Found 23 hits of ic50 for UniProtKB: P49763 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Placenta growth factor
(Homo sapiens (Human)) | BDBM50339212
(CHEMBL1689483)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)C(C)(C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)NC1=O)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@@H](CCCCNC(C)=O)C(=O)NC(C)(C)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(C)=O)C(C)C |r| Show InChI InChI=1S/C116H168N28O32S2/c1-18-62(6)94-110(171)128-76(28-23-25-44-121-87(149)54-176-55-88(150)127-72-35-30-69(31-36-72)34-40-89(151)144-45-42-90(144)152)99(160)131-78(46-60(2)3)107(168)142-116(15,16)114(175)137-81(50-74-53-119-59-123-74)102(163)135-85(105(166)140-95(66(10)145)111(172)129-77(29-22-24-43-120-67(11)146)106(167)141-115(13,14)113(117)174)57-178-177-56-84(104(165)133-80(49-73-52-118-58-122-73)101(162)132-79(103(164)139-94)47-71-32-37-75(148)38-33-71)136-109(170)93(61(4)5)138-108(169)86(39-41-91(153)154)143(17)112(173)83(48-70-26-20-19-21-27-70)134-98(159)65(9)125-96(157)64(8)126-100(161)82(51-92(155)156)130-97(158)63(7)124-68(12)147/h19-21,26-27,30-33,35-38,52-53,58-66,76-86,93-95,145,148H,18,22-25,28-29,34,39-51,54-57H2,1-17H3,(H2,117,174)(H,118,122)(H,119,123)(H,120,146)(H,121,149)(H,124,147)(H,125,157)(H,126,161)(H,127,150)(H,128,171)(H,129,172)(H,130,158)(H,131,160)(H,132,162)(H,133,165)(H,134,159)(H,135,163)(H,136,170)(H,137,175)(H,138,169)(H,139,164)(H,140,166)(H,141,167)(H,142,168)(H,153,154)(H,155,156)/t62-,63-,64-,65-,66+,76-,77-,78-,79-,80-,81?,82-,83-,84-,85-,86-,93-,94-,95+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PlGF-1-VEGFR-1 interaction by ELISA |
J Med Chem 54: 1256-65 (2011)
Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1 |
More data for this
Ligand-Target Pair | |
Placenta growth factor
(Homo sapiens (Human)) | BDBM50339210
(CHEMBL1689481)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)NC1=O)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(C)C |r,wU:39.41,4.3,64.68,49.56,2.2,145.161,161.170,106.112,132.140,20.21,8.8,wD:56.60,100.108,117.123,156.165,99.105,136.149,35.102,30.136,166.179,(33.81,-1.12,;32.48,-1.89,;31.15,-1.12,;31.14,.41,;29.82,-1.9,;25.88,-4.17,;24.55,-3.39,;23.21,-4.14,;24.57,-1.86,;25.89,-1.11,;25.92,.43,;27.25,1.17,;27.26,2.71,;25.95,3.49,;25.97,5.03,;24.61,2.74,;24.59,1.21,;23.24,-1.06,;21.91,-1.82,;21.89,-3.36,;20.57,-1.03,;20.59,.5,;19.27,1.29,;19.13,2.81,;17.63,3.15,;16.84,1.83,;17.85,.68,;19.23,-1.81,;19.29,-3.29,;20.64,-4.03,;17.93,-4.05,;17.92,-5.6,;19.26,-6.41,;19.25,-7.97,;20.56,-8.79,;20.56,-10.33,;21.88,-11.11,;21.88,-12.65,;20.55,-13.41,;23.2,-13.41,;23.19,-14.96,;21.85,-15.72,;20.45,-15.09,;19.42,-16.23,;20.19,-17.57,;21.7,-17.25,;24.54,-12.66,;25.85,-13.43,;25.84,-14.96,;27.2,-12.66,;28.65,-13.14,;29.56,-11.91,;28.66,-10.66,;27.2,-11.13,;25.86,-10.38,;24.54,-11.14,;25.86,-8.84,;24.53,-8.08,;23.2,-8.85,;21.86,-8.09,;23.2,-10.39,;27.19,-8.06,;27.18,-6.53,;25.84,-5.77,;28.51,-5.75,;29.84,-6.52,;29.83,-8.06,;31.15,-8.83,;31.15,-10.39,;32.49,-11.17,;33.85,-10.39,;33.85,-8.84,;35.19,-11.18,;36.54,-10.4,;37.88,-11.18,;39.24,-10.41,;39.24,-8.85,;40.58,-11.19,;41.93,-10.41,;43.27,-11.2,;44.62,-10.43,;44.63,-8.87,;45.98,-8.09,;47.32,-8.87,;48.67,-8.1,;48.67,-6.54,;50.02,-8.88,;50.41,-10.38,;51.92,-9.97,;51.52,-8.47,;52.3,-7.13,;43.27,-8.09,;41.93,-8.87,;28.54,-4.2,;29.83,-3.45,;31.16,-4.2,;19.22,-11.1,;19.22,-12.63,;17.9,-10.34,;16.57,-11.1,;16.57,-12.63,;15.24,-13.41,;17.9,-13.4,;15.24,-10.32,;15.24,-8.79,;13.9,-11.1,;12.57,-10.32,;12.56,-8.79,;11.22,-8.02,;9.9,-8.79,;8.57,-8.03,;7.24,-8.8,;5.92,-8.03,;7.24,-10.33,;11.22,-11.1,;9.9,-10.34,;11.23,-12.63,;9.92,-13.4,;9.92,-14.96,;8.58,-15.74,;7.23,-14.97,;5.89,-15.75,;5.89,-17.31,;4.55,-18.09,;7.25,-18.08,;8.59,-17.29,;8.58,-12.64,;7.24,-13.42,;8.58,-11.11,;16.61,-3.28,;15.27,-4.03,;15.27,-5.57,;13.93,-3.28,;12.58,-4.05,;11.27,-3.29,;11.27,-1.76,;9.92,-4.07,;9.94,-5.6,;8.61,-6.38,;7.27,-5.63,;5.97,-6.41,;7.26,-4.1,;8.62,-3.3,;8.62,-1.77,;9.95,-1,;7.29,-.99,;7.3,.54,;8.64,1.3,;9.96,.53,;11.29,1.29,;11.31,2.83,;9.97,3.6,;8.64,2.83,;5.96,-1.75,;4.63,-.98,;4.63,.57,;3.29,-1.75,;3.29,-3.3,;1.95,-.98,;.62,-1.75,;.62,-3.3,;-.72,-.98,;-.72,.57,;-2.05,-1.75,;-3.39,-.98,;-3.39,.57,;-4.73,-1.75,;-4.73,-3.3,;-3.39,-4.07,;-2.05,-3.3,;-3.39,-5.62,;-6.07,-.98,;-7.4,-1.76,;-8.73,-.99,;-7.4,-3.3,;13.92,-1.75,;12.58,-.97,;15.25,-.97,)| Show InChI InChI=1S/C116H161N29O31S2/c1-11-62(6)96-113(173)131-76(21-15-16-41-122-89(150)54-176-55-90(151)129-71-31-24-67(25-32-71)30-38-91(152)145-44-40-92(145)153)102(162)138-85(45-60(2)3)115(175)144-43-18-23-88(144)111(171)137-83(50-73-53-121-59-125-73)107(167)139-87(110(170)143-97(65(9)146)114(174)132-77(22-17-42-123-116(118)119)101(161)133-79(98(117)158)46-69-26-33-74(148)34-27-69)57-178-177-56-86(109(169)136-82(49-72-52-120-58-124-72)106(166)135-81(108(168)142-96)48-70-28-35-75(149)36-29-70)140-112(172)95(61(4)5)141-103(163)78(37-39-93(154)155)130-105(165)80(47-68-19-13-12-14-20-68)134-100(160)64(8)126-99(159)63(7)127-104(164)84(51-94(156)157)128-66(10)147/h12-14,19-20,24-29,31-36,52-53,58-65,76-88,95-97,146,148-149H,11,15-18,21-23,30,37-51,54-57H2,1-10H3,(H2,117,158)(H,120,124)(H,121,125)(H,122,150)(H,126,159)(H,127,164)(H,128,147)(H,129,151)(H,130,165)(H,131,173)(H,132,174)(H,133,161)(H,134,160)(H,135,166)(H,136,169)(H,137,171)(H,138,162)(H,139,167)(H,140,172)(H,141,163)(H,142,168)(H,143,170)(H,154,155)(H,156,157)(H4,118,119,123)/t62-,63-,64-,65+,76-,77+,78-,79+,80-,81-,82-,83-,84-,85-,86-,87-,88-,95-,96-,97+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PlGF-1-VEGFR-1 interaction by ELISA |
J Med Chem 54: 1256-65 (2011)
Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1 |
More data for this
Ligand-Target Pair | |
Placenta growth factor
(Homo sapiens (Human)) | BDBM50339191
(CHEMBL1689460)Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NC(=O)COCC(=O)Nc1ccc(CCC(=O)N2CCC2=O)cc1 |r| Show InChI InChI=1S/C107H157N25O25S3/c1-58(2)46-79-107(156)131-43-23-31-82(131)102(151)122-77(49-68-52-111-57-113-68)97(146)124-80(100(149)118-73(30-19-22-42-110)95(144)127-88(59(3)4)103(152)119-74(39-45-158-11)93(142)116-72(29-18-21-41-109)94(143)126-84(136)54-157-53-83(135)115-67-35-32-64(33-36-67)34-37-85(137)132-44-38-86(132)138)55-159-160-56-81(125-104(153)89(60(5)6)128-99(148)78(50-87(139)140)121-96(145)75(114-63(10)134)47-65-24-13-12-14-25-65)101(150)117-71(28-17-20-40-108)92(141)120-76(48-66-51-112-70-27-16-15-26-69(66)70)98(147)129-90(61(7)8)105(154)130-91(62(9)133)106(155)123-79/h12-16,24-27,32-33,35-36,51-52,57-62,71-82,88-91,112,133H,17-23,28-31,34,37-50,53-56,108-110H2,1-11H3,(H,111,113)(H,114,134)(H,115,135)(H,116,142)(H,117,150)(H,118,149)(H,119,152)(H,120,141)(H,121,145)(H,122,151)(H,123,155)(H,124,146)(H,125,153)(H,127,144)(H,128,148)(H,129,147)(H,130,154)(H,139,140)(H,126,136,143)/t62-,71+,72+,73+,74+,75+,76+,77+,78+,79+,80+,81+,82+,88+,89+,90+,91+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PlGF-1-VEGFR-1 interaction by ELISA |
J Med Chem 54: 1256-65 (2011)
Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1 |
More data for this
Ligand-Target Pair | |
Placenta growth factor
(Homo sapiens (Human)) | BDBM50339211
(CHEMBL1689482)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)NC1=O)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(C)=O)C(C)C |r,wU:8.8,39.41,4.3,64.68,49.56,2.2,146.162,162.171,175.184,106.112,132.140,20.21,wD:56.60,100.108,117.123,157.166,99.105,136.149,167.180,35.102,30.136,(38.18,-23.64,;36.84,-24.41,;35.51,-23.65,;35.5,-22.12,;34.18,-24.43,;30.24,-26.69,;28.91,-25.91,;27.57,-26.67,;28.93,-24.38,;30.25,-23.63,;30.28,-22.09,;31.61,-21.35,;31.63,-19.82,;30.31,-19.03,;30.33,-17.49,;28.97,-19.79,;28.96,-21.32,;27.6,-23.59,;26.28,-24.35,;26.26,-25.88,;24.93,-23.56,;24.95,-22.03,;23.63,-21.24,;23.49,-19.72,;22,-19.37,;21.21,-20.7,;22.22,-21.85,;23.6,-24.33,;23.65,-25.82,;25,-26.56,;22.29,-26.58,;22.28,-28.13,;23.62,-28.93,;23.61,-30.5,;24.92,-31.32,;24.92,-32.86,;26.24,-33.64,;26.24,-35.17,;24.91,-35.93,;27.57,-35.94,;27.56,-37.49,;26.21,-38.25,;24.82,-37.62,;23.78,-38.76,;24.55,-40.1,;26.06,-39.78,;28.91,-35.19,;30.21,-35.95,;30.21,-37.49,;31.56,-35.19,;33.01,-35.66,;33.92,-34.43,;33.02,-33.19,;31.56,-33.66,;30.22,-32.91,;28.91,-33.67,;30.22,-31.37,;28.89,-30.61,;27.56,-31.38,;26.23,-30.62,;27.57,-32.92,;31.56,-30.58,;31.54,-29.05,;30.2,-28.3,;32.87,-28.28,;34.2,-29.05,;34.19,-30.59,;35.51,-31.36,;35.51,-32.91,;36.86,-33.7,;38.21,-32.92,;38.21,-31.37,;39.56,-33.7,;40.9,-32.93,;42.25,-33.71,;43.6,-32.93,;43.6,-31.38,;44.95,-33.72,;46.29,-32.94,;47.63,-33.73,;48.99,-32.96,;48.99,-31.4,;50.34,-30.62,;51.68,-31.4,;53.03,-30.62,;53.03,-29.07,;54.38,-31.4,;54.77,-32.9,;56.28,-32.5,;55.88,-31,;56.66,-29.65,;47.63,-30.62,;46.29,-31.39,;32.9,-26.73,;34.2,-25.98,;35.52,-26.73,;23.59,-33.63,;23.59,-35.15,;22.26,-32.86,;20.93,-33.63,;20.93,-35.16,;19.6,-35.94,;22.26,-35.93,;19.6,-32.85,;19.6,-31.32,;18.26,-33.63,;16.93,-32.85,;16.93,-31.32,;15.59,-30.55,;14.27,-31.32,;12.94,-30.55,;11.6,-31.33,;10.28,-30.56,;11.61,-32.86,;15.59,-33.63,;14.26,-32.87,;15.6,-35.16,;14.28,-35.93,;14.29,-37.49,;12.94,-38.27,;11.59,-37.5,;10.25,-38.28,;10.26,-39.84,;8.91,-40.62,;11.61,-40.61,;12.95,-39.82,;12.94,-35.17,;11.61,-35.95,;12.94,-33.64,;20.97,-25.81,;19.63,-26.56,;19.63,-28.1,;18.29,-25.8,;16.95,-26.57,;15.64,-25.82,;15.63,-24.29,;14.28,-26.59,;14.3,-28.12,;12.98,-28.91,;11.63,-28.16,;10.33,-28.94,;11.62,-26.62,;12.98,-25.83,;11.48,-25.42,;12.98,-24.3,;14.32,-23.53,;11.65,-23.52,;11.66,-21.98,;13,-21.22,;14.32,-22,;15.65,-21.24,;15.67,-19.7,;14.33,-18.93,;13,-19.69,;10.32,-24.28,;8.99,-23.51,;8.99,-21.96,;7.65,-24.28,;7.65,-25.82,;6.32,-23.51,;4.98,-24.28,;4.98,-25.83,;3.64,-23.51,;3.64,-21.96,;2.31,-24.28,;.98,-23.51,;.98,-21.96,;-.37,-24.28,;-.37,-25.83,;.98,-26.6,;2.32,-25.82,;.98,-28.14,;-1.7,-23.51,;-3.04,-24.25,;-3.06,-25.8,;-4.37,-23.46,;-4.35,-21.93,;-5.71,-24.22,;-7.03,-23.44,;-8.37,-24.2,;-7.02,-21.9,;18.28,-24.27,;16.95,-23.5,;19.61,-23.5,)| Show InChI InChI=1S/C120H168N30O32S2/c1-13-64(6)99-116(178)134-79(23-17-18-43-126-92(155)56-182-57-93(156)133-74-33-26-70(27-34-74)32-40-94(157)150-46-42-95(150)158)106(168)142-86(47-62(2)3)119(181)149-45-20-25-91(149)114(176)140-84(52-76-55-125-61-129-76)109(171)143-89(112(174)147-100(68(10)151)117(179)135-80(24-19-44-127-120(122)123)105(167)136-81(101(121)163)48-72-28-35-77(153)36-29-72)59-184-183-58-88(111(173)139-83(51-75-54-124-60-128-75)108(170)138-82(110(172)146-99)49-73-30-37-78(154)38-31-73)144-115(177)98(63(4)5)145-113(175)90(39-41-96(159)160)148(12)118(180)87(50-71-21-15-14-16-22-71)141-104(166)67(9)131-102(164)66(8)132-107(169)85(53-97(161)162)137-103(165)65(7)130-69(11)152/h14-16,21-22,26-31,33-38,54-55,60-68,79-91,98-100,151,153-154H,13,17-20,23-25,32,39-53,56-59H2,1-12H3,(H2,121,163)(H,124,128)(H,125,129)(H,126,155)(H,130,152)(H,131,164)(H,132,169)(H,133,156)(H,134,178)(H,135,179)(H,136,167)(H,137,165)(H,138,170)(H,139,173)(H,140,176)(H,141,166)(H,142,168)(H,143,171)(H,144,177)(H,145,175)(H,146,172)(H,147,174)(H,159,160)(H,161,162)(H4,122,123,127)/t64-,65-,66-,67-,68+,79-,80+,81+,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,98-,99-,100+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PlGF-1-VEGFR-1 interaction by ELISA |
J Med Chem 54: 1256-65 (2011)
Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1 |
More data for this
Ligand-Target Pair | |
Placenta growth factor
(Homo sapiens (Human)) | BDBM50339193
(CHEMBL1689463)Show SMILES CSCC[C@H](NC(=O)[C@H](CCCCNC(=O)COCC(=O)Nc1ccc(CCC(=O)N2CCC2=O)cc1)NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(N)=O |r| Show InChI InChI=1S/C102H144N24O26S3/c1-54(2)41-75-102(151)125-38-20-27-78(125)98(147)118-72(44-64-48-105-53-109-64)92(141)120-76(96(145)114-69(25-16-18-36-106-58(8)128)90(139)113-68(89(138)112-67(88(104)137)35-40-153-10)26-17-19-37-107-80(131)49-152-50-81(132)111-63-31-28-60(29-32-63)30-33-82(133)126-39-34-83(126)134)51-154-155-52-77(121-99(148)85(55(3)4)122-95(144)74(46-84(135)136)117-91(140)70(110-59(9)129)42-61-21-12-11-13-22-61)97(146)116-73(45-79(103)130)93(142)115-71(43-62-47-108-66-24-15-14-23-65(62)66)94(143)123-86(56(5)6)100(149)124-87(57(7)127)101(150)119-75/h11-15,21-24,28-29,31-32,47-48,53-57,67-78,85-87,108,127H,16-20,25-27,30,33-46,49-52H2,1-10H3,(H2,103,130)(H2,104,137)(H,105,109)(H,106,128)(H,107,131)(H,110,129)(H,111,132)(H,112,138)(H,113,139)(H,114,145)(H,115,142)(H,116,146)(H,117,140)(H,118,147)(H,119,150)(H,120,141)(H,121,148)(H,122,144)(H,123,143)(H,124,149)(H,135,136)/t57-,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77+,78+,85+,86+,87+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PlGF-1-VEGFR-1 interaction by ELISA |
J Med Chem 54: 1256-65 (2011)
Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1 |
More data for this
Ligand-Target Pair | |
Placenta growth factor
(Homo sapiens (Human)) | BDBM50339191
(CHEMBL1689460)Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NC(=O)COCC(=O)Nc1ccc(CCC(=O)N2CCC2=O)cc1 |r| Show InChI InChI=1S/C107H157N25O25S3/c1-58(2)46-79-107(156)131-43-23-31-82(131)102(151)122-77(49-68-52-111-57-113-68)97(146)124-80(100(149)118-73(30-19-22-42-110)95(144)127-88(59(3)4)103(152)119-74(39-45-158-11)93(142)116-72(29-18-21-41-109)94(143)126-84(136)54-157-53-83(135)115-67-35-32-64(33-36-67)34-37-85(137)132-44-38-86(132)138)55-159-160-56-81(125-104(153)89(60(5)6)128-99(148)78(50-87(139)140)121-96(145)75(114-63(10)134)47-65-24-13-12-14-25-65)101(150)117-71(28-17-20-40-108)92(141)120-76(48-66-51-112-70-27-16-15-26-69(66)70)98(147)129-90(61(7)8)105(154)130-91(62(9)133)106(155)123-79/h12-16,24-27,32-33,35-36,51-52,57-62,71-82,88-91,112,133H,17-23,28-31,34,37-50,53-56,108-110H2,1-11H3,(H,111,113)(H,114,134)(H,115,135)(H,116,142)(H,117,150)(H,118,149)(H,119,152)(H,120,141)(H,121,145)(H,122,151)(H,123,155)(H,124,146)(H,125,153)(H,127,144)(H,128,148)(H,129,147)(H,130,154)(H,139,140)(H,126,136,143)/t62-,71+,72+,73+,74+,75+,76+,77+,78+,79+,80+,81+,82+,88+,89+,90+,91+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PlGF-2-VEGFR-1 interaction by ELISA |
J Med Chem 54: 1256-65 (2011)
Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1 |
More data for this
Ligand-Target Pair | |
Placenta growth factor
(Homo sapiens (Human)) | BDBM50339194
(CHEMBL1689456)Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(N)=O |r| Show InChI InChI=1S/C85H129N21O19S3/c1-44(2)34-62-85(125)106-32-21-28-65(106)80(120)98-60(37-52-40-89-43-91-52)75(115)100-63(78(118)95-57(27-18-20-31-87)73(113)102-67(45(3)4)81(121)93-55(71(88)111)29-33-126-11)41-127-128-42-64(101-82(122)68(46(5)6)103-77(117)61(38-66(109)110)97-74(114)58(92-49(10)108)35-50-22-13-12-14-23-50)79(119)94-56(26-17-19-30-86)72(112)96-59(36-51-39-90-54-25-16-15-24-53(51)54)76(116)104-69(47(7)8)83(123)105-70(48(9)107)84(124)99-62/h12-16,22-25,39-40,43-48,55-65,67-70,90,107H,17-21,26-38,41-42,86-87H2,1-11H3,(H2,88,111)(H,89,91)(H,92,108)(H,93,121)(H,94,119)(H,95,118)(H,96,112)(H,97,114)(H,98,120)(H,99,124)(H,100,115)(H,101,122)(H,102,113)(H,103,117)(H,104,116)(H,105,123)(H,109,110)/t48-,55+,56+,57+,58+,59+,60+,61+,62+,63+,64+,65+,67+,68+,69+,70+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PlGF-1-VEGFR-1 interaction by ELISA |
J Med Chem 54: 1256-65 (2011)
Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1 |
More data for this
Ligand-Target Pair | |
Placenta growth factor
(Homo sapiens (Human)) | BDBM50339215
(CHEMBL1689457)Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(N)=O |r| Show InChI InChI=1S/C83H123N21O20S3/c1-41(2)30-59-83(124)104-28-19-25-62(104)78(119)96-56(33-49-37-87-40-89-49)72(113)98-60(76(117)92-53(24-17-18-27-84)70(111)100-65(42(3)4)79(120)91-52(69(86)110)26-29-125-11)38-126-127-39-61(99-80(121)66(43(5)6)101-75(116)58(35-64(108)109)95-71(112)54(90-46(10)106)31-47-20-13-12-14-21-47)77(118)94-57(34-63(85)107)73(114)93-55(32-48-36-88-51-23-16-15-22-50(48)51)74(115)102-67(44(7)8)81(122)103-68(45(9)105)82(123)97-59/h12-16,20-23,36-37,40-45,52-62,65-68,88,105H,17-19,24-35,38-39,84H2,1-11H3,(H2,85,107)(H2,86,110)(H,87,89)(H,90,106)(H,91,120)(H,92,117)(H,93,114)(H,94,118)(H,95,112)(H,96,119)(H,97,123)(H,98,113)(H,99,121)(H,100,111)(H,101,116)(H,102,115)(H,103,122)(H,108,109)/t45-,52+,53+,54+,55+,56+,57+,58+,59+,60+,61+,62+,65+,66+,67+,68+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PlGF-1-VEGFR-1 interaction by ELISA |
J Med Chem 54: 1256-65 (2011)
Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1 |
More data for this
Ligand-Target Pair | |
Placenta growth factor
(Homo sapiens (Human)) | BDBM50339216
(CHEMBL1689458)Show SMILES CSCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(=O)N[C@@H](CCCC(N)=O)C(N)=O |r| Show InChI InChI=1S/C86H130N22O20S3/c1-45(2)35-63-86(128)108-33-20-28-66(108)82(124)101-61(38-52-41-91-44-93-52)77(119)103-64(80(122)96-56(25-15-17-31-87)73(115)98-58(30-34-129-9)75(117)95-55(72(90)114)27-19-29-67(89)111)42-130-131-43-65(104-83(125)69(46(3)4)105-79(121)62(39-68(112)113)100-76(118)59(94-49(8)110)36-50-21-11-10-12-22-50)81(123)97-57(26-16-18-32-88)74(116)99-60(37-51-40-92-54-24-14-13-23-53(51)54)78(120)106-70(47(5)6)84(126)107-71(48(7)109)85(127)102-63/h10-14,21-24,40-41,44-48,55-66,69-71,92,109H,15-20,25-39,42-43,87-88H2,1-9H3,(H2,89,111)(H2,90,114)(H,91,93)(H,94,110)(H,95,117)(H,96,122)(H,97,123)(H,98,115)(H,99,116)(H,100,118)(H,101,124)(H,102,127)(H,103,119)(H,104,125)(H,105,121)(H,106,120)(H,107,126)(H,112,113)/t48-,55+,56+,57+,58+,59+,60+,61+,62+,63+,64+,65+,66+,69+,70+,71+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PlGF-1-VEGFR-1 interaction by ELISA |
J Med Chem 54: 1256-65 (2011)
Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1 |
More data for this
Ligand-Target Pair | |
Placenta growth factor
(Homo sapiens (Human)) | BDBM50339217
(CHEMBL1689459)Show SMILES CSCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(=O)N[C@@H](CCCC(N)=O)C(N)=O |r| Show InChI InChI=1S/C84H124N22O21S3/c1-42(2)31-60-84(127)106-29-18-25-63(106)80(123)99-57(34-49-38-89-41-91-49)74(117)101-61(78(121)94-53(23-15-16-28-85)71(114)95-54(27-30-128-9)72(115)93-52(70(88)113)24-17-26-64(86)109)39-129-130-40-62(102-81(124)67(43(3)4)103-77(120)59(36-66(111)112)98-73(116)55(92-46(8)108)32-47-19-11-10-12-20-47)79(122)97-58(35-65(87)110)75(118)96-56(33-48-37-90-51-22-14-13-21-50(48)51)76(119)104-68(44(5)6)82(125)105-69(45(7)107)83(126)100-60/h10-14,19-22,37-38,41-45,52-63,67-69,90,107H,15-18,23-36,39-40,85H2,1-9H3,(H2,86,109)(H2,87,110)(H2,88,113)(H,89,91)(H,92,108)(H,93,115)(H,94,121)(H,95,114)(H,96,118)(H,97,122)(H,98,116)(H,99,123)(H,100,126)(H,101,117)(H,102,124)(H,103,120)(H,104,119)(H,105,125)(H,111,112)/t45-,52+,53+,54+,55+,56+,57+,58+,59+,60+,61+,62+,63+,67+,68+,69+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PlGF-1-VEGFR-1 interaction by ELISA |
J Med Chem 54: 1256-65 (2011)
Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1 |
More data for this
Ligand-Target Pair | |
Placenta growth factor
(Homo sapiens (Human)) | BDBM50339192
(CHEMBL1689461)Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(N)=O |r| Show InChI InChI=1S/C99H143N23O23S3/c1-53(2)41-72-99(144)121-38-20-27-75(121)94(139)113-70(44-62-47-103-52-105-62)89(134)115-73(92(137)110-67(26-17-19-37-101)87(132)117-81(54(3)4)95(140)108-65(85(102)130)35-40-146-10)50-147-148-51-74(93(138)109-66(25-16-18-36-100)86(131)111-69(43-60-46-104-64-24-15-14-23-63(60)64)90(135)119-83(56(7)8)97(142)120-84(57(9)123)98(143)114-72)116-96(141)82(55(5)6)118-91(136)71(45-80(128)129)112-88(133)68(42-59-21-12-11-13-22-59)107-77(125)49-145-48-76(124)106-61-31-28-58(29-32-61)30-33-78(126)122-39-34-79(122)127/h11-15,21-24,28-29,31-32,46-47,52-57,65-75,81-84,104,123H,16-20,25-27,30,33-45,48-51,100-101H2,1-10H3,(H2,102,130)(H,103,105)(H,106,124)(H,107,125)(H,108,140)(H,109,138)(H,110,137)(H,111,131)(H,112,133)(H,113,139)(H,114,143)(H,115,134)(H,116,141)(H,117,132)(H,118,136)(H,119,135)(H,120,142)(H,128,129)/t57-,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,81+,82+,83+,84+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PlGF-1-VEGFR-1 interaction by ELISA |
J Med Chem 54: 1256-65 (2011)
Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1 |
More data for this
Ligand-Target Pair | |
Placenta growth factor
(Homo sapiens (Human)) | BDBM50339226
((S)-4-((S)-1-((4R,7S,10S,13S,19S,22S,25S,28R)-7-((...)Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(N)=O |r,wU:62.63,70.71,108.111,84.87,4.4,12.19,32.32,44.52,103.106,wD:28.28,95.98,8.8,36.40,23.22,(-4.06,-50.99,;-2.73,-50.21,;-2.73,-48.67,;-1.39,-47.9,;-1.39,-46.37,;-.05,-45.59,;1.28,-46.37,;1.28,-47.9,;2.61,-45.59,;3.96,-46.37,;5.29,-45.59,;5.29,-44.05,;6.62,-46.37,;6.62,-47.9,;5.29,-48.67,;5.29,-50.21,;3.96,-50.99,;3.96,-52.53,;5.29,-53.3,;2.61,-53.3,;7.95,-45.6,;9.28,-46.37,;9.28,-47.9,;10.61,-45.59,;10.61,-44.06,;9.29,-43.24,;9.31,-41.67,;7.97,-40.87,;7.98,-39.32,;6.66,-38.55,;5.31,-39.29,;5.31,-40.84,;3.97,-38.54,;2.64,-39.31,;1.32,-38.56,;1.32,-37.02,;-.03,-39.33,;-.01,-40.86,;-1.35,-41.66,;-2.71,-40.89,;-1.33,-43.21,;-1.34,-38.57,;-1.33,-37.01,;.02,-36.24,;-2.67,-36.22,;-2.66,-34.67,;-1.31,-33.9,;.03,-34.69,;1.38,-33.92,;1.39,-32.36,;.04,-31.57,;-1.31,-32.35,;-4.02,-36.99,;-5.37,-36.21,;-6.72,-36.98,;-5.36,-34.65,;3.98,-37.01,;5.29,-36.24,;2.63,-36.24,;9.35,-38.55,;10.68,-39.3,;9.29,-37.07,;10.62,-36.3,;10.64,-34.76,;9.29,-33.98,;7.94,-34.74,;9.3,-32.43,;11.96,-37.08,;11.95,-38.62,;13.29,-36.33,;14.62,-37.12,;15.94,-36.37,;15.96,-34.83,;17.22,-33.96,;16.77,-32.49,;15.23,-32.47,;14.22,-31.32,;12.72,-31.62,;12.23,-33.08,;13.24,-34.23,;14.74,-33.93,;14.6,-38.65,;13.26,-39.41,;15.93,-39.43,;19.87,-37.17,;21.2,-36.39,;21.2,-34.86,;22.53,-37.16,;19.88,-38.71,;21.22,-39.47,;18.58,-39.47,;18.56,-41.01,;17.23,-41.79,;15.9,-41.04,;17.25,-43.33,;15.91,-44.11,;14.59,-43.34,;13.24,-44.12,;11.89,-43.34,;13.24,-45.68,;15.92,-45.65,;14.59,-46.41,;17.26,-46.4,;17.25,-47.93,;18.6,-48.71,;15.91,-48.69,;15.9,-50.23,;14.59,-47.92,;13.26,-48.67,;13.24,-50.22,;11.91,-50.99,;10.65,-50.12,;9.44,-51.05,;9.95,-52.5,;11.48,-52.46,;11.93,-47.91,;10.59,-48.67,;11.94,-46.37,;2.61,-44.04,;3.96,-43.25,;1.26,-43.26,;-2.73,-45.59,;-4.06,-46.37,;-2.73,-44.05,)| Show InChI InChI=1S/C79H117N23O19S3/c1-38(2)26-51-68(111)89-42(9)66(109)94-54(29-46-33-84-37-88-46)70(113)98-57(74(117)93-50(22-17-24-85-79(82)83)67(110)101-63(40(5)6)77(120)92-49(65(81)108)23-25-122-11)35-123-124-36-58(99-78(121)64(41(7)8)102-73(116)56(31-61(106)107)97-69(112)52(90-43(10)103)27-44-18-13-12-14-19-44)75(118)96-55(30-59(80)104)71(114)95-53(28-45-32-86-48-21-16-15-20-47(45)48)72(115)100-62(39(3)4)76(119)87-34-60(105)91-51/h12-16,18-21,32-33,37-42,49-58,62-64,86H,17,22-31,34-36H2,1-11H3,(H2,80,104)(H2,81,108)(H,84,88)(H,87,119)(H,89,111)(H,90,103)(H,91,105)(H,92,120)(H,93,117)(H,94,109)(H,95,114)(H,96,118)(H,97,112)(H,98,113)(H,99,121)(H,100,115)(H,101,110)(H,102,116)(H,106,107)(H4,82,83,85)/t42-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,62-,63-,64-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PlGF-1-VEGFR-1 interaction by ELISA |
J Med Chem 54: 1256-65 (2011)
Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1 |
More data for this
Ligand-Target Pair | |
Placenta growth factor
(Homo sapiens (Human)) | BDBM50339229
(CHEMBL1689455)Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(N)=O |r,wU:85.88,4.4,12.19,32.32,44.52,110.113,62.63,71.72,114.118,92.95,wD:8.8,36.40,23.22,28.28,93.97,99.102,(-.78,-19.3,;.55,-18.52,;.55,-16.98,;1.88,-16.21,;1.88,-14.68,;3.22,-13.91,;4.55,-14.68,;4.55,-16.21,;5.88,-13.91,;7.22,-14.68,;8.55,-13.91,;8.55,-12.37,;9.87,-14.68,;9.87,-16.21,;8.55,-16.98,;8.55,-18.52,;7.2,-19.3,;7.2,-20.85,;5.85,-21.63,;8.55,-21.63,;11.21,-13.92,;12.53,-14.68,;12.53,-16.21,;13.86,-13.91,;13.86,-12.38,;12.55,-11.56,;12.56,-9.99,;11.22,-9.19,;11.24,-7.65,;9.91,-6.88,;8.57,-7.62,;8.57,-9.16,;7.24,-6.87,;5.9,-7.64,;4.59,-6.89,;4.59,-5.36,;3.24,-7.66,;3.26,-9.19,;1.92,-9.98,;.57,-9.22,;1.94,-11.54,;1.93,-6.9,;1.94,-5.34,;3.29,-4.57,;.6,-4.56,;.61,-3,;1.96,-2.23,;3.3,-3.03,;4.65,-2.26,;4.66,-.7,;3.31,.08,;1.96,-.69,;-.75,-5.33,;-2.09,-4.54,;-3.44,-5.31,;-2.08,-2.99,;7.24,-5.35,;8.55,-4.57,;5.9,-4.57,;12.6,-6.88,;13.93,-7.63,;12.54,-5.41,;13.87,-4.63,;13.89,-3.1,;12.57,-2.31,;12.59,-.77,;11.27,.02,;11.29,1.56,;15.21,-5.42,;15.2,-6.95,;16.54,-4.66,;17.86,-5.45,;19.18,-4.71,;19.2,-3.17,;20.46,-2.3,;20.01,-.83,;18.47,-.82,;17.47,.33,;15.97,.03,;15.48,-1.42,;16.49,-2.57,;17.98,-2.26,;17.84,-6.98,;16.51,-7.74,;19.17,-7.76,;23.1,-5.5,;24.44,-4.72,;24.43,-3.2,;25.76,-5.5,;23.12,-7.04,;24.45,-7.8,;21.82,-7.79,;21.8,-9.34,;23.14,-10.12,;23.13,-11.68,;24.49,-9.35,;20.47,-10.12,;19.14,-9.36,;20.49,-11.65,;19.15,-12.43,;17.83,-11.66,;16.49,-12.44,;15.14,-11.66,;16.48,-13.99,;19.16,-13.96,;17.84,-14.72,;20.5,-14.71,;21.95,-14.24,;22.85,-15.48,;21.94,-16.72,;20.49,-16.24,;19.15,-17,;19.14,-18.54,;17.83,-16.24,;16.5,-16.99,;16.48,-18.53,;15.13,-19.29,;13.72,-18.65,;12.67,-19.8,;13.43,-21.15,;14.95,-20.84,;15.18,-16.22,;13.84,-16.98,;15.18,-14.69,;5.87,-12.36,;7.22,-11.58,;4.53,-11.58,;.55,-13.91,;-.78,-14.68,;.55,-12.37,)| Show InChI InChI=1S/C85H129N23O19S3/c1-43(2)33-61-84(127)108-31-20-27-64(108)79(122)100-59(36-51-39-90-42-93-51)74(117)102-62(77(120)97-56(26-19-30-91-85(88)89)72(115)104-66(44(3)4)80(123)95-54(70(87)113)28-32-128-11)40-129-130-41-63(103-81(124)67(45(5)6)105-76(119)60(37-65(111)112)99-73(116)57(94-48(10)110)34-49-21-13-12-14-22-49)78(121)96-55(25-17-18-29-86)71(114)98-58(35-50-38-92-53-24-16-15-23-52(50)53)75(118)106-68(46(7)8)82(125)107-69(47(9)109)83(126)101-61/h12-16,21-24,38-39,42-47,54-64,66-69,92,109H,17-20,25-37,40-41,86H2,1-11H3,(H2,87,113)(H,90,93)(H,94,110)(H,95,123)(H,96,121)(H,97,120)(H,98,114)(H,99,116)(H,100,122)(H,101,126)(H,102,117)(H,103,124)(H,104,115)(H,105,119)(H,106,118)(H,107,125)(H,111,112)(H4,88,89,91)/t47-,54+,55+,56+,57+,58+,59+,60+,61+,62+,63+,64+,66+,67+,68+,69+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PlGF-1-VEGFR-1 interaction by ELISA |
J Med Chem 54: 1256-65 (2011)
Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1 |
More data for this
Ligand-Target Pair | |
Placenta growth factor
(Homo sapiens (Human)) | BDBM50339228
((S)-4-((S)-1-((3S,6R,11R,14S,17S,20S,26S,31aS)-3-(...)Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(N)=O |r| Show InChI InChI=1S/C83H125N21O18S3/c1-44(2)33-61-83(122)104-31-20-27-64(104)79(118)98-59(36-51-39-87-43-90-51)74(113)99-62(77(116)95-56(26-17-19-30-85)72(111)102-68(46(5)6)81(120)93-54(70(86)109)28-32-123-10)41-124-125-42-63(100-82(121)69(47(7)8)103-76(115)60(37-66(107)108)97-73(112)57(91-48(9)105)34-49-21-12-11-13-22-49)78(117)94-55(25-16-18-29-84)71(110)96-58(35-50-38-88-53-24-15-14-23-52(50)53)75(114)101-67(45(3)4)80(119)89-40-65(106)92-61/h11-15,21-24,38-39,43-47,54-64,67-69,88H,16-20,25-37,40-42,84-85H2,1-10H3,(H2,86,109)(H,87,90)(H,89,119)(H,91,105)(H,92,106)(H,93,120)(H,94,117)(H,95,116)(H,96,110)(H,97,112)(H,98,118)(H,99,113)(H,100,121)(H,101,114)(H,102,111)(H,103,115)(H,107,108)/t54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,67-,68-,69-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PlGF-1-VEGFR-1 interaction by ELISA |
J Med Chem 54: 1256-65 (2011)
Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1 |
More data for this
Ligand-Target Pair | |
Placenta growth factor
(Homo sapiens (Human)) | BDBM50339222
(CHEMBL1689448)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCCN)NC1=O)[C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(N)=O |r| Show InChI InChI=1S/C85H133N23O20S2/c1-11-46(7)68-82(126)98-57(21-17-33-92-85(89)90)74(118)102-62(35-44(3)4)84(128)108-34-18-22-65(108)81(125)101-60(38-52-40-91-43-93-52)76(120)103-63(79(123)96-55(19-13-15-31-86)72(116)94-48(9)71(115)105-67(45(5)6)70(88)114)41-129-130-42-64(80(124)97-56(20-14-16-32-87)73(117)99-59(77(121)106-68)37-51-25-29-54(111)30-26-51)104-83(127)69(47(8)12-2)107-78(122)61(39-66(112)113)100-75(119)58(95-49(10)109)36-50-23-27-53(110)28-24-50/h23-30,40,43-48,55-65,67-69,110-111H,11-22,31-39,41-42,86-87H2,1-10H3,(H2,88,114)(H,91,93)(H,94,116)(H,95,109)(H,96,123)(H,97,124)(H,98,126)(H,99,117)(H,100,119)(H,101,125)(H,102,118)(H,103,120)(H,104,127)(H,105,115)(H,106,121)(H,107,122)(H,112,113)(H4,89,90,92)/t46-,47-,48-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,67-,68-,69-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PlGF-1-VEGFR-1 interaction by ELISA |
J Med Chem 54: 1256-65 (2011)
Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1 |
More data for this
Ligand-Target Pair | |
Placenta growth factor
(Homo sapiens (Human)) | BDBM50339224
((S)-4-((S)-1-((3S,6R,11R,14S,17S,20S,26S,31aS)-3-(...)Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(N)=O |r,wU:62.63,70.71,110.114,106.109,84.87,4.4,12.19,32.32,44.52,wD:23.22,28.28,95.98,8.8,36.40,(-1.87,-51.42,;-.54,-50.65,;-.54,-49.11,;.8,-48.34,;.8,-46.8,;2.14,-46.03,;3.47,-46.8,;3.47,-48.34,;4.8,-46.03,;6.14,-46.8,;7.47,-46.03,;7.47,-44.49,;8.81,-46.8,;8.81,-48.34,;7.47,-49.11,;7.47,-50.65,;6.14,-51.42,;6.14,-52.97,;7.47,-53.74,;4.8,-53.74,;10.14,-46.04,;11.47,-46.8,;11.47,-48.33,;12.8,-46.03,;12.8,-44.49,;11.48,-43.67,;11.5,-42.1,;10.16,-41.3,;10.17,-39.75,;8.84,-38.98,;7.5,-39.72,;7.5,-41.27,;6.16,-38.97,;4.83,-39.74,;3.51,-38.99,;3.51,-37.46,;2.16,-39.76,;2.18,-41.29,;.84,-42.09,;-.52,-41.33,;.86,-43.65,;.85,-39,;.86,-37.44,;2.21,-36.67,;-.49,-36.66,;-.48,-35.1,;.87,-34.33,;2.22,-35.12,;3.57,-34.35,;3.58,-32.79,;2.22,-32,;.88,-32.78,;-1.84,-37.43,;-3.18,-36.64,;-4.54,-37.41,;-3.18,-35.08,;6.16,-37.44,;7.48,-36.67,;4.82,-36.67,;11.54,-38.99,;12.87,-39.73,;11.48,-37.5,;12.81,-36.73,;12.83,-35.2,;11.48,-34.41,;10.13,-35.17,;11.49,-32.86,;14.15,-37.52,;14.14,-39.05,;15.49,-36.76,;16.81,-37.55,;18.14,-36.8,;18.15,-35.26,;19.42,-34.39,;18.96,-32.92,;17.43,-32.9,;16.42,-31.75,;14.91,-32.05,;14.42,-33.51,;15.44,-34.66,;16.93,-34.36,;16.79,-39.08,;15.45,-39.85,;18.12,-39.87,;22.06,-37.6,;23.4,-36.82,;23.4,-35.29,;24.73,-37.6,;22.08,-39.15,;23.41,-39.9,;20.77,-39.9,;20.75,-41.45,;19.42,-42.23,;18.09,-41.47,;19.44,-43.76,;18.11,-44.54,;16.78,-43.78,;15.44,-44.55,;14.12,-43.78,;15.45,-46.08,;18.11,-46.08,;16.79,-46.84,;19.45,-46.83,;20.91,-46.37,;21.81,-47.62,;20.91,-48.84,;19.45,-48.36,;18.1,-49.13,;18.09,-50.66,;16.78,-48.36,;15.45,-49.11,;15.43,-50.66,;14.1,-51.43,;12.85,-50.55,;11.63,-51.49,;12.14,-52.94,;13.67,-52.9,;14.12,-48.35,;12.79,-49.11,;14.13,-46.81,;4.8,-44.47,;6.15,-43.69,;3.45,-43.69,;-.54,-46.03,;-1.87,-46.8,;-.54,-44.49,)| Show InChI InChI=1S/C81H119N23O19S3/c1-40(2)28-57-80(123)104-26-17-23-60(104)76(119)98-54(31-47-35-86-39-90-47)70(113)99-58(74(117)94-51(22-16-25-87-81(84)85)68(111)102-65(42(5)6)78(121)93-50(67(83)110)24-27-124-10)37-125-126-38-59(100-79(122)66(43(7)8)103-73(116)56(33-63(108)109)97-69(112)52(91-44(9)105)29-45-18-12-11-13-19-45)75(118)96-55(32-61(82)106)71(114)95-53(30-46-34-88-49-21-15-14-20-48(46)49)72(115)101-64(41(3)4)77(120)89-36-62(107)92-57/h11-15,18-21,34-35,39-43,50-60,64-66,88H,16-17,22-33,36-38H2,1-10H3,(H2,82,106)(H2,83,110)(H,86,90)(H,89,120)(H,91,105)(H,92,107)(H,93,121)(H,94,117)(H,95,114)(H,96,118)(H,97,112)(H,98,119)(H,99,113)(H,100,122)(H,101,115)(H,102,111)(H,103,116)(H,108,109)(H4,84,85,87)/t50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,64-,65-,66-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PlGF-1-VEGFR-1 interaction by ELISA |
J Med Chem 54: 1256-65 (2011)
Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1 |
More data for this
Ligand-Target Pair | |
Placenta growth factor
(Homo sapiens (Human)) | BDBM50339221
(CHEMBL1689447)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCCN)NC1=O)[C@@H](C)CC)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(N)=O |r,wU:125.129,109.113,93.97,81.84,41.42,51.57,66.69,77.106,102.107,4.4,16.25,wD:8.12,37.110,120.125,32.32,58.61,2.2,(3.82,-3.69,;3.82,-5.21,;5.17,-5.99,;6.48,-5.21,;5.16,-7.52,;3.83,-8.3,;2.5,-7.54,;2.5,-6,;1.15,-8.32,;1.17,-9.86,;2.51,-10.64,;3.85,-9.86,;2.51,-12.17,;-.17,-7.55,;-1.52,-8.33,;-1.5,-9.88,;-2.83,-7.56,;-2.84,-6.04,;-1.52,-5.27,;-.19,-6.03,;1.15,-5.25,;1.15,-3.7,;2.46,-2.93,;-.2,-2.92,;-1.52,-3.72,;-4.17,-8.34,;-5.51,-7.58,;-6.84,-8.36,;-5.52,-6.04,;6.51,-8.28,;6.5,-9.83,;7.86,-7.53,;9.19,-8.31,;9.17,-9.86,;10.53,-10.66,;10.51,-12.24,;11.82,-13.06,;11.82,-14.61,;13.16,-15.38,;13.15,-16.93,;11.81,-17.69,;14.48,-17.7,;14.47,-19.25,;13.13,-20.01,;11.68,-19.48,;10.74,-20.7,;11.61,-21.97,;13.09,-21.54,;15.82,-16.94,;17.14,-17.71,;17.14,-19.26,;18.49,-16.95,;19.95,-17.42,;20.86,-16.18,;19.95,-14.94,;18.49,-15.41,;17.16,-14.65,;15.82,-15.42,;17.15,-13.11,;15.81,-12.34,;14.48,-13.12,;13.14,-12.35,;14.48,-14.65,;18.48,-12.33,;18.47,-10.79,;17.13,-10.02,;19.81,-10.01,;21.14,-10.78,;21.15,-12.32,;22.49,-13.08,;23.82,-12.31,;25.16,-13.07,;26.49,-12.29,;25.16,-14.61,;19.83,-8.46,;21.13,-7.69,;22.47,-8.46,;21.12,-6.15,;17.16,-8.43,;15.83,-7.64,;14.49,-8.4,;15.84,-6.1,;17.18,-5.34,;17.19,-3.81,;18.54,-3.06,;18.56,-1.51,;17.23,-.73,;17.24,.81,;15.88,-1.49,;15.87,-3.03,;14.52,-5.31,;13.18,-6.06,;13.16,-7.61,;11.84,-5.28,;11.85,-3.74,;10.52,-2.96,;10.52,-1.4,;9.17,-.61,;9.18,.95,;10.5,-6.04,;10.55,-7.53,;11.9,-8.28,;22.46,-5.37,;22.45,-3.84,;23.79,-6.14,;25.13,-5.36,;10.49,-15.38,;10.49,-16.91,;9.14,-14.6,;7.81,-15.37,;7.81,-16.92,;6.48,-17.69,;6.49,-19.22,;5.14,-20.01,;5.16,-21.57,;3.81,-22.36,;6.52,-22.34,;6.48,-14.61,;6.49,-13.09,;5.19,-15.43,;3.86,-14.64,;3.79,-13.1,;2.52,-15.39,;2.5,-16.96,;1.15,-14.67,;-.16,-15.39,;-.18,-16.99,;-1.51,-17.74,;1.19,-17.71,;-1.52,-14.69,;-2.84,-15.43,;-1.51,-13.12,)| Show InChI InChI=1S/C85H133N25O20S2/c1-11-45(7)67-81(128)100-56(20-16-32-94-85(90)91)73(120)104-61(34-43(3)4)83(130)110-33-17-21-64(110)80(127)103-59(37-51-39-92-42-95-51)75(122)105-62(78(125)99-55(19-15-31-93-84(88)89)71(118)96-47(9)70(117)107-66(44(5)6)69(87)116)40-131-132-41-63(79(126)98-54(18-13-14-30-86)72(119)101-58(76(123)108-67)36-50-24-28-53(113)29-25-50)106-82(129)68(46(8)12-2)109-77(124)60(38-65(114)115)102-74(121)57(97-48(10)111)35-49-22-26-52(112)27-23-49/h22-29,39,42-47,54-64,66-68,112-113H,11-21,30-38,40-41,86H2,1-10H3,(H2,87,116)(H,92,95)(H,96,118)(H,97,111)(H,98,126)(H,99,125)(H,100,128)(H,101,119)(H,102,121)(H,103,127)(H,104,120)(H,105,122)(H,106,129)(H,107,117)(H,108,123)(H,109,124)(H,114,115)(H4,88,89,93)(H4,90,91,94)/t45-,46-,47-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,66-,67-,68-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PlGF-1-VEGFR-1 interaction by ELISA |
J Med Chem 54: 1256-65 (2011)
Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1 |
More data for this
Ligand-Target Pair | |
Placenta growth factor
(Homo sapiens (Human)) | BDBM50339223
((S)-2-((S)-2-((S)-1-((3S,6R,11R,14S,17S,20S,23S,26...)Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(C)C)[C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(N)=O |r| Show InChI InChI=1S/C86H123N19O20S4/c1-44(2)36-62-85(124)104-32-16-23-66(104)81(120)97-60(39-51-41-90-54-21-15-14-20-53(51)54)76(115)100-64(86(125)105-33-17-22-65(105)80(119)94-56(30-34-126-9)73(112)92-55(72(89)111)28-29-67(87)109)43-129-128-42-63(99-82(121)69(45(3)4)101-74(113)57(31-35-127-10)93-75(114)58(91-48(8)107)37-49-18-12-11-13-19-49)79(118)96-61(40-68(88)110)77(116)95-59(38-50-24-26-52(108)27-25-50)78(117)102-70(46(5)6)83(122)103-71(47(7)106)84(123)98-62/h11-15,18-21,24-27,41,44-47,55-66,69-71,90,106,108H,16-17,22-23,28-40,42-43H2,1-10H3,(H2,87,109)(H2,88,110)(H2,89,111)(H,91,107)(H,92,112)(H,93,114)(H,94,119)(H,95,116)(H,96,118)(H,97,120)(H,98,123)(H,99,121)(H,100,115)(H,101,113)(H,102,117)(H,103,122)/t47-,55+,56+,57+,58+,59+,60+,61+,62+,63+,64+,65+,66+,69+,70+,71+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PlGF-1-VEGFR-1 interaction by ELISA |
J Med Chem 54: 1256-65 (2011)
Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1 |
More data for this
Ligand-Target Pair | |
Placenta growth factor
(Homo sapiens (Human)) | BDBM50339218
(CHEMBL1689444)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)[C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(N)=O |r| Show InChI InChI=1S/C88H125N23O20S2/c1-11-47(7)71-85(129)99-58(20-16-30-94-88(90)91)75(119)105-65(32-45(3)4)87(131)111-31-17-21-68(111)84(128)104-63(37-55-40-93-44-96-55)79(123)106-66(82(126)101-60(33-51-18-14-13-15-19-51)76(120)97-49(9)74(118)108-70(46(5)6)73(89)117)41-132-133-42-67(83(127)102-62(36-54-39-92-43-95-54)78(122)100-61(80(124)109-71)35-53-24-28-57(114)29-25-53)107-86(130)72(48(8)12-2)110-81(125)64(38-69(115)116)103-77(121)59(98-50(10)112)34-52-22-26-56(113)27-23-52/h13-15,18-19,22-29,39-40,43-49,58-68,70-72,113-114H,11-12,16-17,20-21,30-38,41-42H2,1-10H3,(H2,89,117)(H,92,95)(H,93,96)(H,97,120)(H,98,112)(H,99,129)(H,100,122)(H,101,126)(H,102,127)(H,103,121)(H,104,128)(H,105,119)(H,106,123)(H,107,130)(H,108,118)(H,109,124)(H,110,125)(H,115,116)(H4,90,91,94)/t47-,48-,49-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,70-,71-,72-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PlGF-1-VEGFR-1 interaction by ELISA |
J Med Chem 54: 1256-65 (2011)
Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1 |
More data for this
Ligand-Target Pair | |
Placenta growth factor
(Homo sapiens (Human)) | BDBM50339220
(CHEMBL1689446)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(C)=O)[C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(N)=O |r| Show InChI InChI=1S/C86H127N21O21S2/c1-13-44(8)68-82(124)98-56(30-42(4)5)77(119)106-71(47(11)108)85(127)100-61(31-43(6)7)86(128)107-29-21-26-64(107)81(123)97-59(34-51-38-90-41-92-51)76(118)101-63(80(122)105-69(45(9)14-2)83(125)99-57(32-49-22-17-16-18-23-49)74(116)95-55(72(89)114)35-66(88)111)40-130-129-39-62(79(121)96-60(36-67(112)113)78(120)104-68)102-84(126)70(46(10)15-3)103-73(115)54(27-28-65(87)110)94-75(117)58(93-48(12)109)33-50-37-91-53-25-20-19-24-52(50)53/h16-20,22-25,37-38,41-47,54-64,68-71,91,108H,13-15,21,26-36,39-40H2,1-12H3,(H2,87,110)(H2,88,111)(H2,89,114)(H,90,92)(H,93,109)(H,94,117)(H,95,116)(H,96,121)(H,97,123)(H,98,124)(H,99,125)(H,100,127)(H,101,118)(H,102,126)(H,103,115)(H,104,120)(H,105,122)(H,106,119)(H,112,113)/t44-,45-,46-,47+,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,68-,69-,70-,71-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PlGF-1-VEGFR-1 interaction by ELISA |
J Med Chem 54: 1256-65 (2011)
Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1 |
More data for this
Ligand-Target Pair | |
Placenta growth factor
(Homo sapiens (Human)) | BDBM50339219
((S)-4-((S)-1-((3S,6R,11R,14S,17S,20S,23S,26S,31aS)...)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(C)=O)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(N)=O |r| Show InChI InChI=1S/C80H125N19O19S2/c1-17-44(14)65(66(81)104)98-67(105)45(15)85-68(106)52(26-39(4)5)87-75(113)59-35-119-120-36-60(95-79(117)64(43(12)13)97-73(111)56(31-62(102)103)90-69(107)51(25-38(2)3)86-46(16)101)76(114)88-53(27-40(6)7)70(108)89-54(29-47-32-83-50-22-19-18-21-49(47)50)72(110)96-63(42(10)11)78(116)93-58(34-100)74(112)92-57(28-41(8)9)80(118)99-24-20-23-61(99)77(115)91-55(71(109)94-59)30-48-33-82-37-84-48/h18-19,21-22,32-33,37-45,51-61,63-65,83,100H,17,20,23-31,34-36H2,1-16H3,(H2,81,104)(H,82,84)(H,85,106)(H,86,101)(H,87,113)(H,88,114)(H,89,108)(H,90,107)(H,91,115)(H,92,112)(H,93,116)(H,94,109)(H,95,117)(H,96,110)(H,97,111)(H,98,105)(H,102,103)/t44-,45-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,63-,64-,65-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PlGF-1-VEGFR-1 interaction by ELISA |
J Med Chem 54: 1256-65 (2011)
Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1 |
More data for this
Ligand-Target Pair | |
Placenta growth factor
(Homo sapiens (Human)) | BDBM50339227
((S)-4-((S)-1-((3S,6R,11R,14S,17S,20S,26S,31aS)-17-...)Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](C)C(=O)N1)C(C)C)C(N)=O |r,wU:70.71,110.114,84.87,4.4,12.19,32.32,44.52,106.109,62.63,wD:95.98,8.8,36.40,23.22,28.28,(-3.76,-50.23,;-2.43,-49.45,;-2.43,-47.91,;-1.09,-47.14,;-1.09,-45.61,;.25,-44.83,;1.58,-45.61,;1.58,-47.14,;2.91,-44.83,;4.26,-45.61,;5.59,-44.83,;5.59,-43.29,;6.92,-45.61,;6.92,-47.14,;5.59,-47.91,;5.59,-49.45,;4.26,-50.23,;4.26,-51.77,;5.59,-52.54,;2.91,-52.54,;8.25,-44.84,;9.58,-45.61,;9.58,-47.14,;10.91,-44.83,;10.91,-43.3,;9.59,-42.48,;9.61,-40.91,;8.27,-40.11,;8.28,-38.55,;6.96,-37.79,;5.61,-38.53,;5.61,-40.07,;4.27,-37.78,;2.94,-38.55,;1.62,-37.79,;1.62,-36.26,;.27,-38.57,;.29,-40.1,;-1.05,-40.89,;-2.41,-40.13,;-1.03,-42.45,;-1.04,-37.8,;-1.03,-36.25,;.32,-35.48,;-2.37,-35.46,;-2.37,-33.9,;-1.01,-33.13,;.33,-33.92,;1.68,-33.15,;1.69,-31.6,;.34,-30.81,;-1.01,-31.58,;-3.73,-36.23,;-5.07,-35.45,;-6.42,-36.22,;-5.06,-33.89,;4.28,-36.25,;5.59,-35.47,;2.93,-35.48,;9.65,-37.79,;10.98,-38.53,;9.59,-36.31,;10.92,-35.53,;10.94,-34,;9.59,-33.22,;8.24,-33.98,;9.6,-31.66,;12.26,-36.32,;12.25,-37.86,;13.6,-35.57,;14.92,-36.36,;16.24,-35.61,;16.26,-34.07,;17.53,-33.2,;17.07,-31.73,;15.53,-31.71,;14.52,-30.56,;13.02,-30.86,;12.53,-32.32,;13.55,-33.46,;15.04,-33.16,;14.9,-37.89,;13.56,-38.65,;16.23,-38.67,;20.17,-36.4,;21.51,-35.63,;21.5,-34.1,;22.83,-36.4,;20.19,-37.95,;21.52,-38.71,;18.88,-38.7,;18.86,-40.25,;17.53,-41.03,;16.2,-40.28,;17.55,-42.57,;16.21,-43.35,;14.89,-42.58,;13.54,-43.36,;12.19,-42.58,;13.54,-44.92,;16.22,-44.88,;14.9,-45.65,;17.56,-45.63,;19.02,-45.16,;19.92,-46.41,;19.01,-47.65,;17.55,-47.17,;16.21,-47.93,;16.2,-49.47,;14.89,-47.16,;13.56,-47.91,;13.54,-49.46,;12.23,-47.15,;10.9,-47.91,;12.24,-45.61,;2.91,-43.27,;4.26,-42.49,;1.56,-42.5,;-2.43,-44.83,;-3.76,-45.61,;-2.43,-43.29,)| Show InChI InChI=1S/C78H117N21O19S3/c1-38(2)29-54-77(118)99-27-18-24-57(99)73(114)86-42(9)65(106)94-55(71(112)90-49(23-17-26-83-78(81)82)66(107)97-62(40(5)6)75(116)89-48(64(80)105)25-28-119-11)36-120-121-37-56(95-76(117)63(41(7)8)98-70(111)53(33-60(103)104)93-67(108)50(87-43(10)100)30-44-19-13-12-14-20-44)72(113)92-52(32-58(79)101)68(109)91-51(31-45-34-84-47-22-16-15-21-46(45)47)69(110)96-61(39(3)4)74(115)85-35-59(102)88-54/h12-16,19-22,34,38-42,48-57,61-63,84H,17-18,23-33,35-37H2,1-11H3,(H2,79,101)(H2,80,105)(H,85,115)(H,86,114)(H,87,100)(H,88,102)(H,89,116)(H,90,112)(H,91,109)(H,92,113)(H,93,108)(H,94,106)(H,95,117)(H,96,110)(H,97,107)(H,98,111)(H,103,104)(H4,81,82,83)/t42-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,61-,62-,63-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+7 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PlGF-1-VEGFR-1 interaction by ELISA |
J Med Chem 54: 1256-65 (2011)
Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1 |
More data for this
Ligand-Target Pair | |
Placenta growth factor
(Homo sapiens (Human)) | BDBM50339225
((S)-4-((S)-1-((3S,6R,11R,14S,17S,20S,26S,31aS)-3-(...)Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(N)=O |r,wU:62.63,70.71,107.111,103.106,84.87,4.4,12.19,32.32,44.52,wD:23.22,28.28,95.98,8.8,36.40,(-4.06,-51.01,;-2.73,-50.23,;-2.73,-48.69,;-1.39,-47.92,;-1.39,-46.39,;-.05,-45.61,;1.28,-46.39,;1.28,-47.92,;2.61,-45.61,;3.96,-46.39,;5.29,-45.61,;5.29,-44.07,;6.62,-46.39,;6.62,-47.92,;5.29,-48.69,;5.29,-50.23,;3.96,-51.01,;3.96,-52.55,;5.29,-53.32,;2.61,-53.32,;7.96,-45.62,;9.28,-46.39,;9.28,-47.92,;10.62,-45.61,;10.62,-44.08,;9.3,-43.26,;9.31,-41.69,;7.97,-40.88,;7.98,-39.33,;6.66,-38.56,;5.31,-39.31,;5.31,-40.85,;3.97,-38.56,;2.64,-39.33,;1.32,-38.57,;1.32,-37.04,;-.03,-39.35,;-.01,-40.88,;-1.35,-41.67,;-2.71,-40.91,;-1.33,-43.23,;-1.34,-38.58,;-1.33,-37.02,;.02,-36.25,;-2.67,-36.24,;-2.67,-34.68,;-1.31,-33.91,;.03,-34.7,;1.38,-33.93,;1.39,-32.37,;.04,-31.59,;-1.31,-32.36,;-4.03,-37.01,;-5.37,-36.22,;-6.72,-37,;-5.36,-34.67,;3.98,-37.03,;5.29,-36.25,;2.63,-36.25,;9.35,-38.57,;10.68,-39.31,;9.29,-37.09,;10.62,-36.31,;10.65,-34.78,;9.29,-33.99,;7.94,-34.76,;9.31,-32.44,;11.97,-37.1,;11.95,-38.64,;13.3,-36.34,;14.62,-37.14,;15.95,-36.39,;15.96,-34.85,;17.23,-33.97,;16.78,-32.5,;15.24,-32.49,;14.23,-31.34,;12.72,-31.64,;12.24,-33.1,;13.25,-34.24,;14.74,-33.94,;14.61,-38.67,;13.27,-39.43,;15.93,-39.45,;19.88,-37.18,;21.21,-36.4,;21.21,-34.88,;22.54,-37.18,;19.89,-38.73,;21.23,-39.48,;18.59,-39.48,;18.57,-41.03,;17.23,-41.81,;15.9,-41.06,;17.26,-43.35,;15.92,-44.12,;14.59,-43.36,;15.92,-45.66,;14.6,-46.43,;17.26,-46.42,;18.72,-45.95,;19.63,-47.2,;18.72,-48.43,;17.26,-47.95,;15.91,-48.71,;15.91,-50.25,;14.59,-47.94,;13.26,-48.69,;13.24,-50.24,;11.91,-51.01,;10.66,-50.14,;9.44,-51.08,;9.95,-52.52,;11.48,-52.49,;11.94,-47.93,;10.6,-48.69,;11.94,-46.39,;2.61,-44.05,;3.96,-43.27,;1.26,-43.28,;-2.73,-45.61,;-4.06,-46.39,;-2.73,-44.07,)| Show InChI InChI=1S/C78H113N23O19S3/c1-38(2)61-74(117)86-34-59(104)88-41(7)77(120)101-25-16-22-57(101)73(116)95-52(29-45-33-83-37-87-45)67(110)96-55(71(114)91-49(21-15-24-84-78(81)82)65(108)99-62(39(3)4)75(118)90-48(64(80)107)23-26-121-9)35-122-123-36-56(72(115)93-53(30-58(79)103)68(111)92-51(69(112)98-61)28-44-32-85-47-20-14-13-19-46(44)47)97-76(119)63(40(5)6)100-70(113)54(31-60(105)106)94-66(109)50(89-42(8)102)27-43-17-11-10-12-18-43/h10-14,17-20,32-33,37-41,48-57,61-63,85H,15-16,21-31,34-36H2,1-9H3,(H2,79,103)(H2,80,107)(H,83,87)(H,86,117)(H,88,104)(H,89,102)(H,90,118)(H,91,114)(H,92,111)(H,93,115)(H,94,109)(H,95,116)(H,96,110)(H,97,119)(H,98,112)(H,99,108)(H,100,113)(H,105,106)(H4,81,82,84)/t41-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,61-,62-,63-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+7 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PlGF-1-VEGFR-1 interaction by ELISA |
J Med Chem 54: 1256-65 (2011)
Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1 |
More data for this
Ligand-Target Pair | |
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