Found 38 hits of ki for UniProtKB: P70606 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Small conductance calcium-activated potassium channel protein 1/2/3
(Rattus norvegicus-RAT-Rattus norvegicus (Rat)) | BDBM50260153
(Apamin | CHEMBL525408 | Octadecapeptide venom)Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CSSC[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N2)NC1=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)[C@@H](C)O |r,wU:83.102,47.101,13.138,4.3,33.34,88.89,78.79,67.68,107.109,116.118,125.127,wD:26.30,52.106,56.57,17.17,135.140,8.8,38.39,93.94,(27.83,-36.7,;27.83,-35.16,;26.49,-34.38,;29.15,-34.38,;29.15,-32.85,;30.49,-32.08,;31.8,-32.85,;31.8,-34.38,;33.14,-32.08,;33.14,-30.53,;34.47,-32.85,;35.8,-32.08,;35.8,-30.53,;40.01,-33.02,;41.6,-32.04,;43.23,-32.89,;43.23,-34.42,;44.54,-32.11,;44.54,-30.57,;45.89,-29.8,;45.89,-28.26,;44.54,-27.49,;47.21,-27.49,;45.89,-32.89,;48.48,-32.23,;48.91,-30.87,;50.38,-34.89,;52.13,-34.44,;53.01,-35.96,;51.84,-36.95,;50.38,-36.43,;48.34,-38.91,;48.77,-40.45,;46.11,-38.58,;46.11,-37.03,;44.16,-39.41,;42.33,-38.62,;42.33,-37.09,;40.7,-39.47,;40.7,-40.99,;39.37,-41.76,;39.37,-43.3,;38.05,-44.06,;38.05,-45.59,;38.29,-38.35,;35.39,-39.38,;35.39,-40.91,;34.06,-38.61,;40.93,-30.71,;40.94,-27.32,;39.36,-26.12,;39.37,-23.14,;38.05,-22.37,;36.72,-23.15,;35.39,-22.38,;35.4,-20.84,;34.06,-23.15,;34.06,-24.68,;32.73,-25.46,;32.73,-26.98,;31.4,-27.31,;30.08,-26.97,;28.36,-27.74,;30.08,-25.44,;32.73,-22.39,;31.4,-23.16,;31.41,-24.7,;28.69,-22.34,;28.69,-20.8,;30.02,-20.04,;30.02,-18.5,;31.34,-17.73,;31.34,-16.2,;32.68,-15.42,;30.02,-15.42,;26.07,-23.55,;26.08,-25.1,;27.41,-25.88,;23.8,-26.94,;22.48,-26.19,;23.83,-29.77,;25.16,-30.53,;26.5,-29.77,;25.16,-32.08,;23.84,-32.85,;23.84,-34.38,;24.76,-36.3,;26.09,-37.07,;26.09,-38.61,;24.77,-39.38,;27.42,-39.38,;27.42,-40.91,;28.75,-38.61,;30.09,-39.38,;30.09,-40.91,;31.42,-41.68,;31.42,-43.23,;32.75,-40.91,;31.41,-38.61,;31.41,-37.07,;32.73,-39.38,;26.5,-32.85,;27.83,-32.08,;27.83,-30.53,;38.04,-20.83,;36.7,-20.07,;39.36,-20.06,;39.36,-18.52,;38.03,-17.74,;38.03,-16.21,;36.71,-15.43,;36.71,-13.9,;35.38,-16.21,;40.7,-17.74,;40.69,-16.21,;42.03,-18.52,;43.37,-17.74,;43.37,-16.2,;44.7,-15.42,;44.7,-13.89,;46.03,-13.1,;43.36,-13.12,;44.71,-18.51,;44.7,-20.05,;46.04,-17.73,;47.37,-18.52,;48.68,-17.74,;50.05,-18.53,;50.21,-20.07,;51.72,-20.4,;52.48,-19.07,;51.47,-17.91,;47.36,-20.05,;48.68,-20.83,;46.03,-20.83,;40.01,-34.57,;38.67,-35.33,;41.74,-35.33,)| Show InChI InChI=1S/C79H131N31O24S4/c1-35(2)26-49-70(127)107-51-31-136-135-30-41(81)63(120)105-50(28-57(84)114)71(128)108-53(73(130)99-42(12-7-8-22-80)64(121)96-38(5)77(134)110-25-11-15-54(110)75(132)102-47(18-21-58(115)116)69(126)109-59(39(6)111)76(133)95-37(4)62(119)104-49)33-138-137-32-52(106-66(123)44(14-10-24-92-79(88)89)98-65(122)43(13-9-23-91-78(86)87)97-61(118)36(3)94-72(51)129)74(131)101-45(16-19-55(82)112)67(124)100-46(17-20-56(83)113)68(125)103-48(60(85)117)27-40-29-90-34-93-40/h29,34-39,41-54,59,111H,7-28,30-33,80-81H2,1-6H3,(H2,82,112)(H2,83,113)(H2,84,114)(H2,85,117)(H,90,93)(H,94,129)(H,95,133)(H,96,121)(H,97,118)(H,98,122)(H,99,130)(H,100,124)(H,101,131)(H,102,132)(H,103,125)(H,104,119)(H,105,120)(H,106,123)(H,107,127)(H,108,128)(H,109,126)(H,115,116)(H4,86,87,91)(H4,88,89,92)/t36-,37-,38-,39+,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,59-/m0/s1 | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.00400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Li£ge
Curated by ChEMBL
| Assay Description
Displacement of [125I]apamin from Wistar rat cortical apamin-sensitive site |
J Med Chem 49: 7208-14 (2006)
Article DOI: 10.1021/jm0607395
BindingDB Entry DOI: 10.7270/Q2S75K20 |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 1/2/3
(Rattus norvegicus-RAT-Rattus norvegicus (Rat)) | BDBM50476799
(CHEMBL397282)Show SMILES [I-].[I-].COc1cc2cc[n+](C)c(Cc3cccc(Cc4[n+](C)ccc5cc(OC)c(OC)c(OC)c45)c3)c2c(OC)c1OC Show InChI InChI=1S/C34H38N2O6/c1-35-14-12-23-19-27(37-3)31(39-5)33(41-7)29(23)25(35)17-21-10-9-11-22(16-21)18-26-30-24(13-15-36(26)2)20-28(38-4)32(40-6)34(30)42-8/h9-16,19-20H,17-18H2,1-8H3/q+2 | PDB
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| Article
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| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Li£ge
Curated by ChEMBL
| Assay Description
Displacement of [125I]apamin from SK channel in Wistar rat cortex |
J Med Chem 50: 5070-5 (2007)
Article DOI: 10.1021/jm070412j
BindingDB Entry DOI: 10.7270/Q28055C0 |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 1/2/3
(Rattus norvegicus-RAT-Rattus norvegicus (Rat)) | BDBM50476809
(CHEMBL394773)Show SMILES [I-].[I-].COc1cc2cc[n+](C)c(Cc3ccccc3Cc3[n+](C)ccc4cc(OC)c(OC)cc34)c2cc1OC Show InChI InChI=1S/C32H34N2O4/c1-33-13-11-23-17-29(35-3)31(37-5)19-25(23)27(33)15-21-9-7-8-10-22(21)16-28-26-20-32(38-6)30(36-4)18-24(26)12-14-34(28)2/h7-14,17-20H,15-16H2,1-6H3/q+2 | PDB
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| 33 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Li£ge
Curated by ChEMBL
| Assay Description
Displacement of [125I]apamin from SK channel in Wistar rat cortex |
J Med Chem 50: 5070-5 (2007)
Article DOI: 10.1021/jm070412j
BindingDB Entry DOI: 10.7270/Q28055C0 |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 1/2/3
(Rattus norvegicus-RAT-Rattus norvegicus (Rat)) | BDBM50476802
(CHEMBL395568)Show SMILES [I-].[I-].COc1cc2cc[n+](C)c(Cc3ccccc3Cc3[n+](C)ccc4cc(OC)c(OC)c(OC)c34)c2c(OC)c1OC Show InChI InChI=1S/C34H38N2O6/c1-35-15-13-23-19-27(37-3)31(39-5)33(41-7)29(23)25(35)17-21-11-9-10-12-22(21)18-26-30-24(14-16-36(26)2)20-28(38-4)32(40-6)34(30)42-8/h9-16,19-20H,17-18H2,1-8H3/q+2 | PDB
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| Article
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| 35 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Li£ge
Curated by ChEMBL
| Assay Description
Displacement of [125I]apamin from SK channel in Wistar rat cortex |
J Med Chem 50: 5070-5 (2007)
Article DOI: 10.1021/jm070412j
BindingDB Entry DOI: 10.7270/Q28055C0 |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 1/2/3
(Rattus norvegicus-RAT-Rattus norvegicus (Rat)) | BDBM50476800
(CHEMBL242790)Show SMILES [I-].[I-].COc1cc2cc[n+](C)c(CCCCc3[n+](C)ccc4cc(OC)c(OC)c(OC)c34)c2c(OC)c1OC Show InChI InChI=1S/C30H38N2O6/c1-31-15-13-19-17-23(33-3)27(35-5)29(37-7)25(19)21(31)11-9-10-12-22-26-20(14-16-32(22)2)18-24(34-4)28(36-6)30(26)38-8/h13-18H,9-12H2,1-8H3/q+2 | PDB
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| Article
PubMed
| 42 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Li£ge
Curated by ChEMBL
| Assay Description
Displacement of [125I]apamin from SK channel in Wistar rat cortex |
J Med Chem 50: 5070-5 (2007)
Article DOI: 10.1021/jm070412j
BindingDB Entry DOI: 10.7270/Q28055C0 |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 1/2/3
(Rattus norvegicus-RAT-Rattus norvegicus (Rat)) | BDBM50476798
(CHEMBL242789)Show SMILES [I-].[I-].COc1cc2cc[n+](C)c(CCCc3[n+](C)ccc4cc(OC)c(OC)c(OC)c34)c2c(OC)c1OC Show InChI InChI=1S/C29H36N2O6/c1-30-14-12-18-16-22(32-3)26(34-5)28(36-7)24(18)20(30)10-9-11-21-25-19(13-15-31(21)2)17-23(33-4)27(35-6)29(25)37-8/h12-17H,9-11H2,1-8H3/q+2 | PDB
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| PC cid
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UniChem
| Article
PubMed
| 90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Li£ge
Curated by ChEMBL
| Assay Description
Displacement of [125I]apamin from SK channel in Wistar rat cortex |
J Med Chem 50: 5070-5 (2007)
Article DOI: 10.1021/jm070412j
BindingDB Entry DOI: 10.7270/Q28055C0 |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 1/2/3
(Rattus norvegicus-RAT-Rattus norvegicus (Rat)) | BDBM50476801
(CHEMBL241952)Show SMILES [I-].[I-].COc1cc2cc[n+](C)c(Cc3cccc(Cc4[n+](C)ccc5cc(OC)c(OC)cc45)c3)c2cc1OC Show InChI InChI=1S/C32H34N2O4/c1-33-12-10-23-17-29(35-3)31(37-5)19-25(23)27(33)15-21-8-7-9-22(14-21)16-28-26-20-32(38-6)30(36-4)18-24(26)11-13-34(28)2/h7-14,17-20H,15-16H2,1-6H3/q+2 | PDB
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| Article
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| 106 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Li£ge
Curated by ChEMBL
| Assay Description
Displacement of [125I]apamin from SK channel in Wistar rat cortex |
J Med Chem 50: 5070-5 (2007)
Article DOI: 10.1021/jm070412j
BindingDB Entry DOI: 10.7270/Q28055C0 |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 1/2/3
(Rattus norvegicus-RAT-Rattus norvegicus (Rat)) | BDBM50476807
(CHEMBL242791)Show SMILES [I-].[I-].C[n+]1ccc2ccccc2c1Cc1cccc(Cc2[n+](C)ccc3ccccc23)c1 Show InChI InChI=1S/C28H26N2/c1-29-16-14-23-10-3-5-12-25(23)27(29)19-21-8-7-9-22(18-21)20-28-26-13-6-4-11-24(26)15-17-30(28)2/h3-18H,19-20H2,1-2H3/q+2 | PDB
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| PC cid
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UniChem
| Article
PubMed
| 132 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Li£ge
Curated by ChEMBL
| Assay Description
Displacement of [125I]apamin from SK channel in Wistar rat cortex |
J Med Chem 50: 5070-5 (2007)
Article DOI: 10.1021/jm070412j
BindingDB Entry DOI: 10.7270/Q28055C0 |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 1/2/3
(Rattus norvegicus-RAT-Rattus norvegicus (Rat)) | BDBM50476803
(CHEMBL242579)Show SMILES [I-].[I-].COc1cc2cc[n+](C)c(CCCCCc3[n+](C)ccc4cc(OC)c(OC)cc34)c2cc1OC Show InChI InChI=1S/C29H36N2O4/c1-30-14-12-20-16-26(32-3)28(34-5)18-22(20)24(30)10-8-7-9-11-25-23-19-29(35-6)27(33-4)17-21(23)13-15-31(25)2/h12-19H,7-11H2,1-6H3/q+2 | PDB
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| 150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Li£ge
Curated by ChEMBL
| Assay Description
Displacement of [125I]apamin from SK channel in Wistar rat cortex |
J Med Chem 50: 5070-5 (2007)
Article DOI: 10.1021/jm070412j
BindingDB Entry DOI: 10.7270/Q28055C0 |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 1/2/3
(Rattus norvegicus-RAT-Rattus norvegicus (Rat)) | BDBM50476813
(CHEMBL241953)Show SMILES [I-].[I-].COc1cc2cc[n+](C)c(Cc3ccc(Cc4[n+](C)ccc5cc(OC)c(OC)cc45)cc3)c2cc1OC Show InChI InChI=1S/C32H34N2O4/c1-33-13-11-23-17-29(35-3)31(37-5)19-25(23)27(33)15-21-7-9-22(10-8-21)16-28-26-20-32(38-6)30(36-4)18-24(26)12-14-34(28)2/h7-14,17-20H,15-16H2,1-6H3/q+2 | PDB
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| 163 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Li£ge
Curated by ChEMBL
| Assay Description
Displacement of [125I]apamin from SK channel in Wistar rat cortex |
J Med Chem 50: 5070-5 (2007)
Article DOI: 10.1021/jm070412j
BindingDB Entry DOI: 10.7270/Q28055C0 |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 1/2/3
(Rattus norvegicus-RAT-Rattus norvegicus (Rat)) | BDBM50476810
(CHEMBL242578)Show SMILES [I-].[I-].COc1cc2cc[n+](C)c(CCCCc3[n+](C)ccc4cc(OC)c(OC)cc34)c2cc1OC Show InChI InChI=1S/C28H34N2O4/c1-29-13-11-19-15-25(31-3)27(33-5)17-21(19)23(29)9-7-8-10-24-22-18-28(34-6)26(32-4)16-20(22)12-14-30(24)2/h11-18H,7-10H2,1-6H3/q+2 | PDB
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| 164 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Li£ge
Curated by ChEMBL
| Assay Description
Displacement of [125I]apamin from SK channel in Wistar rat cortex |
J Med Chem 50: 5070-5 (2007)
Article DOI: 10.1021/jm070412j
BindingDB Entry DOI: 10.7270/Q28055C0 |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 1/2/3
(Rattus norvegicus-RAT-Rattus norvegicus (Rat)) | BDBM50476805
(CHEMBL390923)Show SMILES [I-].[I-].COc1cc2cc[n+](C)c(CCCc3[n+](C)ccc4cc(OC)c(OC)cc34)c2cc1OC Show InChI InChI=1S/C27H32N2O4/c1-28-12-10-18-14-24(30-3)26(32-5)16-20(18)22(28)8-7-9-23-21-17-27(33-6)25(31-4)15-19(21)11-13-29(23)2/h10-17H,7-9H2,1-6H3/q+2 | PDB
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| 196 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Li£ge
Curated by ChEMBL
| Assay Description
Displacement of [125I]apamin from SK channel in Wistar rat cortex |
J Med Chem 50: 5070-5 (2007)
Article DOI: 10.1021/jm070412j
BindingDB Entry DOI: 10.7270/Q28055C0 |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 1/2/3
(Rattus norvegicus-RAT-Rattus norvegicus (Rat)) | BDBM50048403
(1,1'-(Deca-4,6-diyne-1,10-diyl)bis(4-amino-2-methy...)Show SMILES Cc1cc(=[NH2+])c2ccccc2n1CCCCCCCCCCn1c(C)cc(=[NH2+])c2ccccc12 Show InChI InChI=1S/C30H38N4/c1-23-21-27(31)25-15-9-11-17-29(25)33(23)19-13-7-5-3-4-6-8-14-20-34-24(2)22-28(32)26-16-10-12-18-30(26)34/h9-12,15-18,21-22,31-32H,3-8,13-14,19-20H2,1-2H3/p+2 | PDB
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| 221 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Li£ge
Curated by ChEMBL
| Assay Description
Displacement of [125I]apamin from SK channel in Wistar rat cortex |
J Med Chem 50: 5070-5 (2007)
Article DOI: 10.1021/jm070412j
BindingDB Entry DOI: 10.7270/Q28055C0 |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 1/2/3
(Rattus norvegicus-RAT-Rattus norvegicus (Rat)) | BDBM50476806
(CHEMBL244261)Show SMILES [I-].[I-].COc1cc2cc[n+](C)c(Cc3ccc(Cc4[n+](C)ccc5cc(OC)c(OC)c(OC)c45)cc3)c2c(OC)c1OC Show InChI InChI=1S/C34H38N2O6/c1-35-15-13-23-19-27(37-3)31(39-5)33(41-7)29(23)25(35)17-21-9-11-22(12-10-21)18-26-30-24(14-16-36(26)2)20-28(38-4)32(40-6)34(30)42-8/h9-16,19-20H,17-18H2,1-8H3/q+2 | PDB
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| 280 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Li£ge
Curated by ChEMBL
| Assay Description
Displacement of [125I]apamin from SK channel in Wistar rat cortex |
J Med Chem 50: 5070-5 (2007)
Article DOI: 10.1021/jm070412j
BindingDB Entry DOI: 10.7270/Q28055C0 |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 1/2/3
(Rattus norvegicus-RAT-Rattus norvegicus (Rat)) | BDBM50476804
(CHEMBL390924)Show SMILES [I-].[I-].C[n+]1ccc2ccccc2c1Cc1ccccc1Cc1[n+](C)ccc2ccccc12 Show InChI InChI=1S/C28H26N2/c1-29-17-15-21-9-5-7-13-25(21)27(29)19-23-11-3-4-12-24(23)20-28-26-14-8-6-10-22(26)16-18-30(28)2/h3-18H,19-20H2,1-2H3/q+2 | PDB
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| 438 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Li£ge
Curated by ChEMBL
| Assay Description
Displacement of [125I]apamin from SK channel in Wistar rat cortex |
J Med Chem 50: 5070-5 (2007)
Article DOI: 10.1021/jm070412j
BindingDB Entry DOI: 10.7270/Q28055C0 |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 1/2/3
(Rattus norvegicus-RAT-Rattus norvegicus (Rat)) | BDBM50476033
(CHEMBL215533)Show SMILES [I-].COc1ccc(CC2c3c(CC[N+]2(C)C)cc(OC)c(OC)c3OC)cc1OC Show InChI InChI=1S/C23H32NO5.HI/c1-24(2)11-10-16-14-20(27-5)22(28-6)23(29-7)21(16)17(24)12-15-8-9-18(25-3)19(13-15)26-4;/h8-9,13-14,17H,10-12H2,1-7H3;1H/q+1;/p-1 | PDB
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| 730 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Li£ge
Curated by ChEMBL
| Assay Description
Displacement of [125I]apamin from Wistar rat cortical apamin-sensitive site |
J Med Chem 49: 7208-14 (2006)
Article DOI: 10.1021/jm0607395
BindingDB Entry DOI: 10.7270/Q2S75K20 |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 1/2/3
(Rattus norvegicus-RAT-Rattus norvegicus (Rat)) | BDBM50476031
(CHEMBL215029)Show SMILES [I-].COc1cc2CC[N+](C)(C)C(Cc3ccc4ccccc4c3)c2cc1OC Show InChI InChI=1S/C24H28NO2.HI/c1-25(2)12-11-20-15-23(26-3)24(27-4)16-21(20)22(25)14-17-9-10-18-7-5-6-8-19(18)13-17;/h5-10,13,15-16,22H,11-12,14H2,1-4H3;1H/q+1;/p-1 | PDB
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University of Li£ge
Curated by ChEMBL
| Assay Description
Displacement of [125I]apamin from Wistar rat cortical apamin-sensitive site |
J Med Chem 49: 7208-14 (2006)
Article DOI: 10.1021/jm0607395
BindingDB Entry DOI: 10.7270/Q2S75K20 |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 1/2/3
(Rattus norvegicus-RAT-Rattus norvegicus (Rat)) | BDBM50476814
(CHEMBL241951)Show SMILES [I-].[I-].C[n+]1ccc2ccccc2c1Cc1ccc(Cc2[n+](C)ccc3ccccc23)cc1 Show InChI InChI=1S/C28H26N2/c1-29-17-15-23-7-3-5-9-25(23)27(29)19-21-11-13-22(14-12-21)20-28-26-10-6-4-8-24(26)16-18-30(28)2/h3-18H,19-20H2,1-2H3/q+2 | PDB
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| 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Li£ge
Curated by ChEMBL
| Assay Description
Displacement of [125I]apamin from SK channel in Wistar rat cortex |
J Med Chem 50: 5070-5 (2007)
Article DOI: 10.1021/jm070412j
BindingDB Entry DOI: 10.7270/Q28055C0 |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 1/2/3
(Rattus norvegicus-RAT-Rattus norvegicus (Rat)) | BDBM50199404
(1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-2,2-dimethy...)Show SMILES COc1ccc(C[C@H]2c3cc(OC)c(OC)cc3CC[N+]2(C)C)cc1OC Show InChI InChI=1S/C22H30NO4/c1-23(2)10-9-16-13-21(26-5)22(27-6)14-17(16)18(23)11-15-7-8-19(24-3)20(12-15)25-4/h7-8,12-14,18H,9-11H2,1-6H3/q+1/t18-/m0/s1 | PDB
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| 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Li£ge
Curated by ChEMBL
| Assay Description
Displacement of [125I]apamin from SK channel in Wistar rat cortex |
J Med Chem 50: 5070-5 (2007)
Article DOI: 10.1021/jm070412j
BindingDB Entry DOI: 10.7270/Q28055C0 |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 1/2/3
(Rattus norvegicus-RAT-Rattus norvegicus (Rat)) | BDBM50199404
(1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-2,2-dimethy...)Show SMILES COc1ccc(C[C@H]2c3cc(OC)c(OC)cc3CC[N+]2(C)C)cc1OC Show InChI InChI=1S/C22H30NO4/c1-23(2)10-9-16-13-21(26-5)22(27-6)14-17(16)18(23)11-15-7-8-19(24-3)20(12-15)25-4/h7-8,12-14,18H,9-11H2,1-6H3/q+1/t18-/m0/s1 | PDB
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| 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Li£ge
Curated by ChEMBL
| Assay Description
Displacement of [125I]apamin from Wistar rat cortical apamin-sensitive site |
J Med Chem 49: 7208-14 (2006)
Article DOI: 10.1021/jm0607395
BindingDB Entry DOI: 10.7270/Q2S75K20 |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 1/2/3
(Rattus norvegicus-RAT-Rattus norvegicus (Rat)) | BDBM50476812
(CHEMBL242577)Show SMILES [I-].[I-].C[n+]1ccc2ccccc2c1CCCCCc1[n+](C)ccc2ccccc12 Show InChI InChI=1S/C25H28N2/c1-26-18-16-20-10-6-8-12-22(20)24(26)14-4-3-5-15-25-23-13-9-7-11-21(23)17-19-27(25)2/h6-13,16-19H,3-5,14-15H2,1-2H3/q+2 | PDB
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| 1.47E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Li£ge
Curated by ChEMBL
| Assay Description
Displacement of [125I]apamin from SK channel in Wistar rat cortex |
J Med Chem 50: 5070-5 (2007)
Article DOI: 10.1021/jm070412j
BindingDB Entry DOI: 10.7270/Q28055C0 |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 1/2/3
(Rattus norvegicus-RAT-Rattus norvegicus (Rat)) | BDBM50475213
(CHEMBL365744)Show SMILES [I-].COc1ccc(CC2c3c(CC[N+]2(C)C)cccc3C(C)C)cc1OC Show InChI InChI=1S/C23H32NO2.HI/c1-16(2)19-9-7-8-18-12-13-24(3,4)20(23(18)19)14-17-10-11-21(25-5)22(15-17)26-6;/h7-11,15-16,20H,12-14H2,1-6H3;1H/q+1;/p-1 | PDB
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| 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Li£ge
Curated by ChEMBL
| Assay Description
Inhibition of [125I]apamin binding to calcium-activated potassium (SK) channel of rat cortex |
J Med Chem 48: 4972-82 (2005)
Article DOI: 10.1021/jm049025p
BindingDB Entry DOI: 10.7270/Q2TH8QFS |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 1/2/3
(Rattus norvegicus-RAT-Rattus norvegicus (Rat)) | BDBM50199404
(1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-2,2-dimethy...)Show SMILES COc1ccc(C[C@H]2c3cc(OC)c(OC)cc3CC[N+]2(C)C)cc1OC Show InChI InChI=1S/C22H30NO4/c1-23(2)10-9-16-13-21(26-5)22(27-6)14-17(16)18(23)11-15-7-8-19(24-3)20(12-15)25-4/h7-8,12-14,18H,9-11H2,1-6H3/q+1/t18-/m0/s1 | PDB
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| 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Li£ge
Curated by ChEMBL
| Assay Description
Inhibition of [125I]apamin binding to calcium-activated potassium (SK) channel of rat cortex |
J Med Chem 48: 4972-82 (2005)
Article DOI: 10.1021/jm049025p
BindingDB Entry DOI: 10.7270/Q2TH8QFS |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 1/2/3
(Rattus norvegicus-RAT-Rattus norvegicus (Rat)) | BDBM50476808
(CHEMBL242372)Show SMILES [I-].[I-].C[n+]1ccc2ccccc2c1CCCc1[n+](C)ccc2ccccc12 Show InChI InChI=1S/C23H24N2/c1-24-16-14-18-8-3-5-10-20(18)22(24)12-7-13-23-21-11-6-4-9-19(21)15-17-25(23)2/h3-6,8-11,14-17H,7,12-13H2,1-2H3/q+2 | PDB
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| 1.69E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Li£ge
Curated by ChEMBL
| Assay Description
Displacement of [125I]apamin from SK channel in Wistar rat cortex |
J Med Chem 50: 5070-5 (2007)
Article DOI: 10.1021/jm070412j
BindingDB Entry DOI: 10.7270/Q28055C0 |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 1/2/3
(Rattus norvegicus-RAT-Rattus norvegicus (Rat)) | BDBM50476811
(CHEMBL429280)Show SMILES [I-].[I-].C[n+]1ccc2ccccc2c1CCCCc1[n+](C)ccc2ccccc12 Show InChI InChI=1S/C24H26N2/c1-25-17-15-19-9-3-5-11-21(19)23(25)13-7-8-14-24-22-12-6-4-10-20(22)16-18-26(24)2/h3-6,9-12,15-18H,7-8,13-14H2,1-2H3/q+2 | PDB
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| 1.96E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Li£ge
Curated by ChEMBL
| Assay Description
Displacement of [125I]apamin from SK channel in Wistar rat cortex |
J Med Chem 50: 5070-5 (2007)
Article DOI: 10.1021/jm070412j
BindingDB Entry DOI: 10.7270/Q28055C0 |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 1/2/3
(Rattus norvegicus-RAT-Rattus norvegicus (Rat)) | BDBM50476029
(CHEMBL215037)Show SMILES [I-].COc1cc2CC[N+](C)(C)C(Cc3ccc4ccccc4c3)c2c(OC)c1OC Show InChI InChI=1S/C25H30NO3.HI/c1-26(2)13-12-20-16-22(27-3)24(28-4)25(29-5)23(20)21(26)15-17-10-11-18-8-6-7-9-19(18)14-17;/h6-11,14,16,21H,12-13,15H2,1-5H3;1H/q+1;/p-1 | PDB
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| 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Li£ge
Curated by ChEMBL
| Assay Description
Displacement of [125I]apamin from Wistar rat cortical apamin-sensitive site |
J Med Chem 49: 7208-14 (2006)
Article DOI: 10.1021/jm0607395
BindingDB Entry DOI: 10.7270/Q2S75K20 |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 1/2/3
(Rattus norvegicus-RAT-Rattus norvegicus (Rat)) | BDBM50475209
(CHEMBL186011)Show SMILES [I-].CCc1cccc2CC[N+](C)(C)C(Cc3ccc(OC)c(OC)c3)c12 Show InChI InChI=1S/C22H30NO2.HI/c1-6-17-8-7-9-18-12-13-23(2,3)19(22(17)18)14-16-10-11-20(24-4)21(15-16)25-5;/h7-11,15,19H,6,12-14H2,1-5H3;1H/q+1;/p-1 | PDB
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| 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Li£ge
Curated by ChEMBL
| Assay Description
Inhibition of [125I]apamin binding to calcium-activated potassium (SK) channel of rat cortex |
J Med Chem 48: 4972-82 (2005)
Article DOI: 10.1021/jm049025p
BindingDB Entry DOI: 10.7270/Q2TH8QFS |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 1/2/3
(Rattus norvegicus-RAT-Rattus norvegicus (Rat)) | BDBM50475206
(CHEMBL190220)Show SMILES [I-].COc1ccc2C(OC(=O)c2c1OC)C1c2c(CC[N+]1(C)C)cc1OCOc1c2OC Show InChI InChI=1S/C23H26NO7.HI/c1-24(2)9-8-12-10-15-21(30-11-29-15)22(28-5)16(12)18(24)19-13-6-7-14(26-3)20(27-4)17(13)23(25)31-19;/h6-7,10,18-19H,8-9,11H2,1-5H3;1H/q+1;/p-1 | PDB
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| 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Li£ge
Curated by ChEMBL
| Assay Description
Inhibition of [125I]apamin binding to calcium-activated potassium (SK) channel of rat cortex |
J Med Chem 48: 4972-82 (2005)
Article DOI: 10.1021/jm049025p
BindingDB Entry DOI: 10.7270/Q2TH8QFS |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 1/2/3
(Rattus norvegicus-RAT-Rattus norvegicus (Rat)) | BDBM50476028
(CHEMBL386836 | N-Methyl-Noscapine)Show SMILES [I-].[H][C@@]1(OC(=O)c2c1ccc(OC)c2OC)[C@@]1([H])c2c(CC[N+]1(C)C)cc1OCOc1c2OC |r| Show InChI InChI=1S/C23H26NO7.HI/c1-24(2)9-8-12-10-15-21(30-11-29-15)22(28-5)16(12)18(24)19-13-6-7-14(26-3)20(27-4)17(13)23(25)31-19;/h6-7,10,18-19H,8-9,11H2,1-5H3;1H/q+1;/p-1/t18-,19+;/m1./s1 | PDB
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| 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Li£ge
Curated by ChEMBL
| Assay Description
Displacement of [125I]apamin from Wistar rat cortical apamin-sensitive site |
J Med Chem 49: 7208-14 (2006)
Article DOI: 10.1021/jm0607395
BindingDB Entry DOI: 10.7270/Q2S75K20 |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 1/2/3
(Rattus norvegicus-RAT-Rattus norvegicus (Rat)) | BDBM50260153
(Apamin | CHEMBL525408 | Octadecapeptide venom)Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CSSC[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N2)NC1=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)[C@@H](C)O |r,wU:83.102,47.101,13.138,4.3,33.34,88.89,78.79,67.68,107.109,116.118,125.127,wD:26.30,52.106,56.57,17.17,135.140,8.8,38.39,93.94,(27.83,-36.7,;27.83,-35.16,;26.49,-34.38,;29.15,-34.38,;29.15,-32.85,;30.49,-32.08,;31.8,-32.85,;31.8,-34.38,;33.14,-32.08,;33.14,-30.53,;34.47,-32.85,;35.8,-32.08,;35.8,-30.53,;40.01,-33.02,;41.6,-32.04,;43.23,-32.89,;43.23,-34.42,;44.54,-32.11,;44.54,-30.57,;45.89,-29.8,;45.89,-28.26,;44.54,-27.49,;47.21,-27.49,;45.89,-32.89,;48.48,-32.23,;48.91,-30.87,;50.38,-34.89,;52.13,-34.44,;53.01,-35.96,;51.84,-36.95,;50.38,-36.43,;48.34,-38.91,;48.77,-40.45,;46.11,-38.58,;46.11,-37.03,;44.16,-39.41,;42.33,-38.62,;42.33,-37.09,;40.7,-39.47,;40.7,-40.99,;39.37,-41.76,;39.37,-43.3,;38.05,-44.06,;38.05,-45.59,;38.29,-38.35,;35.39,-39.38,;35.39,-40.91,;34.06,-38.61,;40.93,-30.71,;40.94,-27.32,;39.36,-26.12,;39.37,-23.14,;38.05,-22.37,;36.72,-23.15,;35.39,-22.38,;35.4,-20.84,;34.06,-23.15,;34.06,-24.68,;32.73,-25.46,;32.73,-26.98,;31.4,-27.31,;30.08,-26.97,;28.36,-27.74,;30.08,-25.44,;32.73,-22.39,;31.4,-23.16,;31.41,-24.7,;28.69,-22.34,;28.69,-20.8,;30.02,-20.04,;30.02,-18.5,;31.34,-17.73,;31.34,-16.2,;32.68,-15.42,;30.02,-15.42,;26.07,-23.55,;26.08,-25.1,;27.41,-25.88,;23.8,-26.94,;22.48,-26.19,;23.83,-29.77,;25.16,-30.53,;26.5,-29.77,;25.16,-32.08,;23.84,-32.85,;23.84,-34.38,;24.76,-36.3,;26.09,-37.07,;26.09,-38.61,;24.77,-39.38,;27.42,-39.38,;27.42,-40.91,;28.75,-38.61,;30.09,-39.38,;30.09,-40.91,;31.42,-41.68,;31.42,-43.23,;32.75,-40.91,;31.41,-38.61,;31.41,-37.07,;32.73,-39.38,;26.5,-32.85,;27.83,-32.08,;27.83,-30.53,;38.04,-20.83,;36.7,-20.07,;39.36,-20.06,;39.36,-18.52,;38.03,-17.74,;38.03,-16.21,;36.71,-15.43,;36.71,-13.9,;35.38,-16.21,;40.7,-17.74,;40.69,-16.21,;42.03,-18.52,;43.37,-17.74,;43.37,-16.2,;44.7,-15.42,;44.7,-13.89,;46.03,-13.1,;43.36,-13.12,;44.71,-18.51,;44.7,-20.05,;46.04,-17.73,;47.37,-18.52,;48.68,-17.74,;50.05,-18.53,;50.21,-20.07,;51.72,-20.4,;52.48,-19.07,;51.47,-17.91,;47.36,-20.05,;48.68,-20.83,;46.03,-20.83,;40.01,-34.57,;38.67,-35.33,;41.74,-35.33,)| Show InChI InChI=1S/C79H131N31O24S4/c1-35(2)26-49-70(127)107-51-31-136-135-30-41(81)63(120)105-50(28-57(84)114)71(128)108-53(73(130)99-42(12-7-8-22-80)64(121)96-38(5)77(134)110-25-11-15-54(110)75(132)102-47(18-21-58(115)116)69(126)109-59(39(6)111)76(133)95-37(4)62(119)104-49)33-138-137-32-52(106-66(123)44(14-10-24-92-79(88)89)98-65(122)43(13-9-23-91-78(86)87)97-61(118)36(3)94-72(51)129)74(131)101-45(16-19-55(82)112)67(124)100-46(17-20-56(83)113)68(125)103-48(60(85)117)27-40-29-90-34-93-40/h29,34-39,41-54,59,111H,7-28,30-33,80-81H2,1-6H3,(H2,82,112)(H2,83,113)(H2,84,114)(H2,85,117)(H,90,93)(H,94,129)(H,95,133)(H,96,121)(H,97,118)(H,98,122)(H,99,130)(H,100,124)(H,101,131)(H,102,132)(H,103,125)(H,104,119)(H,105,120)(H,106,123)(H,107,127)(H,108,128)(H,109,126)(H,115,116)(H4,86,87,91)(H4,88,89,92)/t36-,37-,38-,39+,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,59-/m0/s1 | PDB
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| CHEMBL
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UniChem
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PubMed
| 3.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Li£ge
Curated by ChEMBL
| Assay Description
Inhibition of [125I]apamin binding to calcium-activated potassium (SK) channel of rat cortex |
J Med Chem 48: 4972-82 (2005)
Article DOI: 10.1021/jm049025p
BindingDB Entry DOI: 10.7270/Q2TH8QFS |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 1/2/3
(Rattus norvegicus-RAT-Rattus norvegicus (Rat)) | BDBM50475212
(CHEMBL190992)Show InChI InChI=1S/C20H25BrNO2/c1-22(2)11-10-15-16(6-5-7-17(15)21)18(22)12-14-8-9-19(23-3)20(13-14)24-4/h5-9,13,18H,10-12H2,1-4H3/q+1 | PDB
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| PC cid
PC sid
UniChem
| Article
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| 4.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Li£ge
Curated by ChEMBL
| Assay Description
Inhibition of [125I]apamin binding to calcium-activated potassium (SK) channel of rat cortex |
J Med Chem 48: 4972-82 (2005)
Article DOI: 10.1021/jm049025p
BindingDB Entry DOI: 10.7270/Q2TH8QFS |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 1/2/3
(Rattus norvegicus-RAT-Rattus norvegicus (Rat)) | BDBM50476032
(CHEMBL214787)Show SMILES [I-].COc1ccc(CCC2c3cc(OC)c(OC)cc3CC[N+]2(C)C)cc1OC Show InChI InChI=1S/C23H32NO4.HI/c1-24(2)12-11-17-14-22(27-5)23(28-6)15-18(17)19(24)9-7-16-8-10-20(25-3)21(13-16)26-4;/h8,10,13-15,19H,7,9,11-12H2,1-6H3;1H/q+1;/p-1 | PDB
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UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| Article
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| 5.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Li£ge
Curated by ChEMBL
| Assay Description
Displacement of [125I]apamin from Wistar rat cortical apamin-sensitive site |
J Med Chem 49: 7208-14 (2006)
Article DOI: 10.1021/jm0607395
BindingDB Entry DOI: 10.7270/Q2S75K20 |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 1/2/3
(Rattus norvegicus-RAT-Rattus norvegicus (Rat)) | BDBM50475208
(CHEMBL188644)Show SMILES [I-].COc1ccc(CC2c3c(C)cccc3CC[N+]2(C)C)cc1OC Show InChI InChI=1S/C21H28NO2.HI/c1-15-7-6-8-17-11-12-22(2,3)18(21(15)17)13-16-9-10-19(23-4)20(14-16)24-5;/h6-10,14,18H,11-13H2,1-5H3;1H/q+1;/p-1 | PDB
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UniProtKB/SwissProt
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| PC cid
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UniChem
| Article
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| 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Li£ge
Curated by ChEMBL
| Assay Description
Inhibition of [125I]apamin binding to calcium-activated potassium (SK) channel of rat cortex |
J Med Chem 48: 4972-82 (2005)
Article DOI: 10.1021/jm049025p
BindingDB Entry DOI: 10.7270/Q2TH8QFS |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 1/2/3
(Rattus norvegicus-RAT-Rattus norvegicus (Rat)) | BDBM50476030
(CHEMBL215382)Show SMILES COc1ccc(CC2N(C)CCc3cc(OC)c(OC)c(OC)c23)cc1OC Show InChI InChI=1S/C22H29NO5/c1-23-10-9-15-13-19(26-4)21(27-5)22(28-6)20(15)16(23)11-14-7-8-17(24-2)18(12-14)25-3/h7-8,12-13,16H,9-11H2,1-6H3 | PDB
KEGG
UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| Article
PubMed
| 5.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Li£ge
Curated by ChEMBL
| Assay Description
Displacement of [125I]apamin from Wistar rat cortical apamin-sensitive site |
J Med Chem 49: 7208-14 (2006)
Article DOI: 10.1021/jm0607395
BindingDB Entry DOI: 10.7270/Q2S75K20 |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 1/2/3
(Rattus norvegicus-RAT-Rattus norvegicus (Rat)) | BDBM50475211
(CHEMBL187736)Show SMILES [I-].COc1ccc(CC2c3c(Br)cccc3CC[N+]2(C)C)cc1OC Show InChI InChI=1S/C20H25BrNO2.HI/c1-22(2)11-10-15-6-5-7-16(21)20(15)17(22)12-14-8-9-18(23-3)19(13-14)24-4;/h5-9,13,17H,10-12H2,1-4H3;1H/q+1;/p-1 | PDB
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UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| Article
PubMed
| 6.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Li£ge
Curated by ChEMBL
| Assay Description
Inhibition of [125I]apamin binding to calcium-activated potassium (SK) channel of rat cortex |
J Med Chem 48: 4972-82 (2005)
Article DOI: 10.1021/jm049025p
BindingDB Entry DOI: 10.7270/Q2TH8QFS |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 1/2/3
(Rattus norvegicus-RAT-Rattus norvegicus (Rat)) | BDBM50475207
(CHEMBL427162)Show InChI InChI=1S/C20H25ClNO2/c1-22(2)11-10-15-16(6-5-7-17(15)21)18(22)12-14-8-9-19(23-3)20(13-14)24-4/h5-9,13,18H,10-12H2,1-4H3/q+1 | PDB
KEGG
UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| Article
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| 7.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Li£ge
Curated by ChEMBL
| Assay Description
Inhibition of [125I]apamin binding to calcium-activated potassium (SK) channel of rat cortex |
J Med Chem 48: 4972-82 (2005)
Article DOI: 10.1021/jm049025p
BindingDB Entry DOI: 10.7270/Q2TH8QFS |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 1/2/3
(Rattus norvegicus-RAT-Rattus norvegicus (Rat)) | BDBM50475210
(CHEMBL190003)Show SMILES [I-].COc1ccc(CC2c3c(Cl)cccc3CC[N+]2(C)C)cc1OC Show InChI InChI=1S/C20H25ClNO2.HI/c1-22(2)11-10-15-6-5-7-16(21)20(15)17(22)12-14-8-9-18(23-3)19(13-14)24-4;/h5-9,13,17H,10-12H2,1-4H3;1H/q+1;/p-1 | PDB
KEGG
UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| Article
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| 9.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Li£ge
Curated by ChEMBL
| Assay Description
Inhibition of [125I]apamin binding to calcium-activated potassium (SK) channel of rat cortex |
J Med Chem 48: 4972-82 (2005)
Article DOI: 10.1021/jm049025p
BindingDB Entry DOI: 10.7270/Q2TH8QFS |
More data for this
Ligand-Target Pair | |
Small conductance calcium-activated potassium channel protein 1
(RAT) | BDBM50133817
(4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic ...)Show SMILES CC(C)(C)c1ccc(NC(=O)N2CCN(CC2)c2ncccc2Cl)cc1 Show InChI InChI=1S/C20H25ClN4O/c1-20(2,3)15-6-8-16(9-7-15)23-19(26)25-13-11-24(12-14-25)18-17(21)5-4-10-22-18/h4-10H,11-14H2,1-3H3,(H,23,26) | Reactome pathway
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pudue Pharma Discovery Research
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 306: 377-86 (2003)
Article DOI: 10.1124/jpet.102.045674
BindingDB Entry DOI: 10.7270/Q2TX3CX5 |
More data for this
Ligand-Target Pair | |
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