Compile Data Set for Download or QSAR

Found 7 hits of ec50 for UniProtKB: Q64725   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Rattus norvegicus)	BDBM50132451 (3-((5-methoxy-1-methyl-1H-indol-3-yl)methylene)-N-...) Show SMILES CNC(=O)c1ccc2NC(=O)\C(=C/c3cn(C)c4ccc(OC)cc34)c2c1 Show InChI InChI=1S/C21H19N3O3/c1-22-20(25)12-4-6-18-16(8-12)17(21(26)23-18)9-13-11-24(2)19-7-5-14(27-3)10-15(13)19/h4-11H,1-3H3,(H,22,25)(H,23,26)/b17-9-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a
Rigel, Inc. Curated by ChEMBL					Assay Description Inhibition of SYK in rat RBL2H3 cells assessed as reduction in DNP-BSA-stimulated Fcepsilon receptor 1-mediated 5-HT release				J Med Chem 55: 3614-43 (2012) Article DOI: 10.1021/jm201271b BindingDB Entry DOI: 10.7270/Q2NZ88RC
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Rattus norvegicus)	BDBM50132433 (3-[1-(5-Methoxy-1-methyl-1H-indol-3-yl)-meth-(Z)-y...) Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3cn(C)c4ccc(OC)cc34)c2c1 Show InChI InChI=1S/C20H19N3O4S/c1-21-28(25,26)14-5-6-18-16(10-14)17(20(24)22-18)8-12-11-23(2)19-7-4-13(27-3)9-15(12)19/h4-11,21H,1-3H3,(H,22,24)/b17-8-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	110	n/a	n/a	n/a	n/a
Rigel, Inc. Curated by ChEMBL					Assay Description Inhibition of SYK in rat RBL2H3 cells assessed as reduction in DNP-BSA-stimulated Fcepsilon receptor 1-mediated 5-HT release				J Med Chem 55: 3614-43 (2012) Article DOI: 10.1021/jm201271b BindingDB Entry DOI: 10.7270/Q2NZ88RC
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Rattus norvegicus)	BDBM50132436 (3-((1-methyl-1H-indol-3-yl)methylene)-2-oxoindolin...) Show SMILES Cn1cc(\C=C2/C(=O)Nc3ccc(cc23)S(N)(=O)=O)c2ccccc12 Show InChI InChI=1S/C18H15N3O3S/c1-21-10-11(13-4-2-3-5-17(13)21)8-15-14-9-12(25(19,23)24)6-7-16(14)20-18(15)22/h2-10H,1H3,(H,20,22)(H2,19,23,24)/b15-8-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	313	n/a	n/a	n/a	n/a
Rigel, Inc. Curated by ChEMBL					Assay Description Inhibition of SYK in rat RBL2H3 cells assessed as reduction in DNP-BSA-stimulated Fcepsilon receptor 1-mediated 5-HT release				J Med Chem 55: 3614-43 (2012) Article DOI: 10.1021/jm201271b BindingDB Entry DOI: 10.7270/Q2NZ88RC
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Rattus norvegicus)	BDBM50015448 (CHEMBL3265032) Show SMILES C1CN(CCO1)c1ccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)cc1 Show InChI InChI=1S/C23H21N7O/c1-2-17-14-25-28-20(17)13-16(1)21-15-30-8-7-24-23(30)22(27-21)26-18-3-5-19(6-4-18)29-9-11-31-12-10-29/h1-8,13-15H,9-12H2,(H,25,28)(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. Curated by ChEMBL					Assay Description In vitro inhibition of Syk phosphorylation in rat whole blood				J Med Chem 57: 3856-73 (2014) Article DOI: 10.1021/jm500228a BindingDB Entry DOI: 10.7270/Q2B27WV1
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase SYK (Rattus norvegicus)	BDBM50132435 (3-((5-methoxy-1-methyl-1H-indol-3-yl)methylene)-2-...) Show SMILES COc1ccc2n(C)cc(\C=C3/C(=O)Nc4ccc(cc34)C(O)=O)c2c1 Show InChI InChI=1S/C20H16N2O4/c1-22-10-12(14-9-13(26-2)4-6-18(14)22)8-16-15-7-11(20(24)25)3-5-17(15)21-19(16)23/h3-10H,1-2H3,(H,21,23)(H,24,25)/b16-8-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a
Rigel, Inc. Curated by ChEMBL					Assay Description Inhibition of SYK in rat RBL2H3 cells assessed as reduction in DNP-BSA-stimulated Fcepsilon receptor 1-mediated 5-HT release				J Med Chem 55: 3614-43 (2012) Article DOI: 10.1021/jm201271b BindingDB Entry DOI: 10.7270/Q2NZ88RC
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Rattus norvegicus)	BDBM50132443 (4-{5-Methoxy-3-[2-oxo-5-sulfamoyl-1,2-dihydro-indo...) Show SMILES COc1ccc2n(CCCC(N)=O)cc(\C=C3/C(=O)Nc4ccc(cc34)S(N)(=O)=O)c2c1 Show InChI InChI=1S/C22H22N4O5S/c1-31-14-4-7-20-16(10-14)13(12-26(20)8-2-3-21(23)27)9-18-17-11-15(32(24,29)30)5-6-19(17)25-22(18)28/h4-7,9-12H,2-3,8H2,1H3,(H2,23,27)(H,25,28)(H2,24,29,30)/b18-9-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Rigel, Inc. Curated by ChEMBL					Assay Description Inhibition of SYK in rat RBL2H3 cells assessed as reduction in DNP-BSA-stimulated Fcepsilon receptor 1-mediated 5-HT release				J Med Chem 55: 3614-43 (2012) Article DOI: 10.1021/jm201271b BindingDB Entry DOI: 10.7270/Q2NZ88RC
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Rattus norvegicus)	BDBM50132437 (3-((1-(3-hydroxypropyl)-5-methoxy-1H-indol-3-yl)me...) Show SMILES COc1ccc2n(CCCO)cc(\C=C3/C(=O)Nc4ccc(cc34)S(N)(=O)=O)c2c1 Show InChI InChI=1S/C21H21N3O5S/c1-29-14-3-6-20-16(10-14)13(12-24(20)7-2-8-25)9-18-17-11-15(30(22,27)28)4-5-19(17)23-21(18)26/h3-6,9-12,25H,2,7-8H2,1H3,(H,23,26)(H2,22,27,28)/b18-9-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Rigel, Inc. Curated by ChEMBL					Assay Description Inhibition of SYK in rat RBL2H3 cells assessed as reduction in DNP-BSA-stimulated Fcepsilon receptor 1-mediated 5-HT release				J Med Chem 55: 3614-43 (2012) Article DOI: 10.1021/jm201271b BindingDB Entry DOI: 10.7270/Q2NZ88RC
					More data for this Ligand-Target Pair