Compile Data Set for Download or QSAR

Found 146 hits of ic50 for UniProtKB: P70597   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM50252472 (CHEMBL4085914) Show SMILES Cc1cc(nn1Cc1cc(Cl)cc2sc(nc12)N1CCC=CC1)C(O)=O |c:23| Show InChI InChI=1S/C18H17ClN4O2S/c1-11-7-14(17(24)25)21-23(11)10-12-8-13(19)9-15-16(12)20-18(26-15)22-5-3-2-4-6-22/h2-3,7-9H,4-6,10H2,1H3,(H,24,25)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Watarase Research Center, Discovery Research Headquarters, Kyorin Pharmaceutical Co., Ltd., 1848, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan. Curated by ChEMBL					Assay Description Antagonist activity at rat EP1 receptor expressed in African green monkey COS1 cells assessed as inhibition of prostaglandin-E2-induced increase in i...				Bioorg Med Chem 25: 3406-3430 (2017) Article DOI: 10.1016/j.bmc.2017.04.028 BindingDB Entry DOI: 10.7270/Q2JW8HB8
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM50260732 (CHEMBL4105205) Show SMILES COc1ccc2c(Cc3cccc(n3)C(O)=O)c(nn2c1)-c1ccccc1 Show InChI InChI=1S/C21H17N3O3/c1-27-16-10-11-19-17(12-15-8-5-9-18(22-15)21(25)26)20(23-24(19)13-16)14-6-3-2-4-7-14/h2-11,13H,12H2,1H3,(H,25,26)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Watarase Research Center, Discovery Research Headquarters, Kyorin Pharmaceutical Co., Ltd., 1848, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan. Curated by ChEMBL					Assay Description Antagonist activity at rat His-tagged EP1 receptor expressed in African green monkey COS1 cells assessed as reduction in PGE2-induced increase in int...				Bioorg Med Chem Lett 27: 4044-4050 (2017) Article DOI: 10.1016/j.bmcl.2017.07.055 BindingDB Entry DOI: 10.7270/Q2PN983F
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM50252483 (CHEMBL4081524) Show SMILES CCN(CC)c1nc2c(Cn3nc(cc3C)C(O)=O)cc(Cl)cc2s1 Show InChI InChI=1S/C17H19ClN4O2S/c1-4-21(5-2)17-19-15-11(7-12(18)8-14(15)25-17)9-22-10(3)6-13(20-22)16(23)24/h6-8H,4-5,9H2,1-3H3,(H,23,24)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.20	n/a	n/a	n/a	n/a	n/a	n/a
Watarase Research Center, Discovery Research Headquarters, Kyorin Pharmaceutical Co., Ltd., 1848, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan. Curated by ChEMBL					Assay Description Antagonist activity at rat EP1 receptor expressed in African green monkey COS1 cells assessed as inhibition of prostaglandin-E2-induced increase in i...				Bioorg Med Chem 25: 3406-3430 (2017) Article DOI: 10.1016/j.bmc.2017.04.028 BindingDB Entry DOI: 10.7270/Q2JW8HB8
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM50252452 (CHEMBL4074797) Show SMILES OC(=O)c1ccc(Sc2cc(Cl)cc3sc(nc23)N2CCC=CC2)o1 |c:23| Show InChI InChI=1S/C17H13ClN2O3S2/c18-10-8-12(24-14-5-4-11(23-14)16(21)22)15-13(9-10)25-17(19-15)20-6-2-1-3-7-20/h1-2,4-5,8-9H,3,6-7H2,(H,21,22)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.40	n/a	n/a	n/a	n/a	n/a	n/a
Watarase Research Center, Discovery Research Headquarters, Kyorin Pharmaceutical Co., Ltd., 1848, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan. Curated by ChEMBL					Assay Description Antagonist activity at rat EP1 receptor expressed in African green monkey COS1 cells assessed as inhibition of prostaglandin-E2-induced increase in i...				Bioorg Med Chem 25: 3406-3430 (2017) Article DOI: 10.1016/j.bmc.2017.04.028 BindingDB Entry DOI: 10.7270/Q2JW8HB8
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM50260740 (CHEMBL4100262) Show SMILES OC(=O)c1cccc(Cc2c(nn3cc(Cl)ccc23)-c2ccccc2)n1 Show InChI InChI=1S/C20H14ClN3O2/c21-14-9-10-18-16(11-15-7-4-8-17(22-15)20(25)26)19(23-24(18)12-14)13-5-2-1-3-6-13/h1-10,12H,11H2,(H,25,26)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Watarase Research Center, Discovery Research Headquarters, Kyorin Pharmaceutical Co., Ltd., 1848, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan. Curated by ChEMBL					Assay Description Antagonist activity at rat His-tagged EP1 receptor expressed in African green monkey COS1 cells assessed as reduction in PGE2-induced increase in int...				Bioorg Med Chem Lett 27: 4044-4050 (2017) Article DOI: 10.1016/j.bmcl.2017.07.055 BindingDB Entry DOI: 10.7270/Q2PN983F
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM50240170 (CHEMBL4064816) Show SMILES Cc1cc(nn1Cc1cc(Cl)cc2cc(nn12)-c1ccccc1)C(O)=O Show InChI InChI=1S/C19H15ClN4O2/c1-12-7-18(19(25)26)21-23(12)11-16-9-14(20)8-15-10-17(22-24(15)16)13-5-3-2-4-6-13/h2-10H,11H2,1H3,(H,25,26)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.40	n/a	n/a	n/a	n/a	n/a	n/a
Kyorin Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against dog gastric proton-pump enzyme H+/K+ ATPase				Bioorg Med Chem 25: 2635-2642 (2017) Article DOI: 10.1016/j.bmc.2017.03.003 BindingDB Entry DOI: 10.7270/Q29Z9728
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM50240170 (CHEMBL4064816) Show SMILES Cc1cc(nn1Cc1cc(Cl)cc2cc(nn12)-c1ccccc1)C(O)=O Show InChI InChI=1S/C19H15ClN4O2/c1-12-7-18(19(25)26)21-23(12)11-16-9-14(20)8-15-10-17(22-24(15)16)13-5-3-2-4-6-13/h2-10H,11H2,1H3,(H,25,26)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.40	n/a	n/a	n/a	n/a	n/a	n/a
Watarase Research Center, Discovery Research Headquarters, Kyorin Pharmaceutical Co., Ltd., 1848, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan. Curated by ChEMBL					Assay Description Antagonist activity at rat EP1 receptor expressed in African green monkey COS1 cells assessed as inhibition of prostaglandin-E2-induced increase in i...				Bioorg Med Chem 25: 3406-3430 (2017) Article DOI: 10.1016/j.bmc.2017.04.028 BindingDB Entry DOI: 10.7270/Q2JW8HB8
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM50252462 (CHEMBL4104333) Show SMILES Cc1cc(nn1Cc1cc(C=C)cc2sc(nc12)N1CCC=CC1)C(O)=O |c:24| Show InChI InChI=1S/C20H20N4O2S/c1-3-14-10-15(12-24-13(2)9-16(22-24)19(25)26)18-17(11-14)27-20(21-18)23-7-5-4-6-8-23/h3-5,9-11H,1,6-8,12H2,2H3,(H,25,26)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.90	n/a	n/a	n/a	n/a	n/a	n/a
Watarase Research Center, Discovery Research Headquarters, Kyorin Pharmaceutical Co., Ltd., 1848, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan. Curated by ChEMBL					Assay Description Antagonist activity at rat EP1 receptor expressed in African green monkey COS1 cells assessed as inhibition of prostaglandin-E2-induced increase in i...				Bioorg Med Chem 25: 3406-3430 (2017) Article DOI: 10.1016/j.bmc.2017.04.028 BindingDB Entry DOI: 10.7270/Q2JW8HB8
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM50260656 (CHEMBL4083796) Show SMILES OC(=O)c1cccc(Cc2c(nn3cc(Br)ccc23)-c2ccccc2)n1 Show InChI InChI=1S/C20H14BrN3O2/c21-14-9-10-18-16(11-15-7-4-8-17(22-15)20(25)26)19(23-24(18)12-14)13-5-2-1-3-6-13/h1-10,12H,11H2,(H,25,26)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Watarase Research Center, Discovery Research Headquarters, Kyorin Pharmaceutical Co., Ltd., 1848, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan. Curated by ChEMBL					Assay Description Antagonist activity at rat His-tagged EP1 receptor expressed in African green monkey COS1 cells assessed as reduction in PGE2-induced increase in int...				Bioorg Med Chem Lett 27: 4044-4050 (2017) Article DOI: 10.1016/j.bmcl.2017.07.055 BindingDB Entry DOI: 10.7270/Q2PN983F
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM119458 (US8680120, 9-32) Show SMILES COc1ccc2n(Cc3cccc(c3)C(O)=O)c(cc2c1)-c1ccoc1 Show InChI InChI=1S/C21H17NO4/c1-25-18-5-6-19-17(10-18)11-20(16-7-8-26-13-16)22(19)12-14-3-2-4-15(9-14)21(23)24/h2-11,13H,12H2,1H3,(H,23,24)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Co., Ltd. US Patent					Assay Description The rat EP1 receptor-expressing cells were washed with the assay buffer. 100 μL of a fluorescent calcium indicator (Fluo-4 NW Calcium Assay Kit ...				US Patent US8680120 (2014) BindingDB Entry DOI: 10.7270/Q2183554
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM50259548 (6-(5'-chloro-2'-isobutoxy-biphenyl-2-yl)-pyridine-...) Show SMILES CC(C)COc1ccc(Cl)cc1-c1ccccc1-c1cccc(n1)C([O-])=O Show InChI InChI=1S/C22H20ClNO3/c1-14(2)13-27-21-11-10-15(23)12-18(21)16-6-3-4-7-17(16)19-8-5-9-20(24-19)22(25)26/h3-12,14H,13H2,1-2H3,(H,25,26)/p-1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12.6	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Binding affinity to rat EP1 receptor				Bioorg Med Chem Lett 19: 497-501 (2008) Article DOI: 10.1016/j.bmcl.2008.11.032 BindingDB Entry DOI: 10.7270/Q2N879N5
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM119460 (US8680120, 9-43) Show SMILES COc1cc2cc(-c3ccccc3)n(Cc3cccc(c3)C(O)=O)c2cc1F Show InChI InChI=1S/C23H18FNO3/c1-28-22-12-18-11-20(16-7-3-2-4-8-16)25(21(18)13-19(22)24)14-15-6-5-9-17(10-15)23(26)27/h2-13H,14H2,1H3,(H,26,27)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Co., Ltd. US Patent					Assay Description The rat EP1 receptor-expressing cells were washed with the assay buffer. 100 μL of a fluorescent calcium indicator (Fluo-4 NW Calcium Assay Kit ...				US Patent US8680120 (2014) BindingDB Entry DOI: 10.7270/Q2183554
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM119456 (US8680120, 9-21) Show SMILES COc1ccc2n(Cc3cccc(n3)C(O)=O)c(cc2c1)-c1ccccc1 Show InChI InChI=1S/C22H18N2O3/c1-27-18-10-11-20-16(12-18)13-21(15-6-3-2-4-7-15)24(20)14-17-8-5-9-19(23-17)22(25)26/h2-13H,14H2,1H3,(H,25,26)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Co., Ltd. US Patent					Assay Description The rat EP1 receptor-expressing cells were washed with the assay buffer. 100 μL of a fluorescent calcium indicator (Fluo-4 NW Calcium Assay Kit ...				US Patent US8680120 (2014) BindingDB Entry DOI: 10.7270/Q2183554
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM50252484 (CHEMBL4059569) Show SMILES CCN(C)c1nc2c(Cn3nc(cc3C)C(O)=O)cc(Cl)cc2s1 Show InChI InChI=1S/C16H17ClN4O2S/c1-4-20(3)16-18-14-10(6-11(17)7-13(14)24-16)8-21-9(2)5-12(19-21)15(22)23/h5-7H,4,8H2,1-3H3,(H,22,23)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Watarase Research Center, Discovery Research Headquarters, Kyorin Pharmaceutical Co., Ltd., 1848, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan. Curated by ChEMBL					Assay Description Antagonist activity at rat EP1 receptor expressed in African green monkey COS1 cells assessed as inhibition of prostaglandin-E2-induced increase in i...				Bioorg Med Chem 25: 3406-3430 (2017) Article DOI: 10.1016/j.bmc.2017.04.028 BindingDB Entry DOI: 10.7270/Q2JW8HB8
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM50260658 (CHEMBL4091580) Show SMILES OC(=O)c1cccc(Cc2c(nn3cc(ccc23)C(F)(F)F)-c2ccccc2)n1 Show InChI InChI=1S/C21H14F3N3O2/c22-21(23,24)14-9-10-18-16(11-15-7-4-8-17(25-15)20(28)29)19(26-27(18)12-14)13-5-2-1-3-6-13/h1-10,12H,11H2,(H,28,29)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Watarase Research Center, Discovery Research Headquarters, Kyorin Pharmaceutical Co., Ltd., 1848, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan. Curated by ChEMBL					Assay Description Antagonist activity at rat His-tagged EP1 receptor expressed in African green monkey COS1 cells assessed as reduction in PGE2-induced increase in int...				Bioorg Med Chem Lett 27: 4044-4050 (2017) Article DOI: 10.1016/j.bmcl.2017.07.055 BindingDB Entry DOI: 10.7270/Q2PN983F
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM50252509 (CHEMBL4060696) Show SMILES Cc1cc(nn1Cc1cc(F)cc2sc(nc12)N1CCC=CC1)C(O)=O |c:23| Show InChI InChI=1S/C18H17FN4O2S/c1-11-7-14(17(24)25)21-23(11)10-12-8-13(19)9-15-16(12)20-18(26-15)22-5-3-2-4-6-22/h2-3,7-9H,4-6,10H2,1H3,(H,24,25)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Watarase Research Center, Discovery Research Headquarters, Kyorin Pharmaceutical Co., Ltd., 1848, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan. Curated by ChEMBL					Assay Description Antagonist activity at rat EP1 receptor expressed in African green monkey COS1 cells assessed as inhibition of prostaglandin-E2-induced increase in i...				Bioorg Med Chem 25: 3406-3430 (2017) Article DOI: 10.1016/j.bmc.2017.04.028 BindingDB Entry DOI: 10.7270/Q2JW8HB8
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM119468 (US8680120, 25-18) Show SMILES COc1ccc2n(Cc3cccc(c3)C(O)=O)c(cc2c1)-c1cccc(F)c1 Show InChI InChI=1S/C23H18FNO3/c1-28-20-8-9-21-18(12-20)13-22(16-5-3-7-19(24)11-16)25(21)14-15-4-2-6-17(10-15)23(26)27/h2-13H,14H2,1H3,(H,26,27)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Co., Ltd. US Patent					Assay Description The rat EP1 receptor-expressing cells were washed with the assay buffer. 100 μL of a fluorescent calcium indicator (Calcium kit II, Fluo 4 (Doji...				US Patent US8680120 (2014) BindingDB Entry DOI: 10.7270/Q2183554
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM119471 (US8680120, 25-26) Show SMILES COc1cc2cc(-c3ccccc3)n(Cc3ccc(o3)C(O)=O)c2cc1Cl Show InChI InChI=1S/C21H16ClNO4/c1-26-20-10-14-9-17(13-5-3-2-4-6-13)23(18(14)11-16(20)22)12-15-7-8-19(27-15)21(24)25/h2-11H,12H2,1H3,(H,24,25)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Co., Ltd. US Patent					Assay Description The rat EP1 receptor-expressing cells were washed with the assay buffer. 100 μL of a fluorescent calcium indicator (Calcium kit II, Fluo 4 (Doji...				US Patent US8680120 (2014) BindingDB Entry DOI: 10.7270/Q2183554
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM50260657 (CHEMBL4062060) Show SMILES Cc1ccc2c(Cc3cccc(n3)C(O)=O)c(nn2c1)-c1ccccc1 Show InChI InChI=1S/C21H17N3O2/c1-14-10-11-19-17(12-16-8-5-9-18(22-16)21(25)26)20(23-24(19)13-14)15-6-3-2-4-7-15/h2-11,13H,12H2,1H3,(H,25,26)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Watarase Research Center, Discovery Research Headquarters, Kyorin Pharmaceutical Co., Ltd., 1848, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan. Curated by ChEMBL					Assay Description Antagonist activity at rat His-tagged EP1 receptor expressed in African green monkey COS1 cells assessed as reduction in PGE2-induced increase in int...				Bioorg Med Chem Lett 27: 4044-4050 (2017) Article DOI: 10.1016/j.bmcl.2017.07.055 BindingDB Entry DOI: 10.7270/Q2PN983F
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM119461 (US8680120, 9-44) Show SMILES COc1ccc2n(Cc3cccc(C(O)=O)c3F)c(cc2c1)-c1ccccc1 Show InChI InChI=1S/C23H18FNO3/c1-28-18-10-11-20-17(12-18)13-21(15-6-3-2-4-7-15)25(20)14-16-8-5-9-19(22(16)24)23(26)27/h2-13H,14H2,1H3,(H,26,27)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Co., Ltd. US Patent					Assay Description The rat EP1 receptor-expressing cells were washed with the assay buffer. 100 μL of a fluorescent calcium indicator (Fluo-4 NW Calcium Assay Kit ...				US Patent US8680120 (2014) BindingDB Entry DOI: 10.7270/Q2183554
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM50260660 (CHEMBL4088835) Show SMILES OC(=O)c1cccc(Cc2c(nn3cc(C=C)ccc23)-c2ccccc2)n1 Show InChI InChI=1S/C22H17N3O2/c1-2-15-11-12-20-18(13-17-9-6-10-19(23-17)22(26)27)21(24-25(20)14-15)16-7-4-3-5-8-16/h2-12,14H,1,13H2,(H,26,27)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Watarase Research Center, Discovery Research Headquarters, Kyorin Pharmaceutical Co., Ltd., 1848, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan. Curated by ChEMBL					Assay Description Antagonist activity at rat His-tagged EP1 receptor expressed in African green monkey COS1 cells assessed as reduction in PGE2-induced increase in int...				Bioorg Med Chem Lett 27: 4044-4050 (2017) Article DOI: 10.1016/j.bmcl.2017.07.055 BindingDB Entry DOI: 10.7270/Q2PN983F
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM119453 (US8680120, 9-1) Show SMILES COc1ccc2n(Cc3cccc(c3)C(O)=O)c(cc2c1)-c1ccccc1 Show InChI InChI=1S/C23H19NO3/c1-27-20-10-11-21-19(13-20)14-22(17-7-3-2-4-8-17)24(21)15-16-6-5-9-18(12-16)23(25)26/h2-14H,15H2,1H3,(H,25,26)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Co., Ltd. US Patent					Assay Description The rat EP1 receptor-expressing cells were washed with the assay buffer. 100 μL of a fluorescent calcium indicator (Fluo-4 NW Calcium Assay Kit ...				US Patent US8680120 (2014) BindingDB Entry DOI: 10.7270/Q2183554
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM50252464 (CHEMBL4081022) Show SMILES Cc1cc(nn1Cc1cc(Br)cc2sc(nc12)N1CCC=CC1)C(O)=O |c:23| Show InChI InChI=1S/C18H17BrN4O2S/c1-11-7-14(17(24)25)21-23(11)10-12-8-13(19)9-15-16(12)20-18(26-15)22-5-3-2-4-6-22/h2-3,7-9H,4-6,10H2,1H3,(H,24,25)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Watarase Research Center, Discovery Research Headquarters, Kyorin Pharmaceutical Co., Ltd., 1848, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan. Curated by ChEMBL					Assay Description Antagonist activity at rat EP1 receptor expressed in African green monkey COS1 cells assessed as inhibition of prostaglandin-E2-induced increase in i...				Bioorg Med Chem 25: 3406-3430 (2017) Article DOI: 10.1016/j.bmc.2017.04.028 BindingDB Entry DOI: 10.7270/Q2JW8HB8
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM50419410 (CHEMBL1915252) Show SMILES Cc1cc(nn1Cc1cc(Cl)cc2cc(oc12)-c1ccccc1)C(O)=O Show InChI InChI=1S/C20H15ClN2O3/c1-12-7-17(20(24)25)22-23(12)11-15-9-16(21)8-14-10-18(26-19(14)15)13-5-3-2-4-6-13/h2-10H,11H2,1H3,(H,24,25)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Kyorin Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against dog gastric proton-pump enzyme H+/K+ ATPase				Bioorg Med Chem 25: 2635-2642 (2017) Article DOI: 10.1016/j.bmc.2017.03.003 BindingDB Entry DOI: 10.7270/Q29Z9728
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM119455 (US8680120, 9-15) Show SMILES COc1ccc2n(Cc3cccc(c3)C(O)=O)c(cc2c1)C(C)C Show InChI InChI=1S/C20H21NO3/c1-13(2)19-11-16-10-17(24-3)7-8-18(16)21(19)12-14-5-4-6-15(9-14)20(22)23/h4-11,13H,12H2,1-3H3,(H,22,23)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Co., Ltd. US Patent					Assay Description The rat EP1 receptor-expressing cells were washed with the assay buffer. 100 μL of a fluorescent calcium indicator (Fluo-4 NW Calcium Assay Kit ...				US Patent US8680120 (2014) BindingDB Entry DOI: 10.7270/Q2183554
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM119479 (US8680120, 25-38) Show SMILES COc1cc2cc(-c3ccoc3)n(Cc3ccc(o3)C(O)=O)c2cc1Cl Show InChI InChI=1S/C19H14ClNO5/c1-24-18-7-12-6-15(11-4-5-25-10-11)21(16(12)8-14(18)20)9-13-2-3-17(26-13)19(22)23/h2-8,10H,9H2,1H3,(H,22,23)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Co., Ltd. US Patent					Assay Description The rat EP1 receptor-expressing cells were washed with the assay buffer. 100 μL of a fluorescent calcium indicator (Calcium kit II, Fluo 4 (Doji...				US Patent US8680120 (2014) BindingDB Entry DOI: 10.7270/Q2183554
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM119459 (US8680120, 9-35) Show SMILES COc1ccc2n(Cc3cccc(n3)C(O)=O)c(cc2c1)-c1ccsc1 Show InChI InChI=1S/C20H16N2O3S/c1-25-16-5-6-18-14(9-16)10-19(13-7-8-26-12-13)22(18)11-15-3-2-4-17(21-15)20(23)24/h2-10,12H,11H2,1H3,(H,23,24)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Co., Ltd. US Patent					Assay Description The rat EP1 receptor-expressing cells were washed with the assay buffer. 100 μL of a fluorescent calcium indicator (Fluo-4 NW Calcium Assay Kit ...				US Patent US8680120 (2014) BindingDB Entry DOI: 10.7270/Q2183554
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM119481 (US8680120, 25-41) Show SMILES COc1ccc2n(Cc3cccc(n3)C(O)=O)c(cc2c1)-c1cc(F)ccc1F Show InChI InChI=1S/C22H16F2N2O3/c1-29-16-6-8-20-13(9-16)10-21(17-11-14(23)5-7-18(17)24)26(20)12-15-3-2-4-19(25-15)22(27)28/h2-11H,12H2,1H3,(H,27,28)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Co., Ltd. US Patent					Assay Description The rat EP1 receptor-expressing cells were washed with the assay buffer. 100 μL of a fluorescent calcium indicator (Calcium kit II, Fluo 4 (Doji...				US Patent US8680120 (2014) BindingDB Entry DOI: 10.7270/Q2183554
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM119473 (US8680120, 25-29) Show SMILES COc1cc2cc(-c3cccc(F)c3)n(Cc3cccc(n3)C(O)=O)c2cc1F Show InChI InChI=1S/C22H16F2N2O3/c1-29-21-10-14-9-19(13-4-2-5-15(23)8-13)26(20(14)11-17(21)24)12-16-6-3-7-18(25-16)22(27)28/h2-11H,12H2,1H3,(H,27,28)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Co., Ltd. US Patent					Assay Description The rat EP1 receptor-expressing cells were washed with the assay buffer. 100 μL of a fluorescent calcium indicator (Calcium kit II, Fluo 4 (Doji...				US Patent US8680120 (2014) BindingDB Entry DOI: 10.7270/Q2183554
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM119478 (US8680120, 25-37) Show SMILES COc1cc2cc(-c3ccoc3)n(Cc3cccc(n3)C(O)=O)c2cc1Cl Show InChI InChI=1S/C20H15ClN2O4/c1-26-19-8-13-7-17(12-5-6-27-11-12)23(18(13)9-15(19)21)10-14-3-2-4-16(22-14)20(24)25/h2-9,11H,10H2,1H3,(H,24,25)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Co., Ltd. US Patent					Assay Description The rat EP1 receptor-expressing cells were washed with the assay buffer. 100 μL of a fluorescent calcium indicator (Calcium kit II, Fluo 4 (Doji...				US Patent US8680120 (2014) BindingDB Entry DOI: 10.7270/Q2183554
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM119472 (US8680120, 25-28) Show SMILES COc1cc2cc(-c3ccccc3F)n(Cc3cccc(n3)C(O)=O)c2cc1F Show InChI InChI=1S/C22H16F2N2O3/c1-29-21-10-13-9-20(15-6-2-3-7-16(15)23)26(19(13)11-17(21)24)12-14-5-4-8-18(25-14)22(27)28/h2-11H,12H2,1H3,(H,27,28)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Co., Ltd. US Patent					Assay Description The rat EP1 receptor-expressing cells were washed with the assay buffer. 100 μL of a fluorescent calcium indicator (Calcium kit II, Fluo 4 (Doji...				US Patent US8680120 (2014) BindingDB Entry DOI: 10.7270/Q2183554
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM119482 (US8680120, 25-42) Show SMILES COc1cc2cc(-c3cccnc3)n(Cc3cccc(n3)C(O)=O)c2cc1Cl Show InChI InChI=1S/C21H16ClN3O3/c1-28-20-9-14-8-18(13-4-3-7-23-11-13)25(19(14)10-16(20)22)12-15-5-2-6-17(24-15)21(26)27/h2-11H,12H2,1H3,(H,26,27)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Co., Ltd. US Patent					Assay Description The rat EP1 receptor-expressing cells were washed with the assay buffer. 100 μL of a fluorescent calcium indicator (Calcium kit II, Fluo 4 (Doji...				US Patent US8680120 (2014) BindingDB Entry DOI: 10.7270/Q2183554
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM50260702 (CHEMBL4089536) Show SMILES OC(=O)c1cccc(Cc2c(nn3cc(Cl)ccc23)-c2ccccc2)c1 Show InChI InChI=1S/C21H15ClN2O2/c22-17-9-10-19-18(12-14-5-4-8-16(11-14)21(25)26)20(23-24(19)13-17)15-6-2-1-3-7-15/h1-11,13H,12H2,(H,25,26)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Watarase Research Center, Discovery Research Headquarters, Kyorin Pharmaceutical Co., Ltd., 1848, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan. Curated by ChEMBL					Assay Description Antagonist activity at rat His-tagged EP1 receptor expressed in African green monkey COS1 cells assessed as reduction in PGE2-induced increase in int...				Bioorg Med Chem Lett 27: 4044-4050 (2017) Article DOI: 10.1016/j.bmcl.2017.07.055 BindingDB Entry DOI: 10.7270/Q2PN983F
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM50252510 (CHEMBL4076413) Show SMILES Cc1cc(nn1Cc1cc(Cl)cc2sc(nc12)N1CCC=C(C)C1)C(O)=O |t:23| Show InChI InChI=1S/C19H19ClN4O2S/c1-11-4-3-5-23(9-11)19-21-17-13(7-14(20)8-16(17)27-19)10-24-12(2)6-15(22-24)18(25)26/h4,6-8H,3,5,9-10H2,1-2H3,(H,25,26)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Watarase Research Center, Discovery Research Headquarters, Kyorin Pharmaceutical Co., Ltd., 1848, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan. Curated by ChEMBL					Assay Description Antagonist activity at rat EP1 receptor expressed in African green monkey COS1 cells assessed as inhibition of prostaglandin-E2-induced increase in i...				Bioorg Med Chem 25: 3406-3430 (2017) Article DOI: 10.1016/j.bmc.2017.04.028 BindingDB Entry DOI: 10.7270/Q2JW8HB8
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM50252481 (CHEMBL4079088) Show SMILES Cc1cc(nn1Cc1cc(Cl)cc2sc(nc12)N1CCCC1)C(O)=O Show InChI InChI=1S/C17H17ClN4O2S/c1-10-6-13(16(23)24)20-22(10)9-11-7-12(18)8-14-15(11)19-17(25-14)21-4-2-3-5-21/h6-8H,2-5,9H2,1H3,(H,23,24)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Watarase Research Center, Discovery Research Headquarters, Kyorin Pharmaceutical Co., Ltd., 1848, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan. Curated by ChEMBL					Assay Description Antagonist activity at rat EP1 receptor expressed in African green monkey COS1 cells assessed as inhibition of prostaglandin-E2-induced increase in i...				Bioorg Med Chem 25: 3406-3430 (2017) Article DOI: 10.1016/j.bmc.2017.04.028 BindingDB Entry DOI: 10.7270/Q2JW8HB8
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM50252494 (CHEMBL4105272) Show SMILES Cc1cc(nn1Cc1cc(Cl)cc2sc(nc12)-c1ccccc1)C(O)=O Show InChI InChI=1S/C19H14ClN3O2S/c1-11-7-15(19(24)25)22-23(11)10-13-8-14(20)9-16-17(13)21-18(26-16)12-5-3-2-4-6-12/h2-9H,10H2,1H3,(H,24,25)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
Watarase Research Center, Discovery Research Headquarters, Kyorin Pharmaceutical Co., Ltd., 1848, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan. Curated by ChEMBL					Assay Description Antagonist activity at rat EP1 receptor expressed in African green monkey COS1 cells assessed as inhibition of prostaglandin-E2-induced increase in i...				Bioorg Med Chem 25: 3406-3430 (2017) Article DOI: 10.1016/j.bmc.2017.04.028 BindingDB Entry DOI: 10.7270/Q2JW8HB8
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM50252465 (CHEMBL4088913) Show SMILES Cc1cc(nn1Cc1cccc2sc(nc12)N1CCC=CC1)C(O)=O |c:22| Show InChI InChI=1S/C18H18N4O2S/c1-12-10-14(17(23)24)20-22(12)11-13-6-5-7-15-16(13)19-18(25-15)21-8-3-2-4-9-21/h2-3,5-7,10H,4,8-9,11H2,1H3,(H,23,24)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Watarase Research Center, Discovery Research Headquarters, Kyorin Pharmaceutical Co., Ltd., 1848, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan. Curated by ChEMBL					Assay Description Antagonist activity at rat EP1 receptor expressed in African green monkey COS1 cells assessed as inhibition of prostaglandin-E2-induced increase in i...				Bioorg Med Chem 25: 3406-3430 (2017) Article DOI: 10.1016/j.bmc.2017.04.028 BindingDB Entry DOI: 10.7270/Q2JW8HB8
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM119470 (US8680120, 25-23) Show SMILES COc1cc2cc(-c3cccc(F)c3)n(Cc3cccc(n3)C(O)=O)c2cc1Cl Show InChI InChI=1S/C22H16ClFN2O3/c1-29-21-10-14-9-19(13-4-2-5-15(24)8-13)26(20(14)11-17(21)23)12-16-6-3-7-18(25-16)22(27)28/h2-11H,12H2,1H3,(H,27,28)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Co., Ltd. US Patent					Assay Description The rat EP1 receptor-expressing cells were washed with the assay buffer. 100 μL of a fluorescent calcium indicator (Calcium kit II, Fluo 4 (Doji...				US Patent US8680120 (2014) BindingDB Entry DOI: 10.7270/Q2183554
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM119467 (US8680120, 25-17) Show SMILES COc1ccc2n(Cc3cccc(c3)C(O)=O)c(cc2c1)-c1ccccc1F Show InChI InChI=1S/C23H18FNO3/c1-28-18-9-10-21-17(12-18)13-22(19-7-2-3-8-20(19)24)25(21)14-15-5-4-6-16(11-15)23(26)27/h2-13H,14H2,1H3,(H,26,27)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Co., Ltd. US Patent					Assay Description The rat EP1 receptor-expressing cells were washed with the assay buffer. 100 μL of a fluorescent calcium indicator (Calcium kit II, Fluo 4 (Doji...				US Patent US8680120 (2014) BindingDB Entry DOI: 10.7270/Q2183554
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM50252492 (CHEMBL4062313) Show SMILES CC(=C)c1nc2c(Cn3nc(cc3C)C(O)=O)cc(Cl)cc2s1 Show InChI InChI=1S/C16H14ClN3O2S/c1-8(2)15-18-14-10(5-11(17)6-13(14)23-15)7-20-9(3)4-12(19-20)16(21)22/h4-6H,1,7H2,2-3H3,(H,21,22)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
Watarase Research Center, Discovery Research Headquarters, Kyorin Pharmaceutical Co., Ltd., 1848, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan. Curated by ChEMBL					Assay Description Antagonist activity at rat EP1 receptor expressed in African green monkey COS1 cells assessed as inhibition of prostaglandin-E2-induced increase in i...				Bioorg Med Chem 25: 3406-3430 (2017) Article DOI: 10.1016/j.bmc.2017.04.028 BindingDB Entry DOI: 10.7270/Q2JW8HB8
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM119474 (US8680120, 25-31) Show SMILES COc1cc2cc(-c3ccc(F)cc3)n(Cc3cccc(n3)C(O)=O)c2cc1F Show InChI InChI=1S/C22H16F2N2O3/c1-29-21-10-14-9-19(13-5-7-15(23)8-6-13)26(20(14)11-17(21)24)12-16-3-2-4-18(25-16)22(27)28/h2-11H,12H2,1H3,(H,27,28)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Co., Ltd. US Patent					Assay Description The rat EP1 receptor-expressing cells were washed with the assay buffer. 100 μL of a fluorescent calcium indicator (Calcium kit II, Fluo 4 (Doji...				US Patent US8680120 (2014) BindingDB Entry DOI: 10.7270/Q2183554
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM119463 (US8680120, 25-11) Show SMILES COc1ccc2n(Cc3ccc(o3)C(O)=O)c(cc2c1)-c1cccc(F)c1 Show InChI InChI=1S/C21H16FNO4/c1-26-16-5-7-18-14(10-16)11-19(13-3-2-4-15(22)9-13)23(18)12-17-6-8-20(27-17)21(24)25/h2-11H,12H2,1H3,(H,24,25)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Co., Ltd. US Patent					Assay Description The rat EP1 receptor-expressing cells were washed with the assay buffer. 100 μL of a fluorescent calcium indicator (Calcium kit II, Fluo 4 (Doji...				US Patent US8680120 (2014) BindingDB Entry DOI: 10.7270/Q2183554
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM119457 (US8680120, 9-25) Show SMILES COc1ccc2n(Cc3cccc(c3)C(O)=O)c(cc2c1)-c1ccsc1 Show InChI InChI=1S/C21H17NO3S/c1-25-18-5-6-19-17(10-18)11-20(16-7-8-26-13-16)22(19)12-14-3-2-4-15(9-14)21(23)24/h2-11,13H,12H2,1H3,(H,23,24)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Co., Ltd. US Patent					Assay Description The rat EP1 receptor-expressing cells were washed with the assay buffer. 100 μL of a fluorescent calcium indicator (Fluo-4 NW Calcium Assay Kit ...				US Patent US8680120 (2014) BindingDB Entry DOI: 10.7270/Q2183554
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM119477 (US8680120, 25-36) Show SMILES COc1cc2cc(-c3ccccc3)n(Cc3ccc(o3)C(O)=O)c2cc1C Show InChI InChI=1S/C22H19NO4/c1-14-10-18-16(12-21(14)26-2)11-19(15-6-4-3-5-7-15)23(18)13-17-8-9-20(27-17)22(24)25/h3-12H,13H2,1-2H3,(H,24,25)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Co., Ltd. US Patent					Assay Description The rat EP1 receptor-expressing cells were washed with the assay buffer. 100 μL of a fluorescent calcium indicator (Calcium kit II, Fluo 4 (Doji...				US Patent US8680120 (2014) BindingDB Entry DOI: 10.7270/Q2183554
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM119469 (US8680120, 25-19) Show SMILES COc1ccc2n(Cc3cccc(c3)C(O)=O)c(cc2c1)-c1ccc(F)cc1 Show InChI InChI=1S/C23H18FNO3/c1-28-20-9-10-21-18(12-20)13-22(16-5-7-19(24)8-6-16)25(21)14-15-3-2-4-17(11-15)23(26)27/h2-13H,14H2,1H3,(H,26,27)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Co., Ltd. US Patent					Assay Description The rat EP1 receptor-expressing cells were washed with the assay buffer. 100 μL of a fluorescent calcium indicator (Calcium kit II, Fluo 4 (Doji...				US Patent US8680120 (2014) BindingDB Entry DOI: 10.7270/Q2183554
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM50252508 (CHEMBL4096603) Show SMILES COc1cc(Cn2nc(cc2C)C(O)=O)c2nc(sc2c1)N1CCC=CC1 |c:27| Show InChI InChI=1S/C19H20N4O3S/c1-12-8-15(18(24)25)21-23(12)11-13-9-14(26-2)10-16-17(13)20-19(27-16)22-6-4-3-5-7-22/h3-4,8-10H,5-7,11H2,1-2H3,(H,24,25)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
Watarase Research Center, Discovery Research Headquarters, Kyorin Pharmaceutical Co., Ltd., 1848, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan. Curated by ChEMBL					Assay Description Antagonist activity at rat EP1 receptor expressed in African green monkey COS1 cells assessed as inhibition of prostaglandin-E2-induced increase in i...				Bioorg Med Chem 25: 3406-3430 (2017) Article DOI: 10.1016/j.bmc.2017.04.028 BindingDB Entry DOI: 10.7270/Q2JW8HB8
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM119480 (US8680120, 25-39) Show SMILES COc1cc2cc(-c3ccsc3)n(Cc3cccc(n3)C(O)=O)c2cc1C Show InChI InChI=1S/C21H18N2O3S/c1-13-8-18-15(10-20(13)26-2)9-19(14-6-7-27-12-14)23(18)11-16-4-3-5-17(22-16)21(24)25/h3-10,12H,11H2,1-2H3,(H,24,25)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Co., Ltd. US Patent					Assay Description The rat EP1 receptor-expressing cells were washed with the assay buffer. 100 μL of a fluorescent calcium indicator (Calcium kit II, Fluo 4 (Doji...				US Patent US8680120 (2014) BindingDB Entry DOI: 10.7270/Q2183554
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM119465 (US8680120, 25-13) Show SMILES COc1ccc2n(Cc3cccc(c3)C(O)=O)c(cc2c1)-c1cccnc1 Show InChI InChI=1S/C22H18N2O3/c1-27-19-7-8-20-18(11-19)12-21(17-6-3-9-23-13-17)24(20)14-15-4-2-5-16(10-15)22(25)26/h2-13H,14H2,1H3,(H,25,26)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Co., Ltd. US Patent					Assay Description The rat EP1 receptor-expressing cells were washed with the assay buffer. 100 μL of a fluorescent calcium indicator (Calcium kit II, Fluo 4 (Doji...				US Patent US8680120 (2014) BindingDB Entry DOI: 10.7270/Q2183554
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM119466 (US8680120, 25-16) Show SMILES COc1cc2cc(-c3ccccc3)n(Cc3cccc(n3)C(O)=O)c2cc1C Show InChI InChI=1S/C23H20N2O3/c1-15-11-20-17(13-22(15)28-2)12-21(16-7-4-3-5-8-16)25(20)14-18-9-6-10-19(24-18)23(26)27/h3-13H,14H2,1-2H3,(H,26,27)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Co., Ltd. US Patent					Assay Description The rat EP1 receptor-expressing cells were washed with the assay buffer. 100 μL of a fluorescent calcium indicator (Calcium kit II, Fluo 4 (Doji...				US Patent US8680120 (2014) BindingDB Entry DOI: 10.7270/Q2183554
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Rattus norvegicus (Rat))	BDBM50252480 (CHEMBL4097108) Show SMILES Cc1cc(nn1Cc1cc(Cl)cc2sc(nc12)N1CCCCC1)C(O)=O Show InChI InChI=1S/C18H19ClN4O2S/c1-11-7-14(17(24)25)21-23(11)10-12-8-13(19)9-15-16(12)20-18(26-15)22-5-3-2-4-6-22/h7-9H,2-6,10H2,1H3,(H,24,25)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
Watarase Research Center, Discovery Research Headquarters, Kyorin Pharmaceutical Co., Ltd., 1848, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan. Curated by ChEMBL					Assay Description Antagonist activity at rat EP1 receptor expressed in African green monkey COS1 cells assessed as inhibition of prostaglandin-E2-induced increase in i...				Bioorg Med Chem 25: 3406-3430 (2017) Article DOI: 10.1016/j.bmc.2017.04.028 BindingDB Entry DOI: 10.7270/Q2JW8HB8
					More data for this Ligand-Target Pair

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