Found 18 hits of ic50 for UniProtKB: P51787 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Potassium voltage-gated channel subfamily KQT member 1
(Homo sapiens (Human)) | BDBM50371391
(SENICAPOC)Show InChI InChI=1S/C20H15F2NO/c21-17-10-6-15(7-11-17)20(19(23)24,14-4-2-1-3-5-14)16-8-12-18(22)13-9-16/h1-13H,(H2,23,24) | PDB
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| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of voltage-gated K channel 7.1 (unknown origin) |
J Med Chem 56: 593-624 (2013)
Article DOI: 10.1021/jm3011433
BindingDB Entry DOI: 10.7270/Q23B61GZ |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 1
(Homo sapiens (Human)) | BDBM50254401
(CHEMBL4093377)Show InChI InChI=1S/C13H8ClF3N4/c14-11-4-2-8(6-18-11)19-12-9-3-1-7(13(15,16)17)5-10(9)20-21-12/h1-6H,(H2,19,20,21) | PDB
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| n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Worldwide Medicinal Chemistry, Neuroscience and Pain Research Unit, Portway Building, Granta Park, Great Abington, Cambridgeshire CB21 6GS, U.K.
Curated by ChEMBL
| Assay Description
Inhibition of KCNQ1 (unknown origin) |
ACS Med Chem Lett 8: 666-671 (2017)
Article DOI: 10.1021/acsmedchemlett.7b00140
BindingDB Entry DOI: 10.7270/Q2C24ZWG |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 1
(Homo sapiens (Human)) | BDBM50254387
(CHEMBL4062193)Show InChI InChI=1S/C13H7F5N4O/c14-8-2-1-6(3-9(8)15)20-12-11-10(21-22-12)4-7(5-19-11)23-13(16,17)18/h1-5H,(H2,20,21,22) | PDB
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| n/a | n/a | 2.64E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Worldwide Medicinal Chemistry, Neuroscience and Pain Research Unit, Portway Building, Granta Park, Great Abington, Cambridgeshire CB21 6GS, U.K.
Curated by ChEMBL
| Assay Description
Inhibition of KCNQ1 (unknown origin) |
ACS Med Chem Lett 8: 666-671 (2017)
Article DOI: 10.1021/acsmedchemlett.7b00140
BindingDB Entry DOI: 10.7270/Q2C24ZWG |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 1
(Homo sapiens (Human)) | BDBM50395464
(CHEMBL2164048)Show InChI InChI=1S/C20H24N2O/c1-2-17(16-10-4-3-5-11-16)20(23)21-18-12-6-7-13-19(18)22-14-8-9-15-22/h3-7,10-13,17H,2,8-9,14-15H2,1H3,(H,21,23)/t17-/m0/s1 | PDB
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| n/a | n/a | 2.92E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center
Curated by ChEMBL
| Assay Description
Antagonist activity at KCNQ1 expressed in CHO cells incubated for 3 mins by automated patch clamp assay |
J Med Chem 55: 6975-9 (2012)
Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 1
(Homo sapiens (Human)) | BDBM50254388
(CHEMBL4101680)Show InChI InChI=1S/C15H8F3N3O/c16-15(17,18)22-11-5-6-12-13(7-11)20-21-14(12)10-3-1-9(8-19)2-4-10/h1-7H,(H,20,21) | PDB
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Pfizer Worldwide Medicinal Chemistry, Neuroscience and Pain Research Unit, Portway Building, Granta Park, Great Abington, Cambridgeshire CB21 6GS, U.K.
Curated by ChEMBL
| Assay Description
Inhibition of KCNQ1 (unknown origin) |
ACS Med Chem Lett 8: 666-671 (2017)
Article DOI: 10.1021/acsmedchemlett.7b00140
BindingDB Entry DOI: 10.7270/Q2C24ZWG |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 1
(Homo sapiens (Human)) | BDBM328993
(5-[[4-[[(2R)-morpholin-2-yl]methylamino]-5-(triflu...)Show SMILES FC(F)(F)c1cnc(Nc2cnc(cn2)C#N)cc1NC[C@H]1CNCCO1 |r| Show InChI InChI=1S/C16H16F3N7O/c17-16(18,19)12-8-25-14(26-15-9-22-10(4-20)5-24-15)3-13(12)23-7-11-6-21-1-2-27-11/h3,5,8-9,11,21H,1-2,6-7H2,(H2,23,24,25,26)/t11-/m1/s1 | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human KCNQ1 |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.5b01938
BindingDB Entry DOI: 10.7270/Q2MG7T5V |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 1
(Homo sapiens (Human)) | BDBM50557680
(CHEMBL4741793)Show SMILES C[C@H](NC(=O)c1cc(nn1C)C(F)(F)F)c1nc(no1)-c1ccnc(c1)C(F)(F)F |r| | PDB
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| n/a | n/a | 1.85E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of Iks (unknown origin) by patch clamp analysis |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00675
BindingDB Entry DOI: 10.7270/Q2QF8XJ0 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 1
(Homo sapiens (Human)) | BDBM50507839
(PF-6305591 | Pf-06305591)Show SMILES C[C@H]([C@H](N)c1nc2ccc(cc2[nH]1)C(C)(C)C)C(N)=O Show InChI InChI=1S/C15H22N4O/c1-8(13(17)20)12(16)14-18-10-6-5-9(15(2,3)4)7-11(10)19-14/h5-8,12H,16H2,1-4H3,(H2,17,20)(H,18,19)/t8-,12+/m1/s1 | PDB
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Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of KvLQT1 (unknown origin) |
Bioorg Med Chem 27: 230-239 (2019)
Article DOI: 10.1016/j.bmc.2018.12.002
BindingDB Entry DOI: 10.7270/Q2ZK5KZN |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 1
(Homo sapiens (Human)) | BDBM50524101
(CHEMBL4474619)Show SMILES Cc1cc(n[nH]1)-c1ccc(cc1)C(=O)[C@@H]1CCCC[C@H]1C(=O)Nc1cnn(C)c1S(N)(=O)=O |r| Show InChI InChI=1S/C22H26N6O4S/c1-13-11-18(27-26-13)14-7-9-15(10-8-14)20(29)16-5-3-4-6-17(16)21(30)25-19-12-24-28(2)22(19)33(23,31)32/h7-12,16-17H,3-6H2,1-2H3,(H,25,30)(H,26,27)(H2,23,31,32)/t16-,17-/m1/s1 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Inhibition of human Kv7.1 by Ion-work electrophysiology assay |
J Med Chem 62: 4312-4324 (2019)
Article DOI: 10.1021/acs.jmedchem.8b02004
BindingDB Entry DOI: 10.7270/Q25T3PXZ |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 1
(Homo sapiens (Human)) | BDBM50524102
(CHEMBL4542281)Show SMILES Cc1cc(n[nH]1)-c1ccc(cc1)C(=O)[C@@H]1CCCC[C@H]1C(=O)Nc1cnn2CCNC(=O)c12 |r| Show InChI InChI=1S/C24H26N6O3/c1-14-12-19(29-28-14)15-6-8-16(9-7-15)22(31)17-4-2-3-5-18(17)23(32)27-20-13-26-30-11-10-25-24(33)21(20)30/h6-9,12-13,17-18H,2-5,10-11H2,1H3,(H,25,33)(H,27,32)(H,28,29)/t17-,18-/m1/s1 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Inhibition of human Kv7.1 by Ion-work electrophysiology assay |
J Med Chem 62: 4312-4324 (2019)
Article DOI: 10.1021/acs.jmedchem.8b02004
BindingDB Entry DOI: 10.7270/Q25T3PXZ |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 1
(Homo sapiens (Human)) | BDBM50524103
(CHEMBL4563459)Show SMILES Cc1cc([nH]n1)-c1ccc(cc1)C(=O)[C@@H]1CCCC[C@H]1C(=O)Nc1cnn(C)c1C(=O)NOC(C)(C)C |r| Show InChI InChI=1S/C27H34N6O4/c1-16-14-21(31-30-16)17-10-12-18(13-11-17)24(34)19-8-6-7-9-20(19)25(35)29-22-15-28-33(5)23(22)26(36)32-37-27(2,3)4/h10-15,19-20H,6-9H2,1-5H3,(H,29,35)(H,30,31)(H,32,36)/t19-,20-/m1/s1 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Inhibition of human Kv7.1 by Ion-work electrophysiology assay |
J Med Chem 62: 4312-4324 (2019)
Article DOI: 10.1021/acs.jmedchem.8b02004
BindingDB Entry DOI: 10.7270/Q25T3PXZ |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 1
(Homo sapiens (Human)) | BDBM50613992
(CHEMBL5282689) | PDB
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TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 1
(Homo sapiens (Human)) | BDBM50395399
(CHEMBL2165063)Show SMILES COc1ccc2ncc(=O)n(CCN3CCC(CC3)NCc3ccc4OCC(=O)Nc4n3)c2c1 Show InChI InChI=1S/C24H28N6O4/c1-33-18-3-4-19-20(12-18)30(23(32)14-26-19)11-10-29-8-6-16(7-9-29)25-13-17-2-5-21-24(27-17)28-22(31)15-34-21/h2-5,12,14,16,25H,6-11,13,15H2,1H3,(H,27,28,31) | PDB
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| n/a | n/a | 3.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of potassium channel IKs (unknown origin) |
Bioorg Med Chem 22: 5392-409 (2014)
Article DOI: 10.1016/j.bmc.2014.07.040
BindingDB Entry DOI: 10.7270/Q2VQ3480 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 1
(Homo sapiens (Human)) | BDBM585680
(US11530213, Example 1)Show SMILES OC[C@H](O)COc1ncc(Cl)c2n(c(CO)cc(=O)c12)-c1c(Cl)cccc1Cl |r,wU:2.2,(-4.27,-7.27,;-4.67,-5.78,;-3.33,-5.01,;-2.25,-6.1,;-3.33,-3.47,;-2,-2.7,;-2,-1.16,;-3.33,-.39,;-3.33,1.15,;-2,1.92,;-2,3.46,;-.67,1.15,;.67,1.92,;2,1.15,;3.33,1.92,;4.67,1.15,;2,-.39,;.67,-1.16,;.67,-2.7,;-.67,-.39,;.67,4.19,;-.67,4.96,;-2,4.19,;-.67,6.5,;.67,7.27,;2,6.5,;2,4.96,;3.33,4.19,)| | PDB
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TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 1
(Homo sapiens (Human)) | BDBM50613993
(CHEMBL5286246) | PDB
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TBA
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Citation and Details
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More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 1
(Homo sapiens (Human)) | BDBM585681
((R)-8-chloro-1-(2,6- dichlorophenyl)-5-(2,3- dihyd...)Show SMILES OC[C@@H](O)COc1ncc(Cl)c2n(c(CO)cc(=O)c12)-c1c(Cl)cccc1Cl |r,wD:2.2,(-3.78,-7.53,;-4.55,-6.2,;-3.46,-5.11,;-2.12,-5.88,;-3.46,-3.57,;-2.12,-2.8,;-2.12,-1.26,;-3.46,-.49,;-3.46,1.05,;-2.12,1.82,;-2.12,3.36,;-.79,1.05,;.54,1.82,;1.88,1.05,;3.21,1.82,;4.55,1.05,;1.88,-.49,;.54,-1.26,;.54,-2.8,;-.79,-.49,;.54,4.45,;-.79,5.22,;-2.12,4.45,;-.79,6.76,;.54,7.53,;1.88,6.76,;1.88,5.22,;3.21,4.45,)| | PDB
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TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 1
(Homo sapiens (Human)) | BDBM50023582
(CHEMBL3355575)Show SMILES [H][C@@]1(CC[C@@H](CC1)NCc1ccc2OCC(=O)Nc2n1)[C@@H](N)Cn1c2cc(OC)cnc2ccc1=O |r,wU:20.23,wD:4.7,1.0,(9.66,-8.53,;8.34,-7.77,;7,-7.01,;7,-5.46,;8.33,-4.69,;9.67,-5.46,;9.67,-6.99,;8.33,-3.15,;9.66,-2.38,;11,-3.14,;10.99,-4.69,;12.32,-5.46,;13.65,-4.69,;14.99,-5.46,;16.33,-4.68,;16.33,-3.13,;17.66,-2.36,;14.98,-2.36,;13.65,-3.14,;12.31,-2.38,;8.35,-9.3,;9.68,-10.07,;7.02,-10.08,;7.03,-11.62,;5.69,-12.41,;4.36,-11.64,;3.03,-12.41,;1.7,-11.65,;.36,-12.42,;3.03,-13.96,;4.36,-14.73,;5.7,-13.96,;7.04,-14.73,;8.38,-13.95,;8.38,-12.4,;9.71,-11.62,)| Show InChI InChI=1S/C25H30N6O4/c1-34-18-10-21-20(28-12-18)7-9-24(33)31(21)13-19(26)15-2-4-16(5-3-15)27-11-17-6-8-22-25(29-17)30-23(32)14-35-22/h6-10,12,15-16,19,27H,2-5,11,13-14,26H2,1H3,(H,29,30,32)/t15-,16-,19-/m0/s1 | PDB
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AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of potassium channel IKs (unknown origin) |
Bioorg Med Chem 22: 5392-409 (2014)
Article DOI: 10.1016/j.bmc.2014.07.040
BindingDB Entry DOI: 10.7270/Q2VQ3480 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 1
(Homo sapiens (Human)) | BDBM50023589
(CHEMBL3355573)Show SMILES [H][C@@]1(CC[C@@H](CC1)NCc1ncc2OCC(=O)Nc2n1)[C@@H](N)Cn1c2cc(F)ccc2ncc1=O |r,wU:20.23,wD:4.7,1.0,(25.26,-46.78,;23.93,-46.02,;22.6,-45.26,;22.59,-43.72,;23.93,-42.94,;25.26,-43.71,;25.27,-45.24,;23.92,-41.4,;25.26,-40.63,;26.59,-41.4,;26.58,-42.95,;27.92,-43.71,;29.25,-42.94,;30.58,-43.71,;31.92,-42.94,;31.92,-41.39,;33.25,-40.62,;30.58,-40.61,;29.24,-41.39,;27.91,-40.63,;23.94,-47.56,;25.28,-48.32,;22.61,-48.34,;22.62,-49.88,;21.29,-50.66,;19.95,-49.9,;18.62,-50.67,;17.29,-49.9,;18.62,-52.21,;19.96,-52.98,;21.29,-52.22,;22.63,-52.99,;23.98,-52.21,;23.97,-50.65,;25.3,-49.88,)| Show InChI InChI=1S/C23H26FN7O3/c24-14-3-6-17-18(7-14)31(22(33)10-27-17)11-16(25)13-1-4-15(5-2-13)26-9-20-28-8-19-23(29-20)30-21(32)12-34-19/h3,6-8,10,13,15-16,26H,1-2,4-5,9,11-12,25H2,(H,28,29,30,32)/t13-,15-,16-/m0/s1 | PDB
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AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of potassium channel IKs (unknown origin) |
Bioorg Med Chem 22: 5392-409 (2014)
Article DOI: 10.1016/j.bmc.2014.07.040
BindingDB Entry DOI: 10.7270/Q2VQ3480 |
More data for this
Ligand-Target Pair | |
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