Compile Data Set for Download or QSAR

Found 27 hits of ic50 for UniProtKB: P15539   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cytochrome P450 11B2, mitochondrial (Mus musculus)	BDBM50238115 (CHEMBL4082403) Show SMILES CS(=O)(=O)N1CCC(CC1)C(O)(c1cncnc1Nc1ccc(F)cc1)C(F)(F)F Show InChI InChI=1S/C18H20F4N4O3S/c1-30(28,29)26-8-6-12(7-9-26)17(27,18(20,21)22)15-10-23-11-24-16(15)25-14-4-2-13(19)3-5-14/h2-5,10-12,27H,6-9H2,1H3,(H,23,24,25)	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi-Sankyo Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of mouse CYP11B2 expressed in HEK293 cells using deoxycorticosterone as substrate pretreated for 1 hr followed by substrate addition after...				Bioorg Med Chem Lett 27: 1902-1906 (2017) Article DOI: 10.1016/j.bmcl.2017.03.034 BindingDB Entry DOI: 10.7270/Q2KS6TTS
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Mus musculus)	BDBM50238115 (CHEMBL4082403) Show SMILES CS(=O)(=O)N1CCC(CC1)C(O)(c1cncnc1Nc1ccc(F)cc1)C(F)(F)F Show InChI InChI=1S/C18H20F4N4O3S/c1-30(28,29)26-8-6-12(7-9-26)17(27,18(20,21)22)15-10-23-11-24-16(15)25-14-4-2-13(19)3-5-14/h2-5,10-12,27H,6-9H2,1H3,(H,23,24,25)	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi-Sankyo Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of mouse CYP11B2 expressed in HEK293 cells using deoxycorticosterone as substrate pretreated for 1 hr followed by substrate addition after...				Bioorg Med Chem Lett 27: 1902-1906 (2017) Article DOI: 10.1016/j.bmcl.2017.03.034 BindingDB Entry DOI: 10.7270/Q2KS6TTS
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Mus musculus)	BDBM50238114 (CHEMBL4093575) Show SMILES CC(C)C(O)(C1CCN(CC1)S(C)(=O)=O)c1cncnc1Nc1ccc(F)cc1 Show InChI InChI=1S/C20H27FN4O3S/c1-14(2)20(26,15-8-10-25(11-9-15)29(3,27)28)18-12-22-13-23-19(18)24-17-6-4-16(21)5-7-17/h4-7,12-15,26H,8-11H2,1-3H3,(H,22,23,24)	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi-Sankyo Co., Ltd. Curated by ChEMBL					Assay Description Concentration required to inhibit the activity of Angiotensin I converting enzyme by 50%				Bioorg Med Chem Lett 27: 1902-1906 (2017) Article DOI: 10.1016/j.bmcl.2017.03.034 BindingDB Entry DOI: 10.7270/Q2KS6TTS
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Mus musculus)	BDBM50238115 (CHEMBL4082403) Show SMILES CS(=O)(=O)N1CCC(CC1)C(O)(c1cncnc1Nc1ccc(F)cc1)C(F)(F)F Show InChI InChI=1S/C18H20F4N4O3S/c1-30(28,29)26-8-6-12(7-9-26)17(27,18(20,21)22)15-10-23-11-24-16(15)25-14-4-2-13(19)3-5-14/h2-5,10-12,27H,6-9H2,1H3,(H,23,24,25)	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi-Sankyo Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of mouse CYP11B2 expressed in HEK293 cells using deoxycorticosterone as substrate pretreated for 1 hr followed by substrate addition after...				Bioorg Med Chem Lett 27: 1902-1906 (2017) Article DOI: 10.1016/j.bmcl.2017.03.034 BindingDB Entry DOI: 10.7270/Q2KS6TTS
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Mus musculus)	BDBM50238103 (CHEMBL4070323) Show SMILES CC(O)(C1CCN(CC1)S(C)(=O)=O)c1cncnc1Nc1ccc(F)cc1 Show InChI InChI=1S/C18H23FN4O3S/c1-18(24,13-7-9-23(10-8-13)27(2,25)26)16-11-20-12-21-17(16)22-15-5-3-14(19)4-6-15/h3-6,11-13,24H,7-10H2,1-2H3,(H,20,21,22)	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	102	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi-Sankyo Co., Ltd. Curated by ChEMBL					Assay Description Concentration required to inhibit the activity of Angiotensin I converting enzyme by 50%				Bioorg Med Chem Lett 27: 1902-1906 (2017) Article DOI: 10.1016/j.bmcl.2017.03.034 BindingDB Entry DOI: 10.7270/Q2KS6TTS
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Mus musculus)	BDBM50238104 (CHEMBL4072871) Show SMILES CCCCC(O)(C1CCN(CC1)S(C)(=O)=O)c1cncnc1Nc1ccc(F)cc1 Show InChI InChI=1S/C21H29FN4O3S/c1-3-4-11-21(27,16-9-12-26(13-10-16)30(2,28)29)19-14-23-15-24-20(19)25-18-7-5-17(22)6-8-18/h5-8,14-16,27H,3-4,9-13H2,1-2H3,(H,23,24,25)	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi-Sankyo Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of mouse CYP11B2 expressed in HEK293 cells using deoxycorticosterone as substrate pretreated for 1 hr followed by substrate addition after...				Bioorg Med Chem Lett 27: 1902-1906 (2017) Article DOI: 10.1016/j.bmcl.2017.03.034 BindingDB Entry DOI: 10.7270/Q2KS6TTS
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Mus musculus)	BDBM8611 (4-{5H,6H,7H,8H-imidazo[1,5-a]pyridin-5-yl}benzonit...) Show SMILES N#Cc1ccc(cc1)C1CCCc2cncn12 Show InChI InChI=1S/C14H13N3/c15-8-11-4-6-12(7-5-11)14-3-1-2-13-9-16-10-17(13)14/h4-7,9-10,14H,1-3H2	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
Roche Pharma Research and Early Development (pRED) Curated by ChEMBL					Assay Description Inhibition of mouse CYP11B2 expressed in renal leiomyoblastoma cells				J Med Chem 58: 8054-65 (2015) Article DOI: 10.1021/acs.jmedchem.5b00851 BindingDB Entry DOI: 10.7270/Q2K0763C
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Mus musculus)	BDBM50444549 (CHEMBL3099695) Show SMILES Fc1cc(ccc1[C@H]1CCc2cncn12)C#N |r| Show InChI InChI=1S/C13H10FN3/c14-12-5-9(6-15)1-3-11(12)13-4-2-10-7-16-8-17(10)13/h1,3,5,7-8,13H,2,4H2/t13-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
Roche Pharma Research and Early Development (pRED) Curated by ChEMBL					Assay Description Inhibition of mouse CYP11B2 expressed in renal leiomyoblastoma cells				J Med Chem 58: 8054-65 (2015) Article DOI: 10.1021/acs.jmedchem.5b00851 BindingDB Entry DOI: 10.7270/Q2K0763C
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Mus musculus)	BDBM50238110 (CHEMBL4088766) Show SMILES CS(=O)(=O)N1CCC(CC1)C(O)c1cncnc1Sc1ccc(F)cc1 Show InChI InChI=1S/C17H20FN3O3S2/c1-26(23,24)21-8-6-12(7-9-21)16(22)15-10-19-11-20-17(15)25-14-4-2-13(18)3-5-14/h2-5,10-12,16,22H,6-9H2,1H3	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	257	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi-Sankyo Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of mouse CYP11B2 expressed in HEK293 cells using deoxycorticosterone as substrate pretreated for 1 hr followed by substrate addition after...				Bioorg Med Chem Lett 27: 1902-1906 (2017) Article DOI: 10.1016/j.bmcl.2017.03.034 BindingDB Entry DOI: 10.7270/Q2KS6TTS
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Mus musculus)	BDBM50238105 (CHEMBL4099824) Show SMILES CS(=O)(=O)N1CCC(CC1)C(O)c1cncnc1Nc1ccc(F)cc1 Show InChI InChI=1S/C17H21FN4O3S/c1-26(24,25)22-8-6-12(7-9-22)16(23)15-10-19-11-20-17(15)21-14-4-2-13(18)3-5-14/h2-5,10-12,16,23H,6-9H2,1H3,(H,19,20,21)	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi-Sankyo Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of mouse CYP11B2 expressed in HEK293 cells using deoxycorticosterone as substrate pretreated for 1 hr followed by substrate addition after...				Bioorg Med Chem Lett 27: 1902-1906 (2017) Article DOI: 10.1016/j.bmcl.2017.03.034 BindingDB Entry DOI: 10.7270/Q2KS6TTS
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Mus musculus)	BDBM50238102 (CHEMBL4065476) Show SMILES OC(c1ccccc1)c1cncnc1Nc1ccc(F)cc1 Show InChI InChI=1S/C17H14FN3O/c18-13-6-8-14(9-7-13)21-17-15(10-19-11-20-17)16(22)12-4-2-1-3-5-12/h1-11,16,22H,(H,19,20,21)	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	440	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi-Sankyo Co., Ltd. Curated by ChEMBL					Assay Description Concentration required to inhibit the activity of Angiotensin I converting enzyme by 50%				Bioorg Med Chem Lett 27: 1902-1906 (2017) Article DOI: 10.1016/j.bmcl.2017.03.034 BindingDB Entry DOI: 10.7270/Q2KS6TTS
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Mus musculus)	BDBM50125049 (CHEMBL3623830) Show SMILES CCC(=O)N[C@@H]1CCCc2c1cncc2-c1ccc(cc1)C#N |r| Show InChI InChI=1S/C19H19N3O/c1-2-19(23)22-18-5-3-4-15-16(11-21-12-17(15)18)14-8-6-13(10-20)7-9-14/h6-9,11-12,18H,2-5H2,1H3,(H,22,23)/t18-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	530	n/a	n/a	n/a	n/a	n/a	n/a
Roche Pharma Research and Early Development (pRED) Curated by ChEMBL					Assay Description Inhibition of mouse CYP11B2 expressed in human renal leiomyoblastoma cells using 11-deoxycorticosterone as substrate assessed as formation of aldoste...				J Med Chem 58: 8054-65 (2015) Article DOI: 10.1021/acs.jmedchem.5b00851 BindingDB Entry DOI: 10.7270/Q2K0763C
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Mus musculus)	BDBM50238109 (CHEMBL4091167) Show SMILES CS(=O)(=O)N1CCC(CC1)C(O)c1cncnc1Nc1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C18H21F3N4O3S/c1-29(27,28)25-8-6-12(7-9-25)16(26)15-10-22-11-23-17(15)24-14-4-2-13(3-5-14)18(19,20)21/h2-5,10-12,16,26H,6-9H2,1H3,(H,22,23,24)	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	798	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi-Sankyo Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of mouse CYP11B2 expressed in HEK293 cells using deoxycorticosterone as substrate pretreated for 1 hr followed by substrate addition after...				Bioorg Med Chem Lett 27: 1902-1906 (2017) Article DOI: 10.1016/j.bmcl.2017.03.034 BindingDB Entry DOI: 10.7270/Q2KS6TTS
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Mus musculus)	BDBM50238101 (CHEMBL4104118) Show SMILES CCCC(O)c1cncnc1Nc1ccc(F)cc1 Show InChI InChI=1S/C14H16FN3O/c1-2-3-13(19)12-8-16-9-17-14(12)18-11-6-4-10(15)5-7-11/h4-9,13,19H,2-3H2,1H3,(H,16,17,18)	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	911	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi-Sankyo Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of mouse CYP11B2 expressed in HEK293 cells using deoxycorticosterone as substrate pretreated for 1 hr followed by substrate addition after...				Bioorg Med Chem Lett 27: 1902-1906 (2017) Article DOI: 10.1016/j.bmcl.2017.03.034 BindingDB Entry DOI: 10.7270/Q2KS6TTS
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Mus musculus)	BDBM50238106 (CHEMBL4072943) Show SMILES CS(=O)(=O)N1CCC(CC1)C(O)c1cncnc1Nc1cccc(F)c1 Show InChI InChI=1S/C17H21FN4O3S/c1-26(24,25)22-7-5-12(6-8-22)16(23)15-10-19-11-20-17(15)21-14-4-2-3-13(18)9-14/h2-4,9-12,16,23H,5-8H2,1H3,(H,19,20,21)	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi-Sankyo Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of mouse CYP11B2 expressed in HEK293 cells using deoxycorticosterone as substrate pretreated for 1 hr followed by substrate addition after...				Bioorg Med Chem Lett 27: 1902-1906 (2017) Article DOI: 10.1016/j.bmcl.2017.03.034 BindingDB Entry DOI: 10.7270/Q2KS6TTS
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Mus musculus)	BDBM50238121 (CHEMBL4077051) Show SMILES OC(C1CCNCC1)c1cncnc1Nc1ccc(F)cc1 Show InChI InChI=1S/C16H19FN4O/c17-12-1-3-13(4-2-12)21-16-14(9-19-10-20-16)15(22)11-5-7-18-8-6-11/h1-4,9-11,15,18,22H,5-8H2,(H,19,20,21)	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.31E+3	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi-Sankyo Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of mouse CYP11B2 expressed in HEK293 cells using deoxycorticosterone as substrate pretreated for 1 hr followed by substrate addition after...				Bioorg Med Chem Lett 27: 1902-1906 (2017) Article DOI: 10.1016/j.bmcl.2017.03.034 BindingDB Entry DOI: 10.7270/Q2KS6TTS
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Mus musculus)	BDBM50238108 (CHEMBL4070230) Show SMILES CS(=O)(=O)N1CCC(CC1)C(O)c1cncnc1Nc1ccc(cc1)C#N Show InChI InChI=1S/C18H21N5O3S/c1-27(25,26)23-8-6-14(7-9-23)17(24)16-11-20-12-21-18(16)22-15-4-2-13(10-19)3-5-15/h2-5,11-12,14,17,24H,6-9H2,1H3,(H,20,21,22)	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.34E+3	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi-Sankyo Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of mouse CYP11B2 expressed in HEK293 cells using deoxycorticosterone as substrate pretreated for 1 hr followed by substrate addition after...				Bioorg Med Chem Lett 27: 1902-1906 (2017) Article DOI: 10.1016/j.bmcl.2017.03.034 BindingDB Entry DOI: 10.7270/Q2KS6TTS
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Mus musculus)	BDBM50238111 (CHEMBL4060559) Show SMILES CS(=O)(=O)N1CCC(O)(CC1)c1cncnc1Nc1ccc(F)cc1 Show InChI InChI=1S/C16H19FN4O3S/c1-25(23,24)21-8-6-16(22,7-9-21)14-10-18-11-19-15(14)20-13-4-2-12(17)3-5-13/h2-5,10-11,22H,6-9H2,1H3,(H,18,19,20)	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.38E+3	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi-Sankyo Co., Ltd. Curated by ChEMBL					Assay Description Concentration required to inhibit the activity of Angiotensin I converting enzyme by 50%				Bioorg Med Chem Lett 27: 1902-1906 (2017) Article DOI: 10.1016/j.bmcl.2017.03.034 BindingDB Entry DOI: 10.7270/Q2KS6TTS
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Mus musculus)	BDBM50238119 (CHEMBL4075207) Show SMILES CS(=O)(=O)N1CCC(C1)C(O)c1cncnc1Nc1ccc(F)cc1 Show InChI InChI=1S/C16H19FN4O3S/c1-25(23,24)21-7-6-11(9-21)15(22)14-8-18-10-19-16(14)20-13-4-2-12(17)3-5-13/h2-5,8,10-11,15,22H,6-7,9H2,1H3,(H,18,19,20)	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.47E+3	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi-Sankyo Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of mouse CYP11B2 expressed in HEK293 cells using deoxycorticosterone as substrate pretreated for 1 hr followed by substrate addition after...				Bioorg Med Chem Lett 27: 1902-1906 (2017) Article DOI: 10.1016/j.bmcl.2017.03.034 BindingDB Entry DOI: 10.7270/Q2KS6TTS
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Mus musculus)	BDBM50238116 (CHEMBL4079006) Show SMILES CS(=O)(=O)N1CCC(CC1)C(O)c1cncnc1Nc1ccccc1 Show InChI InChI=1S/C17H22N4O3S/c1-25(23,24)21-9-7-13(8-10-21)16(22)15-11-18-12-19-17(15)20-14-5-3-2-4-6-14/h2-6,11-13,16,22H,7-10H2,1H3,(H,18,19,20)	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.76E+3	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi-Sankyo Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of mouse CYP11B2 expressed in HEK293 cells using deoxycorticosterone as substrate pretreated for 1 hr followed by substrate addition after...				Bioorg Med Chem Lett 27: 1902-1906 (2017) Article DOI: 10.1016/j.bmcl.2017.03.034 BindingDB Entry DOI: 10.7270/Q2KS6TTS
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Mus musculus)	BDBM50238117 (CHEMBL4092081) Show SMILES Cc1ccc(Nc2ncncc2C(O)C2CCN(CC2)S(C)(=O)=O)cc1 Show InChI InChI=1S/C18H24N4O3S/c1-13-3-5-15(6-4-13)21-18-16(11-19-12-20-18)17(23)14-7-9-22(10-8-14)26(2,24)25/h3-6,11-12,14,17,23H,7-10H2,1-2H3,(H,19,20,21)	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.89E+3	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi-Sankyo Co., Ltd. Curated by ChEMBL					Assay Description Concentration required to inhibit the activity of Angiotensin I converting enzyme by 50%				Bioorg Med Chem Lett 27: 1902-1906 (2017) Article DOI: 10.1016/j.bmcl.2017.03.034 BindingDB Entry DOI: 10.7270/Q2KS6TTS
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Mus musculus)	BDBM50047262 ((R)-4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-y...) Show SMILES N#Cc1ccc(cc1)[C@H]1CCCc2cncn12 Show InChI InChI=1S/C14H13N3/c15-8-11-4-6-12(7-5-11)14-3-1-2-13-9-16-10-17(13)14/h4-7,9-10,14H,1-3H2/t14-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.07E+3	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi-Sankyo Co., Ltd. Curated by ChEMBL					Assay Description Concentration required to inhibit the activity of Angiotensin I converting enzyme by 50%				Bioorg Med Chem Lett 27: 1902-1906 (2017) Article DOI: 10.1016/j.bmcl.2017.03.034 BindingDB Entry DOI: 10.7270/Q2KS6TTS
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Mus musculus)	BDBM50238123 (CHEMBL4061565) Show SMILES CS(=O)(=O)N1CCC(CC1)C(O)c1cncnc1Nc1cccc2ccccc12 Show InChI InChI=1S/C21H24N4O3S/c1-29(27,28)25-11-9-16(10-12-25)20(26)18-13-22-14-23-21(18)24-19-8-4-6-15-5-2-3-7-17(15)19/h2-8,13-14,16,20,26H,9-12H2,1H3,(H,22,23,24)	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.74E+3	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi-Sankyo Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of mouse CYP11B2 expressed in HEK293 cells using deoxycorticosterone as substrate pretreated for 1 hr followed by substrate addition after...				Bioorg Med Chem Lett 27: 1902-1906 (2017) Article DOI: 10.1016/j.bmcl.2017.03.034 BindingDB Entry DOI: 10.7270/Q2KS6TTS
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Mus musculus)	BDBM50238112 (CHEMBL4101118) Show SMILES CS(=O)(=O)N1CCC(CC(O)c2cncnc2Nc2ccc(F)cc2)CC1 Show InChI InChI=1S/C18H23FN4O3S/c1-27(25,26)23-8-6-13(7-9-23)10-17(24)16-11-20-12-21-18(16)22-15-4-2-14(19)3-5-15/h2-5,11-13,17,24H,6-10H2,1H3,(H,20,21,22)	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.13E+3	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi-Sankyo Co., Ltd. Curated by ChEMBL					Assay Description Concentration required to inhibit the activity of Angiotensin I converting enzyme by 50%				Bioorg Med Chem Lett 27: 1902-1906 (2017) Article DOI: 10.1016/j.bmcl.2017.03.034 BindingDB Entry DOI: 10.7270/Q2KS6TTS
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Mus musculus)	BDBM50238113 (CHEMBL4067686) Show SMILES CS(=O)(=O)N1CCC(CC1)C(=O)c1cncnc1Nc1ccc(F)cc1 Show InChI InChI=1S/C17H19FN4O3S/c1-26(24,25)22-8-6-12(7-9-22)16(23)15-10-19-11-20-17(15)21-14-4-2-13(18)3-5-14/h2-5,10-12H,6-9H2,1H3,(H,19,20,21)	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi-Sankyo Co., Ltd. Curated by ChEMBL					Assay Description Concentration required to inhibit the activity of Angiotensin I converting enzyme by 50%				Bioorg Med Chem Lett 27: 1902-1906 (2017) Article DOI: 10.1016/j.bmcl.2017.03.034 BindingDB Entry DOI: 10.7270/Q2KS6TTS
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Mus musculus)	BDBM50238107 (CHEMBL4064367) Show SMILES COc1ccc(Nc2ncncc2C(O)C2CCN(CC2)S(C)(=O)=O)cc1 Show InChI InChI=1S/C18H24N4O4S/c1-26-15-5-3-14(4-6-15)21-18-16(11-19-12-20-18)17(23)13-7-9-22(10-8-13)27(2,24)25/h3-6,11-13,17,23H,7-10H2,1-2H3,(H,19,20,21)	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi-Sankyo Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of mouse CYP11B2 expressed in HEK293 cells using deoxycorticosterone as substrate pretreated for 1 hr followed by substrate addition after...				Bioorg Med Chem Lett 27: 1902-1906 (2017) Article DOI: 10.1016/j.bmcl.2017.03.034 BindingDB Entry DOI: 10.7270/Q2KS6TTS
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Mus musculus)	BDBM50125050 (CHEMBL3623831) Show SMILES CCC(=O)N[C@H]1CCCc2c1cncc2-c1ccc(cc1)C#N |r| Show InChI InChI=1S/C19H19N3O/c1-2-19(23)22-18-5-3-4-15-16(11-21-12-17(15)18)14-8-6-13(10-20)7-9-14/h6-9,11-12,18H,2-5H2,1H3,(H,22,23)/t18-/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Roche Pharma Research and Early Development (pRED) Curated by ChEMBL					Assay Description Inhibition of mouse CYP11B2 expressed in human renal leiomyoblastoma cells using 11-deoxycorticosterone as substrate assessed as formation of aldoste...				J Med Chem 58: 8054-65 (2015) Article DOI: 10.1021/acs.jmedchem.5b00851 BindingDB Entry DOI: 10.7270/Q2K0763C
					More data for this Ligand-Target Pair