF
					More data for this Ligand-Target Pair
Histamine H2 receptor (RAT)	BDBM50000962 (CHEMBL3228816) Show SMILES CC(C)N(CCn1c2ncccc2ccc1=O)C(C)C Show InChI InChI=1S/C16H23N3O/c1-12(2)18(13(3)4)10-11-19-15(20)8-7-14-6-5-9-17-16(14)19/h5-9,12-13H,10-11H2,1-4H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	7.70E+4	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at histamine H2 receptor in Charles River rat assessed as inhibition of histamine-mediated electrically stimulated uterine contra...				J Med Chem 22: 301-6 (1979) BindingDB Entry DOI: 10.7270/Q25140QF
					More data for this Ligand-Target Pair
Histamine H2 receptor (RAT)	BDBM50000963 (CHEMBL3228805) Show SMILES CNCCn1c2nc(C)cc(C)c2ccc1=O Show InChI InChI=1S/C13H17N3O/c1-9-8-10(2)15-13-11(9)4-5-12(17)16(13)7-6-14-3/h4-5,8,14H,6-7H2,1-3H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	9.10E+4	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at histamine H2 receptor in Charles River rat assessed as inhibition of histamine-mediated electrically stimulated uterine contra...				J Med Chem 22: 301-6 (1979) BindingDB Entry DOI: 10.7270/Q25140QF
					More data for this Ligand-Target Pair
Histamine H2 receptor (RAT)	BDBM50000964 (CHEMBL3228804) Show SMILES Cc1cc(C)c2ccc(=O)n(CCN)c2n1 Show InChI InChI=1S/C12H15N3O/c1-8-7-9(2)14-12-10(8)3-4-11(16)15(12)6-5-13/h3-4,7H,5-6,13H2,1-2H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	1.60E+5	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at histamine H2 receptor in Charles River rat assessed as inhibition of histamine-mediated electrically stimulated uterine contra...				J Med Chem 22: 301-6 (1979) BindingDB Entry DOI: 10.7270/Q25140QF
					More data for this Ligand-Target Pair