Compile Data Set for Download or QSAR

Found 28 hits of ic50 for UniProtKB: P30099   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cytochrome P450 11B2, mitochondrial (Rattus norvegicus)	BDBM50444550 (CHEMBL3099704) Show SMILES Fc1ccc(cc1)-c1cc(ccc1[C@H]1CCCCc2cncn12)C#N |r| Show InChI InChI=1S/C21H18FN3/c22-17-8-6-16(7-9-17)20-11-15(12-23)5-10-19(20)21-4-2-1-3-18-13-24-14-25(18)21/h5-11,13-14,21H,1-4H2/t21-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of rat recombinant CYP11B2 using 11-deoxycorticosterone as substrate by cell-based assay				ACS Med Chem Lett 4: 1203-7 (2013) Article DOI: 10.1021/ml400324c BindingDB Entry DOI: 10.7270/Q2NZ8938
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Rattus norvegicus)	BDBM50249047 (CHEMBL4080420) Show SMILES Cc1nn(-c2cncc(c2)C(C)(C)O)c2cccc(F)c12 Show InChI InChI=1S/C16H16FN3O/c1-10-15-13(17)5-4-6-14(15)20(19-10)12-7-11(8-18-9-12)16(2,3)21/h4-9,21H,1-3H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of rat CYP11B2-1F4 expressed in Chinese hamster V79 cells using 11-deoxycorticosterone as substrate preincubated for 1 hr followed by subs...				Bioorg Med Chem Lett 27: 2384-2388 (2017) Article DOI: 10.1016/j.bmcl.2017.04.021 BindingDB Entry DOI: 10.7270/Q2MC92F2
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Rattus norvegicus)	BDBM50249044 (CHEMBL4067000) Show SMILES CC(C)(O)c1cncc(c1)-n1ncc2c(cccc12)C(F)(F)F Show InChI InChI=1S/C16H14F3N3O/c1-15(2,23)10-6-11(8-20-7-10)22-14-5-3-4-13(16(17,18)19)12(14)9-21-22/h3-9,23H,1-2H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of rat CYP11B2-1F4 expressed in Chinese hamster V79 cells using 11-deoxycorticosterone as substrate preincubated for 1 hr followed by subs...				Bioorg Med Chem Lett 27: 2384-2388 (2017) Article DOI: 10.1016/j.bmcl.2017.04.021 BindingDB Entry DOI: 10.7270/Q2MC92F2
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Rattus norvegicus)	BDBM50249045 (CHEMBL4098297) Show SMILES Cc1nn(-c2cncc(c2)[C@](C)(O)C(F)(F)F)c2ccccc12 |r| Show InChI InChI=1S/C16H14F3N3O/c1-10-13-5-3-4-6-14(13)22(21-10)12-7-11(8-20-9-12)15(2,23)16(17,18)19/h3-9,23H,1-2H3/t15-/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of rat CYP11B2-1F4 expressed in Chinese hamster V79 cells using 11-deoxycorticosterone as substrate preincubated for 1 hr followed by subs...				Bioorg Med Chem Lett 27: 2384-2388 (2017) Article DOI: 10.1016/j.bmcl.2017.04.021 BindingDB Entry DOI: 10.7270/Q2MC92F2
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Rattus norvegicus)	BDBM50444548 (CHEMBL3099696) Show SMILES Cc1cc(ccc1[C@H]1CCc2cncn12)C#N |r| Show InChI InChI=1S/C14H13N3/c1-10-6-11(7-15)2-4-13(10)14-5-3-12-8-16-9-17(12)14/h2,4,6,8-9,14H,3,5H2,1H3/t14-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of rat recombinant CYP11B2 using 11-deoxycorticosterone as substrate by cell-based assay				ACS Med Chem Lett 4: 1203-7 (2013) Article DOI: 10.1021/ml400324c BindingDB Entry DOI: 10.7270/Q2NZ8938
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Rattus norvegicus)	BDBM50249048 (CHEMBL4080256) Show SMILES Cc1nn(-c2cncc(c2)[C@@](C)(O)C(F)(F)F)c2ccccc12 |r| Show InChI InChI=1S/C16H14F3N3O/c1-10-13-5-3-4-6-14(13)22(21-10)12-7-11(8-20-9-12)15(2,23)16(17,18)19/h3-9,23H,1-2H3/t15-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of rat CYP11B2-1F4 expressed in Chinese hamster V79 cells using 11-deoxycorticosterone as substrate preincubated for 1 hr followed by subs...				Bioorg Med Chem Lett 27: 2384-2388 (2017) Article DOI: 10.1016/j.bmcl.2017.04.021 BindingDB Entry DOI: 10.7270/Q2MC92F2
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Rattus norvegicus)	BDBM50249046 (CHEMBL4071689) Show SMILES C[C@](O)(c1cncc(c1)-n1nc(c2ccccc12)C(F)(F)F)C(F)(F)F |r| Show InChI InChI=1S/C16H11F6N3O/c1-14(26,16(20,21)22)9-6-10(8-23-7-9)25-12-5-3-2-4-11(12)13(24-25)15(17,18)19/h2-8,26H,1H3/t14-/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	77	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of rat CYP11B2-1F4 expressed in Chinese hamster V79 cells using 11-deoxycorticosterone as substrate preincubated for 1 hr followed by subs...				Bioorg Med Chem Lett 27: 2384-2388 (2017) Article DOI: 10.1016/j.bmcl.2017.04.021 BindingDB Entry DOI: 10.7270/Q2MC92F2
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Rattus norvegicus)	BDBM50444549 (CHEMBL3099695) Show SMILES Fc1cc(ccc1[C@H]1CCc2cncn12)C#N |r| Show InChI InChI=1S/C13H10FN3/c14-12-5-9(6-15)1-3-11(12)13-4-2-10-7-16-8-17(10)13/h1,3,5,7-8,13H,2,4H2/t13-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	111	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of rat recombinant CYP11B2 using 11-deoxycorticosterone as substrate by cell-based assay				ACS Med Chem Lett 4: 1203-7 (2013) Article DOI: 10.1021/ml400324c BindingDB Entry DOI: 10.7270/Q2NZ8938
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Rattus norvegicus)	BDBM50047262 ((R)-4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-y...) Show SMILES N#Cc1ccc(cc1)[C@H]1CCCc2cncn12 Show InChI InChI=1S/C14H13N3/c15-8-11-4-6-12(7-5-11)14-3-1-2-13-9-16-10-17(13)14/h4-7,9-10,14H,1-3H2/t14-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	118	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of rat recombinant CYP11B2 using 11-deoxycorticosterone as substrate by cell-based assay				ACS Med Chem Lett 4: 1203-7 (2013) Article DOI: 10.1021/ml400324c BindingDB Entry DOI: 10.7270/Q2NZ8938
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Rattus norvegicus)	BDBM50238105 (CHEMBL4099824) Show SMILES CS(=O)(=O)N1CCC(CC1)C(O)c1cncnc1Nc1ccc(F)cc1 Show InChI InChI=1S/C17H21FN4O3S/c1-26(24,25)22-8-6-12(7-9-22)16(23)15-10-19-11-20-17(15)21-14-4-2-13(18)3-5-14/h2-5,10-12,16,23H,6-9H2,1H3,(H,19,20,21)	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi-Sankyo Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of rat CYP11B2				Bioorg Med Chem Lett 27: 1902-1906 (2017) Article DOI: 10.1016/j.bmcl.2017.03.034 BindingDB Entry DOI: 10.7270/Q2KS6TTS
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Rattus norvegicus)	BDBM8611 (4-{5H,6H,7H,8H-imidazo[1,5-a]pyridin-5-yl}benzonit...) Show SMILES N#Cc1ccc(cc1)C1CCCc2cncn12 Show InChI InChI=1S/C14H13N3/c15-8-11-4-6-12(7-5-11)14-3-1-2-13-9-16-10-17(13)14/h4-7,9-10,14H,1-3H2	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
Universität des Saarlandes Curated by ChEMBL					Assay Description In vitro inhibition of ACTH-stimulated aldosterone biosynthesis in rat adrenal slices				J Med Chem 38: 2103-11 (1995) BindingDB Entry DOI: 10.7270/Q2NV9H9S
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Rattus norvegicus)	BDBM50500189 (CHEMBL3746175) Show SMILES CN(C)S(=O)(=O)Oc1cncc(c1)-c1c(C#N)c2ccccc2n1C Show InChI InChI=1S/C17H16N4O3S/c1-20(2)25(22,23)24-13-8-12(10-19-11-13)17-15(9-18)14-6-4-5-7-16(14)21(17)3/h4-8,10-11H,1-3H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant rat CYP11B2 using 11-deoxycorticosterone as substrate after 2 hrs by scintillation proximity assay				J Med Chem 58: 9382-94 (2015) Article DOI: 10.1021/acs.jmedchem.5b01545 BindingDB Entry DOI: 10.7270/Q2CC13QV
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Rattus norvegicus)	BDBM50035209 (4-(1a,2,3,7b-Tetrahydro-1H-cyclopropa[a]naphthalen...) Show SMILES C1Cc2ccccc2C2C1C2c1ccncc1 Show InChI InChI=1S/C16H15N/c1-2-4-13-11(3-1)5-6-14-15(16(13)14)12-7-9-17-10-8-12/h1-4,7-10,14-16H,5-6H2	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universität des Saarlandes Curated by ChEMBL					Assay Description In vitro inhibition of ACTH-stimulated aldosterone biosynthesis in rat adrenal slices				J Med Chem 38: 2103-11 (1995) BindingDB Entry DOI: 10.7270/Q2NV9H9S
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Rattus norvegicus)	BDBM50500185 (CHEMBL3746125) Show SMILES Cc1c([nH]c2ccccc12)-c1cccnc1 Show InChI InChI=1S/C14H12N2/c1-10-12-6-2-3-7-13(12)16-14(10)11-5-4-8-15-9-11/h2-9,16H,1H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant rat CYP11B2 using 11-deoxycorticosterone as substrate after 2 hrs by scintillation proximity assay				J Med Chem 58: 9382-94 (2015) Article DOI: 10.1021/acs.jmedchem.5b01545 BindingDB Entry DOI: 10.7270/Q2CC13QV
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Rattus norvegicus)	BDBM50035208 (1-Pyridin-4-yl-1a,2,3,7b-tetrahydro-1H-cyclopropa[...) Show SMILES Oc1ccc2CCC3C(C3c2c1)c1ccncc1 Show InChI InChI=1S/C16H15NO/c18-12-3-1-10-2-4-13-15(16(13)14(10)9-12)11-5-7-17-8-6-11/h1,3,5-9,13,15-16,18H,2,4H2	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universität des Saarlandes Curated by ChEMBL					Assay Description In vitro inhibition of ACTH-stimulated aldosterone biosynthesis in rat adrenal slices				J Med Chem 38: 2103-11 (1995) BindingDB Entry DOI: 10.7270/Q2NV9H9S
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Rattus norvegicus)	BDBM50500187 (CHEMBL3747269) Show SMILES Cn1c(c(C#N)c2ccc(Cl)cc12)-c1cccnc1 Show InChI InChI=1S/C15H10ClN3/c1-19-14-7-11(16)4-5-12(14)13(8-17)15(19)10-3-2-6-18-9-10/h2-7,9H,1H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant rat CYP11B2 using 11-deoxycorticosterone as substrate after 2 hrs by scintillation proximity assay				J Med Chem 58: 9382-94 (2015) Article DOI: 10.1021/acs.jmedchem.5b01545 BindingDB Entry DOI: 10.7270/Q2CC13QV
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Rattus norvegicus)	BDBM50035204 (4-(6-Methoxy-1a,2,3,7b-tetrahydro-1H-cyclopropa[a]...) Show SMILES COc1ccc2CCC3C(C3c2c1)c1ccncc1 Show InChI InChI=1S/C17H17NO/c1-19-13-4-2-11-3-5-14-16(17(14)15(11)10-13)12-6-8-18-9-7-12/h2,4,6-10,14,16-17H,3,5H2,1H3	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universität des Saarlandes Curated by ChEMBL					Assay Description In vitro inhibition of ACTH-stimulated aldosterone biosynthesis in rat adrenal slices				J Med Chem 38: 2103-11 (1995) BindingDB Entry DOI: 10.7270/Q2NV9H9S
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Rattus norvegicus)	BDBM50035204 (4-(6-Methoxy-1a,2,3,7b-tetrahydro-1H-cyclopropa[a]...) Show SMILES COc1ccc2CCC3C(C3c2c1)c1ccncc1 Show InChI InChI=1S/C17H17NO/c1-19-13-4-2-11-3-5-14-16(17(14)15(11)10-13)12-6-8-18-9-7-12/h2,4,6-10,14,16-17H,3,5H2,1H3	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universität des Saarlandes Curated by ChEMBL					Assay Description In vitro inhibition of ACTH-stimulated aldosterone biosynthesis in rat adrenal slices				J Med Chem 38: 2103-11 (1995) BindingDB Entry DOI: 10.7270/Q2NV9H9S
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Rattus norvegicus)	BDBM50500184 (CHEMBL3746868) Show SMILES Cn1c(c(C#N)c2ccccc12)-c1cccnc1 Show InChI InChI=1S/C15H11N3/c1-18-14-7-3-2-6-12(14)13(9-16)15(18)11-5-4-8-17-10-11/h2-8,10H,1H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.09E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant rat CYP11B2 using 11-deoxycorticosterone as substrate after 2 hrs by scintillation proximity assay				J Med Chem 58: 9382-94 (2015) Article DOI: 10.1021/acs.jmedchem.5b01545 BindingDB Entry DOI: 10.7270/Q2CC13QV
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Rattus norvegicus)	BDBM50378780 ((S)-VOROZOLE) Show SMILES Cn1nnc2ccc(cc12)[C@H](c1ccc(Cl)cc1)n1cncn1 |r| Show InChI InChI=1S/C16H13ClN6/c1-22-15-8-12(4-7-14(15)20-21-22)16(23-10-18-9-19-23)11-2-5-13(17)6-3-11/h2-10,16H,1H3/t16-/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universität des Saarlandes Curated by ChEMBL					Assay Description In vitro inhibition of ACTH-stimulated aldosterone biosynthesis in rat adrenal slices				J Med Chem 38: 2103-11 (1995) BindingDB Entry DOI: 10.7270/Q2NV9H9S
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Rattus norvegicus)	BDBM50500188 (CHEMBL3747562) Show SMILES CCS(=O)(=O)NCc1cncc(c1)-c1c(C#N)c2ccc(Cl)cc2n1C Show InChI InChI=1S/C18H17ClN4O2S/c1-3-26(24,25)22-10-12-6-13(11-21-9-12)18-16(8-20)15-5-4-14(19)7-17(15)23(18)2/h4-7,9,11,22H,3,10H2,1-2H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.74E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant rat CYP11B2 using 11-deoxycorticosterone as substrate after 2 hrs by scintillation proximity assay				J Med Chem 58: 9382-94 (2015) Article DOI: 10.1021/acs.jmedchem.5b01545 BindingDB Entry DOI: 10.7270/Q2CC13QV
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Rattus norvegicus)	BDBM50011762 ((1R,5S)1-(4-Amino-phenyl)-3-cyclohexylmethyl-3-aza...) Show SMILES Nc1ccc(cc1)C12CC1C(=O)N(CC1CCCCC1)C2=O Show InChI InChI=1S/C18H22N2O2/c19-14-8-6-13(7-9-14)18-10-15(18)16(21)20(17(18)22)11-12-4-2-1-3-5-12/h6-9,12,15H,1-5,10-11,19H2	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>3.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY AG. Curated by ChEMBL					Assay Description In vitro inhibition of aldosterone production in rat adrenal tissue				J Med Chem 34: 1329-34 (1991) BindingDB Entry DOI: 10.7270/Q2QN65RW
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Rattus norvegicus)	BDBM9460 (3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...) Show SMILES CCC1(CCC(=O)NC1=O)c1ccc(N)cc1 Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17)	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universität des Saarlandes Curated by ChEMBL					Assay Description In vitro inhibition of ACTH-stimulated aldosterone biosynthesis in rat adrenal slices				J Med Chem 38: 2103-11 (1995) BindingDB Entry DOI: 10.7270/Q2NV9H9S
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Rattus norvegicus)	BDBM50500186 (CHEMBL3747069) Show SMILES CCS(=O)(=O)Nc1cncc(c1)-c1c(C#N)c2ccc(Cl)cc2n1C Show InChI InChI=1S/C17H15ClN4O2S/c1-3-25(23,24)21-13-6-11(9-20-10-13)17-15(8-19)14-5-4-12(18)7-16(14)22(17)2/h4-7,9-10,21H,3H2,1-2H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.31E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant rat CYP11B2 using 11-deoxycorticosterone as substrate after 2 hrs by scintillation proximity assay				J Med Chem 58: 9382-94 (2015) Article DOI: 10.1021/acs.jmedchem.5b01545 BindingDB Entry DOI: 10.7270/Q2CC13QV
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Rattus norvegicus)	BDBM9460 (3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...) Show SMILES CCC1(CCC(=O)NC1=O)c1ccc(N)cc1 Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17)	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	8.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universität des Saarlandes Curated by ChEMBL					Assay Description In vitro inhibition of ACTH-stimulated aldosterone biosynthesis in rat adrenal slices				J Med Chem 38: 2103-11 (1995) BindingDB Entry DOI: 10.7270/Q2NV9H9S
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Rattus norvegicus)	BDBM9460 (3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...) Show SMILES CCC1(CCC(=O)NC1=O)c1ccc(N)cc1 Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17)	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	1.10E+5	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY AG. Curated by ChEMBL					Assay Description In vitro inhibition of aldosterone production in rat adrenal tissue				J Med Chem 34: 1329-34 (1991) BindingDB Entry DOI: 10.7270/Q2QN65RW
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Rattus norvegicus)	BDBM50011756 (1-(4-Amino-phenyl)-3-cyclohexyl-3-aza-bicyclo[3.1....) Show SMILES Nc1ccc(cc1)C12CC(C1)C(=O)N(C1CCCCC1)C2=O |(8.24,.27,;6.91,-.5,;6.9,-2.04,;5.55,-2.81,;4.22,-2.02,;4.21,-.47,;5.55,.28,;2.88,-2.79,;1.55,-2.02,;.23,-2.79,;1.57,-3.56,;.23,-4.33,;-1.11,-5.11,;1.55,-5.11,;1.55,-6.65,;2.88,-7.4,;2.88,-8.96,;1.55,-9.71,;.22,-8.94,;.22,-7.4,;2.88,-4.33,;4.22,-5.11,)| Show InChI InChI=1S/C18H22N2O2/c19-14-8-6-13(7-9-14)18-10-12(11-18)16(21)20(17(18)22)15-4-2-1-3-5-15/h6-9,12,15H,1-5,10-11,19H2	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.40E+5	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY AG. Curated by ChEMBL					Assay Description In vitro inhibition of aldosterone production in rat adrenal tissue				J Med Chem 34: 1329-34 (1991) BindingDB Entry DOI: 10.7270/Q2QN65RW
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Rattus norvegicus)	BDBM50011762 ((1R,5S)1-(4-Amino-phenyl)-3-cyclohexylmethyl-3-aza...) Show SMILES Nc1ccc(cc1)C12CC1C(=O)N(CC1CCCCC1)C2=O Show InChI InChI=1S/C18H22N2O2/c19-14-8-6-13(7-9-14)18-10-15(18)16(21)20(17(18)22)11-12-4-2-1-3-5-12/h6-9,12,15H,1-5,10-11,19H2	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>3.30E+5	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY AG. Curated by ChEMBL					Assay Description In vitro inhibition of estrogen production in hamster ovarian tissue				J Med Chem 34: 1329-34 (1991) BindingDB Entry DOI: 10.7270/Q2QN65RW
					More data for this Ligand-Target Pair