Found 13 hits of ic50 for UniProtKB: P53792 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Sodium/glucose cotransporter 2
(Rattus norvegicus) | BDBM50342885
((1S,2S,3S,4R,5S)-5-[4-Chloro-3-(4-ethoxybenzyl)phe...)Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@]23OC[C@](CO)(O2)[C@@H](O)[C@H](O)[C@H]3O)cc1 |r| Show InChI InChI=1S/C22H25ClO7/c1-2-28-16-6-3-13(4-7-16)9-14-10-15(5-8-17(14)23)22-20(27)18(25)19(26)21(11-24,30-22)12-29-22/h3-8,10,18-20,24-27H,2,9,11-12H2,1H3/t18-,19-,20+,21-,22-/m0/s1 | PDB
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| n/a | n/a | 1.15 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat SGLT2 |
J Med Chem 54: 2952-60 (2011)
Article DOI: 10.1021/jm200049r
BindingDB Entry DOI: 10.7270/Q2NZ880H |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Rattus norvegicus) | BDBM50344685
(4-((5-(2,3-dihydro-1H-inden-2-yl)-4-propyl-4H-1,2,...)Show SMILES CCCn1c(CN2C(=O)COc3c(C)cc(C)cc23)nnc1C1Cc2ccccc2C1 Show InChI InChI=1S/C25H28N4O2/c1-4-9-28-22(26-27-25(28)20-12-18-7-5-6-8-19(18)13-20)14-29-21-11-16(2)10-17(3)24(21)31-15-23(29)30/h5-8,10-11,20H,4,9,12-15H2,1-3H3 | PDB
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| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat SGLT2 |
Bioorg Med Chem Lett 21: 3774-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.04.053
BindingDB Entry DOI: 10.7270/Q2KK9C32 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Rattus norvegicus) | BDBM50344681
(6,8-dimethyl-4-((4-propyl-5-(pyridin-2-yl)-4H-1,2,...)Show SMILES CCCn1c(CN2C(=O)COc3c(C)cc(C)cc23)nnc1-c1ccccn1 Show InChI InChI=1S/C21H23N5O2/c1-4-9-25-18(23-24-21(25)16-7-5-6-8-22-16)12-26-17-11-14(2)10-15(3)20(17)28-13-19(26)27/h5-8,10-11H,4,9,12-13H2,1-3H3 | PDB
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| n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat SGLT2 |
Bioorg Med Chem Lett 21: 3774-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.04.053
BindingDB Entry DOI: 10.7270/Q2KK9C32 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Rattus norvegicus) | BDBM50467750
(CHEMBL4279519)Show SMILES COc1c2CCOc2c(Cc2ccc3OCCOc3c2)cc1[C@@H]1O[C@H](CO)[C@@H](F)[C@H](O)[C@H]1O |r| Show InChI InChI=1S/C24H27FO8/c1-29-23-14-4-5-32-22(14)13(8-12-2-3-16-17(9-12)31-7-6-30-16)10-15(23)24-21(28)20(27)19(25)18(11-26)33-24/h2-3,9-10,18-21,24,26-28H,4-8,11H2,1H3/t18-,19-,20+,21-,24+/m1/s1 | PDB
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| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research & Development, L.L.C.
Curated by ChEMBL
| Assay Description
Inhibition of rat SGLT2 expressed in CHOK1 cells assessed as reduction in Na-dependent [14C]-AMG uptake preincubated for 10 mins followed by [14C]-AM... |
Bioorg Med Chem Lett 28: 3446-3453 (2018)
Article DOI: 10.1016/j.bmcl.2018.09.025
BindingDB Entry DOI: 10.7270/Q2RB779G |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Rattus norvegicus) | BDBM20875
(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)Show SMILES OC[C@H]1O[C@@H](Oc2cc(O)cc(O)c2C(=O)CCc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O Show InChI InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1 | PDB
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| n/a | n/a | 96 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company
Curated by ChEMBL
| Assay Description
Inhibition of rat SGLT2 expressed in COS7 cells assessed as reduction of [14C]-AMG uptake |
Bioorg Med Chem 20: 6598-612 (2012)
Article DOI: 10.1016/j.bmc.2012.09.037
BindingDB Entry DOI: 10.7270/Q26D5V36 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Sodium/glucose cotransporter 2
(Rattus norvegicus) | BDBM50340014
(4-((5-(4-chlorobenzylthio)-4-methyl-4H-1,2,4-triaz...)Show SMILES Cn1c(CN2C(=O)CSc3ccc(cc23)C(F)(F)F)nnc1SCc1ccc(Cl)cc1 Show InChI InChI=1S/C20H16ClF3N4OS2/c1-27-17(25-26-19(27)31-10-12-2-5-14(21)6-3-12)9-28-15-8-13(20(22,23)24)4-7-16(15)30-11-18(28)29/h2-8H,9-11H2,1H3 | PDB
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| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillatio... |
Bioorg Med Chem Lett 21: 2472-5 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Rattus norvegicus) | BDBM50426887
(CHEMBL2323695)Show SMILES CC(C)c1n[nH]c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1Cc1ccc(CCCC(=O)NC(C)(C)C(=O)N2CCNCC2)cc1C |r| Show InChI InChI=1S/C32H49N5O8/c1-18(2)25-22(29(36-35-25)45-30-28(42)27(41)26(40)23(17-38)44-30)16-21-10-9-20(15-19(21)3)7-6-8-24(39)34-32(4,5)31(43)37-13-11-33-12-14-37/h9-10,15,18,23,26-28,30,33,38,40-42H,6-8,11-14,16-17H2,1-5H3,(H,34,39)(H,35,36)/t23-,26-,27+,28-,30+/m1/s1 | PDB
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Kissei Pharmaceutical Company
Curated by ChEMBL
| Assay Description
Inhibition of rat SGLT2 |
Bioorg Med Chem 21: 748-65 (2013)
Article DOI: 10.1016/j.bmc.2012.11.041
BindingDB Entry DOI: 10.7270/Q2445NS9 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Rattus norvegicus) | BDBM50426888
(CHEMBL2323694)Show SMILES CC(C)c1n[nH]c(O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)c1Cc1ccc(CCCC(=O)NC(C)(C)C(=O)N2CCNCC2)cc1 |r| Show InChI InChI=1S/C31H47N5O8/c1-18(2)24-21(28(35-34-24)44-29-27(41)26(40)25(39)22(17-37)43-29)16-20-10-8-19(9-11-20)6-5-7-23(38)33-31(3,4)30(42)36-14-12-32-13-15-36/h8-11,18,22,25-27,29,32,37,39-41H,5-7,12-17H2,1-4H3,(H,33,38)(H,34,35)/t22-,25+,26+,27-,29+/m1/s1 | PDB
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| n/a | n/a | 4.28E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company
Curated by ChEMBL
| Assay Description
Inhibition of rat SGLT2 |
Bioorg Med Chem 21: 748-65 (2013)
Article DOI: 10.1016/j.bmc.2012.11.041
BindingDB Entry DOI: 10.7270/Q2445NS9 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Rattus norvegicus) | BDBM50394533
(CHEMBL2159101)Show SMILES CC(C)c1n[nH]c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1Cc1ccc(O)cc1C |r| Show InChI InChI=1S/C20H28N2O7/c1-9(2)15-13(7-11-4-5-12(24)6-10(11)3)19(22-21-15)29-20-18(27)17(26)16(25)14(8-23)28-20/h4-6,9,14,16-18,20,23-27H,7-8H2,1-3H3,(H,21,22)/t14-,16-,17+,18-,20+/m1/s1 | PDB
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| n/a | n/a | 4.37E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company
Curated by ChEMBL
| Assay Description
Inhibition of rat SGLT2 |
Bioorg Med Chem 21: 748-65 (2013)
Article DOI: 10.1016/j.bmc.2012.11.041
BindingDB Entry DOI: 10.7270/Q2445NS9 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Rattus norvegicus) | BDBM50394533
(CHEMBL2159101)Show SMILES CC(C)c1n[nH]c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1Cc1ccc(O)cc1C |r| Show InChI InChI=1S/C20H28N2O7/c1-9(2)15-13(7-11-4-5-12(24)6-10(11)3)19(22-21-15)29-20-18(27)17(26)16(25)14(8-23)28-20/h4-6,9,14,16-18,20,23-27H,7-8H2,1-3H3,(H,21,22)/t14-,16-,17+,18-,20+/m1/s1 | PDB
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| n/a | n/a | 4.37E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company
Curated by ChEMBL
| Assay Description
Inhibition of rat SGLT2 expressed in COS7 cells assessed as reduction of [14C]-AMG uptake |
Bioorg Med Chem 20: 6598-612 (2012)
Article DOI: 10.1016/j.bmc.2012.09.037
BindingDB Entry DOI: 10.7270/Q26D5V36 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Rattus norvegicus) | BDBM50394534
(CHEMBL2159102)Show SMILES CC(C)c1n[nH]c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1Cc1ccc(C)cc1C |r| Show InChI InChI=1S/C21H30N2O6/c1-10(2)16-14(8-13-6-5-11(3)7-12(13)4)20(23-22-16)29-21-19(27)18(26)17(25)15(9-24)28-21/h5-7,10,15,17-19,21,24-27H,8-9H2,1-4H3,(H,22,23)/t15-,17-,18+,19-,21+/m1/s1 | PDB
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| n/a | n/a | 4.65E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company
Curated by ChEMBL
| Assay Description
Inhibition of rat SGLT2 expressed in COS7 cells assessed as reduction of [14C]-AMG uptake |
Bioorg Med Chem 20: 6598-612 (2012)
Article DOI: 10.1016/j.bmc.2012.09.037
BindingDB Entry DOI: 10.7270/Q26D5V36 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Rattus norvegicus) | BDBM50394532
(CHEMBL2159094)Show SMILES OC[C@H]1O[C@@H](Oc2[nH]nc(c2Cc2ccccc2OCc2ccccc2)C(F)(F)F)[C@H](O)[C@@H](O)[C@@H]1O |r| Show InChI InChI=1S/C24H25F3N2O7/c25-24(26,27)21-15(10-14-8-4-5-9-16(14)34-12-13-6-2-1-3-7-13)22(29-28-21)36-23-20(33)19(32)18(31)17(11-30)35-23/h1-9,17-20,23,30-33H,10-12H2,(H,28,29)/t17-,18-,19+,20-,23+/m1/s1 | PDB
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| n/a | n/a | 4.08E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company
Curated by ChEMBL
| Assay Description
Inhibition of rat SGLT2 expressed in COS7 cells assessed as reduction of [14C]-AMG uptake |
Bioorg Med Chem 20: 6598-612 (2012)
Article DOI: 10.1016/j.bmc.2012.09.037
BindingDB Entry DOI: 10.7270/Q26D5V36 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Rattus norvegicus) | BDBM50394531
(CHEMBL2159091)Show SMILES CC(C)c1n[nH]c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1Cc1ccccc1OCc1ccccc1 |r| Show InChI InChI=1S/C26H32N2O7/c1-15(2)21-18(12-17-10-6-7-11-19(17)33-14-16-8-4-3-5-9-16)25(28-27-21)35-26-24(32)23(31)22(30)20(13-29)34-26/h3-11,15,20,22-24,26,29-32H,12-14H2,1-2H3,(H,27,28)/t20-,22-,23+,24-,26+/m1/s1 | PDB
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| n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company
Curated by ChEMBL
| Assay Description
Inhibition of rat SGLT2 expressed in COS7 cells assessed as reduction of [14C]-AMG uptake |
Bioorg Med Chem 20: 6598-612 (2012)
Article DOI: 10.1016/j.bmc.2012.09.037
BindingDB Entry DOI: 10.7270/Q26D5V36 |
More data for this
Ligand-Target Pair | |
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