BindingDB PrimarySearch

Found 8 hits of ec50 for UniProtKB: P21817
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Ryanodine receptor 1 (Homo sapiens (Human))	BDBM50191286 (Bastadin-5 \| CHEMBL439151 \| bastadin 5) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a
Polish Academy of Sciences Curated by ChEMBL					Assay Description Binding affinity to RYR1 channels by calcium mobilization assay				Bioorg Med Chem Lett 18: 5734-7 (2009) Article DOI: 10.1016/j.bmcl.2008.09.080 BindingDB Entry DOI: 10.7270/Q2NV9K5T
Polish Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Ryanodine receptor 1 (Homo sapiens (Human))	BDBM50241984 (BASTADIN 6 \| CHEMBL505907 \| bastadin-6) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Displacement of [3H]ryanodine from RyR1 calcium channel in sarcoplasmic reticulum assessed as calcium mobilization				J Nat Prod 66: 112-4 (2003) Article DOI: 10.1021/np020382h BindingDB Entry DOI: 10.7270/Q2HM587T
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Ryanodine receptor 1 (Homo sapiens (Human))	BDBM50241986 (Bastadin-10 \| CHEMBL504851) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	5.80E+3	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Displacement of [3H]ryanodine from RyR1 calcium channel in sarcoplasmic reticulum assessed as calcium mobilization				J Nat Prod 66: 112-4 (2003) Article DOI: 10.1021/np020382h BindingDB Entry DOI: 10.7270/Q2HM587T
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Ryanodine receptor 1 (Homo sapiens (Human))	BDBM50150778 (Bastadin-7 \| Bastadins 7 \| CHEMBL360190 \| bastadin...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	6.30E+3	n/a	n/a	n/a	n/a
Polish Academy of Sciences Curated by ChEMBL					Assay Description Binding affinity to RYR1 channels by calcium mobilization assay				Bioorg Med Chem Lett 18: 5734-7 (2009) Article DOI: 10.1016/j.bmcl.2008.09.080 BindingDB Entry DOI: 10.7270/Q2NV9K5T
Polish Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Ryanodine receptor 1 (Homo sapiens (Human))	BDBM50191278 ((+/-)-5,17-dibromo-4-hydroxy-2-oxa-10-aza-tricyclo...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a
Polish Academy of Sciences Curated by ChEMBL					Assay Description Binding affinity to RYR1 channels by calcium mobilization assay				Bioorg Med Chem Lett 18: 5734-7 (2009) Article DOI: 10.1016/j.bmcl.2008.09.080 BindingDB Entry DOI: 10.7270/Q2NV9K5T
Polish Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Ryanodine receptor 1 (Homo sapiens (Human))	BDBM50241983 (Bastadin 4 \| Bastadin-4 \| CHEMBL453147) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.47E+4	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Displacement of [3H]ryanodine from RyR1 calcium channel in sarcoplasmic reticulum assessed as calcium mobilization				J Nat Prod 66: 112-4 (2003) Article DOI: 10.1021/np020382h BindingDB Entry DOI: 10.7270/Q2HM587T
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Ryanodine receptor 1 (Homo sapiens (Human))	BDBM50241985 ((E,Z)bastadin-19 \| Bastadin-19 \| CHEMBL506286 \| CH...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Polish Academy of Sciences Curated by ChEMBL					Assay Description Binding affinity to RYR1 channels by calcium mobilization assay				Bioorg Med Chem Lett 18: 5734-7 (2009) Article DOI: 10.1016/j.bmcl.2008.09.080 BindingDB Entry DOI: 10.7270/Q2NV9K5T
Polish Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Ryanodine receptor 1 (Homo sapiens (Human))	BDBM50241985 ((E,Z)bastadin-19 \| Bastadin-19 \| CHEMBL506286 \| CH...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Displacement of [3H]ryanodine from RyR1 calcium channel in sarcoplasmic reticulum assessed as calcium mobilization				J Nat Prod 66: 112-4 (2003) Article DOI: 10.1021/np020382h BindingDB Entry DOI: 10.7270/Q2HM587T
University of California Curated by ChEMBL					More data for this Ligand-Target Pair