Compile Data Set for Download or QSAR

Found 6 hits of ic50 for UniProtKB: P35739   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Rattus norvegicus)	BDBM226354 (US9328096, 47) Show SMILES CC(C)(O)CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 Show InChI InChI=1S/C26H23Cl2N5O3/c1-26(2,36)15-30-25(35)22-14-23(33(32-22)16-8-4-3-5-9-16)31-24(34)18-12-17(19(27)13-20(18)28)21-10-6-7-11-29-21/h3-14,36H,15H2,1-2H3,(H,30,35)(H,31,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at unphosphorylated rat TrkA expressed in baculovirus expression system preincubated for 20 mins followed by TK-substrate-Biotin ...				J Med Chem 62: 247-265 (2019) Article DOI: 10.1021/acs.jmedchem.8b00280 BindingDB Entry DOI: 10.7270/Q2QR51CZ
					More data for this Ligand-Target Pair				3D Structure (crystal)
High affinity nerve growth factor receptor (Rattus norvegicus)	BDBM50502896 (CHEMBL4458913) Show SMILES Cc1ccc2nc(CSc3nnc(NC(=O)Nc4cccc(c4)C(F)(F)F)s3)cc(=O)n2c1 Show InChI InChI=1S/C20H15F3N6O2S2/c1-11-5-6-15-24-14(8-16(30)29(15)9-11)10-32-19-28-27-18(33-19)26-17(31)25-13-4-2-3-12(7-13)20(21,22)23/h2-9H,10H2,1H3,(H2,25,26,27,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Zoetis Inc Curated by ChEMBL					Assay Description Inhibition of TrkA in rat PC12 cells assessed as reduction in beta-NGF-induced neurite outgrowth preincubated for 30 mins followed by beta-NGF stimul...				Bioorg Med Chem Lett 29: (2019) Article DOI: 10.1016/j.bmcl.2019.126680 BindingDB Entry DOI: 10.7270/Q2280BVB
					More data for this Ligand-Target Pair				3D Structure (crystal)
High affinity nerve growth factor receptor (Rattus norvegicus)	BDBM226354 (US9328096, 47) Show SMILES CC(C)(O)CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 Show InChI InChI=1S/C26H23Cl2N5O3/c1-26(2,36)15-30-25(35)22-14-23(33(32-22)16-8-4-3-5-9-16)31-24(34)18-12-17(19(27)13-20(18)28)21-10-6-7-11-29-21/h3-14,36H,15H2,1-2H3,(H,30,35)(H,31,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	57	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at TrkA in rat DRG assessed as inhibition of NGF-induced ERK phosphorylation preincubated for 60 mins followed by NGF addition an...				J Med Chem 62: 247-265 (2019) Article DOI: 10.1021/acs.jmedchem.8b00280 BindingDB Entry DOI: 10.7270/Q2QR51CZ
					More data for this Ligand-Target Pair				3D Structure (crystal)
High affinity nerve growth factor receptor (Rattus norvegicus)	BDBM50525706 (CHEMBL4447685) Show SMILES CC(C)(C)c1cc(NC(=O)COC(=O)c2ccc(cc2)-n2cnnn2)n(n1)-c1ccccc1 Show InChI InChI=1S/C23H23N7O3/c1-23(2,3)19-13-20(30(26-19)18-7-5-4-6-8-18)25-21(31)14-33-22(32)16-9-11-17(12-10-16)29-15-24-27-28-29/h4-13,15H,14H2,1-3H3,(H,25,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	429	n/a	n/a	n/a	n/a	n/a	n/a
Zoetis Curated by ChEMBL					Assay Description Inhibition of TrkA in rat PC12 cells assessed as reduction in beta-NGF-induced neurite outgrowth incubated for 7 days by live cell imaging analysis				Bioorg Med Chem Lett 29: (2019) Article DOI: 10.1016/j.bmcl.2019.126624 BindingDB Entry DOI: 10.7270/Q2BV7M2B
					More data for this Ligand-Target Pair				3D Structure (crystal)
High affinity nerve growth factor receptor (Rattus norvegicus)	BDBM50111443 (2-(2-Hydroxy-ethylamino)-5-nitro-benzo[de]isoquino...) Show SMILES OCCNN1C(=O)c2cccc3cc(cc(C1=O)c23)[N+]([O-])=O Show InChI InChI=1S/C14H11N3O5/c18-5-4-15-16-13(19)10-3-1-2-8-6-9(17(21)22)7-11(12(8)10)14(16)20/h1-3,6-7,15,18H,4-5H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	5.88E+3	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of binding of [125I]-NGF to TrkA in rat PC12 cells incubated for 2 hrs by gamma counting method				J Med Chem 60: 66-88 (2017) Article DOI: 10.1021/acs.jmedchem.6b00964 BindingDB Entry DOI: 10.7270/Q2C24ZCR
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Rattus norvegicus)	BDBM50525709 (CHEMBL4555143) Show SMILES CC(C)(C)c1cc(NC(=O)CSc2nnnn2-c2ccccc2)n(n1)-c1ccccc1 Show InChI InChI=1S/C22H23N7OS/c1-22(2,3)18-14-19(28(25-18)16-10-6-4-7-11-16)23-20(30)15-31-21-24-26-27-29(21)17-12-8-5-9-13-17/h4-14H,15H2,1-3H3,(H,23,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Zoetis Curated by ChEMBL					Assay Description Inhibition of TrkA in rat PC12 cells assessed as reduction in beta-NGF-induced neurite outgrowth incubated for 7 days by live cell imaging analysis				Bioorg Med Chem Lett 29: (2019) Article DOI: 10.1016/j.bmcl.2019.126624 BindingDB Entry DOI: 10.7270/Q2BV7M2B
					More data for this Ligand-Target Pair