Compile Data Set for Download or QSAR

Found 801 hits of ec50 for UniProtKB: P31421   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50467057 (CHEMBL4295230) Show SMILES Cc1cccc(c1C)-c1ccc(OC[C@@H]2Cn3c(O2)nc(=O)cc3C)cc1 |r| Show InChI InChI=1S/C22H22N2O3/c1-14-5-4-6-20(16(14)3)17-7-9-18(10-8-17)26-13-19-12-24-15(2)11-21(25)23-22(24)27-19/h4-11,19H,12-13H2,1-3H3/t19-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
Sanofi US Curated by ChEMBL					Assay Description Positive allosteric modulation of recombinant rat Gi-coupled mGluR2 expressed in HEK293 Flp-in-T-REx cells with Galpha16 assessed as increase in glut...				Bioorg Med Chem Lett 28: 3194-3196 (2018) Article DOI: 10.1016/j.bmcl.2018.08.022 BindingDB Entry DOI: 10.7270/Q2Z60RRB
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50576816 (CHEMBL4846872) Show SMILES COc1ccc(OCCCCOc2ccc(C(=O)CC(C)(C)C)c(O)c2C)cc1C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a
TBA					Assay Description Positive allosteric modulator activity at rat mGlu2 receptor transfected in GIRK channel overexpressing cells assessed as potentiation of glutamate-i...				Citation and Details Article DOI: 10.1016/j.bmcl.2021.128342 BindingDB Entry DOI: 10.7270/Q22F7S71
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50467052 (CHEMBL4279401) Show SMILES CCc1cn2C[C@@H](COc3ccc(cc3)-c3cccc(C)c3C)Oc2nc1=O |r| Show InChI InChI=1S/C23H24N2O3/c1-4-17-12-25-13-20(28-23(25)24-22(17)26)14-27-19-10-8-18(9-11-19)21-7-5-6-15(2)16(21)3/h5-12,20H,4,13-14H2,1-3H3/t20-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
Sanofi US Curated by ChEMBL					Assay Description Positive allosteric modulation of recombinant rat Gi-coupled mGluR2 expressed in HEK293 Flp-in-T-REx cells with Galpha16 assessed as increase in glut...				Bioorg Med Chem Lett 28: 3194-3196 (2018) Article DOI: 10.1016/j.bmcl.2018.08.022 BindingDB Entry DOI: 10.7270/Q2Z60RRB
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393906 (US10597367, Example 203 | US9969726, Example 203) Show SMILES Cc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)C#CCO |c:4| Show InChI InChI=1S/C20H15F3N2O2/c1-12-8-17-18(10-15(12)20(21,22)23)25-19(27)11-16(24-17)14-6-2-4-13(9-14)5-3-7-26/h2,4,6,8-10,26H,7,11H2,1H3,(H,25,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393882 (US10597367, Example 179 | US9969726, Example 179) Show SMILES Brc1ccc2N=C(CC(=O)Nc2c1)c1cccc(c1)-c1cccnc1 |c:5| Show InChI InChI=1S/C20H14BrN3O/c21-16-6-7-17-19(10-16)24-20(25)11-18(23-17)14-4-1-3-13(9-14)15-5-2-8-22-12-15/h1-10,12H,11H2,(H,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE US Patent					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				US Patent US10597367 (2020) BindingDB Entry DOI: 10.7270/Q2GB272Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393882 (US10597367, Example 179 | US9969726, Example 179) Show SMILES Brc1ccc2N=C(CC(=O)Nc2c1)c1cccc(c1)-c1cccnc1 |c:5| Show InChI InChI=1S/C20H14BrN3O/c21-16-6-7-17-19(10-16)24-20(25)11-18(23-17)14-4-1-3-13(9-14)15-5-2-8-22-12-15/h1-10,12H,11H2,(H,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393857 (US10597367, Example 149 | US9969726, Example 149) Show SMILES Cc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(Oc2ncccn2)c1 |c:4| Show InChI InChI=1S/C21H15F3N4O2/c1-12-8-17-18(10-15(12)21(22,23)24)28-19(29)11-16(27-17)13-4-2-5-14(9-13)30-20-25-6-3-7-26-20/h2-10H,11H2,1H3,(H,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE US Patent					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				US Patent US10597367 (2020) BindingDB Entry DOI: 10.7270/Q2GB272Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393857 (US10597367, Example 149 | US9969726, Example 149) Show SMILES Cc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(Oc2ncccn2)c1 |c:4| Show InChI InChI=1S/C21H15F3N4O2/c1-12-8-17-18(10-15(12)21(22,23)24)28-19(29)11-16(27-17)13-4-2-5-14(9-13)30-20-25-6-3-7-26-20/h2-10H,11H2,1H3,(H,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393906 (US10597367, Example 203 | US9969726, Example 203) Show SMILES Cc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)C#CCO |c:4| Show InChI InChI=1S/C20H15F3N2O2/c1-12-8-17-18(10-15(12)20(21,22)23)25-19(27)11-16(24-17)14-6-2-4-13(9-14)5-3-7-26/h2,4,6,8-10,26H,7,11H2,1H3,(H,25,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE US Patent					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				US Patent US10597367 (2020) BindingDB Entry DOI: 10.7270/Q2GB272Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50576836 (CHEMBL4853369) Show SMILES COc1cc(ccc1OC[C@H](C)COc1ccc(C(=O)CC(C)(C)C)c(O)c1C)C(O)=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	28	n/a	n/a	n/a	n/a
TBA					Assay Description Positive allosteric modulator activity at rat mGlu2 receptor transfected in GIRK channel overexpressing cells assessed as potentiation of glutamate-i...				Citation and Details Article DOI: 10.1016/j.bmcl.2021.128342 BindingDB Entry DOI: 10.7270/Q22F7S71
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50576811 (CHEMBL4863303) Show SMILES Cc1ncc(OCCCCOc2ccc(C(=O)CC(C)(C)C)c(O)c2C)cc1C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	28	n/a	n/a	n/a	n/a
TBA					Assay Description Positive allosteric modulator activity at rat mGlu2 receptor transfected in GIRK channel overexpressing cells assessed as potentiation of glutamate-i...				Citation and Details Article DOI: 10.1016/j.bmcl.2021.128342 BindingDB Entry DOI: 10.7270/Q22F7S71
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393886 (US10597367, Example 183 | US9969726, Example 183) Show SMILES Ic1ccc2N=C(CC(=O)Nc2c1)c1ccnc(c1)C#N |c:5| Show InChI InChI=1S/C15H9IN4O/c16-10-1-2-12-14(6-10)20-15(21)7-13(19-12)9-3-4-18-11(5-9)8-17/h1-6H,7H2,(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	30	n/a	n/a	n/a	n/a
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE US Patent					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				US Patent US10597367 (2020) BindingDB Entry DOI: 10.7270/Q2GB272Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50467054 (CHEMBL4288731) Show SMILES Cc1cccc(c1C)-c1ccc(OC[C@@H]2Cn3ccc(=O)nc3O2)cc1 |r| Show InChI InChI=1S/C21H20N2O3/c1-14-4-3-5-19(15(14)2)16-6-8-17(9-7-16)25-13-18-12-23-11-10-20(24)22-21(23)26-18/h3-11,18H,12-13H2,1-2H3/t18-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	30	n/a	n/a	n/a	n/a
Sanofi US Curated by ChEMBL					Assay Description Positive allosteric modulation of recombinant rat Gi-coupled mGluR2 expressed in HEK293 Flp-in-T-REx cells with Galpha16 assessed as increase in glut...				Bioorg Med Chem Lett 28: 3194-3196 (2018) Article DOI: 10.1016/j.bmcl.2018.08.022 BindingDB Entry DOI: 10.7270/Q2Z60RRB
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393886 (US10597367, Example 183 | US9969726, Example 183) Show SMILES Ic1ccc2N=C(CC(=O)Nc2c1)c1ccnc(c1)C#N |c:5| Show InChI InChI=1S/C15H9IN4O/c16-10-1-2-12-14(6-10)20-15(21)7-13(19-12)9-3-4-18-11(5-9)8-17/h1-6H,7H2,(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	30	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50056272 ((1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dic...) Show SMILES N[C@]1(CC[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C8H11NO4/c9-8(7(12)13)2-1-3-4(5(3)8)6(10)11/h3-5H,1-2,9H2,(H,10,11)(H,12,13)/t3-,4-,5-,8-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article	n/a	n/a	n/a	n/a	35	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Tested for the agonistic activity against Metabotropic glutamate receptor 2				Bioorg Med Chem Lett 7: 601-606 (1997) Article DOI: 10.1016/S0960-894X(97)00068-1 BindingDB Entry DOI: 10.7270/Q27944QG
					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393885 (US10597367, Example 182 | US9969726, Example 182) Show SMILES Brc1ccc2N=C(CC(=O)Nc2c1)c1ccnc(c1)C#N |c:5| Show InChI InChI=1S/C15H9BrN4O/c16-10-1-2-12-14(6-10)20-15(21)7-13(19-12)9-3-4-18-11(5-9)8-17/h1-6H,7H2,(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393885 (US10597367, Example 182 | US9969726, Example 182) Show SMILES Brc1ccc2N=C(CC(=O)Nc2c1)c1ccnc(c1)C#N |c:5| Show InChI InChI=1S/C15H9BrN4O/c16-10-1-2-12-14(6-10)20-15(21)7-13(19-12)9-3-4-18-11(5-9)8-17/h1-6H,7H2,(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393885 (US10597367, Example 182 | US9969726, Example 182) Show SMILES Brc1ccc2N=C(CC(=O)Nc2c1)c1ccnc(c1)C#N |c:5| Show InChI InChI=1S/C15H9BrN4O/c16-10-1-2-12-14(6-10)20-15(21)7-13(19-12)9-3-4-18-11(5-9)8-17/h1-6H,7H2,(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE US Patent					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				US Patent US10597367 (2020) BindingDB Entry DOI: 10.7270/Q2GB272Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393848 (US10597367, Example 136 | US9969726, Example 136) Show SMILES Cc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(Sc2ncccn2)c1 |c:4| Show InChI InChI=1S/C21H15F3N4OS/c1-12-8-17-18(10-15(12)21(22,23)24)28-19(29)11-16(27-17)13-4-2-5-14(9-13)30-20-25-6-3-7-26-20/h2-10H,11H2,1H3,(H,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393885 (US10597367, Example 182 | US9969726, Example 182) Show SMILES Brc1ccc2N=C(CC(=O)Nc2c1)c1ccnc(c1)C#N |c:5| Show InChI InChI=1S/C15H9BrN4O/c16-10-1-2-12-14(6-10)20-15(21)7-13(19-12)9-3-4-18-11(5-9)8-17/h1-6H,7H2,(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE US Patent					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				US Patent US10597367 (2020) BindingDB Entry DOI: 10.7270/Q2GB272Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393797 (US10597367, Example 86 | US9969726, Example 86) Show SMILES OC(=O)c1cc(ccc1F)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccccc1 Show InChI InChI=1S/C24H14F4N2O2/c25-19-10-9-16(12-18(19)23(31)32)15-7-4-8-17(11-15)22-29-20(14-5-2-1-3-6-14)13-21(30-22)24(26,27)28/h1-13H,(H,31,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393848 (US10597367, Example 136 | US9969726, Example 136) Show SMILES Cc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(Sc2ncccn2)c1 |c:4| Show InChI InChI=1S/C21H15F3N4OS/c1-12-8-17-18(10-15(12)21(22,23)24)28-19(29)11-16(27-17)13-4-2-5-14(9-13)30-20-25-6-3-7-26-20/h2-10H,11H2,1H3,(H,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE US Patent					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				US Patent US10597367 (2020) BindingDB Entry DOI: 10.7270/Q2GB272Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393797 (US10597367, Example 86 | US9969726, Example 86) Show SMILES OC(=O)c1cc(ccc1F)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccccc1 Show InChI InChI=1S/C24H14F4N2O2/c25-19-10-9-16(12-18(19)23(31)32)15-7-4-8-17(11-15)22-29-20(14-5-2-1-3-6-14)13-21(30-22)24(26,27)28/h1-13H,(H,31,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE US Patent					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				US Patent US10597367 (2020) BindingDB Entry DOI: 10.7270/Q2GB272Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393749 (US10597367, Example 39 | US9969726, Example 39) Show SMILES c1ccc(cc1)-c1nc(ns1)-c1cccc(c1)-c1ccccc1 Show InChI InChI=1S/C20H14N2S/c1-3-8-15(9-4-1)17-12-7-13-18(14-17)19-21-20(23-22-19)16-10-5-2-6-11-16/h1-14H	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE US Patent					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				US Patent US10597367 (2020) BindingDB Entry DOI: 10.7270/Q2GB272Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393831 (US10597367, Example 119 | US9969726, Example 119) Show SMILES Cc1cc(nc(n1)-c1cccc(c1)-c1cccc(c1)C(O)=O)-c1ccoc1 Show InChI InChI=1S/C22H16N2O3/c1-14-10-20(19-8-9-27-13-19)24-21(23-14)17-6-2-4-15(11-17)16-5-3-7-18(12-16)22(25)26/h2-13H,1H3,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393749 (US10597367, Example 39 | US9969726, Example 39) Show SMILES c1ccc(cc1)-c1nc(ns1)-c1cccc(c1)-c1ccccc1 Show InChI InChI=1S/C20H14N2S/c1-3-8-15(9-4-1)17-12-7-13-18(14-17)19-21-20(23-22-19)16-10-5-2-6-11-16/h1-14H	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393748 (US10597367, Example 38 | US9969726, Example 38) Show SMILES Fc1ccc(cc1)-c1cccc(c1)-c1nsc(n1)-c1ccccc1 Show InChI InChI=1S/C20H13FN2S/c21-18-11-9-14(10-12-18)16-7-4-8-17(13-16)19-22-20(24-23-19)15-5-2-1-3-6-15/h1-13H	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50576842 (CHEMBL4866466) Show SMILES C[C@@H](COc1ccc(C(O)=O)c(Cl)c1)COc1ccc(C(=O)CC(C)(C)C)c(O)c1C |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a
TBA					Assay Description Positive allosteric modulator activity at rat mGlu2 receptor transfected in GIRK channel overexpressing cells assessed as potentiation of glutamate-i...				Citation and Details Article DOI: 10.1016/j.bmcl.2021.128342 BindingDB Entry DOI: 10.7270/Q22F7S71
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393748 (US10597367, Example 38 | US9969726, Example 38) Show SMILES Fc1ccc(cc1)-c1cccc(c1)-c1nsc(n1)-c1ccccc1 Show InChI InChI=1S/C20H13FN2S/c21-18-11-9-14(10-12-18)16-7-4-8-17(13-16)19-22-20(24-23-19)15-5-2-1-3-6-15/h1-13H	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE US Patent					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				US Patent US10597367 (2020) BindingDB Entry DOI: 10.7270/Q2GB272Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393831 (US10597367, Example 119 | US9969726, Example 119) Show SMILES Cc1cc(nc(n1)-c1cccc(c1)-c1cccc(c1)C(O)=O)-c1ccoc1 Show InChI InChI=1S/C22H16N2O3/c1-14-10-20(19-8-9-27-13-19)24-21(23-14)17-6-2-4-15(11-17)16-5-3-7-18(12-16)22(25)26/h2-13H,1H3,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE US Patent					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				US Patent US10597367 (2020) BindingDB Entry DOI: 10.7270/Q2GB272Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50559786 (CHEMBL4800093) Show SMILES [Na;v0+].[#6]-[#8]-c1cc(-[#7]-[#6](=O)-c2ccccn2)ccc1-[#7]-[#6](=O)-c1ccc(-[#7]-[#6](=O)-[#6]-[#8]-[#6]-[#6](=O)-[#7]-[#6]-[#6]-[#6]-[#7]-[#6](=O)-[#6]-[#8]-c2ccc(cc2-[#6](-[#8-])=O)-c2cccc(-[#6]-[#8]-c3cc4-[#6]-[#6](-[#6]-5-[#6]-[#6]-[#6]-[#6]-5)-[#6](=O)-c4c(-[#6])c3-[#6])c2)cc1Cl Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	54	n/a	n/a	n/a	n/a
TBA					Assay Description Positive allosteric modulation of rat mGlu2 receptor expressed in HEK293 cells coexpressing GIRK assessed as thallium influx in presence of EC20 glut...				Citation and Details Article DOI: 10.1016/j.bmcl.2020.127212 BindingDB Entry DOI: 10.7270/Q27H1P86
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393798 (US10597367, Example 87 | US9969726, Example 87) Show SMILES COc1ccc(cc1)-c1cc(nc(n1)-c1cccc(c1)-c1ccc(F)c(c1)C(O)=O)C(F)(F)F Show InChI InChI=1S/C25H16F4N2O3/c1-34-18-8-5-14(6-9-18)21-13-22(25(27,28)29)31-23(30-21)17-4-2-3-15(11-17)16-7-10-20(26)19(12-16)24(32)33/h2-13H,1H3,(H,32,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	60	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393831 (US10597367, Example 119 | US9969726, Example 119) Show SMILES Cc1cc(nc(n1)-c1cccc(c1)-c1cccc(c1)C(O)=O)-c1ccoc1 Show InChI InChI=1S/C22H16N2O3/c1-14-10-20(19-8-9-27-13-19)24-21(23-14)17-6-2-4-15(11-17)16-5-3-7-18(12-16)22(25)26/h2-13H,1H3,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	60	n/a	n/a	n/a	n/a
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE US Patent					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				US Patent US10597367 (2020) BindingDB Entry DOI: 10.7270/Q2GB272Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393849 (US10597367, Example 137 | US9969726, Example 137) Show SMILES Cc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)S(=O)(=O)c1ncccn1 |c:4| Show InChI InChI=1S/C21H15F3N4O3S/c1-12-8-17-18(10-15(12)21(22,23)24)28-19(29)11-16(27-17)13-4-2-5-14(9-13)32(30,31)20-25-6-3-7-26-20/h2-10H,11H2,1H3,(H,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	60	n/a	n/a	n/a	n/a
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE US Patent					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				US Patent US10597367 (2020) BindingDB Entry DOI: 10.7270/Q2GB272Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393831 (US10597367, Example 119 | US9969726, Example 119) Show SMILES Cc1cc(nc(n1)-c1cccc(c1)-c1cccc(c1)C(O)=O)-c1ccoc1 Show InChI InChI=1S/C22H16N2O3/c1-14-10-20(19-8-9-27-13-19)24-21(23-14)17-6-2-4-15(11-17)16-5-3-7-18(12-16)22(25)26/h2-13H,1H3,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	60	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393798 (US10597367, Example 87 | US9969726, Example 87) Show SMILES COc1ccc(cc1)-c1cc(nc(n1)-c1cccc(c1)-c1ccc(F)c(c1)C(O)=O)C(F)(F)F Show InChI InChI=1S/C25H16F4N2O3/c1-34-18-8-5-14(6-9-18)21-13-22(25(27,28)29)31-23(30-21)17-4-2-3-15(11-17)16-7-10-20(26)19(12-16)24(32)33/h2-13H,1H3,(H,32,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	60	n/a	n/a	n/a	n/a
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE US Patent					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				US Patent US10597367 (2020) BindingDB Entry DOI: 10.7270/Q2GB272Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393849 (US10597367, Example 137 | US9969726, Example 137) Show SMILES Cc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)S(=O)(=O)c1ncccn1 |c:4| Show InChI InChI=1S/C21H15F3N4O3S/c1-12-8-17-18(10-15(12)21(22,23)24)28-19(29)11-16(27-17)13-4-2-5-14(9-13)32(30,31)20-25-6-3-7-26-20/h2-10H,11H2,1H3,(H,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	60	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50559795 (CHEMBL4779278) Show SMILES Cc1c2C(=O)C(Cc2cc(OCc2cccc(c2)-c2ccc(O)c(c2)C(O)=O)c1C)C1CCCC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	62	n/a	n/a	n/a	n/a
TBA					Assay Description Positive allosteric modulation of rat mGlu2 receptor expressed in HEK293 cells coexpressing GIRK assessed as thallium influx in presence of EC20 glut...				Citation and Details Article DOI: 10.1016/j.bmcl.2020.127212 BindingDB Entry DOI: 10.7270/Q27H1P86
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50559789 (CHEMBL4762369) Show SMILES [Na;v0+].[#6]-[#8]-c1cc(-[#7]-[#6](=O)-c2ccccn2)ccc1-[#7]-[#6](=O)-c1ccc(-[#7]-[#6](=O)-[#6]-[#8]-[#6]-[#6](=O)-[#7]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#7]-[#6](=O)-[#6]-[#8]-c2ccc(cc2-[#6](-[#8-])=O)-c2cccc(-[#6]-[#8]-c3cc4-[#6]-[#6](-[#6]-5-[#6]-[#6]-[#6]-[#6]-5)-[#6](=O)-c4c(-[#6])c3-[#6])c2)cc1Cl Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	62	n/a	n/a	n/a	n/a
TBA					Assay Description Positive allosteric modulation of rat mGlu2 receptor expressed in HEK293 cells coexpressing GIRK assessed as thallium influx in presence of EC20 glut...				Citation and Details Article DOI: 10.1016/j.bmcl.2020.127212 BindingDB Entry DOI: 10.7270/Q27H1P86
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50576832 (CHEMBL4855540) Show SMILES COc1ccc(cc1OC[C@H](C)COc1ccc(C(=O)CC(C)(C)C)c(O)c1C)C(O)=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	63	n/a	n/a	n/a	n/a
TBA					Assay Description Positive allosteric modulator activity at rat mGlu2 receptor transfected in GIRK channel overexpressing cells assessed as potentiation of glutamate-i...				Citation and Details Article DOI: 10.1016/j.bmcl.2021.128342 BindingDB Entry DOI: 10.7270/Q22F7S71
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50559794 (CHEMBL4752318) Show SMILES Cc1c2C(=O)C(Cc2cc(OCc2cccc(c2)-c2cccc(c2)C(O)=O)c1C)C1CCCC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	69	n/a	n/a	n/a	n/a
TBA					Assay Description Positive allosteric modulation of rat mGlu2 receptor expressed in HEK293 cells coexpressing GIRK assessed as thallium influx in presence of EC20 glut...				Citation and Details Article DOI: 10.1016/j.bmcl.2020.127212 BindingDB Entry DOI: 10.7270/Q27H1P86
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393829 (US10597367, Example 117 | US9969726, Example 117) Show SMILES Cc1cc(nc(n1)-c1cccc(c1)-c1ccc(F)c(c1)C(O)=O)-c1ccoc1 Show InChI InChI=1S/C22H15FN2O3/c1-13-9-20(17-7-8-28-12-17)25-21(24-13)16-4-2-3-14(10-16)15-5-6-19(23)18(11-15)22(26)27/h2-12H,1H3,(H,26,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	70	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393887 (US10597367, Example 184 | US9969726, Example 184) Show SMILES FC(F)(F)c1ccc2N=C(CC(=O)Nc2c1)c1ccnc(c1)C#N |c:8| Show InChI InChI=1S/C16H9F3N4O/c17-16(18,19)10-1-2-12-14(6-10)23-15(24)7-13(22-12)9-3-4-21-11(5-9)8-20/h1-6H,7H2,(H,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	70	n/a	n/a	n/a	n/a
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE US Patent					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				US Patent US10597367 (2020) BindingDB Entry DOI: 10.7270/Q2GB272Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393834 (US10597367, Example 122 | US9969726, Example 122) Show SMILES OC(=O)c1cc(ccc1F)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccsc1 Show InChI InChI=1S/C22H12F4N2O2S/c23-17-5-4-13(9-16(17)21(29)30)12-2-1-3-14(8-12)20-27-18(15-6-7-31-11-15)10-19(28-20)22(24,25)26/h1-11H,(H,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	70	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393887 (US10597367, Example 184 | US9969726, Example 184) Show SMILES FC(F)(F)c1ccc2N=C(CC(=O)Nc2c1)c1ccnc(c1)C#N |c:8| Show InChI InChI=1S/C16H9F3N4O/c17-16(18,19)10-1-2-12-14(6-10)23-15(24)7-13(22-12)9-3-4-21-11(5-9)8-20/h1-6H,7H2,(H,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	70	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393829 (US10597367, Example 117 | US9969726, Example 117) Show SMILES Cc1cc(nc(n1)-c1cccc(c1)-c1ccc(F)c(c1)C(O)=O)-c1ccoc1 Show InChI InChI=1S/C22H15FN2O3/c1-13-9-20(17-7-8-28-12-17)25-21(24-13)16-4-2-3-14(10-16)15-5-6-19(23)18(11-15)22(26)27/h2-12H,1H3,(H,26,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	70	n/a	n/a	n/a	n/a
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE US Patent					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				US Patent US10597367 (2020) BindingDB Entry DOI: 10.7270/Q2GB272Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393834 (US10597367, Example 122 | US9969726, Example 122) Show SMILES OC(=O)c1cc(ccc1F)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccsc1 Show InChI InChI=1S/C22H12F4N2O2S/c23-17-5-4-13(9-16(17)21(29)30)12-2-1-3-14(8-12)20-27-18(15-6-7-31-11-15)10-19(28-20)22(24,25)26/h1-11H,(H,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	70	n/a	n/a	n/a	n/a
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE US Patent					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				US Patent US10597367 (2020) BindingDB Entry DOI: 10.7270/Q2GB272Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50576820 (CHEMBL4856556) Show SMILES Cc1c(O)c(ccc1OCCCCOc1ccc(cc1F)C(O)=O)C(=O)CC(C)(C)C Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	75	n/a	n/a	n/a	n/a
TBA					Assay Description Positive allosteric modulator activity at rat mGlu2 receptor transfected in GIRK channel overexpressing cells assessed as potentiation of glutamate-i...				Citation and Details Article DOI: 10.1016/j.bmcl.2021.128342 BindingDB Entry DOI: 10.7270/Q22F7S71
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50576828 (CHEMBL4860693) Show SMILES COc1ccc(cc1OC[C@@H](C)Oc1ccc(C(=O)CC(C)(C)C)c(O)c1C)C(O)=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	78	n/a	n/a	n/a	n/a
TBA					Assay Description Positive allosteric modulator activity at rat mGlu2 receptor transfected in GIRK channel overexpressing cells assessed as potentiation of glutamate-i...				Citation and Details Article DOI: 10.1016/j.bmcl.2021.128342 BindingDB Entry DOI: 10.7270/Q22F7S71
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393829 (US10597367, Example 117 | US9969726, Example 117) Show SMILES Cc1cc(nc(n1)-c1cccc(c1)-c1ccc(F)c(c1)C(O)=O)-c1ccoc1 Show InChI InChI=1S/C22H15FN2O3/c1-13-9-20(17-7-8-28-12-17)25-21(24-13)16-4-2-3-14(10-16)15-5-6-19(23)18(11-15)22(26)27/h2-12H,1H3,(H,26,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	80	n/a	n/a	n/a	n/a
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE US Patent					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				US Patent US10597367 (2020) BindingDB Entry DOI: 10.7270/Q2GB272Z
					More data for this Ligand-Target Pair

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