Compile Data Set for Download or QSAR

Found 8 hits of ic50 for UniProtKB: Q24451   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Alpha-mannosidase 2 (Drosophila melanogaster (Fruit fly))	BDBM84869 (Swainsonine derivative, 4) Show SMILES CC(C)(C)c1ccc(cc1)C(=O)C[C@H]1CC[C@@H](O)C2[C@H](O)[C@H](O)CN12 |r| Show InChI InChI=1S/C20H29NO4/c1-20(2,3)13-6-4-12(5-7-13)16(23)10-14-8-9-15(22)18-19(25)17(24)11-21(14)18/h4-7,14-15,17-19,22,24-25H,8-11H2,1-3H3/t14-,15-,17-,18?,19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	2.70	-11.7	29	n/a	n/a	n/a	n/a	5.75	25
University of Toronto					Assay Description Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car...				Chembiochem 11: 673-80 (2010) Article DOI: 10.1002/cbic.200900750 BindingDB Entry DOI: 10.7270/Q2WS8RRM
					More data for this Ligand-Target Pair
Alpha-mannosidase 2 (Drosophila melanogaster (Fruit fly))	BDBM84868 (Swainsonine derivative, 3) Show SMILES Cc1ccc(cc1)C(=O)C[C@H]1CC[C@@H](O)C2[C@H](O)[C@H](O)CN12 |r| Show InChI InChI=1S/C17H23NO4/c1-10-2-4-11(5-3-10)14(20)8-12-6-7-13(19)16-17(22)15(21)9-18(12)16/h2-5,12-13,15-17,19,21-22H,6-9H2,1H3/t12-,13-,15-,16?,17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	2.70	-11.7	29	n/a	n/a	n/a	n/a	5.75	25
University of Toronto					Assay Description Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car...				Chembiochem 11: 673-80 (2010) Article DOI: 10.1002/cbic.200900750 BindingDB Entry DOI: 10.7270/Q2WS8RRM
					More data for this Ligand-Target Pair
Alpha-mannosidase 2 (Drosophila melanogaster (Fruit fly))	BDBM84867 (Swainsonine derivative, 2) Show SMILES O[C@@H]1CN2C([C@@H]1O)[C@H](O)CC[C@@H]2CC(=O)c1ccccc1 |r| Show InChI InChI=1S/C16H21NO4/c18-12-7-6-11(17-9-14(20)16(21)15(12)17)8-13(19)10-4-2-1-3-5-10/h1-5,11-12,14-16,18,20-21H,6-9H2/t11-,12-,14-,15?,16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	2.80	-11.7	30	n/a	n/a	n/a	n/a	5.75	25
University of Toronto					Assay Description Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car...				Chembiochem 11: 673-80 (2010) Article DOI: 10.1002/cbic.200900750 BindingDB Entry DOI: 10.7270/Q2WS8RRM
					More data for this Ligand-Target Pair
Alpha-mannosidase 2 (Drosophila melanogaster (Fruit fly))	BDBM50168995 ((-)-swainsonine | (1S,2R,8R,8aR)-Octahydro-indoliz...) Show SMILES O[C@@H]1CN2CCC[C@@H](O)[C@@H]2[C@@H]1O |r| Show InChI InChI=1S/C8H15NO3/c10-5-2-1-3-9-4-6(11)8(12)7(5)9/h5-8,10-12H,1-4H2/t5-,6-,7-,8-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	3	-11.6	37	n/a	n/a	n/a	n/a	5.75	25
University of Toronto					Assay Description Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car...				Chembiochem 11: 673-80 (2010) Article DOI: 10.1002/cbic.200900750 BindingDB Entry DOI: 10.7270/Q2WS8RRM
					More data for this Ligand-Target Pair				3D Structure (crystal)
Alpha-mannosidase 2 (Drosophila melanogaster (Fruit fly))	BDBM84871 (Swainsonine derivative, 6) Show SMILES CC(C)(C)c1ccc(CC[C@H]2CC[C@@H](O)C3[C@H](O)[C@H](O)CN23)cc1 |r| Show InChI InChI=1S/C20H31NO3/c1-20(2,3)14-7-4-13(5-8-14)6-9-15-10-11-16(22)18-19(24)17(23)12-21(15)18/h4-5,7-8,15-19,22-24H,6,9-12H2,1-3H3/t15-,16+,17+,18?,19+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	44	n/a	n/a	n/a	n/a	5.75	25
University of Toronto					Assay Description Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car...				Chembiochem 11: 673-80 (2010) Article DOI: 10.1002/cbic.200900750 BindingDB Entry DOI: 10.7270/Q2WS8RRM
					More data for this Ligand-Target Pair
Alpha-mannosidase 2 (Drosophila melanogaster (Fruit fly))	BDBM84872 (Swainsonine derivative, 7) Show SMILES CC(C)(C)c1ccc(CC[C@@H]2CC[C@@H](O)C3[C@H](O)[C@H](O)CN23)cc1 |r| Show InChI InChI=1S/C20H31NO3/c1-20(2,3)14-7-4-13(5-8-14)6-9-15-10-11-16(22)18-19(24)17(23)12-21(15)18/h4-5,7-8,15-19,22-24H,6,9-12H2,1-3H3/t15-,16-,17-,18?,19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	5.75	25
University of Toronto					Assay Description Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car...				Chembiochem 11: 673-80 (2010) Article DOI: 10.1002/cbic.200900750 BindingDB Entry DOI: 10.7270/Q2WS8RRM
					More data for this Ligand-Target Pair
Alpha-mannosidase 2 (Drosophila melanogaster (Fruit fly))	BDBM84870 (Swainsonine derivative, 5) Show SMILES CC(C)(C)c1ccc(cc1)C(=O)C[C@@H]1CC[C@@H](O)C2[C@H](O)[C@H](O)CN12 |r| Show InChI InChI=1S/C20H29NO4/c1-20(2,3)13-6-4-12(5-7-13)16(23)10-14-8-9-15(22)18-19(25)17(24)11-21(14)18/h4-7,14-15,17-19,22,24-25H,8-11H2,1-3H3/t14-,15+,17+,18?,19+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	5.75	25
University of Toronto					Assay Description Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car...				Chembiochem 11: 673-80 (2010) Article DOI: 10.1002/cbic.200900750 BindingDB Entry DOI: 10.7270/Q2WS8RRM
					More data for this Ligand-Target Pair
Alpha-mannosidase 2 (Drosophila melanogaster (Fruit fly))	BDBM84468 (Mannostatin analogue, 4b | Meso-aminocyclopentitet...) Show SMILES N[C@@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H]1O |r| Show InChI InChI=1S/C5H11NO4/c6-1-2(7)4(9)5(10)3(1)8/h1-5,7-10H,6H2/t1-,2+,3-,4+,5-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB Article PubMed	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Toronto					Assay Description The rate of hydrolysis catalyzed by drosophila golgi alpha-mannosidase II (dGMII)and in the presence of different concentration of inhibitor was meas...				Chembiochem 10: 268-77 (2009) Article DOI: 10.1002/cbic.200800538 BindingDB Entry DOI: 10.7270/Q2DZ06T7
					More data for this Ligand-Target Pair				3D Structure (crystal)