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Compile Data Set for Download or QSAR

Found 80 hits of ic50 for UniProtKB: P28028   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50468557
PNG
(CHEMBL4294787)
Show SMILES S=C(Nc1ccccc1)N1N=C(CC1c1ccc2OCCOc2c1)c1ccc(OCc2ccccc2)cc1 |c:11|
Show InChI InChI=1S/C31H27N3O3S/c38-31(32-25-9-5-2-6-10-25)34-28(24-13-16-29-30(19-24)36-18-17-35-29)20-27(33-34)23-11-14-26(15-12-23)37-21-22-7-3-1-4-8-22/h1-16,19,28H,17-18,20-21H2,(H,32,38)
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Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...

Eur J Med Chem 155: 725-735 (2018)


Article DOI: 10.1016/j.ejmech.2018.06.043
BindingDB Entry DOI: 10.7270/Q2639SF8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50396483
PNG
(PLX-4032 | RG 7204 | Ro 5185426 | US10570155, Vemu...)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F
Show InChI InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28)
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Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...

Eur J Med Chem 155: 725-735 (2018)


Article DOI: 10.1016/j.ejmech.2018.06.043
BindingDB Entry DOI: 10.7270/Q2639SF8
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50457788
PNG
(CHEMBL4209555)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccccc2)c1F
Show InChI InChI=1S/C23H19F2N3O3S/c1-2-10-32(30,31)28-19-9-8-18(24)20(21(19)25)22(29)17-13-27-23-16(17)11-15(12-26-23)14-6-4-3-5-7-14/h3-9,11-13,28H,2,10H2,1H3,(H,26,27)
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Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of full-length GST-tagged mouse BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...

Bioorg Med Chem Lett 28: 2382-2390 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.028
BindingDB Entry DOI: 10.7270/Q2TM7DQ9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM5446
PNG
(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)
Show SMILES COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCOC
Show InChI InChI=1S/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25)
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n/an/a 40n/an/an/an/an/an/a



Nahda University

Curated by ChEMBL


Assay Description
Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human His6-tagged MEK1 as substrate preincubated for 1 hr followed by ...

Eur J Med Chem 156: 774-789 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.024
BindingDB Entry DOI: 10.7270/Q2GF0X69
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50468570
PNG
(CHEMBL4290513)
Show SMILES Brc1ccc(cc1)C1=NN(C(C1)c1ccc2OCCOc2c1)C(=S)Nc1ccccc1 |t:8|
Show InChI InChI=1S/C24H20BrN3O2S/c25-18-9-6-16(7-10-18)20-15-21(17-8-11-22-23(14-17)30-13-12-29-22)28(27-20)24(31)26-19-4-2-1-3-5-19/h1-11,14,21H,12-13,15H2,(H,26,31)
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Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...

Eur J Med Chem 155: 725-735 (2018)


Article DOI: 10.1016/j.ejmech.2018.06.043
BindingDB Entry DOI: 10.7270/Q2639SF8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM5446
PNG
(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)
Show SMILES COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCOC
Show InChI InChI=1S/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25)
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Aljouf University

Curated by ChEMBL


Assay Description
Inhibition of mouse full-length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...

Eur J Med Chem 146: 260-273 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.042
BindingDB Entry DOI: 10.7270/Q25X2CKD
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50468565
PNG
(CHEMBL4277125)
Show SMILES COc1cccc(c1)C1=NN(C(C1)c1ccc2OCCOc2c1)C(=S)Nc1ccccc1 |t:9|
Show InChI InChI=1S/C25H23N3O3S/c1-29-20-9-5-6-17(14-20)21-16-22(18-10-11-23-24(15-18)31-13-12-30-23)28(27-21)25(32)26-19-7-3-2-4-8-19/h2-11,14-15,22H,12-13,16H2,1H3,(H,26,32)
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Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...

Eur J Med Chem 155: 725-735 (2018)


Article DOI: 10.1016/j.ejmech.2018.06.043
BindingDB Entry DOI: 10.7270/Q2639SF8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50457924
PNG
(CHEMBL4208224)
Show SMILES Cc1c2cc(Cl)ccc2n2cc(Cc3ccccc3)[nH]c(=O)c12
Show InChI InChI=1S/C19H15ClN2O/c1-12-16-10-14(20)7-8-17(16)22-11-15(21-19(23)18(12)22)9-13-5-3-2-4-6-13/h2-8,10-11H,9H2,1H3,(H,21,23)
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Aljouf University

Curated by ChEMBL


Assay Description
Inhibition of mouse full-length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...

Eur J Med Chem 146: 260-273 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.042
BindingDB Entry DOI: 10.7270/Q25X2CKD
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50457806
PNG
(CHEMBL4206547)
Show SMILES COc1ccc(cc1)-n1cc(NC(=O)Cn2ccc(n2)-c2cccc(Cl)c2)cn1
Show InChI InChI=1S/C21H18ClN5O2/c1-29-19-7-5-18(6-8-19)27-13-17(12-23-27)24-21(28)14-26-10-9-20(25-26)15-3-2-4-16(22)11-15/h2-13H,14H2,1H3,(H,24,28)
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Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of full-length GST-tagged mouse BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...

Bioorg Med Chem Lett 28: 2382-2390 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.028
BindingDB Entry DOI: 10.7270/Q2TM7DQ9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM16673
PNG
(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)
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n/an/a 130n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...

Bioorg Med Chem 26: 2372-2380 (2018)


Article DOI: 10.1016/j.bmc.2018.03.038
BindingDB Entry DOI: 10.7270/Q27M0BKR
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50461196
PNG
(CHEMBL4228405)
Show SMILES FC(F)(F)c1ccc(cc1)C(=O)Nc1cccc(c1)C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C22H15F3N4O2/c23-22(24,25)16-6-4-13(5-7-16)20(30)27-17-3-1-2-14(10-17)21(31)28-18-8-9-19-15(11-18)12-26-29-19/h1-12H,(H,26,29)(H,27,30)(H,28,31)
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Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...

Bioorg Med Chem 26: 2372-2380 (2018)


Article DOI: 10.1016/j.bmc.2018.03.038
BindingDB Entry DOI: 10.7270/Q27M0BKR
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50457786
PNG
(CHEMBL4210074)
Show SMILES COc1cccc(c1)-n1cc(NC(=O)Cn2ccc(n2)-c2ccccn2)cn1
Show InChI InChI=1S/C20H18N6O2/c1-28-17-6-4-5-16(11-17)26-13-15(12-22-26)23-20(27)14-25-10-8-19(24-25)18-7-2-3-9-21-18/h2-13H,14H2,1H3,(H,23,27)
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Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of full-length GST-tagged mouse BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...

Bioorg Med Chem Lett 28: 2382-2390 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.028
BindingDB Entry DOI: 10.7270/Q2TM7DQ9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50457789
PNG
(CHEMBL4211435)
Show SMILES Clc1cccc(c1)-c1ccn(CC(=O)Nc2cnn(Cc3ccccc3)c2)n1
Show InChI InChI=1S/C21H18ClN5O/c22-18-8-4-7-17(11-18)20-9-10-26(25-20)15-21(28)24-19-12-23-27(14-19)13-16-5-2-1-3-6-16/h1-12,14H,13,15H2,(H,24,28)
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Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of full-length GST-tagged mouse BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...

Bioorg Med Chem Lett 28: 2382-2390 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.028
BindingDB Entry DOI: 10.7270/Q2TM7DQ9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50457805
PNG
(CHEMBL4217956)
Show SMILES COc1cccc(c1)-n1cc(NC(=O)Cc2ccc(OC)c(OC)c2)cn1
Show InChI InChI=1S/C20H21N3O4/c1-25-17-6-4-5-16(11-17)23-13-15(12-21-23)22-20(24)10-14-7-8-18(26-2)19(9-14)27-3/h4-9,11-13H,10H2,1-3H3,(H,22,24)
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Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of full-length GST-tagged mouse BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...

Bioorg Med Chem Lett 28: 2382-2390 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.028
BindingDB Entry DOI: 10.7270/Q2TM7DQ9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50457796
PNG
(CHEMBL4208630)
Show SMILES COc1ccc(cc1)-n1cc(NC(=O)Cc2ccc(OC)c(OC)c2)cn1
Show InChI InChI=1S/C20H21N3O4/c1-25-17-7-5-16(6-8-17)23-13-15(12-21-23)22-20(24)11-14-4-9-18(26-2)19(10-14)27-3/h4-10,12-13H,11H2,1-3H3,(H,22,24)
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Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of full-length GST-tagged mouse BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...

Bioorg Med Chem Lett 28: 2382-2390 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.028
BindingDB Entry DOI: 10.7270/Q2TM7DQ9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50457797
PNG
(CHEMBL4213568)
Show SMILES COc1ccc(CC(=O)Nc2cnn(c2)-c2ccc(C)cc2)cc1OC
Show InChI InChI=1S/C20H21N3O3/c1-14-4-7-17(8-5-14)23-13-16(12-21-23)22-20(24)11-15-6-9-18(25-2)19(10-15)26-3/h4-10,12-13H,11H2,1-3H3,(H,22,24)
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Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of full-length GST-tagged mouse BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...

Bioorg Med Chem Lett 28: 2382-2390 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.028
BindingDB Entry DOI: 10.7270/Q2TM7DQ9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50461206
PNG
(CHEMBL4225898)
Show SMILES Brc1ccc(nc1)C(=O)Nc1cccc(c1)C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C20H14BrN5O2/c21-14-4-6-18(22-11-14)20(28)25-15-3-1-2-12(8-15)19(27)24-16-5-7-17-13(9-16)10-23-26-17/h1-11H,(H,23,26)(H,24,27)(H,25,28)
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Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...

Bioorg Med Chem 26: 2372-2380 (2018)


Article DOI: 10.1016/j.bmc.2018.03.038
BindingDB Entry DOI: 10.7270/Q27M0BKR
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50457792
PNG
(CHEMBL4215335)
Show SMILES COc1cccc(c1)-n1cc(NC(=O)Cn2ccc3ccccc23)cn1
Show InChI InChI=1S/C20H18N4O2/c1-26-18-7-4-6-17(11-18)24-13-16(12-21-24)22-20(25)14-23-10-9-15-5-2-3-8-19(15)23/h2-13H,14H2,1H3,(H,22,25)
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Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of full-length GST-tagged mouse BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...

Bioorg Med Chem Lett 28: 2382-2390 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.028
BindingDB Entry DOI: 10.7270/Q2TM7DQ9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50457810
PNG
(CHEMBL4205180)
Show SMILES COc1ccc(cc1)-n1cc(NC(=O)Cn2ccc(n2)-c2ccccn2)cn1
Show InChI InChI=1S/C20H18N6O2/c1-28-17-7-5-16(6-8-17)26-13-15(12-22-26)23-20(27)14-25-11-9-19(24-25)18-4-2-3-10-21-18/h2-13H,14H2,1H3,(H,23,27)
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Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of full-length GST-tagged mouse BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...

Bioorg Med Chem Lett 28: 2382-2390 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.028
BindingDB Entry DOI: 10.7270/Q2TM7DQ9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50457798
PNG
(CHEMBL4210104)
Show SMILES COc1ccc(CC(=O)Nc2cnn(Cc3ccccc3)c2)cc1OC
Show InChI InChI=1S/C20H21N3O3/c1-25-18-9-8-16(10-19(18)26-2)11-20(24)22-17-12-21-23(14-17)13-15-6-4-3-5-7-15/h3-10,12,14H,11,13H2,1-2H3,(H,22,24)
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Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of full-length GST-tagged mouse BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...

Bioorg Med Chem Lett 28: 2382-2390 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.028
BindingDB Entry DOI: 10.7270/Q2TM7DQ9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50457802
PNG
(CHEMBL4205709)
Show SMILES O=C(Cn1ccc(n1)-c1ccccn1)Nc1cnn(c1)-c1ccccc1
Show InChI InChI=1S/C19H16N6O/c26-19(14-24-11-9-18(23-24)17-8-4-5-10-20-17)22-15-12-21-25(13-15)16-6-2-1-3-7-16/h1-13H,14H2,(H,22,26)
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Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of full-length GST-tagged mouse BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...

Bioorg Med Chem Lett 28: 2382-2390 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.028
BindingDB Entry DOI: 10.7270/Q2TM7DQ9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50457807
PNG
(CHEMBL4217416)
Show SMILES O=C(Cn1ccc(n1)-c1ccccn1)Nc1cnn(Cc2ccccc2)c1
Show InChI InChI=1S/C20H18N6O/c27-20(15-25-11-9-19(24-25)18-8-4-5-10-21-18)23-17-12-22-26(14-17)13-16-6-2-1-3-7-16/h1-12,14H,13,15H2,(H,23,27)
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Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of full-length GST-tagged mouse BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...

Bioorg Med Chem Lett 28: 2382-2390 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.028
BindingDB Entry DOI: 10.7270/Q2TM7DQ9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50457809
PNG
(CHEMBL4209989)
Show SMILES COc1ccc(CC(=O)Nc2cnn(c2)-c2ccccc2)cc1OC
Show InChI InChI=1S/C19H19N3O3/c1-24-17-9-8-14(10-18(17)25-2)11-19(23)21-15-12-20-22(13-15)16-6-4-3-5-7-16/h3-10,12-13H,11H2,1-2H3,(H,21,23)
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Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of full-length GST-tagged mouse BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...

Bioorg Med Chem Lett 28: 2382-2390 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.028
BindingDB Entry DOI: 10.7270/Q2TM7DQ9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50461204
PNG
(CHEMBL4227576)
Show SMILES CC(C)(C)c1ccc(cc1)C(=O)Nc1cccc(c1)C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C25H24N4O2/c1-25(2,3)19-9-7-16(8-10-19)23(30)27-20-6-4-5-17(13-20)24(31)28-21-11-12-22-18(14-21)15-26-29-22/h4-15H,1-3H3,(H,26,29)(H,27,30)(H,28,31)
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n/an/a 750n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...

Bioorg Med Chem 26: 2372-2380 (2018)


Article DOI: 10.1016/j.bmc.2018.03.038
BindingDB Entry DOI: 10.7270/Q27M0BKR
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50481441
PNG
(CHEMBL5280636)
Show SMILES OC(=O)c1ccc(cc1)\N=N\c1cc2Cc3cc(cc(Cc4cc(cc(Cc5cc(cc(Cc(c1)c2O)c5O)\N=N\c1ccc(cc1)C(O)=O)c4O)\N=N\c1ccc(cc1)C(O)=O)c3O)\N=N\c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C56H40N8O12/c65-49-33-17-35-23-46(62-58-42-11-3-30(4-12-42)54(71)72)25-37(50(35)66)19-39-27-48(64-60-44-15-7-32(8-16-44)56(75)76)28-40(52(39)68)20-38-26-47(63-59-43-13-5-31(6-14-43)55(73)74)24-36(51(38)67)18-34(49)22-45(21-33)61-57-41-9-1-29(2-10-41)53(69)70/h1-16,21-28,65-68H,17-20H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)/b61-57+,62-58+,63-59+,64-60+
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More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50461197
PNG
(CHEMBL4226687)
Show SMILES Cc1cccc(n1)C(=O)Nc1cccc(c1)C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C21H17N5O2/c1-13-4-2-7-19(23-13)21(28)25-16-6-3-5-14(10-16)20(27)24-17-8-9-18-15(11-17)12-22-26-18/h2-12H,1H3,(H,22,26)(H,24,27)(H,25,28)
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Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...

Bioorg Med Chem 26: 2372-2380 (2018)


Article DOI: 10.1016/j.bmc.2018.03.038
BindingDB Entry DOI: 10.7270/Q27M0BKR
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50468572
PNG
(CHEMBL4279170)
Show SMILES S=C(Nc1ccccc1)N1N=C(CC1c1ccc2OCCOc2c1)c1ccccc1 |c:11|
Show InChI InChI=1S/C24H21N3O2S/c30-24(25-19-9-5-2-6-10-19)27-21(16-20(26-27)17-7-3-1-4-8-17)18-11-12-22-23(15-18)29-14-13-28-22/h1-12,15,21H,13-14,16H2,(H,25,30)
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Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...

Eur J Med Chem 155: 725-735 (2018)


Article DOI: 10.1016/j.ejmech.2018.06.043
BindingDB Entry DOI: 10.7270/Q2639SF8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50172062
PNG
(CHEMBL3806108)
Show SMILES CN(C)c1ccc(cc1)C1CC(=NN1c1ccccc1)c1ccc2OCCOc2c1 |c:12|
Show InChI InChI=1S/C25H25N3O2/c1-27(2)20-11-8-18(9-12-20)23-17-22(26-28(23)21-6-4-3-5-7-21)19-10-13-24-25(16-19)30-15-14-29-24/h3-13,16,23H,14-15,17H2,1-2H3
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n/an/a 870n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of mouse wild type BRAF assessed as reduction in human full length N-terminal His-tagged MEK1 phosphorylation pre-incubated for 1 hr befor...

Bioorg Med Chem 24: 3052-3061 (2016)


Article DOI: 10.1016/j.bmc.2016.05.012
BindingDB Entry DOI: 10.7270/Q2HX1FKZ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50457928
PNG
(CHEMBL4213146)
Show SMILES CCc1c2cc(ccc2n2cc(Cc3ccccc3)[nH]c(=O)c12)C(F)(F)F
Show InChI InChI=1S/C21H17F3N2O/c1-2-16-17-11-14(21(22,23)24)8-9-18(17)26-12-15(25-20(27)19(16)26)10-13-6-4-3-5-7-13/h3-9,11-12H,2,10H2,1H3,(H,25,27)
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Aljouf University

Curated by ChEMBL


Assay Description
Inhibition of mouse full-length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...

Eur J Med Chem 146: 260-273 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.042
BindingDB Entry DOI: 10.7270/Q25X2CKD
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50481443
PNG
(CHEMBL5270977)
Show SMILES OC(=O)COc1c2cccc1sc1cccc(sc3cccc(sc4cccc(s2)c4OCC(O)=O)c3OCC(O)=O)c1OCC(O)=O
Show InChI InChI=1S/C32H24O12S4/c33-25(34)13-41-29-17-5-1-6-18(29)46-20-8-3-10-22(31(20)43-15-27(37)38)48-24-12-4-11-23(32(24)44-16-28(39)40)47-21-9-2-7-19(45-17)30(21)42-14-26(35)36/h1-12H,13-16H2,(H,33,34)(H,35,36)(H,37,38)(H,39,40)
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Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50457927
PNG
(CHEMBL4208745)
Show SMILES Clc1ccc2c(cc3n2cc(Cc2ccccc2)[nH]c3=O)c1
Show InChI InChI=1S/C18H13ClN2O/c19-14-6-7-16-13(9-14)10-17-18(22)20-15(11-21(16)17)8-12-4-2-1-3-5-12/h1-7,9-11H,8H2,(H,20,22)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Aljouf University

Curated by ChEMBL


Assay Description
Inhibition of mouse full-length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...

Eur J Med Chem 146: 260-273 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.042
BindingDB Entry DOI: 10.7270/Q25X2CKD
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50457925
PNG
(CHEMBL4207316)
Show SMILES CCc1c([nH]c2ccc(cc12)C(F)(F)F)C(=O)NC(CO)Cc1ccccc1
Show InChI InChI=1S/C21H21F3N2O2/c1-2-16-17-11-14(21(22,23)24)8-9-18(17)26-19(16)20(28)25-15(12-27)10-13-6-4-3-5-7-13/h3-9,11,15,26-27H,2,10,12H2,1H3,(H,25,28)
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Aljouf University

Curated by ChEMBL


Assay Description
Inhibition of mouse full-length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...

Eur J Med Chem 146: 260-273 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.042
BindingDB Entry DOI: 10.7270/Q25X2CKD
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50461198
PNG
(CHEMBL4225848)
Show SMILES Clc1cccc(n1)C(=O)Nc1cccc(c1)C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C20H14ClN5O2/c21-18-6-2-5-17(25-18)20(28)24-14-4-1-3-12(9-14)19(27)23-15-7-8-16-13(10-15)11-22-26-16/h1-11H,(H,22,26)(H,23,27)(H,24,28)
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Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...

Bioorg Med Chem 26: 2372-2380 (2018)


Article DOI: 10.1016/j.bmc.2018.03.038
BindingDB Entry DOI: 10.7270/Q27M0BKR
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50172059
PNG
(CHEMBL3805508)
Show SMILES C(Oc1cccc(c1)C1CC(=NN1c1ccccc1)c1ccc2OCCOc2c1)c1ccccc1 |c:11|
Show InChI InChI=1S/C30H26N2O3/c1-3-8-22(9-4-1)21-35-26-13-7-10-24(18-26)28-20-27(31-32(28)25-11-5-2-6-12-25)23-14-15-29-30(19-23)34-17-16-33-29/h1-15,18-19,28H,16-17,20-21H2
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n/an/a 1.06E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of mouse wild type BRAF assessed as reduction in human full length N-terminal His-tagged MEK1 phosphorylation pre-incubated for 1 hr befor...

Bioorg Med Chem 24: 3052-3061 (2016)


Article DOI: 10.1016/j.bmc.2016.05.012
BindingDB Entry DOI: 10.7270/Q2HX1FKZ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50461205
PNG
(CHEMBL4225048)
Show SMILES Clc1ccnc(c1)C(=O)Nc1cccc(c1)C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C20H14ClN5O2/c21-14-6-7-22-18(10-14)20(28)25-15-3-1-2-12(8-15)19(27)24-16-4-5-17-13(9-16)11-23-26-17/h1-11H,(H,23,26)(H,24,27)(H,25,28)
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n/an/a 1.14E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...

Bioorg Med Chem 26: 2372-2380 (2018)


Article DOI: 10.1016/j.bmc.2018.03.038
BindingDB Entry DOI: 10.7270/Q27M0BKR
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50457801
PNG
(CHEMBL4210916)
Show SMILES CCn1cc(NC(=O)Cn2ccc(n2)-c2cccc(Cl)c2)cn1
Show InChI InChI=1S/C16H16ClN5O/c1-2-21-10-14(9-18-21)19-16(23)11-22-7-6-15(20-22)12-4-3-5-13(17)8-12/h3-10H,2,11H2,1H3,(H,19,23)
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n/an/a 1.19E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of full-length GST-tagged mouse BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...

Bioorg Med Chem Lett 28: 2382-2390 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.028
BindingDB Entry DOI: 10.7270/Q2TM7DQ9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50457787
PNG
(CHEMBL4208019)
Show SMILES O=C(Cn1ccc2ccccc12)Nc1cnn(c1)-c1ccccc1
Show InChI InChI=1S/C19H16N4O/c24-19(14-22-11-10-15-6-4-5-9-18(15)22)21-16-12-20-23(13-16)17-7-2-1-3-8-17/h1-13H,14H2,(H,21,24)
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Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of full-length GST-tagged mouse BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...

Bioorg Med Chem Lett 28: 2382-2390 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.028
BindingDB Entry DOI: 10.7270/Q2TM7DQ9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50457793
PNG
(CHEMBL4203663)
Show SMILES COc1ccc(cc1)-n1cc(NC(=O)Cn2ccc3ccccc23)cn1
Show InChI InChI=1S/C20H18N4O2/c1-26-18-8-6-17(7-9-18)24-13-16(12-21-24)22-20(25)14-23-11-10-15-4-2-3-5-19(15)23/h2-13H,14H2,1H3,(H,22,25)
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Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of full-length GST-tagged mouse BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...

Bioorg Med Chem Lett 28: 2382-2390 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.028
BindingDB Entry DOI: 10.7270/Q2TM7DQ9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50461194
PNG
(CHEMBL4228935)
Show SMILES Fc1ccc(cc1)C(=O)Nc1cccc(c1)C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C21H15FN4O2/c22-16-6-4-13(5-7-16)20(27)24-17-3-1-2-14(10-17)21(28)25-18-8-9-19-15(11-18)12-23-26-19/h1-12H,(H,23,26)(H,24,27)(H,25,28)
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n/an/a 1.57E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...

Bioorg Med Chem 26: 2372-2380 (2018)


Article DOI: 10.1016/j.bmc.2018.03.038
BindingDB Entry DOI: 10.7270/Q27M0BKR
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50457791
PNG
(CHEMBL4215872)
Show SMILES Cn1cc(NC(=O)Cn2ccc(n2)-c2cccc(Cl)c2)cn1
Show InChI InChI=1S/C15H14ClN5O/c1-20-9-13(8-17-20)18-15(22)10-21-6-5-14(19-21)11-3-2-4-12(16)7-11/h2-9H,10H2,1H3,(H,18,22)
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n/an/a 1.67E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of full-length GST-tagged mouse BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...

Bioorg Med Chem Lett 28: 2382-2390 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.028
BindingDB Entry DOI: 10.7270/Q2TM7DQ9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50457795
PNG
(CHEMBL4211407)
Show SMILES CCn1cc(NC(=O)Cn2ccc3ccccc23)cn1
Show InChI InChI=1S/C15H16N4O/c1-2-19-10-13(9-16-19)17-15(20)11-18-8-7-12-5-3-4-6-14(12)18/h3-10H,2,11H2,1H3,(H,17,20)
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n/an/a 1.82E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of full-length GST-tagged mouse BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...

Bioorg Med Chem Lett 28: 2382-2390 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.028
BindingDB Entry DOI: 10.7270/Q2TM7DQ9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50172060
PNG
(CHEMBL3805409)
Show SMILES Clc1cccc(c1)C1CC(=NN1c1ccccc1)c1ccc2OCCOc2c1 |c:10|
Show InChI InChI=1S/C23H19ClN2O2/c24-18-6-4-5-17(13-18)21-15-20(25-26(21)19-7-2-1-3-8-19)16-9-10-22-23(14-16)28-12-11-27-22/h1-10,13-14,21H,11-12,15H2
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n/an/a 1.83E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of mouse wild type BRAF assessed as reduction in human full length N-terminal His-tagged MEK1 phosphorylation pre-incubated for 1 hr befor...

Bioorg Med Chem 24: 3052-3061 (2016)


Article DOI: 10.1016/j.bmc.2016.05.012
BindingDB Entry DOI: 10.7270/Q2HX1FKZ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50457808
PNG
(CHEMBL4218392)
Show SMILES O=C(Cn1ccc2ccccc12)Nc1cnn(Cc2ccccc2)c1
Show InChI InChI=1S/C20H18N4O/c25-20(15-23-11-10-17-8-4-5-9-19(17)23)22-18-12-21-24(14-18)13-16-6-2-1-3-7-16/h1-12,14H,13,15H2,(H,22,25)
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n/an/a 1.96E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of full-length GST-tagged mouse BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...

Bioorg Med Chem Lett 28: 2382-2390 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.028
BindingDB Entry DOI: 10.7270/Q2TM7DQ9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50461200
PNG
(CHEMBL4225322)
Show SMILES O=C(Nc1cccc(c1)C(=O)Nc1ccc2[nH]ccc2c1)c1ccccc1
Show InChI InChI=1S/C22H17N3O2/c26-21(15-5-2-1-3-6-15)24-18-8-4-7-17(14-18)22(27)25-19-9-10-20-16(13-19)11-12-23-20/h1-14,23H,(H,24,26)(H,25,27)
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n/an/a 2.11E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...

Bioorg Med Chem 26: 2372-2380 (2018)


Article DOI: 10.1016/j.bmc.2018.03.038
BindingDB Entry DOI: 10.7270/Q27M0BKR
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50457794
PNG
(CHEMBL4203142)
Show SMILES Cc1ccc(cc1)-n1cc(NC(=O)Cn2ccc3ccccc23)cn1
Show InChI InChI=1S/C20H18N4O/c1-15-6-8-18(9-7-15)24-13-17(12-21-24)22-20(25)14-23-11-10-16-4-2-3-5-19(16)23/h2-13H,14H2,1H3,(H,22,25)
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n/an/a 2.34E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of full-length GST-tagged mouse BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...

Bioorg Med Chem Lett 28: 2382-2390 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.028
BindingDB Entry DOI: 10.7270/Q2TM7DQ9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50172061
PNG
(CHEMBL3805893)
Show SMILES C(Oc1ccc(cc1)C1CC(=NN1c1ccccc1)c1ccc2OCCOc2c1)c1ccccc1 |c:11|
Show InChI InChI=1S/C30H26N2O3/c1-3-7-22(8-4-1)21-35-26-14-11-23(12-15-26)28-20-27(31-32(28)25-9-5-2-6-10-25)24-13-16-29-30(19-24)34-18-17-33-29/h1-16,19,28H,17-18,20-21H2
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n/an/a 2.51E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of mouse wild type BRAF assessed as reduction in human full length N-terminal His-tagged MEK1 phosphorylation pre-incubated for 1 hr befor...

Bioorg Med Chem 24: 3052-3061 (2016)


Article DOI: 10.1016/j.bmc.2016.05.012
BindingDB Entry DOI: 10.7270/Q2HX1FKZ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50457804
PNG
(CHEMBL4208969)
Show SMILES Cn1cc(NC(=O)Cn2ccc(n2)-c2ccccn2)cn1
Show InChI InChI=1S/C14H14N6O/c1-19-9-11(8-16-19)17-14(21)10-20-7-5-13(18-20)12-4-2-3-6-15-12/h2-9H,10H2,1H3,(H,17,21)
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n/an/a 2.54E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of full-length GST-tagged mouse BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...

Bioorg Med Chem Lett 28: 2382-2390 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.028
BindingDB Entry DOI: 10.7270/Q2TM7DQ9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50461192
PNG
(CHEMBL4225380)
Show SMILES Clc1ccc(cc1)C(=O)Nc1cccc(c1)C(=O)Nc1ccc2[nH]ccc2c1
Show InChI InChI=1S/C22H16ClN3O2/c23-17-6-4-14(5-7-17)21(27)25-18-3-1-2-16(13-18)22(28)26-19-8-9-20-15(12-19)10-11-24-20/h1-13,24H,(H,25,27)(H,26,28)
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n/an/a 2.61E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...

Bioorg Med Chem 26: 2372-2380 (2018)


Article DOI: 10.1016/j.bmc.2018.03.038
BindingDB Entry DOI: 10.7270/Q27M0BKR
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50172058
PNG
(CHEMBL3805675)
Show SMILES COc1cccc(c1)C1CC(=NN1c1ccccc1)c1ccc2OCCOc2c1 |c:11|
Show InChI InChI=1S/C24H22N2O3/c1-27-20-9-5-6-18(14-20)22-16-21(25-26(22)19-7-3-2-4-8-19)17-10-11-23-24(15-17)29-13-12-28-23/h2-11,14-15,22H,12-13,16H2,1H3
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n/an/a 2.62E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of mouse wild type BRAF assessed as reduction in human full length N-terminal His-tagged MEK1 phosphorylation pre-incubated for 1 hr befor...

Bioorg Med Chem 24: 3052-3061 (2016)


Article DOI: 10.1016/j.bmc.2016.05.012
BindingDB Entry DOI: 10.7270/Q2HX1FKZ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Mus musculus)		BDBM50461191
PNG
(CHEMBL4228262)
Show SMILES Brc1ccc(cc1)C(=O)Nc1cccc(c1)C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C21H15BrN4O2/c22-16-6-4-13(5-7-16)20(27)24-17-3-1-2-14(10-17)21(28)25-18-8-9-19-15(11-18)12-23-26-19/h1-12H,(H,23,26)(H,24,27)(H,25,28)
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n/an/a 2.78E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...

Bioorg Med Chem 26: 2372-2380 (2018)


Article DOI: 10.1016/j.bmc.2018.03.038
BindingDB Entry DOI: 10.7270/Q27M0BKR
More data for this
Ligand-Target Pair
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