BindingDB PrimarySearch

Found 11 hits of ic50 for UniProtKB: P23219
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Prostaglandin G/H synthase 1 [582-599] (Homo sapiens (Human))	BDBM17638 (2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...) Show SMILES Show InChI	MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
University of Alexandria					Assay Description The compounds that exhibited potent anti-inflammatory profiles were futher tested for their ability to inhibit human COX-1 and COX-2 enzymes in-vitro...				J Enzyme Inhib Med Chem 24: 296-309 (2009) Article DOI: 10.1080/14756360802188404 BindingDB Entry DOI: 10.7270/Q2S1813W
University of Alexandria					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 [582-599] (Homo sapiens (Human))	BDBM11639 (4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...) Show SMILES Show InChI	MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars		n/a	n/a	2.43E+4	n/a	n/a	n/a	n/a	n/a	n/a
Shahid Beheshti University					Assay Description The ability of the test compounds to inhibit ovine COX-1 and COX-2 was determined using chemiluminescent enzyme assays kit according to our previousl...				Med Chem Res 19: 782-793 (2009) BindingDB Entry DOI: 10.7270/Q2T72G2X
Shahid Beheshti University					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 [582-599] (Homo sapiens (Human))	BDBM93106 (COX inhibitor, 9) Show SMILES CC1SC(N(Cc2ccccc2)C1=O)c1ccccc1 Show InChI	MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars		n/a	n/a	7.56E+4	n/a	n/a	n/a	n/a	n/a	n/a
Shahid Beheshti University					Assay Description The ability of the test compounds to inhibit ovine COX-1 and COX-2 was determined using chemiluminescent enzyme assays kit according to our previousl...				Med Chem Res 19: 782-793 (2009) BindingDB Entry DOI: 10.7270/Q2T72G2X
Shahid Beheshti University					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 [582-599] (Homo sapiens (Human))	BDBM91679 (Pyrazolyl benzenesulfonamide derivative, 7b) Show SMILES Show InChI	MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.64E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Alexandria					Assay Description The compounds that exhibited potent anti-inflammatory profiles were futher tested for their ability to inhibit human COX-1 and COX-2 enzymes in-vitro...				J Enzyme Inhib Med Chem 24: 296-309 (2009) Article DOI: 10.1080/14756360802188404 BindingDB Entry DOI: 10.7270/Q2S1813W
University of Alexandria					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 [582-599] (Homo sapiens (Human))	BDBM91678 (Pyrazolyl benzenesulfonamide derivative, 7a) Show SMILES Show InChI	MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.36E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Alexandria					Assay Description The compounds that exhibited potent anti-inflammatory profiles were futher tested for their ability to inhibit human COX-1 and COX-2 enzymes in-vitro...				J Enzyme Inhib Med Chem 24: 296-309 (2009) Article DOI: 10.1080/14756360802188404 BindingDB Entry DOI: 10.7270/Q2S1813W
University of Alexandria					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 [582-599] (Homo sapiens (Human))	BDBM93105 (COX inhibitor, 8) Show SMILES CC1OC(N(Cc2ccccc2)C1=O)c1ccccc1 Show InChI	MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars		n/a	n/a	8.59E+4	n/a	n/a	n/a	n/a	n/a	n/a
Shahid Beheshti University					Assay Description The ability of the test compounds to inhibit ovine COX-1 and COX-2 was determined using chemiluminescent enzyme assays kit according to our previousl...				Med Chem Res 19: 782-793 (2009) BindingDB Entry DOI: 10.7270/Q2T72G2X
Shahid Beheshti University					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 [582-599] (Homo sapiens (Human))	BDBM91685 (Pyrazolyl benzenesulfonamide derivative, 9b) Show SMILES Show InChI	MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.42E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Alexandria					Assay Description The compounds that exhibited potent anti-inflammatory profiles were futher tested for their ability to inhibit human COX-1 and COX-2 enzymes in-vitro...				J Enzyme Inhib Med Chem 24: 296-309 (2009) Article DOI: 10.1080/14756360802188404 BindingDB Entry DOI: 10.7270/Q2S1813W
University of Alexandria					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 [582-599] (Homo sapiens (Human))	BDBM93103 (COX inhibitor, 5a) Show SMILES O=C1COC(N1Cc1ccccc1)c1ccccc1 Show InChI	MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Shahid Beheshti University					Assay Description The ability of the test compounds to inhibit ovine COX-1 and COX-2 was determined using chemiluminescent enzyme assays kit according to our previousl...				Med Chem Res 19: 782-793 (2009) BindingDB Entry DOI: 10.7270/Q2T72G2X
Shahid Beheshti University					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 [582-599] (Homo sapiens (Human))	BDBM93104 (COX inhibitor, 5b) Show SMILES O=C1CSC(N1Cc1ccccc1)c1ccccc1 Show InChI	MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Shahid Beheshti University					Assay Description The ability of the test compounds to inhibit ovine COX-1 and COX-2 was determined using chemiluminescent enzyme assays kit according to our previousl...				Med Chem Res 19: 782-793 (2009) BindingDB Entry DOI: 10.7270/Q2T72G2X
Shahid Beheshti University					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 [582-599] (Homo sapiens (Human))	BDBM91684 (Pyrazolyl benzenesulfonamide derivative, 9a) Show SMILES Show InChI	MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Alexandria					Assay Description The compounds that exhibited potent anti-inflammatory profiles were futher tested for their ability to inhibit human COX-1 and COX-2 enzymes in-vitro...				J Enzyme Inhib Med Chem 24: 296-309 (2009) Article DOI: 10.1080/14756360802188404 BindingDB Entry DOI: 10.7270/Q2S1813W
University of Alexandria					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 [582-599] (Homo sapiens (Human))	BDBM11639 (4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...) Show SMILES Show InChI	MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Alexandria					Assay Description The compounds that exhibited potent anti-inflammatory profiles were futher tested for their ability to inhibit human COX-1 and COX-2 enzymes in-vitro...				J Enzyme Inhib Med Chem 24: 296-309 (2009) Article DOI: 10.1080/14756360802188404 BindingDB Entry DOI: 10.7270/Q2S1813W
University of Alexandria					More data for this Ligand-Target Pair