Found 10 hits of ic50 data for polymerid = 50004761 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Solute carrier family 22 member 6
(Rattus norvegicus) | BDBM50022271
(2-(3-Benzoylphenyl)propionic acid | 2-(3-benzoylph...)Show InChI InChI=1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19) | PDB
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| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of MTX uptake in Xenopus laevis oocytes |
Eur J Pharmacol 409: 31-6 (2001)
BindingDB Entry DOI: 10.7270/Q20Z74JR |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 6
(Rattus norvegicus) | BDBM50390999
(CEFOPERAZONE)Show SMILES CCN1CCN(C(=O)N[C@@H](C(=O)N[C@H]2[C@H]3SCC(CSc4nnnn4C)=C(N3C2=O)C(O)=O)c2ccc(O)cc2)C(=O)C1=O |c:26| Show InChI InChI=1S/C25H27N9O8S2/c1-3-32-8-9-33(21(39)20(32)38)24(42)27-15(12-4-6-14(35)7-5-12)18(36)26-16-19(37)34-17(23(40)41)13(10-43-22(16)34)11-44-25-28-29-30-31(25)2/h4-7,15-16,22,35H,3,8-11H2,1-2H3,(H,26,36)(H,27,42)(H,40,41)/t15-,16-,22-/m1/s1 | PDB
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| Article
PubMed
| n/a | n/a | 2.98E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytes |
Drug Metab Pharmacokinet 17: 125-9 (2002)
Article DOI: 10.2133/dmpk.17.125
BindingDB Entry DOI: 10.7270/Q2VT1VZX |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 6
(Rattus norvegicus) | BDBM50350468
(CEFAMANDOLE)Show SMILES Cn1nnnc1SCC1=C(N2[C@H](SC1)[C@H](NC(=O)[C@H](O)c1ccccc1)C2=O)C(O)=O |r,t:9| Show InChI InChI=1S/C18H18N6O5S2/c1-23-18(20-21-22-23)31-8-10-7-30-16-11(15(27)24(16)12(10)17(28)29)19-14(26)13(25)9-5-3-2-4-6-9/h2-6,11,13,16,25H,7-8H2,1H3,(H,19,26)(H,28,29)/t11-,13-,16-/m1/s1 | PDB
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| Article
PubMed
| n/a | n/a | 4.50E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyorin University School of Medicine
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of PAH uptake in OAT1-expressing S2 cells |
Life Sci 70: 1861-74 (2002)
Article DOI: 10.1016/s0024-3205(02)01500-x
BindingDB Entry DOI: 10.7270/Q2SN0CV2 |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 6
(Rattus norvegicus) | BDBM50485561
(CHEBI:355510 | Cefotiam | Ceradon | J01DC07)Show SMILES [H][C@]12SCC(CSc3nnnn3CCN(C)C)=C(N1C(=O)[C@H]2NC(=O)Cc1csc(N)n1)C(O)=O |c:17| Show InChI InChI=1S/C18H23N9O4S3/c1-25(2)3-4-26-18(22-23-24-26)34-7-9-6-32-15-12(14(29)27(15)13(9)16(30)31)21-11(28)5-10-8-33-17(19)20-10/h8,12,15H,3-7H2,1-2H3,(H2,19,20)(H,21,28)(H,30,31)/t12-,15-/m1/s1 | PDB
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| Article
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| n/a | n/a | 7.18E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytes |
Drug Metab Pharmacokinet 17: 125-9 (2002)
Article DOI: 10.2133/dmpk.17.125
BindingDB Entry DOI: 10.7270/Q2VT1VZX |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 6
(Rattus norvegicus) | BDBM50103601
(CHEBI:29007 | Ceftriaxone)Show SMILES [H][C@@]1(NC(=O)C(=N/OC)\c2csc(N)n2)C(=O)N2C(C(O)=O)=C(CSc3nc(=O)c(O)nn3C)CS[C@]12[H] |t:22| Show InChI InChI=1S/C18H18N8O7S3/c1-25-18(22-12(28)13(29)23-25)36-4-6-3-34-15-9(14(30)26(15)10(6)16(31)32)21-11(27)8(24-33-2)7-5-35-17(19)20-7/h5,9,15H,3-4H2,1-2H3,(H2,19,20)(H,21,27)(H,23,29)(H,31,32)/b24-8-/t9-,15-/m1/s1 | PDB
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| KEGG
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| Article
PubMed
| n/a | n/a | 8.40E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyorin University School of Medicine
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of PAH uptake in OAT1-expressing S2 cells |
Life Sci 70: 1861-74 (2002)
Article DOI: 10.1016/s0024-3205(02)01500-x
BindingDB Entry DOI: 10.7270/Q2SN0CV2 |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 6
(Rattus norvegicus) | BDBM50350467
(BL-S578 | CEFADROXIL | Cefadrops)Show SMILES CC1=C(N2[C@H](SC1)[C@H](NC(=O)[C@H](N)c1ccc(O)cc1)C2=O)C(O)=O |r,t:1| Show InChI InChI=1S/C16H17N3O5S/c1-7-6-25-15-11(14(22)19(15)12(7)16(23)24)18-13(21)10(17)8-2-4-9(20)5-3-8/h2-5,10-11,15,20H,6,17H2,1H3,(H,18,21)(H,23,24)/t10-,11-,15-/m1/s1 | PDB
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| Article
PubMed
| n/a | n/a | >2.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyorin University School of Medicine
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of PAH uptake in OAT1-expressing S2 cells |
Life Sci 70: 1861-74 (2002)
Article DOI: 10.1016/s0024-3205(02)01500-x
BindingDB Entry DOI: 10.7270/Q2SN0CV2 |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 6
(Rattus norvegicus) | BDBM50482777
(CHEBI:204928 | Cefotaxime)Show SMILES [H][C@]12SCC(COC(C)=O)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\c1csc(N)n1)C(O)=O |c:9| Show InChI InChI=1S/C16H17N5O7S2/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26)/b20-9-/t10-,14-/m1/s1 | PDB
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| Article
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| n/a | n/a | >2.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyorin University School of Medicine
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of PAH uptake in OAT1-expressing S2 cells |
Life Sci 70: 1861-74 (2002)
Article DOI: 10.1016/s0024-3205(02)01500-x
BindingDB Entry DOI: 10.7270/Q2SN0CV2 |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 6
(Rattus norvegicus) | BDBM50139896
((6R,7R)-7-((R)-2-Amino-2-phenyl-acetylamino)-3-met...)Show SMILES CC1=C(N2[C@H](SC1)[C@H](NC(=O)[C@H](N)c1ccccc1)C2=O)C(O)=O |r,t:1| Show InChI InChI=1S/C16H17N3O4S/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9/h2-6,10-11,15H,7,17H2,1H3,(H,18,20)(H,22,23)/t10-,11-,15-/m1/s1 | PDB
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| Article
PubMed
| n/a | n/a | >2.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyorin University School of Medicine
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of PAH uptake in OAT1-expressing S2 cells |
Life Sci 70: 1861-74 (2002)
Article DOI: 10.1016/s0024-3205(02)01500-x
BindingDB Entry DOI: 10.7270/Q2SN0CV2 |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 6
(Rattus norvegicus) | BDBM22889
((Cimetidine) N-Methyl-N''''-[2-(5-methyl-1H-imidaz...)Show InChI InChI=1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14) | PDB
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| n/a | n/a | >2.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyorin University School of Medicine
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of PHA uptake (PHA: 5uM) in rOAT1-expressing S2 cells |
J Pharmacol Sci 94: 197-202 (2004)
BindingDB Entry DOI: 10.7270/Q27M0915 |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 6
(Rattus norvegicus) | BDBM50367502
(CILASTATIN)Show SMILES CC1(C)C[C@@H]1C(=O)N\C(=C/CCCCSC[C@H](N)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C16H26N2O5S/c1-16(2)8-10(16)13(19)18-12(15(22)23)6-4-3-5-7-24-9-11(17)14(20)21/h6,10-11H,3-5,7-9,17H2,1-2H3,(H,18,19)(H,20,21)(H,22,23)/b12-6-/t10-,11+/m1/s1 | PDB
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| n/a | n/a | 2.39E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyorin University School of Medicine
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of PHA uptake (PHA: 5uM) in rOAT1-expressing S2 cells |
J Pharmacol Sci 94: 197-202 (2004)
BindingDB Entry DOI: 10.7270/Q27M0915 |
More data for this
Ligand-Target Pair | |
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