Found 1140 hits of ic50 for UniProtKB: P40763 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50408828
(CHEMBL5270588)Show SMILES CN1CC(COC(=O)C2CCC2)=C[C@H]2[C@H]1Cc1c[nH]c3cccc2c13 |c:12| Show InChI InChI=1S/C21H24N2O2/c1-23-11-13(12-25-21(24)14-4-2-5-14)8-17-16-6-3-7-18-20(16)15(10-22-18)9-19(17)23/h3,6-8,10,14,17,19,22H,2,4-5,9,11-12H2,1H3/t17-,19-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE2 by enzyme immuno assay at 50 uM |
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More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50588525
(CHEMBL5177956)Show SMILES COc1ccc(cc1)-c1noc(n1)-c1cnc(Oc2ccc3cc(C(=O)N4CCN(Cc5ccc(OCC(F)(F)F)cc5)CC4)n(C)c3c2)cn1 | PDB
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UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
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Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01554 BindingDB Entry DOI: 10.7270/Q2RB78J1 |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50588528
(CHEMBL5209107)Show SMILES Cn1c(cc2ccc(Oc3cnc(cn3)-c3nc(no3)-c3ccc(F)cc3)cc12)C(=O)N1CCN(Cc2ccc(OCC(F)(F)F)cc2)CC1 | PDB
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UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01554 BindingDB Entry DOI: 10.7270/Q2RB78J1 |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50588530
(CHEMBL5201151)Show SMILES Cn1c(cc2ccc(Oc3cnc(cn3)-c3nc(no3)-c3ccccc3F)cc12)C(=O)N1CCN(Cc2ccc(OCC(F)(F)F)cc2)CC1 | PDB
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UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
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| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01554 BindingDB Entry DOI: 10.7270/Q2RB78J1 |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50545650
(Delgocitinib | JTE-052 | JTE-052A | LEO 124249 | L...)Show SMILES C[C@H]1CN(C(=O)CC#N)[C@]11CCN(C1)c1ncnc2[nH]ccc12 |r| Show InChI InChI=1S/C16H18N6O/c1-11-8-22(13(23)2-5-17)16(11)4-7-21(9-16)15-12-3-6-18-14(12)19-10-20-15/h3,6,10-11H,2,4,7-9H2,1H3,(H,18,19,20)/t11-,16-/m0/s1 | PDB
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MCE PC cid PC sid UniChem
| | n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
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More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50588531
(CHEMBL5171007)Show SMILES COc1cccc(c1)-c1noc(n1)-c1cnc(Oc2ccc3cc(C(=O)N4CCN(Cc5ccc(OCC(F)(F)F)cc5)CC4)n(C)c3c2)cn1 | PDB
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UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
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| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01554 BindingDB Entry DOI: 10.7270/Q2RB78J1 |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50021656
(BARICITINIB | INCB-028050 | LY-3009104 | US1011290...)Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C16H17N7O2S/c1-2-26(24,25)22-9-16(10-22,4-5-17)23-8-12(7-21-23)14-13-3-6-18-15(13)20-11-19-14/h3,6-8,11H,2,4,9-10H2,1H3,(H,18,19,20) | PDB
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MCE PC cid PC sid PDB UniChem
| | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
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Citation and Details
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More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50588507
(CHEMBL5178622)Show SMILES Cn1c(cc2ccc(Oc3cnc(cn3)-c3nc(no3)-c3ccc(cc3)C(F)(F)F)cc12)C(=O)N1CCN(Cc2ccc(OCC(F)(F)F)cc2)CC1 | PDB
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UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
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Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01554 BindingDB Entry DOI: 10.7270/Q2RB78J1 |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50335201
(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)Show SMILES C[C@H](Nc1ncc(Cl)c(Nc2cc(C)n[nH]2)n1)c1ncc(F)cn1 |r| Show InChI InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1 | PDB
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Similars
| Article PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of Stat3 phosphorylation in human SET2 cells after 1 hr by Western blotting |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50590873
(CHEMBL5176684)Show SMILES FC(F)(F)COc1ccc(CN2CCN(CC2)C(=O)c2ccc(cc2)-c2noc(n2)-c2ccc(cc2)C(F)(F)F)cc1 | PDB
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UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
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| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
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Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00413 BindingDB Entry DOI: 10.7270/Q2RF6006 |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50588526
(CHEMBL5189135)Show SMILES Cn1c(cc2ccc(Oc3cnc(cn3)-c3nc(no3)-c3ccc(Br)cc3)cc12)C(=O)N1CCN(Cc2ccc(OCC(F)(F)F)cc2)CC1 | PDB
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UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
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Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01554 BindingDB Entry DOI: 10.7270/Q2RB78J1 |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50588514
(CHEMBL5184385)Show SMILES FC(F)(F)COc1ccc(CN2CCN(CC2)C(=O)c2cc3ccc(Oc4cnc(cn4)-c4nc(no4)-c4ccc(cc4)C(F)(F)F)cc3[nH]2)cc1 | PDB
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UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
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| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
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Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01554 BindingDB Entry DOI: 10.7270/Q2RB78J1 |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50590921
(CHEMBL5176948)Show SMILES FC(F)(F)COc1ccc(CN2CCN(CC2)C(=O)c2cc(ccn2)-c2nc(no2)-c2ccc(cc2)C(F)(F)F)cc1 | PDB
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UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
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| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00413 BindingDB Entry DOI: 10.7270/Q2RF6006 |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50545650
(Delgocitinib | JTE-052 | JTE-052A | LEO 124249 | L...)Show SMILES C[C@H]1CN(C(=O)CC#N)[C@]11CCN(C1)c1ncnc2[nH]ccc12 |r| Show InChI InChI=1S/C16H18N6O/c1-11-8-22(13(23)2-5-17)16(11)4-7-21(9-16)15-12-3-6-18-14(12)19-10-20-15/h3,6,10-11H,2,4,7-9H2,1H3,(H,18,19,20)/t11-,16-/m0/s1 | PDB
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| | n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
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Citation and Details
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More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50612060
(CHEMBL5279856) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
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Citation and Details
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More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50588527
(CHEMBL5201419)Show SMILES Cn1c(cc2ccc(Oc3cnc(cn3)-c3nc(no3)-c3ccc(Cl)cc3)cc12)C(=O)N1CCN(Cc2ccc(OCC(F)(F)F)cc2)CC1 | PDB
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UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
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Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01554 BindingDB Entry DOI: 10.7270/Q2RB78J1 |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50590882
(CHEMBL5182844)Show SMILES FC(F)(F)COc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)-c2nc(no2)-c2ccc(cc2)C(F)(F)F)cc1 | PDB
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UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
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| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
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Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00413 BindingDB Entry DOI: 10.7270/Q2RF6006 |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50588529
(CHEMBL5209399)Show SMILES Cn1c(cc2ccc(Oc3cnc(cn3)-c3nc(no3)-c3cccc(F)c3)cc12)C(=O)N1CCN(Cc2ccc(OCC(F)(F)F)cc2)CC1 | PDB
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UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
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| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
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Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01554 BindingDB Entry DOI: 10.7270/Q2RB78J1 |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50588524
(CHEMBL5205645)Show SMILES Cn1c(cc2ccc(Oc3cnc(cn3)-c3nc(no3)-c3ccc(OC(F)(F)F)cc3)cc12)C(=O)N1CCN(Cc2ccc(OCC(F)(F)F)cc2)CC1 | PDB
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UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
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| n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
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Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01554 BindingDB Entry DOI: 10.7270/Q2RB78J1 |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50590895
(CHEMBL5185530)Show SMILES FC(F)(F)c1ccc(cc1)-c1noc(n1)-c1ccc(cn1)C(=O)N1CCN(Cc2ccc(Br)cc2)CC1 | PDB
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UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
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| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
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Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00413 BindingDB Entry DOI: 10.7270/Q2RF6006 |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50545650
(Delgocitinib | JTE-052 | JTE-052A | LEO 124249 | L...)Show SMILES C[C@H]1CN(C(=O)CC#N)[C@]11CCN(C1)c1ncnc2[nH]ccc12 |r| Show InChI InChI=1S/C16H18N6O/c1-11-8-22(13(23)2-5-17)16(11)4-7-21(9-16)15-12-3-6-18-14(12)19-10-20-15/h3,6,10-11H,2,4,7-9H2,1H3,(H,18,19,20)/t11-,16-/m0/s1 | PDB
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MCE PC cid PC sid UniChem
| | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
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Citation and Details
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More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50588518
(CHEMBL5175035)Show SMILES COCCn1c(cc2ccc(Oc3cnc(cn3)-c3nc(no3)-c3ccc(cc3)C(F)(F)F)cc12)C(=O)N1CCN(Cc2ccc(OCC(F)(F)F)cc2)CC1 | PDB
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UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
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Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01554 BindingDB Entry DOI: 10.7270/Q2RB78J1 |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50590914
(CHEMBL5199234)Show SMILES Fc1cc(ccc1C(F)(F)F)-c1noc(n1)-c1ccc(cn1)C(=O)N1CCN(Cc2ccc(OCC(F)(F)F)cc2)CC1 | PDB
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UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
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Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00413 BindingDB Entry DOI: 10.7270/Q2RF6006 |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50021656
(BARICITINIB | INCB-028050 | LY-3009104 | US1011290...)Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C16H17N7O2S/c1-2-26(24,25)22-9-16(10-22,4-5-17)23-8-12(7-21-23)14-13-3-6-18-15(13)20-11-19-14/h3,6-8,11H,2,4,9-10H2,1H3,(H,18,19,20) | PDB
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| | n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
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More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50588532
(CHEMBL5200170)Show SMILES COc1ccccc1-c1noc(n1)-c1cnc(Oc2ccc3cc(C(=O)N4CCN(Cc5ccc(OCC(F)(F)F)cc5)CC4)n(C)c3c2)cn1 | PDB
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UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
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Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01554 BindingDB Entry DOI: 10.7270/Q2RB78J1 |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50590923
(CHEMBL5196490)Show SMILES FC(F)(F)COc1ccc(CN2CCN(CC2)C(=O)c2cccc(c2)-c2nc(no2)-c2ccc(cc2)C(F)(F)F)cc1 | PDB
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UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
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| n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
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Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00413 BindingDB Entry DOI: 10.7270/Q2RF6006 |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50590919
(CHEMBL5189947)Show SMILES FC(F)(F)COc1ccc(CN2CCN(CC2)C(=O)c2cnc(cn2)-c2noc(n2)-c2ccc(cc2)C(F)(F)F)cc1 | PDB
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UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
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| n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
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Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00413 BindingDB Entry DOI: 10.7270/Q2RF6006 |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50590911
(CHEMBL5170615)Show SMILES FC(F)(F)COc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)-c2nc(no2)-c2ccc(OC(F)(F)F)cc2)cc1 | PDB
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UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
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| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
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Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00413 BindingDB Entry DOI: 10.7270/Q2RF6006 |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50590879
(CHEMBL5182625)Show SMILES FC(F)(F)Oc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)-c2nc(no2)-c2ccc(cc2)C(F)(F)F)cc1 | PDB
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B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
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| n/a | n/a | 64 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
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Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00413 BindingDB Entry DOI: 10.7270/Q2RF6006 |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50588505
(CHEMBL5206754)Show SMILES COc1ccc(CN2CCN(CC2)C(=O)c2cc3ccc(Oc4cnc(cn4)-c4nc(no4)-c4ccc(cc4)C(F)(F)F)cc3n2C)cc1 | PDB
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UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
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TBA
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Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01554 BindingDB Entry DOI: 10.7270/Q2RB78J1 |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50569071
(CHEMBL4846365)Show SMILES CCCC(C)Oc1ccc(C(=O)Nc2ccc3nc(SCC(=O)N[C@@H](C)c4ccc(OC)cc4)sc3c2)c(OC)c1C |r| | PDB
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B.MOAD antibodypedia GoogleScholar AffyNet
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| Article PubMed
| n/a | n/a | 67 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of IL-6 induced STAT3 transcriptional activity in human HepG2 cells incubated for 1 hr followed by stimulation with IL-6 for 5.5 hrs by lu... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113333 BindingDB Entry DOI: 10.7270/Q2MP571B |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50300648
(4-(3-((S)-1-((cis)-2-((S)-5-amino-1-(benzylamino)-...)Show SMILES CC(C)C[C@H](NC(=O)\C=C\c1ccc(OP(O)(O)=O)cc1)C(=O)N1C[C@H]2C[C@H]2[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)NCc1ccccc1 |r| Show InChI InChI=1S/C33H42N5O9P/c1-20(2)16-27(36-29(40)15-10-21-8-11-24(12-9-21)47-48(44,45)46)33(43)38-19-23-17-25(23)30(38)32(42)37-26(13-14-28(34)39)31(41)35-18-22-6-4-3-5-7-22/h3-12,15,20,23,25-27,30H,13-14,16-19H2,1-2H3,(H2,34,39)(H,35,41)(H,36,40)(H,37,42)(H2,44,45,46)/b15-10+/t23-,25-,26+,27+,30+/m1/s1 | PDB
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| Article PubMed
| n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Texas M. D. Anderson Cancer Center
Curated by ChEMBL
| Assay Description Inhibition of Stat3 SH2 domain by fluorescence polarization assay |
J Med Chem 52: 6126-41 (2009)
Article DOI: 10.1021/jm901105k BindingDB Entry DOI: 10.7270/Q2M045HH |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50300658
(4-((E)-3-((S)-1-((1R,2S,5S)-2-(2-(benzyloxy)ethylc...)Show SMILES CC(C)C[C@H](NC(=O)\C=C\c1ccc(OP(O)(O)=O)cc1)C(=O)N1C[C@H]2C[C@H]2[C@H]1C(=O)NCCOCc1ccccc1 |r| Show InChI InChI=1S/C30H38N3O8P/c1-20(2)16-26(32-27(34)13-10-21-8-11-24(12-9-21)41-42(37,38)39)30(36)33-18-23-17-25(23)28(33)29(35)31-14-15-40-19-22-6-4-3-5-7-22/h3-13,20,23,25-26,28H,14-19H2,1-2H3,(H,31,35)(H,32,34)(H2,37,38,39)/b13-10+/t23-,25-,26+,28+/m1/s1 | PDB
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B.MOAD antibodypedia GoogleScholar AffyNet
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| Article PubMed
| n/a | n/a | 69 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Texas M. D. Anderson Cancer Center
Curated by ChEMBL
| Assay Description Inhibition of Stat3 SH2 domain by fluorescence polarization assay |
J Med Chem 52: 6126-41 (2009)
Article DOI: 10.1021/jm901105k BindingDB Entry DOI: 10.7270/Q2M045HH |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50300657
(4-(3-((S)-1-((cis)-2-((2R,3S)-6-amino-2-(benzyloxy...)Show SMILES CC(C)C[C@H](NC(=O)\C=C\c1ccc(OP(O)(O)=O)cc1)C(=O)N1C[C@H]2C[C@H]2[C@H]1C(=O)N[C@@H](CCC(N)=O)[C@@H](C)OCc1ccccc1 |r| Show InChI InChI=1S/C34H45N4O9P/c1-21(2)17-29(36-31(40)16-11-23-9-12-26(13-10-23)47-48(43,44)45)34(42)38-19-25-18-27(25)32(38)33(41)37-28(14-15-30(35)39)22(3)46-20-24-7-5-4-6-8-24/h4-13,16,21-22,25,27-29,32H,14-15,17-20H2,1-3H3,(H2,35,39)(H,36,40)(H,37,41)(H2,43,44,45)/b16-11+/t22-,25-,27-,28+,29+,32+/m1/s1 | PDB
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B.MOAD antibodypedia GoogleScholar AffyNet
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Similars
| Article PubMed
| n/a | n/a | 69 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Texas M. D. Anderson Cancer Center
Curated by ChEMBL
| Assay Description Inhibition of Stat3 SH2 domain by fluorescence polarization assay |
J Med Chem 52: 6126-41 (2009)
Article DOI: 10.1021/jm901105k BindingDB Entry DOI: 10.7270/Q2M045HH |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50588501
(CHEMBL5193538)Show SMILES Cn1c(cc2ccc(Oc3cnc(cn3)-c3nc(no3)-c3ccc(cc3)C(F)(F)F)cc12)C(=O)N1CCN(Cc2ccc(cc2)C(F)(F)F)CC1 | PDB
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| n/a | n/a | 72 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01554 BindingDB Entry DOI: 10.7270/Q2RB78J1 |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50590920
(CHEMBL5171708)Show SMILES FC(F)(F)COc1ccc(CN2CCN(CC2)C(=O)c2ccc(cn2)-c2nc(no2)-c2ccc(cc2)C(F)(F)F)cc1 | PDB
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| n/a | n/a | 76 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00413 BindingDB Entry DOI: 10.7270/Q2RF6006 |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50588506
(CHEMBL5201590)Show SMILES Cn1c(cc2ccc(Oc3cnc(cn3)-c3nc(no3)-c3ccc(cc3)C(F)(F)F)cc12)C(=O)N1CCN(Cc2ccc(OC(F)(F)F)cc2)CC1 | PDB
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| n/a | n/a | 76 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01554 BindingDB Entry DOI: 10.7270/Q2RB78J1 |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50335201
(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)Show SMILES C[C@H](Nc1ncc(Cl)c(Nc2cc(C)n[nH]2)n1)c1ncc(F)cn1 |r| Show InChI InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1 | PDB
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| Article PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of Stat3 phosphorylation in human HEL cells after 1 hr by Western blotting |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50545650
(Delgocitinib | JTE-052 | JTE-052A | LEO 124249 | L...)Show SMILES C[C@H]1CN(C(=O)CC#N)[C@]11CCN(C1)c1ncnc2[nH]ccc12 |r| Show InChI InChI=1S/C16H18N6O/c1-11-8-22(13(23)2-5-17)16(11)4-7-21(9-16)15-12-3-6-18-14(12)19-10-20-15/h3,6,10-11H,2,4,7-9H2,1H3,(H,18,19,20)/t11-,16-/m0/s1 | PDB
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MCE PC cid PC sid UniChem
| | n/a | n/a | 84 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50590889
(CHEMBL5177332)Show SMILES CC(C)(C)c1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)-c2nc(no2)-c2ccc(cc2)C(F)(F)F)cc1 | PDB
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| n/a | n/a | 88 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00413 BindingDB Entry DOI: 10.7270/Q2RF6006 |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50590909
(CHEMBL5189774)Show SMILES FC(F)(F)COc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)-c2nc(no2)-c2ccc(Br)cc2)cc1 | PDB
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| n/a | n/a | 93 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00413 BindingDB Entry DOI: 10.7270/Q2RF6006 |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50590916
(CHEMBL5183263)Show SMILES FC(F)(F)COc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)-c2nc(co2)-c2ccc(cc2)C(F)(F)F)cc1 | PDB
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| n/a | n/a | 94 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00413 BindingDB Entry DOI: 10.7270/Q2RF6006 |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50300656
(4-(3-((S)-1-((cis)-2-((S)-5-amino-1-(benzyloxy)-5-...)Show SMILES CC(C)C[C@H](NC(=O)\C=C\c1ccc(OP(O)(O)=O)cc1)C(=O)N1C[C@H]2C[C@H]2[C@H]1C(=O)N[C@@H](CCC(N)=O)COCc1ccccc1 |r| Show InChI InChI=1S/C33H43N4O9P/c1-21(2)16-28(36-30(39)15-10-22-8-12-26(13-9-22)46-47(42,43)44)33(41)37-18-24-17-27(24)31(37)32(40)35-25(11-14-29(34)38)20-45-19-23-6-4-3-5-7-23/h3-10,12-13,15,21,24-25,27-28,31H,11,14,16-20H2,1-2H3,(H2,34,38)(H,35,40)(H,36,39)(H2,42,43,44)/b15-10+/t24-,25+,27-,28+,31+/m1/s1 | PDB
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B.MOAD antibodypedia GoogleScholar AffyNet
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| Article PubMed
| n/a | n/a | 94 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Texas M. D. Anderson Cancer Center
Curated by ChEMBL
| Assay Description Inhibition of Stat3 SH2 domain by fluorescence polarization assay |
J Med Chem 52: 6126-41 (2009)
Article DOI: 10.1021/jm901105k BindingDB Entry DOI: 10.7270/Q2M045HH |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM420304
(LLL-12)Show InChI InChI=1S/C14H9NO5S/c15-21(19,20)10-6-2-4-8-12(10)14(18)7-3-1-5-9(16)11(7)13(8)17/h1-6,16H,(H2,15,19,20) | PDB
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MCE UniChem
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| n/a | n/a | 98 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of IL-6 induced STAT3 transcriptional activity in human HepG2 cells incubated for 1 hr followed by stimulation with IL-6 for 5.5 hrs by lu... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113333 BindingDB Entry DOI: 10.7270/Q2MP571B |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50588512
(CHEMBL5201252)Show SMILES Cn1c(cc2ccc(Oc3cnc(cn3)-c3nc(no3)-c3ccc(cc3)C(F)(F)F)cc12)C(=O)N1CCN(Cc2ccc(OCC(F)(F)F)c(F)c2)CC1 | PDB
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| n/a | n/a | 101 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01554 BindingDB Entry DOI: 10.7270/Q2RB78J1 |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50213228
(2-(4-((S)-3-((S)-1-((S)-2-(((S)-5-amino-1-((2S,3R)...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OC(C(O)=O)C(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(O)=O Show InChI InChI=1S/C39H57N7O15/c1-18(2)16-26(43-33(51)25(41-21(6)48)17-22-9-11-23(12-10-22)61-31(38(57)58)39(59)60)36(54)46-15-7-8-27(46)34(52)42-24(13-14-28(40)49)32(50)45-30(20(5)47)35(53)44-29(19(3)4)37(55)56/h9-12,18-20,24-27,29-31,47H,7-8,13-17H2,1-6H3,(H2,40,49)(H,41,48)(H,42,52)(H,43,51)(H,44,53)(H,45,50)(H,55,56)(H,57,58)(H,59,60)/t20-,24+,25+,26+,27+,29+,30+/m1/s1 | PDB
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| Article PubMed
| n/a | n/a | 108 | n/a | n/a | n/a | n/a | n/a | n/a |
Université Paris Descartes
Curated by ChEMBL
| Assay Description Inhibition of STAT3 dimer DNA binding activity by ELISA after 30 mins |
Bioorg Med Chem Lett 17: 3943-6 (2007)
Article DOI: 10.1016/j.bmcl.2007.04.107 BindingDB Entry DOI: 10.7270/Q2736QMV |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50590894
(CHEMBL5199713)Show SMILES FC(F)(F)c1ccc(cc1)-c1noc(n1)-c1ccc(cn1)C(=O)N1CCN(Cc2ccc(Cl)cc2)CC1 | PDB
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| n/a | n/a | 109 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00413 BindingDB Entry DOI: 10.7270/Q2RF6006 |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50300627
(4-(3-((S)-1-((S)-2-((R)-5-amino-5-oxopentan-2-ylca...)Show SMILES CC(C)C[C@H](NC(=O)\C=C\c1ccc(OP(O)(O)=O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)CCC(N)=O |r| Show InChI InChI=1S/C25H37N4O8P/c1-16(2)15-20(28-23(31)13-9-18-7-10-19(11-8-18)37-38(34,35)36)25(33)29-14-4-5-21(29)24(32)27-17(3)6-12-22(26)30/h7-11,13,16-17,20-21H,4-6,12,14-15H2,1-3H3,(H2,26,30)(H,27,32)(H,28,31)(H2,34,35,36)/b13-9+/t17-,20+,21+/m1/s1 | PDB
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| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Texas M. D. Anderson Cancer Center
Curated by ChEMBL
| Assay Description Inhibition of Stat3 SH2 domain by fluorescence polarization assay |
J Med Chem 52: 6126-41 (2009)
Article DOI: 10.1021/jm901105k BindingDB Entry DOI: 10.7270/Q2M045HH |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50590912
(CHEMBL5189465)Show SMILES COc1ccc(cc1)-c1noc(n1)-c1ccc(cn1)C(=O)N1CCN(Cc2ccc(OCC(F)(F)F)cc2)CC1 | PDB
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| n/a | n/a | 113 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00413 BindingDB Entry DOI: 10.7270/Q2RF6006 |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50590918
(CHEMBL5200334)Show SMILES FC(F)(F)COc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)-c2cn(nn2)-c2ccc(cc2)C(F)(F)F)cc1 | PDB
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| n/a | n/a | 113 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00413 BindingDB Entry DOI: 10.7270/Q2RF6006 |
More data for this Ligand-Target Pair | |