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Compile Data Set for Download or QSAR

Found 63 hits of ic50 for UniProtKB: P51531   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM50469330
PNG
(CHEMBL4295096)
Show SMILES OCc1cnc(F)cc1NC(=O)Nc1cc(ns1)C(F)F
Show InChI InChI=1S/C11H9F3N4O2S/c12-8-1-6(5(4-19)3-15-8)16-11(20)17-9-2-7(10(13)14)18-21-9/h1-3,10,19H,4H2,(H2,15,16,17,20)
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n/an/a<5n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant His10-tagged ZZ-HCV3C-BRM ATPase-SnAC (636 to 1331 residues) (unknown origin) expressed in insect sf9 cells preincubated fo...

J Med Chem 61: 10155-10172 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01318
BindingDB Entry DOI: 10.7270/Q2TH8QDB
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM50469324
PNG
(CHEMBL4286345)
Show SMILES Nc1cnc(Cl)cc1NC(=O)Nc1cc(ns1)C(F)F
Show InChI InChI=1S/C10H8ClF2N5OS/c11-7-1-5(4(14)3-15-7)16-10(19)17-8-2-6(9(12)13)18-20-8/h1-3,9H,14H2,(H2,15,16,17,19)
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Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant His10-tagged ZZ-HCV3C-BRM ATPase-SnAC (636 to 1331 residues) (unknown origin) expressed in insect sf9 cells preincubated fo...

J Med Chem 61: 10155-10172 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01318
BindingDB Entry DOI: 10.7270/Q2TH8QDB
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM50469320
PNG
(CHEMBL4293567)
Show SMILES OCc1cnc(Cl)cc1NC(=O)Nc1cc(ns1)C(F)F
Show InChI InChI=1S/C11H9ClF2N4O2S/c12-8-1-6(5(4-19)3-15-8)16-11(20)17-9-2-7(10(13)14)18-21-9/h1-3,10,19H,4H2,(H2,15,16,17,20)
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Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant His10-tagged ZZ-HCV3C-BRM ATPase-SnAC (636 to 1331 residues) (unknown origin) expressed in insect sf9 cells preincubated fo...

J Med Chem 61: 10155-10172 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01318
BindingDB Entry DOI: 10.7270/Q2TH8QDB
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM50469331
PNG
(CHEMBL4282980)
Show SMILES Nc1cnc(F)cc1NC(=O)Nc1cc(ns1)C(F)F
Show InChI InChI=1S/C10H8F3N5OS/c11-7-1-5(4(14)3-15-7)16-10(19)17-8-2-6(9(12)13)18-20-8/h1-3,9H,14H2,(H2,15,16,17,19)
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Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant His10-tagged ZZ-HCV3C-BRM ATPase-SnAC (636 to 1331 residues) (unknown origin) expressed in insect sf9 cells preincubated fo...

J Med Chem 61: 10155-10172 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01318
BindingDB Entry DOI: 10.7270/Q2TH8QDB
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM50469329
PNG
(CHEMBL4278436)
Show SMILES FC(F)c1cc(NC(=O)Nc2ccnc(Cl)c2)sn1
Show InChI InChI=1S/C10H7ClF2N4OS/c11-7-3-5(1-2-14-7)15-10(18)16-8-4-6(9(12)13)17-19-8/h1-4,9H,(H2,14,15,16,18)
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Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant His10-tagged ZZ-HCV3C-BRM ATPase-SnAC (636 to 1331 residues) (unknown origin) expressed in insect sf9 cells preincubated fo...

J Med Chem 61: 10155-10172 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01318
BindingDB Entry DOI: 10.7270/Q2TH8QDB
More data for this
Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486]


(Homo sapiens (Human))		BDBM394585
PNG
(2-(6-amino-5-(1-(1- | US10308614, Example 188)
Show SMILES CC(c1ccccc1)n1cc(cn1)-c1cc(nnc1N)-c1ccccc1O
Show InChI InChI=1S/C21H19N5O/c1-14(15-7-3-2-4-8-15)26-13-16(12-23-26)18-11-19(24-25-21(18)22)17-9-5-6-10-20(17)27/h2-14,27H,1H3,(H2,22,25)
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The Institute of Cancer Research



Assay Description
Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...

J Med Chem 52: 2255-64 (2009)


BindingDB Entry DOI: 10.7270/Q26112NJ
More data for this
Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486]


(Homo sapiens (Human))		BDBM394575
PNG
(2-(6-amino-5-(2- | US10308614, Example 178)
Show SMILES CC(COc1cc(nnc1N)-c1ccccc1O)c1ccccc1
Show InChI InChI=1S/C19H19N3O2/c1-13(14-7-3-2-4-8-14)12-24-18-11-16(21-22-19(18)20)15-9-5-6-10-17(15)23/h2-11,13,23H,12H2,1H3,(H2,20,22)
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The Institute of Cancer Research



Assay Description
Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...

J Med Chem 52: 2255-64 (2009)


BindingDB Entry DOI: 10.7270/Q26112NJ
More data for this
Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486]


(Homo sapiens (Human))		BDBM394605
PNG
(2-(6-amino-5-cyclohexylpyridazin-3-yl)phenol | US1...)
Show SMILES Nc1nnc(cc1C1CCCCC1)-c1ccccc1O
Show InChI InChI=1S/C16H19N3O/c17-16-13(11-6-2-1-3-7-11)10-14(18-19-16)12-8-4-5-9-15(12)20/h4-5,8-11,20H,1-3,6-7H2,(H2,17,19)
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The Institute of Cancer Research



Assay Description
Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...

J Med Chem 52: 2255-64 (2009)


BindingDB Entry DOI: 10.7270/Q26112NJ
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM50469325
PNG
(CHEMBL4294655)
Show SMILES FC(F)(F)c1cc(NC(=O)Nc2ccnc(Cl)c2)sn1
Show InChI InChI=1S/C10H6ClF3N4OS/c11-7-3-5(1-2-15-7)16-9(19)17-8-4-6(18-20-8)10(12,13)14/h1-4H,(H2,15,16,17,19)
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Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant His10-tagged ZZ-HCV3C-BRM ATPase-SnAC (636 to 1331 residues) (unknown origin) expressed in insect sf9 cells preincubated fo...

J Med Chem 61: 10155-10172 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01318
BindingDB Entry DOI: 10.7270/Q2TH8QDB
More data for this
Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486]


(Homo sapiens (Human))		BDBM394584
PNG
(2-(6-amino-5-(1-methyl- | US10308614, Example 187)
Show SMILES Cn1cc(cn1)-c1cc(nnc1N)-c1ccccc1O
Show InChI InChI=1S/C14H13N5O/c1-19-8-9(7-16-19)11-6-12(17-18-14(11)15)10-4-2-3-5-13(10)20/h2-8,20H,1H3,(H2,15,18)
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The Institute of Cancer Research



Assay Description
Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...

J Med Chem 52: 2255-64 (2009)


BindingDB Entry DOI: 10.7270/Q26112NJ
More data for this
Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486]


(Homo sapiens (Human))		BDBM394567
PNG
((S)-2-(6-amino-5-(1- | US10308614, Example 170)
Show SMILES C[C@H](Oc1cc(nnc1N)-c1ccccc1O)c1ccccc1 |r|
Show InChI InChI=1S/C18H17N3O2/c1-12(13-7-3-2-4-8-13)23-17-11-15(20-21-18(17)19)14-9-5-6-10-16(14)22/h2-12,22H,1H3,(H2,19,21)/t12-/m0/s1
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The Institute of Cancer Research



Assay Description
Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...

J Med Chem 52: 2255-64 (2009)


BindingDB Entry DOI: 10.7270/Q26112NJ
More data for this
Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486]


(Homo sapiens (Human))		BDBM394528
PNG
(1-(4-(3-amino-6-(2- | US10308614, Example 129)
Show SMILES CC1CN(CCN1C(=O)C(C)(C)C)c1cc(nnc1N)-c1ccccc1O
Show InChI InChI=1S/C20H27N5O2/c1-13-12-24(9-10-25(13)19(27)20(2,3)4)16-11-15(22-23-18(16)21)14-7-5-6-8-17(14)26/h5-8,11,13,26H,9-10,12H2,1-4H3,(H2,21,23)
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The Institute of Cancer Research



Assay Description
Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...

J Med Chem 52: 2255-64 (2009)


BindingDB Entry DOI: 10.7270/Q26112NJ
More data for this
Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486]


(Homo sapiens (Human))		BDBM394571
PNG
(2-(6-amino-5- | US10308614, Example 174)
Show SMILES Nc1nnc(cc1OCCc1ccccc1)-c1ccccc1O
Show InChI InChI=1S/C18H17N3O2/c19-18-17(23-11-10-13-6-2-1-3-7-13)12-15(20-21-18)14-8-4-5-9-16(14)22/h1-9,12,22H,10-11H2,(H2,19,21)
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The Institute of Cancer Research



Assay Description
Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...

J Med Chem 52: 2255-64 (2009)


BindingDB Entry DOI: 10.7270/Q26112NJ
More data for this
Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486]


(Homo sapiens (Human))		BDBM394403
PNG
(2-(6-amino-5-(4-((dimethylami- | US10308614, Examp...)
Show SMILES CN(C)CC1CCN(CC1)c1cc(nnc1N)-c1ccccc1O
Show InChI InChI=1S/C18H25N5O/c1-22(2)12-13-7-9-23(10-8-13)16-11-15(20-21-18(16)19)14-5-3-4-6-17(14)24/h3-6,11,13,24H,7-10,12H2,1-2H3,(H2,19,21)
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The Institute of Cancer Research



Assay Description
Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...

J Med Chem 52: 2255-64 (2009)


BindingDB Entry DOI: 10.7270/Q26112NJ
More data for this
Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486]


(Homo sapiens (Human))		BDBM394606
PNG
(2-(6-amino-5- | US10308614, Example 210)
Show SMILES Nc1nnc(cc1C1CCCC1)-c1ccccc1O
Show InChI InChI=1S/C15H17N3O/c16-15-12(10-5-1-2-6-10)9-13(17-18-15)11-7-3-4-8-14(11)19/h3-4,7-10,19H,1-2,5-6H2,(H2,16,18)
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The Institute of Cancer Research



Assay Description
Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...

J Med Chem 52: 2255-64 (2009)


BindingDB Entry DOI: 10.7270/Q26112NJ
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM50469321
PNG
(CHEMBL4286757)
Show SMILES Cc1cc(NC(=O)Nc2ccnc(Cl)c2)sn1
Show InChI InChI=1S/C10H9ClN4OS/c1-6-4-9(17-15-6)14-10(16)13-7-2-3-12-8(11)5-7/h2-5H,1H3,(H2,12,13,14,16)
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Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant His10-tagged ZZ-HCV3C-BRM ATPase-SnAC (636 to 1331 residues) (unknown origin) expressed in insect sf9 cells preincubated fo...

J Med Chem 61: 10155-10172 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01318
BindingDB Entry DOI: 10.7270/Q2TH8QDB
More data for this
Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486]


(Homo sapiens (Human))		BDBM394456
PNG
(2-(6-amino-5-(3- | US10308614, Example 57)
Show SMILES Nc1nnc(cc1N1CC(C1)Oc1ccccc1)-c1ccccc1O
Show InChI InChI=1S/C19H18N4O2/c20-19-17(10-16(21-22-19)15-8-4-5-9-18(15)24)23-11-14(12-23)25-13-6-2-1-3-7-13/h1-10,14,24H,11-12H2,(H2,20,22)
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The Institute of Cancer Research



Assay Description
Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...

J Med Chem 52: 2255-64 (2009)


BindingDB Entry DOI: 10.7270/Q26112NJ
More data for this
Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486]


(Homo sapiens (Human))		BDBM394507
PNG
(2-(6-amino-5-(3-methyl-4-(methylsulfonyl)piperazin...)
Show SMILES CC1CN(CCN1S(C)(=O)=O)c1cc(nnc1N)-c1ccccc1O
Show InChI InChI=1S/C16H21N5O3S/c1-11-10-20(7-8-21(11)25(2,23)24)14-9-13(18-19-16(14)17)12-5-3-4-6-15(12)22/h3-6,9,11,22H,7-8,10H2,1-2H3,(H2,17,19)
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The Institute of Cancer Research



Assay Description
Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...

J Med Chem 52: 2255-64 (2009)


BindingDB Entry DOI: 10.7270/Q26112NJ
More data for this
Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486]


(Homo sapiens (Human))		BDBM394414
PNG
(2-(6-amino-5-(4-(1- | US10308614, Example 15)
Show SMILES CC(N1CCN(CC1)c1cc(nnc1N)-c1ccccc1O)c1ccccc1
Show InChI InChI=1S/C22H25N5O/c1-16(17-7-3-2-4-8-17)26-11-13-27(14-12-26)20-15-19(24-25-22(20)23)18-9-5-6-10-21(18)28/h2-10,15-16,28H,11-14H2,1H3,(H2,23,25)
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The Institute of Cancer Research



Assay Description
Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...

J Med Chem 52: 2255-64 (2009)


BindingDB Entry DOI: 10.7270/Q26112NJ
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM394583
PNG
(2-(6-amino-5-phenylpyridazin-3-yl)phenol | US10308...)
Show SMILES Nc1nnc(cc1-c1ccccc1)-c1ccccc1O
Show InChI InChI=1S/C16H13N3O/c17-16-13(11-6-2-1-3-7-11)10-14(18-19-16)12-8-4-5-9-15(12)20/h1-10,20H,(H2,17,19)
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TBA



Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c00662
BindingDB Entry DOI: 10.7270/Q2TB1BX4
More data for this
Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486]


(Homo sapiens (Human))		BDBM394583
PNG
(2-(6-amino-5-phenylpyridazin-3-yl)phenol | US10308...)
Show SMILES Nc1nnc(cc1-c1ccccc1)-c1ccccc1O
Show InChI InChI=1S/C16H13N3O/c17-16-13(11-6-2-1-3-7-11)10-14(18-19-16)12-8-4-5-9-15(12)20/h1-10,20H,(H2,17,19)
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Assay Description
Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...

J Med Chem 52: 2255-64 (2009)


BindingDB Entry DOI: 10.7270/Q26112NJ
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486]


(Homo sapiens (Human))		BDBM394521
PNG
(1-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-2...)
Show SMILES CC1CN(CCN1C(C)=O)c1cc(nnc1N)-c1ccccc1O
Show InChI InChI=1S/C17H21N5O2/c1-11-10-21(7-8-22(11)12(2)23)15-9-14(19-20-17(15)18)13-5-3-4-6-16(13)24/h3-6,9,11,24H,7-8,10H2,1-2H3,(H2,18,20)
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Assay Description
Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...

J Med Chem 52: 2255-64 (2009)


BindingDB Entry DOI: 10.7270/Q26112NJ
More data for this
Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486]


(Homo sapiens (Human))		BDBM394614
PNG
(2-(6-amino-5-(1-benzylpiperidin-4-yl)pyridazin-3-y...)
Show SMILES Nc1nnc(cc1C1CCN(Cc2ccccc2)CC1)-c1ccccc1O
Show InChI InChI=1S/C22H24N4O/c23-22-19(14-20(24-25-22)18-8-4-5-9-21(18)27)17-10-12-26(13-11-17)15-16-6-2-1-3-7-16/h1-9,14,17,27H,10-13,15H2,(H2,23,25)
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The Institute of Cancer Research



Assay Description
Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...

J Med Chem 52: 2255-64 (2009)


BindingDB Entry DOI: 10.7270/Q26112NJ
More data for this
Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486]


(Homo sapiens (Human))		BDBM394490
PNG
(2-(6-amino-5-(piperidin-1-yl)pyridazin-3-yl)phenol...)
Show SMILES Nc1nnc(cc1N1CCCCC1)-c1ccccc1O
Show InChI InChI=1S/C15H18N4O/c16-15-13(19-8-4-1-5-9-19)10-12(17-18-15)11-6-2-3-7-14(11)20/h2-3,6-7,10,20H,1,4-5,8-9H2,(H2,16,18)
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The Institute of Cancer Research



Assay Description
Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...

J Med Chem 52: 2255-64 (2009)


BindingDB Entry DOI: 10.7270/Q26112NJ
More data for this
Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486]


(Homo sapiens (Human))		BDBM394518
PNG
(2-(6-amino-5-(3-benzyl- | US10308614, Example 119)
Show SMILES CS(=O)(=O)N1CCN(CC1Cc1ccccc1)c1cc(nnc1N)-c1ccccc1O
Show InChI InChI=1S/C22H25N5O3S/c1-31(29,30)27-12-11-26(15-17(27)13-16-7-3-2-4-8-16)20-14-19(24-25-22(20)23)18-9-5-6-10-21(18)28/h2-10,14,17,28H,11-13,15H2,1H3,(H2,23,25)
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Assay Description
Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...

J Med Chem 52: 2255-64 (2009)


BindingDB Entry DOI: 10.7270/Q26112NJ
More data for this
Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486]


(Homo sapiens (Human))		BDBM394408
PNG
(2-(6-amino-5-((3aR,6aS)-5- | US10308614, Example 9)
Show SMILES Nc1nnc(cc1N1C[C@@H]2CN(Cc3ccccc3)C[C@@H]2C1)-c1ccccc1O |r|
Show InChI InChI=1S/C23H25N5O/c24-23-21(10-20(25-26-23)19-8-4-5-9-22(19)29)28-14-17-12-27(13-18(17)15-28)11-16-6-2-1-3-7-16/h1-10,17-18,29H,11-15H2,(H2,24,26)/t17-,18+
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The Institute of Cancer Research



Assay Description
Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...

J Med Chem 52: 2255-64 (2009)


BindingDB Entry DOI: 10.7270/Q26112NJ
More data for this
Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486]


(Homo sapiens (Human))		BDBM394586
PNG
(2-(6-amino-5-(4- | US10308614, Example 189)
Show SMILES CN(C)Cc1ccc(cc1)-c1cc(nnc1N)-c1ccccc1O
Show InChI InChI=1S/C19H20N4O/c1-23(2)12-13-7-9-14(10-8-13)16-11-17(21-22-19(16)20)15-5-3-4-6-18(15)24/h3-11,24H,12H2,1-2H3,(H2,20,22)
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Assay Description
Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...

J Med Chem 52: 2255-64 (2009)


BindingDB Entry DOI: 10.7270/Q26112NJ
More data for this
Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486]


(Homo sapiens (Human))		BDBM394577
PNG
(2-(6-amino-5-((1- | US10308614, Example 180)
Show SMILES Nc1nnc(cc1OC1CCN(Cc2ccccc2)C1)-c1ccccc1O
Show InChI InChI=1S/C21H22N4O2/c22-21-20(12-18(23-24-21)17-8-4-5-9-19(17)26)27-16-10-11-25(14-16)13-15-6-2-1-3-7-15/h1-9,12,16,26H,10-11,13-14H2,(H2,22,24)
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The Institute of Cancer Research



Assay Description
Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...

J Med Chem 52: 2255-64 (2009)


BindingDB Entry DOI: 10.7270/Q26112NJ
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM50469333
PNG
(CHEMBL4290175)
Show SMILES FC(F)(F)c1cc(NC(=O)Nc2ccnc(Cl)c2)ccn1
Show InChI InChI=1S/C12H8ClF3N4O/c13-10-6-8(2-4-18-10)20-11(21)19-7-1-3-17-9(5-7)12(14,15)16/h1-6H,(H2,17,18,19,20,21)
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Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant His10-tagged ZZ-HCV3C-BRM ATPase-SnAC (636 to 1331 residues) (unknown origin) expressed in insect sf9 cells preincubated fo...

J Med Chem 61: 10155-10172 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01318
BindingDB Entry DOI: 10.7270/Q2TH8QDB
More data for this
Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486]


(Homo sapiens (Human))		BDBM394401
PNG
(2-(6-amino-5-(4-(pyridin- | US10308614, Example 3)
Show SMILES Nc1nnc(cc1N1CCN(Cc2cccnc2)CC1)-c1ccccc1O
Show InChI InChI=1S/C20H22N6O/c21-20-18(12-17(23-24-20)16-5-1-2-6-19(16)27)26-10-8-25(9-11-26)14-15-4-3-7-22-13-15/h1-7,12-13,27H,8-11,14H2,(H2,21,24)
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Assay Description
Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...

J Med Chem 52: 2255-64 (2009)


BindingDB Entry DOI: 10.7270/Q26112NJ
More data for this
Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486]


(Homo sapiens (Human))		BDBM394432
PNG
(2-(6-amino-5-(2,6- | US10308614, Example 33)
Show SMILES CC1CN(CC(C)O1)c1cc(nnc1N)-c1ccccc1O
Show InChI InChI=1S/C16H20N4O2/c1-10-8-20(9-11(2)22-10)14-7-13(18-19-16(14)17)12-5-3-4-6-15(12)21/h3-7,10-11,21H,8-9H2,1-2H3,(H2,17,19)
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Assay Description
Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...

J Med Chem 52: 2255-64 (2009)


BindingDB Entry DOI: 10.7270/Q26112NJ
More data for this
Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486]


(Homo sapiens (Human))		BDBM394444
PNG
(2-(6-amino-5- | US10308614, Example 45)
Show SMILES Nc1nnc(cc1N1CCOCC1)-c1ccccc1O
Show InChI InChI=1S/C14H16N4O2/c15-14-12(18-5-7-20-8-6-18)9-11(16-17-14)10-3-1-2-4-13(10)19/h1-4,9,19H,5-8H2,(H2,15,17)
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The Institute of Cancer Research



Assay Description
Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...

J Med Chem 52: 2255-64 (2009)


BindingDB Entry DOI: 10.7270/Q26112NJ
More data for this
Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486]


(Homo sapiens (Human))		BDBM394402
PNG
(1-(4-(3-amino-6-(2- | US10308614, Example 4)
Show SMILES CC(=O)N1CCN(CC1)c1cc(nnc1N)-c1ccccc1O
Show InChI InChI=1S/C16H19N5O2/c1-11(22)20-6-8-21(9-7-20)14-10-13(18-19-16(14)17)12-4-2-3-5-15(12)23/h2-5,10,23H,6-9H2,1H3,(H2,17,19)
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Assay Description
Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...

J Med Chem 52: 2255-64 (2009)


BindingDB Entry DOI: 10.7270/Q26112NJ
More data for this
Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486]


(Homo sapiens (Human))		BDBM394415
PNG
(2-(6-amino-5-(8-benzyl-3,8- | US10308614, Example ...)
Show SMILES Nc1nnc(cc1N1CC2CCC(C1)N2Cc1ccccc1)-c1ccccc1O
Show InChI InChI=1S/C23H25N5O/c24-23-21(12-20(25-26-23)19-8-4-5-9-22(19)29)27-14-17-10-11-18(15-27)28(17)13-16-6-2-1-3-7-16/h1-9,12,17-18,29H,10-11,13-15H2,(H2,24,26)
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The Institute of Cancer Research



Assay Description
Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...

J Med Chem 52: 2255-64 (2009)


BindingDB Entry DOI: 10.7270/Q26112NJ
More data for this
Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486]


(Homo sapiens (Human))		BDBM394574
PNG
(2-(6-amino-5-((1- | US10308614, Example 177)
Show SMILES CC(Cc1ccccc1)Oc1cc(nnc1N)-c1ccccc1O
Show InChI InChI=1S/C19H19N3O2/c1-13(11-14-7-3-2-4-8-14)24-18-12-16(21-22-19(18)20)15-9-5-6-10-17(15)23/h2-10,12-13,23H,11H2,1H3,(H2,20,22)
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Assay Description
Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...

J Med Chem 52: 2255-64 (2009)


BindingDB Entry DOI: 10.7270/Q26112NJ
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM646010
PNG
((2S,4R)-4-hydroxy-1-((2S)-2-(2-(2-(2- hydroxypheny...)
Show SMILES C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](NC(=O)CN1CCN2C(CNc3nnc(cc23)-c2ccccc2O)C1)C(C)(C)C)c1ccc(cc1)-c1scnc1C |r|
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Citation and Details
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM646016
PNG
((2S,4R)-4-hydroxy-1-((2S)-2-(3-(2-(4-((2-(2- hydro...)
Show SMILES CC(C)[C@@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)c1ccc(cc1)-c1scnc1C)c1cc(OCCN2CCC(CN3CCN4C(CNc5nnc(cc45)-c4ccccc4O)C3)CC2)no1 |r,w:44.65|
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Citation and Details
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM646014
PNG
((2S,4R)-4-hydroxy-1-((2S)-2-(2-(4-((2-(2- hydroxyp...)
Show SMILES C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](NC(=O)CN1CCC(CN2CCN3C(CNc4nnc(cc34)-c3ccccc3O)C2)CC1)C(C)(C)C)c1ccc(cc1)-c1scnc1C |r|
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Citation and Details
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM646012
PNG
((2S,4R)-4-hydroxy-N-[[4-(5-methyl-1,3- thiazol-4-y...)
Show SMILES Cc1scnc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CN2CCN3C(CNc4nnc(cc34)-c3ccccc3O)C2)C(C)(C)C)cc1 |r|
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Citation and Details
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM646015
PNG
((2S,4R)-4-hydroxy-1-((2R)-2-(3-(2-(2-(2- hydroxyph...)
Show SMILES CC(C)[C@@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)c1ccc(cc1)-c1scnc1C)c1cc(OCCN2CCN3C(CNc4nnc(cc34)-c3ccccc3O)C2)no1 |r,w:39.42|
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More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM50469326
PNG
(CHEMBL4279505)
Show SMILES FC(F)c1cc(NC(=O)Nc2ccnc(Cl)c2)ccn1
Show InChI InChI=1S/C12H9ClF2N4O/c13-10-6-8(2-4-17-10)19-12(20)18-7-1-3-16-9(5-7)11(14)15/h1-6,11H,(H2,16,17,18,19,20)
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Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant His10-tagged ZZ-HCV3C-BRM ATPase-SnAC (636 to 1331 residues) (unknown origin) expressed in insect sf9 cells preincubated fo...

J Med Chem 61: 10155-10172 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01318
BindingDB Entry DOI: 10.7270/Q2TH8QDB
More data for this
Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486]


(Homo sapiens (Human))		BDBM394565
PNG
(2-(6-amino-5-(1- | US10308614, Example 168)
Show SMILES CC(Oc1cc(nnc1N)-c1ccccc1O)C1CCOCC1
Show InChI InChI=1S/C17H21N3O3/c1-11(12-6-8-22-9-7-12)23-16-10-14(19-20-17(16)18)13-4-2-3-5-15(13)21/h2-5,10-12,21H,6-9H2,1H3,(H2,18,20)
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The Institute of Cancer Research



Assay Description
Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...

J Med Chem 52: 2255-64 (2009)


BindingDB Entry DOI: 10.7270/Q26112NJ
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM50469322
PNG
(CHEMBL4281368)
Show SMILES Cc1cc(NC(=O)Nc2ccnc(Cl)c2)ccn1
Show InChI InChI=1S/C12H11ClN4O/c1-8-6-9(2-4-14-8)16-12(18)17-10-3-5-15-11(13)7-10/h2-7H,1H3,(H2,14,15,16,17,18)
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Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant His10-tagged ZZ-HCV3C-BRM ATPase-SnAC (636 to 1331 residues) (unknown origin) expressed in insect sf9 cells preincubated fo...

J Med Chem 61: 10155-10172 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01318
BindingDB Entry DOI: 10.7270/Q2TH8QDB
More data for this
Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486]


(Homo sapiens (Human))		BDBM394570
PNG
(2-(6-amino-5-(2- | US10308614, Example 173)
Show SMILES CN(C)CCOc1cc(nnc1N)-c1ccccc1O
Show InChI InChI=1S/C14H18N4O2/c1-18(2)7-8-20-13-9-11(16-17-14(13)15)10-5-3-4-6-12(10)19/h3-6,9,19H,7-8H2,1-2H3,(H2,15,17)
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The Institute of Cancer Research



Assay Description
Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...

J Med Chem 52: 2255-64 (2009)


BindingDB Entry DOI: 10.7270/Q26112NJ
More data for this
Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486]


(Homo sapiens (Human))		BDBM394602
PNG
(2-(6-amino-5-phenylpyridazin-3-yl)-6-fluorophenol ...)
Show SMILES Nc1nnc(cc1-c1ccccc1)-c1cccc(F)c1O
Show InChI InChI=1S/C16H12FN3O/c17-13-8-4-7-11(15(13)21)14-9-12(16(18)20-19-14)10-5-2-1-3-6-10/h1-9,21H,(H2,18,20)
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The Institute of Cancer Research



Assay Description
Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...

J Med Chem 52: 2255-64 (2009)


BindingDB Entry DOI: 10.7270/Q26112NJ
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM394406
PNG
(2-(6-amino-5-(piperazin- | US10308614, Example 7)
Show SMILES Nc1nnc(cc1N1CCNCC1)-c1ccccc1O
Show InChI InChI=1S/C14H17N5O/c15-14-12(19-7-5-16-6-8-19)9-11(17-18-14)10-3-1-2-4-13(10)20/h1-4,9,16,20H,5-8H2,(H2,15,18)
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Citation and Details
More data for this
Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486]


(Homo sapiens (Human))		BDBM394613
PNG
(2-(6-amino-5-(1-(phenylsulfonyl)pyrrolidin-3-yl)py...)
Show SMILES Nc1nnc(cc1C1CCN(C1)S(=O)(=O)c1ccccc1)-c1ccccc1O
Show InChI InChI=1S/C20H20N4O3S/c21-20-17(12-18(22-23-20)16-8-4-5-9-19(16)25)14-10-11-24(13-14)28(26,27)15-6-2-1-3-7-15/h1-9,12,14,25H,10-11,13H2,(H2,21,23)
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The Institute of Cancer Research



Assay Description
Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...

J Med Chem 52: 2255-64 (2009)


BindingDB Entry DOI: 10.7270/Q26112NJ
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM646010
PNG
((2S,4R)-4-hydroxy-1-((2S)-2-(2-(2-(2- hydroxypheny...)
Show SMILES C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](NC(=O)CN1CCN2C(CNc3nnc(cc23)-c2ccccc2O)C1)C(C)(C)C)c1ccc(cc1)-c1scnc1C |r|
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Citation and Details
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM646012
PNG
((2S,4R)-4-hydroxy-N-[[4-(5-methyl-1,3- thiazol-4-y...)
Show SMILES Cc1scnc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CN2CCN3C(CNc4nnc(cc34)-c3ccccc3O)C2)C(C)(C)C)cc1 |r|
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Citation and Details
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM50481805
PNG
(CHEMBL5278697)
Show SMILES CC1CCN(CCCC(=O)NC2C=CC(C=C2)S(N)(=O)=O)CC1 |c:12,15,(26.65,-10.36,;27.42,-11.7,;28.96,-11.7,;29.72,-13.03,;28.95,-14.36,;29.72,-15.69,;31.26,-15.69,;32.03,-17.02,;33.57,-17.02,;34.34,-15.69,;34.34,-18.35,;35.88,-18.35,;36.66,-19.68,;38.2,-19.68,;38.96,-18.35,;38.2,-17.02,;36.66,-17.02,;40.5,-18.35,;41.27,-19.69,;40.09,-16.85,;41.98,-17.94,;27.41,-14.37,;26.65,-13.03,)|
Show InChI InChI=1S/C16H27N3O3S/c1-13-8-11-19(12-9-13)10-2-3-16(20)18-14-4-6-15(7-5-14)23(17,21)22/h4-7,13-15H,2-3,8-12H2,1H3,(H,18,20)(H2,17,21,22)
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More data for this
Ligand-Target Pair
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