Found 61 hits of ic50 data for polymerid = 50006163 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Urea transporter 1
(Mus musculus) | BDBM50394962
(CHEMBL1394231)Show SMILES CCc1ccc(cc1)S(=O)(=O)c1nnn2c3ccsc3c(NCc3cccs3)nc12 Show InChI InChI=1S/C20H17N5O2S3/c1-2-13-5-7-15(8-6-13)30(26,27)20-19-22-18(21-12-14-4-3-10-28-14)17-16(9-11-29-17)25(19)24-23-20/h3-11H,2,12H2,1H3,(H,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet 
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
San Francisco State University
Curated by ChEMBL
| Assay Description
Inhibition of UT-B in mouse acetamide-loaded erythrocyte assessed as increase of hypotonic lysis |
Bioorg Med Chem Lett 23: 3338-41 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.089
BindingDB Entry DOI: 10.7270/Q2CR5VRQ |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Urea transporter 1
(Mus musculus) | BDBM50394962
(CHEMBL1394231)Show SMILES CCc1ccc(cc1)S(=O)(=O)c1nnn2c3ccsc3c(NCc3cccs3)nc12 Show InChI InChI=1S/C20H17N5O2S3/c1-2-13-5-7-15(8-6-13)30(26,27)20-19-22-18(21-12-14-4-3-10-28-14)17-16(9-11-29-17)25(19)24-23-20/h3-11H,2,12H2,1H3,(H,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
San Francisco State University
Curated by ChEMBL
| Assay Description
Inhibition of UT-B in wild type CD1 mouse erythrocyte assessed as hemolysis after 10 mins |
J Med Chem 55: 5942-50 (2012)
Article DOI: 10.1021/jm300491y
BindingDB Entry DOI: 10.7270/Q29Z961D |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Urea transporter 1
(Mus musculus) | BDBM50394961
(CHEMBL2165788)Show SMILES CC(F)(F)c1ccc(cc1)S(=O)(=O)c1nnn2c3ccsc3c(NCc3cccs3)nc12 Show InChI InChI=1S/C20H15F2N5O2S3/c1-20(21,22)12-4-6-14(7-5-12)32(28,29)19-18-24-17(23-11-13-3-2-9-30-13)16-15(8-10-31-16)27(18)26-25-19/h2-10H,11H2,1H3,(H,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
San Francisco State University
Curated by ChEMBL
| Assay Description
Inhibition of UT-B in mouse acetamide-loaded erythrocyte assessed as increase of hypotonic lysis |
Bioorg Med Chem Lett 23: 3338-41 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.089
BindingDB Entry DOI: 10.7270/Q2CR5VRQ |
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50394961
(CHEMBL2165788)Show SMILES CC(F)(F)c1ccc(cc1)S(=O)(=O)c1nnn2c3ccsc3c(NCc3cccs3)nc12 Show InChI InChI=1S/C20H15F2N5O2S3/c1-20(21,22)12-4-6-14(7-5-12)32(28,29)19-18-24-17(23-11-13-3-2-9-30-13)16-15(8-10-31-16)27(18)26-25-19/h2-10H,11H2,1H3,(H,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
San Francisco State University
Curated by ChEMBL
| Assay Description
Inhibition of UT-B in wild type CD1 mouse erythrocyte assessed as hemolysis after 10 mins |
J Med Chem 55: 5942-50 (2012)
Article DOI: 10.1021/jm300491y
BindingDB Entry DOI: 10.7270/Q29Z961D |
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50394961
(CHEMBL2165788)Show SMILES CC(F)(F)c1ccc(cc1)S(=O)(=O)c1nnn2c3ccsc3c(NCc3cccs3)nc12 Show InChI InChI=1S/C20H15F2N5O2S3/c1-20(21,22)12-4-6-14(7-5-12)32(28,29)19-18-24-17(23-11-13-3-2-9-30-13)16-15(8-10-31-16)27(18)26-25-19/h2-10H,11H2,1H3,(H,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
San Francisco State University
Curated by ChEMBL
| Assay Description
Inhibition of UT-B-mediated urea transport in wild type CD1 mouse erythrocytes incubated for 10 mins prior to urea addition by Stopped-flow light sca... |
J Med Chem 55: 5942-50 (2012)
Article DOI: 10.1021/jm300491y
BindingDB Entry DOI: 10.7270/Q29Z961D |
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50394962
(CHEMBL1394231)Show SMILES CCc1ccc(cc1)S(=O)(=O)c1nnn2c3ccsc3c(NCc3cccs3)nc12 Show InChI InChI=1S/C20H17N5O2S3/c1-2-13-5-7-15(8-6-13)30(26,27)20-19-22-18(21-12-14-4-3-10-28-14)17-16(9-11-29-17)25(19)24-23-20/h3-11H,2,12H2,1H3,(H,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 25.1 | n/a | n/a | n/a | n/a | n/a | n/a |
San Francisco State University
Curated by ChEMBL
| Assay Description
Reversible inhibition of mouse UT-B-mediated urea transport |
J Med Chem 55: 5942-50 (2012)
Article DOI: 10.1021/jm300491y
BindingDB Entry DOI: 10.7270/Q29Z961D |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Urea transporter 1
(Mus musculus) | BDBM50394964
(CHEMBL1590659)Show SMILES Brc1ccc(cc1)S(=O)(=O)c1nnn2c3ccsc3c(NCc3cccs3)nc12 Show InChI InChI=1S/C18H12BrN5O2S3/c19-11-3-5-13(6-4-11)29(25,26)18-17-21-16(20-10-12-2-1-8-27-12)15-14(7-9-28-15)24(17)23-22-18/h1-9H,10H2,(H,20,21) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
San Francisco State University
Curated by ChEMBL
| Assay Description
Inhibition of UT-B in wild type CD1 mouse erythrocyte assessed as hemolysis after 10 mins |
J Med Chem 55: 5942-50 (2012)
Article DOI: 10.1021/jm300491y
BindingDB Entry DOI: 10.7270/Q29Z961D |
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50435308
(CHEMBL2391344)Show SMILES Cc1csc(CNc2nc3c(nnn3c3ccsc23)S(=O)(=O)c2ccc(cc2)C(C)(F)F)c1 Show InChI InChI=1S/C21H17F2N5O2S3/c1-12-9-14(32-11-12)10-24-18-17-16(7-8-31-17)28-19(25-18)20(26-27-28)33(29,30)15-5-3-13(4-6-15)21(2,22)23/h3-9,11H,10H2,1-2H3,(H,24,25) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
San Francisco State University
Curated by ChEMBL
| Assay Description
Inhibition of UT-B in mouse acetamide-loaded erythrocyte assessed as increase of hypotonic lysis |
Bioorg Med Chem Lett 23: 3338-41 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.089
BindingDB Entry DOI: 10.7270/Q2CR5VRQ |
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50435309
(CHEMBL2391345)Show SMILES CC(F)(F)c1ccc(cc1)S(=O)(=O)c1nnn2c3ccsc3c(NCc3ccsc3)nc12 Show InChI InChI=1S/C20H15F2N5O2S3/c1-20(21,22)13-2-4-14(5-3-13)32(28,29)19-18-24-17(23-10-12-6-8-30-11-12)16-15(7-9-31-16)27(18)26-25-19/h2-9,11H,10H2,1H3,(H,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
San Francisco State University
Curated by ChEMBL
| Assay Description
Inhibition of UT-B in mouse acetamide-loaded erythrocyte assessed as increase of hypotonic lysis |
Bioorg Med Chem Lett 23: 3338-41 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.089
BindingDB Entry DOI: 10.7270/Q2CR5VRQ |
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50394967
(CHEMBL2165784)Show SMILES COc1ccc(cc1)S(=O)(=O)c1nnn2c3ccsc3c(NCc3cccs3)nc12 Show InChI InChI=1S/C19H15N5O3S3/c1-27-12-4-6-14(7-5-12)30(25,26)19-18-21-17(20-11-13-3-2-9-28-13)16-15(8-10-29-16)24(18)23-22-19/h2-10H,11H2,1H3,(H,20,21) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 104 | n/a | n/a | n/a | n/a | n/a | n/a |
San Francisco State University
Curated by ChEMBL
| Assay Description
Inhibition of UT-B in wild type CD1 mouse erythrocyte assessed as hemolysis after 10 mins |
J Med Chem 55: 5942-50 (2012)
Article DOI: 10.1021/jm300491y
BindingDB Entry DOI: 10.7270/Q29Z961D |
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50394972
(CHEMBL1372659)Show SMILES CC(C)c1ccc(cc1)S(=O)(=O)c1nnn2c3ccsc3c(NCc3cccs3)nc12 Show InChI InChI=1S/C21H19N5O2S3/c1-13(2)14-5-7-16(8-6-14)31(27,28)21-20-23-19(22-12-15-4-3-10-29-15)18-17(9-11-30-18)26(20)25-24-21/h3-11,13H,12H2,1-2H3,(H,22,23) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 153 | n/a | n/a | n/a | n/a | n/a | n/a |
San Francisco State University
Curated by ChEMBL
| Assay Description
Inhibition of UT-B in wild type CD1 mouse erythrocyte assessed as hemolysis after 10 mins |
J Med Chem 55: 5942-50 (2012)
Article DOI: 10.1021/jm300491y
BindingDB Entry DOI: 10.7270/Q29Z961D |
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50580922
(CHEMBL5087071)Show SMILES CC(=O)c1ccc(o1)C(=O)Nc1ccc(NS(=O)(=O)c2ccccc2)cc1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of mouse UT-B expressed in MDCK cells |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113859
BindingDB Entry DOI: 10.7270/Q2GH9NSQ |
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50394966
(CHEMBL2165785)Show SMILES O=S(=O)(c1cccs1)c1nnn2c1nc(NCc1cccs1)c1sccc21 Show InChI InChI=1S/C16H11N5O2S4/c22-27(23,12-4-2-7-25-12)16-15-18-14(17-9-10-3-1-6-24-10)13-11(5-8-26-13)21(15)20-19-16/h1-8H,9H2,(H,17,18) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 196 | n/a | n/a | n/a | n/a | n/a | n/a |
San Francisco State University
Curated by ChEMBL
| Assay Description
Inhibition of UT-B in wild type CD1 mouse erythrocyte assessed as hemolysis after 10 mins |
J Med Chem 55: 5942-50 (2012)
Article DOI: 10.1021/jm300491y
BindingDB Entry DOI: 10.7270/Q29Z961D |
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50322183
(3-(4-ethylphenylsulfonyl)-N-(3-methoxypropyl)thien...)Show SMILES CCc1ccc(cc1)S(=O)(=O)c1nnn2c3ccsc3c(NCCCOC)nc12 Show InChI InChI=1S/C19H21N5O3S2/c1-3-13-5-7-14(8-6-13)29(25,26)19-18-21-17(20-10-4-11-27-2)16-15(9-12-28-16)24(18)23-22-19/h5-9,12H,3-4,10-11H2,1-2H3,(H,20,21) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 212 | n/a | n/a | n/a | n/a | n/a | n/a |
San Francisco State University
Curated by ChEMBL
| Assay Description
Inhibition of UT-B in wild type CD1 mouse erythrocyte assessed as hemolysis after 10 mins |
J Med Chem 55: 5942-50 (2012)
Article DOI: 10.1021/jm300491y
BindingDB Entry DOI: 10.7270/Q29Z961D |
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50580906
(CHEMBL5074722)Show SMILES [O-][N+](=O)c1ccc(o1)C(=O)Nc1ccc(NS(=O)(=O)c2ccccc2)cc1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of mouse UT-B expressed in MDCK cells |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113859
BindingDB Entry DOI: 10.7270/Q2GH9NSQ |
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50435310
(CHEMBL2391346)Show SMILES CC(F)(F)c1ccc(cc1)S(=O)(=O)c1nnn2c3ccsc3c(NCc3ccco3)nc12 Show InChI InChI=1S/C20H15F2N5O3S2/c1-20(21,22)12-4-6-14(7-5-12)32(28,29)19-18-24-17(23-11-13-3-2-9-30-13)16-15(8-10-31-16)27(18)26-25-19/h2-10H,11H2,1H3,(H,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 353 | n/a | n/a | n/a | n/a | n/a | n/a |
San Francisco State University
Curated by ChEMBL
| Assay Description
Inhibition of UT-B in mouse acetamide-loaded erythrocyte assessed as increase of hypotonic lysis |
Bioorg Med Chem Lett 23: 3338-41 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.089
BindingDB Entry DOI: 10.7270/Q2CR5VRQ |
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50394965
(CHEMBL2165786)Show SMILES Fc1ccc(cc1)S(=O)(=O)c1nnn2c3ccsc3c(NCc3cccs3)nc12 Show InChI InChI=1S/C18H12FN5O2S3/c19-11-3-5-13(6-4-11)29(25,26)18-17-21-16(20-10-12-2-1-8-27-12)15-14(7-9-28-15)24(17)23-22-18/h1-9H,10H2,(H,20,21) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 468 | n/a | n/a | n/a | n/a | n/a | n/a |
San Francisco State University
Curated by ChEMBL
| Assay Description
Inhibition of UT-B in wild type CD1 mouse erythrocyte assessed as hemolysis after 10 mins |
J Med Chem 55: 5942-50 (2012)
Article DOI: 10.1021/jm300491y
BindingDB Entry DOI: 10.7270/Q29Z961D |
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50580917
(CHEMBL5077469) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 480 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of mouse UT-B expressed in MDCK cells |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113859
BindingDB Entry DOI: 10.7270/Q2GH9NSQ |
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50394970
(CHEMBL2165781)Show SMILES FC(F)(F)c1ccc(cc1)S(=O)(=O)c1nnn2c3ccsc3c(NCc3cccs3)nc12 Show InChI InChI=1S/C19H12F3N5O2S3/c20-19(21,22)11-3-5-13(6-4-11)32(28,29)18-17-24-16(23-10-12-2-1-8-30-12)15-14(7-9-31-15)27(17)26-25-18/h1-9H,10H2,(H,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 537 | n/a | n/a | n/a | n/a | n/a | n/a |
San Francisco State University
Curated by ChEMBL
| Assay Description
Inhibition of UT-B in wild type CD1 mouse erythrocyte assessed as hemolysis after 10 mins |
J Med Chem 55: 5942-50 (2012)
Article DOI: 10.1021/jm300491y
BindingDB Entry DOI: 10.7270/Q29Z961D |
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50580912
(CHEMBL5091945)Show SMILES [O-][N+](=O)c1ccc(o1)C(=O)Nc1ccc(NS(=O)(=O)c2ccc(Cl)cc2)cc1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 690 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of mouse UT-B expressed in MDCK cells |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113859
BindingDB Entry DOI: 10.7270/Q2GH9NSQ |
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50607929
(CHEMBL5279934) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | 690 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50435307
(CHEMBL2391349)Show SMILES CC(F)(F)c1ccc(cc1)S(=O)(=O)c1nnn2c3ccsc3c(NCC3CCC3)nc12 Show InChI InChI=1S/C20H19F2N5O2S2/c1-20(21,22)13-5-7-14(8-6-13)31(28,29)19-18-24-17(23-11-12-3-2-4-12)16-15(9-10-30-16)27(18)26-25-19/h5-10,12H,2-4,11H2,1H3,(H,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >800 | n/a | n/a | n/a | n/a | n/a | n/a |
San Francisco State University
Curated by ChEMBL
| Assay Description
Inhibition of UT-B in mouse acetamide-loaded erythrocyte assessed as increase of hypotonic lysis |
Bioorg Med Chem Lett 23: 3338-41 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.089
BindingDB Entry DOI: 10.7270/Q2CR5VRQ |
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50435306
(CHEMBL2391348)Show SMILES CC(F)(F)c1ccc(cc1)S(=O)(=O)c1nnn2c3ccsc3c(NCC3CC3)nc12 Show InChI InChI=1S/C19H17F2N5O2S2/c1-19(20,21)12-4-6-13(7-5-12)30(27,28)18-17-23-16(22-10-11-2-3-11)15-14(8-9-29-15)26(17)25-24-18/h4-9,11H,2-3,10H2,1H3,(H,22,23) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >800 | n/a | n/a | n/a | n/a | n/a | n/a |
San Francisco State University
Curated by ChEMBL
| Assay Description
Inhibition of UT-B in mouse acetamide-loaded erythrocyte assessed as increase of hypotonic lysis |
Bioorg Med Chem Lett 23: 3338-41 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.089
BindingDB Entry DOI: 10.7270/Q2CR5VRQ |
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50435305
(CHEMBL2391347)Show SMILES CC(F)(F)c1ccc(cc1)S(=O)(=O)c1nnn2c3ccsc3c(NCc3ccccc3)nc12 Show InChI InChI=1S/C22H17F2N5O2S2/c1-22(23,24)15-7-9-16(10-8-15)33(30,31)21-20-26-19(25-13-14-5-3-2-4-6-14)18-17(11-12-32-18)29(20)28-27-21/h2-12H,13H2,1H3,(H,25,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >800 | n/a | n/a | n/a | n/a | n/a | n/a |
San Francisco State University
Curated by ChEMBL
| Assay Description
Inhibition of UT-B in mouse acetamide-loaded erythrocyte assessed as increase of hypotonic lysis |
Bioorg Med Chem Lett 23: 3338-41 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.089
BindingDB Entry DOI: 10.7270/Q2CR5VRQ |
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50580905
(CHEMBL5082942)Show SMILES CCS(=O)(=O)Nc1ccc(NC(=O)c2ccc(o2)[N+]([O-])=O)cc1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 840 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of mouse UT-B expressed in MDCK cells |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113859
BindingDB Entry DOI: 10.7270/Q2GH9NSQ |
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50134204
(CHEMBL3740772)Show InChI InChI=1S/C17H14N2O3/c1-9(20)18-11-3-5-13-14-6-4-12(19-10(2)21)8-16(14)17(22)15(13)7-11/h3-8H,1-2H3,(H,18,20)(H,19,21) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50580911
(CHEMBL5075260)Show SMILES [O-][N+](=O)c1ccc(o1)C(=O)Nc1ccc(NS(=O)(=O)c2cccc(Cl)c2)cc1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of mouse UT-B expressed in MDCK cells |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113859
BindingDB Entry DOI: 10.7270/Q2GH9NSQ |
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50580910
(CHEMBL5069410)Show SMILES [O-][N+](=O)c1ccc(o1)C(=O)Nc1ccc(NS(=O)(=O)c2ccccc2Cl)cc1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.05E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of mouse UT-B expressed in MDCK cells |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113859
BindingDB Entry DOI: 10.7270/Q2GH9NSQ |
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50394969
(CHEMBL2165782)Show SMILES FC(F)(F)Oc1ccc(cc1)S(=O)(=O)c1nnn2c3ccsc3c(NCc3cccs3)nc12 Show InChI InChI=1S/C19H12F3N5O3S3/c20-19(21,22)30-11-3-5-13(6-4-11)33(28,29)18-17-24-16(23-10-12-2-1-8-31-12)15-14(7-9-32-15)27(17)26-25-18/h1-9H,10H2,(H,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.11E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
San Francisco State University
Curated by ChEMBL
| Assay Description
Inhibition of UT-B in wild type CD1 mouse erythrocyte assessed as hemolysis after 10 mins |
J Med Chem 55: 5942-50 (2012)
Article DOI: 10.1021/jm300491y
BindingDB Entry DOI: 10.7270/Q29Z961D |
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50580909
(CHEMBL5084723)Show SMILES [O-][N+](=O)c1ccc(o1)C(=O)Nc1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.31E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of mouse UT-B expressed in MDCK cells |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113859
BindingDB Entry DOI: 10.7270/Q2GH9NSQ |
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50580908
(CHEMBL5083627)Show SMILES [O-][N+](=O)c1ccc(o1)C(=O)Nc1ccc(NS(=O)(=O)c2cccc(F)c2)cc1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.32E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of mouse UT-B expressed in MDCK cells |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113859
BindingDB Entry DOI: 10.7270/Q2GH9NSQ |
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50580913
(CHEMBL5085745)Show SMILES [O-][N+](=O)c1ccc(o1)C(=O)Nc1ccc(NS(=O)(=O)c2ccccc2C(F)(F)F)cc1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.49E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of mouse UT-B expressed in MDCK cells |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113859
BindingDB Entry DOI: 10.7270/Q2GH9NSQ |
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50580900
(CHEMBL5081628)Show SMILES [O-][N+](=O)c1ccc(o1)C(=O)Nc1ccc2ccc(=O)[nH]c2c1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of mouse UT-B expressed in MDCK cells |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113859
BindingDB Entry DOI: 10.7270/Q2GH9NSQ |
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50580916
(CHEMBL5085556)Show SMILES [O-][N+](=O)c1ccc(o1)C(=O)Nc1ccc(NS(=O)(=O)c2cccc(Br)c2)cc1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of mouse UT-B expressed in MDCK cells |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113859
BindingDB Entry DOI: 10.7270/Q2GH9NSQ |
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50607929
(CHEMBL5279934) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | 1.61E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50580907
(CHEMBL5094101)Show SMILES [O-][N+](=O)c1ccc(o1)C(=O)Nc1ccc(NS(=O)(=O)c2ccccc2F)cc1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.68E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of mouse UT-B expressed in MDCK cells |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113859
BindingDB Entry DOI: 10.7270/Q2GH9NSQ |
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50580903
(CHEMBL5080875)Show SMILES [O-][N+](=O)c1ccc(o1)C(=O)Nc1ccc2NC(=O)CCc2c1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.19E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of mouse UT-B expressed in MDCK cells |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113859
BindingDB Entry DOI: 10.7270/Q2GH9NSQ |
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50580914
(CHEMBL5072845)Show SMILES [O-][N+](=O)c1ccc(o1)C(=O)Nc1ccc(NS(=O)(=O)c2cccc(c2)C(F)(F)F)cc1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.22E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of mouse UT-B expressed in MDCK cells |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113859
BindingDB Entry DOI: 10.7270/Q2GH9NSQ |
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50580899
(CHEMBL5081622)Show SMILES [O-][N+](=O)c1ccc(o1)C(=O)Nc1ccc2[nH]c(=O)ccc2c1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.34E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of mouse UT-B expressed in MDCK cells |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113859
BindingDB Entry DOI: 10.7270/Q2GH9NSQ |
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50394963
(CHEMBL2165787)Show SMILES CC(C)c1ccc(cc1)S(=O)(=O)c1nnn2c3ccsc3c(NCc3cccc4ccccc34)nc12 Show InChI InChI=1S/C27H23N5O2S2/c1-17(2)18-10-12-21(13-11-18)36(33,34)27-26-29-25(24-23(14-15-35-24)32(26)31-30-27)28-16-20-8-5-7-19-6-3-4-9-22(19)20/h3-15,17H,16H2,1-2H3,(H,28,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
San Francisco State University
Curated by ChEMBL
| Assay Description
Inhibition of UT-B in wild type CD1 mouse erythrocyte assessed as hemolysis after 10 mins |
J Med Chem 55: 5942-50 (2012)
Article DOI: 10.1021/jm300491y
BindingDB Entry DOI: 10.7270/Q29Z961D |
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50580915
(CHEMBL5077837)Show SMILES [O-][N+](=O)c1ccc(o1)C(=O)Nc1ccc(NS(=O)(=O)c2ccc(cc2)C(F)(F)F)cc1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.47E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of mouse UT-B expressed in MDCK cells |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113859
BindingDB Entry DOI: 10.7270/Q2GH9NSQ |
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50607934
(CHEMBL1374572) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | 4.15E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50580904
(CHEMBL5089501)Show SMILES [O-][N+](=O)c1ccc(o1)C(=O)Nc1ccc2NC(=O)Cc2c1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.99E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of mouse UT-B expressed in MDCK cells |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113859
BindingDB Entry DOI: 10.7270/Q2GH9NSQ |
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50394968
(CHEMBL2165783)Show SMILES COc1ccc(CNc2nc3c(nnn3c3ccsc23)S(=O)(=O)c2ccc(cc2)C(C)C)cc1 Show InChI InChI=1S/C24H23N5O3S2/c1-15(2)17-6-10-19(11-7-17)34(30,31)24-23-26-22(21-20(12-13-33-21)29(23)28-27-24)25-14-16-4-8-18(32-3)9-5-16/h4-13,15H,14H2,1-3H3,(H,25,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.29E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
San Francisco State University
Curated by ChEMBL
| Assay Description
Inhibition of UT-B in wild type CD1 mouse erythrocyte assessed as hemolysis after 10 mins |
J Med Chem 55: 5942-50 (2012)
Article DOI: 10.1021/jm300491y
BindingDB Entry DOI: 10.7270/Q29Z961D |
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50394974
(CHEMBL1725922)Show SMILES CCc1ccc(cc1)S(=O)(=O)c1nnn2c3ccsc3c(nc12)N1CCOCC1 Show InChI InChI=1S/C19H19N5O3S2/c1-2-13-3-5-14(6-4-13)29(25,26)19-18-20-17(23-8-10-27-11-9-23)16-15(7-12-28-16)24(18)22-21-19/h3-7,12H,2,8-11H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
San Francisco State University
Curated by ChEMBL
| Assay Description
Inhibition of UT-B in wild type CD1 mouse erythrocyte assessed as hemolysis after 10 mins |
J Med Chem 55: 5942-50 (2012)
Article DOI: 10.1021/jm300491y
BindingDB Entry DOI: 10.7270/Q29Z961D |
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50580898
(CHEMBL5083889)Show SMILES CC(=O)Nc1ccc(NC(=O)c2ccc(o2)[N+]([O-])=O)cc1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.82E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of mouse UT-B expressed in MDCK cells |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113859
BindingDB Entry DOI: 10.7270/Q2GH9NSQ |
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50580918
(CHEMBL5070486)Show SMILES CC(=O)Nc1ccc(NC(=O)c2ccc(o2)C(=O)c2ccccc2)cc1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9.85E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of mouse UT-B expressed in MDCK cells |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113859
BindingDB Entry DOI: 10.7270/Q2GH9NSQ |
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50580921
(CHEMBL5091857) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of mouse UT-B expressed in MDCK cells |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113859
BindingDB Entry DOI: 10.7270/Q2GH9NSQ |
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50580920
(CHEMBL5092110) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of mouse UT-B expressed in MDCK cells |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113859
BindingDB Entry DOI: 10.7270/Q2GH9NSQ |
More data for this
Ligand-Target Pair | |
Urea transporter 1
(Mus musculus) | BDBM50580919
(CHEMBL5094061)Show SMILES CC(=O)Nc1ccc(NC(=O)c2ccc(o2)C(=O)C(C)(C)C)cc1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of mouse UT-B expressed in MDCK cells |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113859
BindingDB Entry DOI: 10.7270/Q2GH9NSQ |
More data for this
Ligand-Target Pair | |
Search and Browse
