| Reaction Details |
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 | Report a problem with these data |
| Target | Urea transporter 1 |
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| Ligand | BDBM50580903 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2149292 (CHEMBL5033690) |
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| IC50 | 2190±n/a nM |
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| Citation |  Wang, S; Xu, Y; Zhao, Y; Zhang, S; Li, M; Li, X; He, J; Zhou, H; Ge, Z; Li, R; Yang, B N-(4-acetamidophenyl)-5-acetylfuran-2-carboxamide as a novel orally available diuretic that targets urea transporters with improved PD and PK properties. Eur J Med Chem226:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Urea transporter 1 |
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| Name: | Urea transporter 1 |
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| Synonyms: | Slc14a1 | Solute carrier family 14 member 1 | UT-B | UT1_MOUSE | Urea transporter B | Urea transporter, erythrocyte |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42130.98 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_964780 |
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| Residue: | 384 |
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| Sequence: | MEDSPTMVKVDRGENQILSCRGRRCGFKVLGYVTGDMKEFANWLKDKPVVLQFMDWILRG
ISQVVFVSNPISGILILVGLLVQNPWWALCGCVGTVVSTLTALLLSQDRSAIAAGLQGYN
ATLVGILMAVFSNKGDYFWWLIFPVSAMSMTCPVFSSALSSVLSKWDLPVFTLPFNMALS
MYLSATGHYNTFFPSKLFTPVSSVPNITWSELSALELLKSLPVGVGQIYGCDNPWTGGIF
LCAILLSSPLMCLHAAIGSLLGVIAGLSLAAPFEDIYFGLWGFNSSLACIAIGGMFMALT
WQTHLLALACALFTAYFGACMAHLMAVVHLPACTWSFCLATLLFLLLTTKNPNIYRMPLS
KVTYSEENRIFYLQNKKRMVESPL
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| BDBM50580903 |
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| n/a |
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| Name | BDBM50580903 |
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| Synonyms: | CHEMBL5080875 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H11N3O5 |
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| Mol. Mass. | 301.2542 |
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| SMILES | [O-][N+](=O)c1ccc(o1)C(=O)Nc1ccc2NC(=O)CCc2c1 |
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| Structure | 
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