Compile Data Set for Download or QSAR

Found 1487 hits of ic50 for UniProtKB: P40763   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50408828 (CHEMBL5270588) Show SMILES CN1CC(COC(=O)C2CCC2)=C[C@H]2[C@H]1Cc1c[nH]c3cccc2c13 |c:12| Show InChI InChI=1S/C21H24N2O2/c1-23-11-13(12-25-21(24)14-4-2-5-14)8-17-16-6-3-7-18-20(16)15(10-22-18)9-19(17)23/h3,6-8,10,14,17,19,22H,2,4-5,9,11-12H2,1H3/t17-,19-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars		n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE2 by enzyme immuno assay at 50 uM				Citation and Details
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Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50588525 (CHEMBL5177956) Show SMILES COc1ccc(cc1)-c1noc(n1)-c1cnc(Oc2ccc3cc(C(=O)N4CCN(Cc5ccc(OCC(F)(F)F)cc5)CC4)n(C)c3c2)cn1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c01554 BindingDB Entry DOI: 10.7270/Q2RB78J1
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Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50588528 (CHEMBL5209107) Show SMILES Cn1c(cc2ccc(Oc3cnc(cn3)-c3nc(no3)-c3ccc(F)cc3)cc12)C(=O)N1CCN(Cc2ccc(OCC(F)(F)F)cc2)CC1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c01554 BindingDB Entry DOI: 10.7270/Q2RB78J1
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Signal transducer and activator of transcription 3 [702-738,740-752] (Homo sapiens (Human))	BDBM43584 (2-[(1-methyl-2-benzimidazolyl)methylamino]phenol |...) Show SMILES Cn1c(CNc2ccccc2O)nc2ccccc12 Show InChI InChI=1S/C15H15N3O/c1-18-13-8-4-2-6-11(13)17-15(18)10-16-12-7-3-5-9-14(12)19/h2-9,16,19H,10H2,1H3	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	>8.49	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay					Assay Description Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2S46QBK
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Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50588530 (CHEMBL5201151) Show SMILES Cn1c(cc2ccc(Oc3cnc(cn3)-c3nc(no3)-c3ccccc3F)cc12)C(=O)N1CCN(Cc2ccc(OCC(F)(F)F)cc2)CC1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c01554 BindingDB Entry DOI: 10.7270/Q2RB78J1
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Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50545650 (Delgocitinib | JTE-052 | JTE-052A | LEO 124249 | L...) Show SMILES C[C@H]1CN(C(=O)CC#N)[C@]11CCN(C1)c1ncnc2[nH]ccc12 |r| Show InChI InChI=1S/C16H18N6O/c1-11-8-22(13(23)2-5-17)16(11)4-7-21(9-16)15-12-3-6-18-14(12)19-10-20-15/h3,6,10-11H,2,4,7-9H2,1H3,(H,18,19,20)/t11-,16-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem		n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50021656 (BARICITINIB | INCB-028050 | LY-3009104 | US1011290...) Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C16H17N7O2S/c1-2-26(24,25)22-9-16(10-22,4-5-17)23-8-12(7-21-23)14-13-3-6-18-15(13)20-11-19-14/h3,6-8,11H,2,4,9-10H2,1H3,(H,18,19,20)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem		n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50588531 (CHEMBL5171007) Show SMILES COc1cccc(c1)-c1noc(n1)-c1cnc(Oc2ccc3cc(C(=O)N4CCN(Cc5ccc(OCC(F)(F)F)cc5)CC4)n(C)c3c2)cn1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c01554 BindingDB Entry DOI: 10.7270/Q2RB78J1
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Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50588507 (CHEMBL5178622) Show SMILES Cn1c(cc2ccc(Oc3cnc(cn3)-c3nc(no3)-c3ccc(cc3)C(F)(F)F)cc12)C(=O)N1CCN(Cc2ccc(OCC(F)(F)F)cc2)CC1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c01554 BindingDB Entry DOI: 10.7270/Q2RB78J1
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Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50335201 (5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...) Show SMILES C[C@H](Nc1ncc(Cl)c(Nc2cc(C)n[nH]2)n1)c1ncc(F)cn1 |r| Show InChI InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Inhibition of Stat3 phosphorylation in human SET2 cells after 1 hr by Western blotting				J Med Chem 54: 262-76 (2011) Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM
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Signal transducer and activator of transcription 3 [702-738,740-752] (Homo sapiens (Human))	BDBM43560 (4-acetyl-N-(2-methoxyphenyl)-3,5-dimethyl-1H-pyrro...) Show SMILES COc1ccccc1NC(=O)c1[nH]c(C)c(C(C)=O)c1C Show InChI InChI=1S/C16H18N2O3/c1-9-14(11(3)19)10(2)17-15(9)16(20)18-12-7-5-6-8-13(12)21-4/h5-8,17H,1-4H3,(H,18,20)	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	>25.5	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay					Assay Description Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2S46QBK
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Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50588526 (CHEMBL5189135) Show SMILES Cn1c(cc2ccc(Oc3cnc(cn3)-c3nc(no3)-c3ccc(Br)cc3)cc12)C(=O)N1CCN(Cc2ccc(OCC(F)(F)F)cc2)CC1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c01554 BindingDB Entry DOI: 10.7270/Q2RB78J1
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Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50590873 (CHEMBL5176684) Show SMILES FC(F)(F)COc1ccc(CN2CCN(CC2)C(=O)c2ccc(cc2)-c2noc(n2)-c2ccc(cc2)C(F)(F)F)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00413 BindingDB Entry DOI: 10.7270/Q2RF6006
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Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50588514 (CHEMBL5184385) Show SMILES FC(F)(F)COc1ccc(CN2CCN(CC2)C(=O)c2cc3ccc(Oc4cnc(cn4)-c4nc(no4)-c4ccc(cc4)C(F)(F)F)cc3[nH]2)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c01554 BindingDB Entry DOI: 10.7270/Q2RB78J1
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Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50590921 (CHEMBL5176948) Show SMILES FC(F)(F)COc1ccc(CN2CCN(CC2)C(=O)c2cc(ccn2)-c2nc(no2)-c2ccc(cc2)C(F)(F)F)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00413 BindingDB Entry DOI: 10.7270/Q2RF6006
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50545650 (Delgocitinib | JTE-052 | JTE-052A | LEO 124249 | L...) Show SMILES C[C@H]1CN(C(=O)CC#N)[C@]11CCN(C1)c1ncnc2[nH]ccc12 |r| Show InChI InChI=1S/C16H18N6O/c1-11-8-22(13(23)2-5-17)16(11)4-7-21(9-16)15-12-3-6-18-14(12)19-10-20-15/h3,6,10-11H,2,4,7-9H2,1H3,(H,18,19,20)/t11-,16-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem		n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50612060 (CHEMBL5279856) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem		n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50588527 (CHEMBL5201419) Show SMILES Cn1c(cc2ccc(Oc3cnc(cn3)-c3nc(no3)-c3ccc(Cl)cc3)cc12)C(=O)N1CCN(Cc2ccc(OCC(F)(F)F)cc2)CC1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c01554 BindingDB Entry DOI: 10.7270/Q2RB78J1
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Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50590882 (CHEMBL5182844) Show SMILES FC(F)(F)COc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)-c2nc(no2)-c2ccc(cc2)C(F)(F)F)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00413 BindingDB Entry DOI: 10.7270/Q2RF6006
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50588529 (CHEMBL5209399) Show SMILES Cn1c(cc2ccc(Oc3cnc(cn3)-c3nc(no3)-c3cccc(F)c3)cc12)C(=O)N1CCN(Cc2ccc(OCC(F)(F)F)cc2)CC1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c01554 BindingDB Entry DOI: 10.7270/Q2RB78J1
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Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50588524 (CHEMBL5205645) Show SMILES Cn1c(cc2ccc(Oc3cnc(cn3)-c3nc(no3)-c3ccc(OC(F)(F)F)cc3)cc12)C(=O)N1CCN(Cc2ccc(OCC(F)(F)F)cc2)CC1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c01554 BindingDB Entry DOI: 10.7270/Q2RB78J1
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50588518 (CHEMBL5175035) Show SMILES COCCn1c(cc2ccc(Oc3cnc(cn3)-c3nc(no3)-c3ccc(cc3)C(F)(F)F)cc12)C(=O)N1CCN(Cc2ccc(OCC(F)(F)F)cc2)CC1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c01554 BindingDB Entry DOI: 10.7270/Q2RB78J1
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Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50590914 (CHEMBL5199234) Show SMILES Fc1cc(ccc1C(F)(F)F)-c1noc(n1)-c1ccc(cn1)C(=O)N1CCN(Cc2ccc(OCC(F)(F)F)cc2)CC1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00413 BindingDB Entry DOI: 10.7270/Q2RF6006
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50590895 (CHEMBL5185530) Show SMILES FC(F)(F)c1ccc(cc1)-c1noc(n1)-c1ccc(cn1)C(=O)N1CCN(Cc2ccc(Br)cc2)CC1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00413 BindingDB Entry DOI: 10.7270/Q2RF6006
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50545650 (Delgocitinib | JTE-052 | JTE-052A | LEO 124249 | L...) Show SMILES C[C@H]1CN(C(=O)CC#N)[C@]11CCN(C1)c1ncnc2[nH]ccc12 |r| Show InChI InChI=1S/C16H18N6O/c1-11-8-22(13(23)2-5-17)16(11)4-7-21(9-16)15-12-3-6-18-14(12)19-10-20-15/h3,6,10-11H,2,4,7-9H2,1H3,(H,18,19,20)/t11-,16-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem		n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50021656 (BARICITINIB | INCB-028050 | LY-3009104 | US1011290...) Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C16H17N7O2S/c1-2-26(24,25)22-9-16(10-22,4-5-17)23-8-12(7-21-23)14-13-3-6-18-15(13)20-11-19-14/h3,6-8,11H,2,4,9-10H2,1H3,(H,18,19,20)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem		n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50588532 (CHEMBL5200170) Show SMILES COc1ccccc1-c1noc(n1)-c1cnc(Oc2ccc3cc(C(=O)N4CCN(Cc5ccc(OCC(F)(F)F)cc5)CC4)n(C)c3c2)cn1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c01554 BindingDB Entry DOI: 10.7270/Q2RB78J1
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50590923 (CHEMBL5196490) Show SMILES FC(F)(F)COc1ccc(CN2CCN(CC2)C(=O)c2cccc(c2)-c2nc(no2)-c2ccc(cc2)C(F)(F)F)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	52	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00413 BindingDB Entry DOI: 10.7270/Q2RF6006
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50590919 (CHEMBL5189947) Show SMILES FC(F)(F)COc1ccc(CN2CCN(CC2)C(=O)c2cnc(cn2)-c2noc(n2)-c2ccc(cc2)C(F)(F)F)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	58	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00413 BindingDB Entry DOI: 10.7270/Q2RF6006
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50590911 (CHEMBL5170615) Show SMILES FC(F)(F)COc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)-c2nc(no2)-c2ccc(OC(F)(F)F)cc2)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00413 BindingDB Entry DOI: 10.7270/Q2RF6006
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50590879 (CHEMBL5182625) Show SMILES FC(F)(F)Oc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)-c2nc(no2)-c2ccc(cc2)C(F)(F)F)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	64	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00413 BindingDB Entry DOI: 10.7270/Q2RF6006
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50588505 (CHEMBL5206754) Show SMILES COc1ccc(CN2CCN(CC2)C(=O)c2cc3ccc(Oc4cnc(cn4)-c4nc(no4)-c4ccc(cc4)C(F)(F)F)cc3n2C)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	64	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c01554 BindingDB Entry DOI: 10.7270/Q2RB78J1
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50569071 (CHEMBL4846365) Show SMILES CCCC(C)Oc1ccc(C(=O)Nc2ccc3nc(SCC(=O)N[C@@H](C)c4ccc(OC)cc4)sc3c2)c(OC)c1C |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	67	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of IL-6 induced STAT3 transcriptional activity in human HepG2 cells incubated for 1 hr followed by stimulation with IL-6 for 5.5 hrs by lu...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113333 BindingDB Entry DOI: 10.7270/Q2MP571B
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50300648 (4-(3-((S)-1-((cis)-2-((S)-5-amino-1-(benzylamino)-...) Show SMILES CC(C)C[C@H](NC(=O)\C=C\c1ccc(OP(O)(O)=O)cc1)C(=O)N1C[C@H]2C[C@H]2[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)NCc1ccccc1 |r| Show InChI InChI=1S/C33H42N5O9P/c1-20(2)16-27(36-29(40)15-10-21-8-11-24(12-9-21)47-48(44,45)46)33(43)38-19-23-17-25(23)30(38)32(42)37-26(13-14-28(34)39)31(41)35-18-22-6-4-3-5-7-22/h3-12,15,20,23,25-27,30H,13-14,16-19H2,1-2H3,(H2,34,39)(H,35,41)(H,36,40)(H,37,42)(H2,44,45,46)/b15-10+/t23-,25-,26+,27+,30+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	68	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas M. D. Anderson Cancer Center Curated by ChEMBL					Assay Description Inhibition of Stat3 SH2 domain by fluorescence polarization assay				J Med Chem 52: 6126-41 (2009) Article DOI: 10.1021/jm901105k BindingDB Entry DOI: 10.7270/Q2M045HH
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50300658 (4-((E)-3-((S)-1-((1R,2S,5S)-2-(2-(benzyloxy)ethylc...) Show SMILES CC(C)C[C@H](NC(=O)\C=C\c1ccc(OP(O)(O)=O)cc1)C(=O)N1C[C@H]2C[C@H]2[C@H]1C(=O)NCCOCc1ccccc1 |r| Show InChI InChI=1S/C30H38N3O8P/c1-20(2)16-26(32-27(34)13-10-21-8-11-24(12-9-21)41-42(37,38)39)30(36)33-18-23-17-25(23)28(33)29(35)31-14-15-40-19-22-6-4-3-5-7-22/h3-13,20,23,25-26,28H,14-19H2,1-2H3,(H,31,35)(H,32,34)(H2,37,38,39)/b13-10+/t23-,25-,26+,28+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	69	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas M. D. Anderson Cancer Center Curated by ChEMBL					Assay Description Inhibition of Stat3 SH2 domain by fluorescence polarization assay				J Med Chem 52: 6126-41 (2009) Article DOI: 10.1021/jm901105k BindingDB Entry DOI: 10.7270/Q2M045HH
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50300657 (4-(3-((S)-1-((cis)-2-((2R,3S)-6-amino-2-(benzyloxy...) Show SMILES CC(C)C[C@H](NC(=O)\C=C\c1ccc(OP(O)(O)=O)cc1)C(=O)N1C[C@H]2C[C@H]2[C@H]1C(=O)N[C@@H](CCC(N)=O)[C@@H](C)OCc1ccccc1 |r| Show InChI InChI=1S/C34H45N4O9P/c1-21(2)17-29(36-31(40)16-11-23-9-12-26(13-10-23)47-48(43,44)45)34(42)38-19-25-18-27(25)32(38)33(41)37-28(14-15-30(35)39)22(3)46-20-24-7-5-4-6-8-24/h4-13,16,21-22,25,27-29,32H,14-15,17-20H2,1-3H3,(H2,35,39)(H,36,40)(H,37,41)(H2,43,44,45)/b16-11+/t22-,25-,27-,28+,29+,32+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	69	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas M. D. Anderson Cancer Center Curated by ChEMBL					Assay Description Inhibition of Stat3 SH2 domain by fluorescence polarization assay				J Med Chem 52: 6126-41 (2009) Article DOI: 10.1021/jm901105k BindingDB Entry DOI: 10.7270/Q2M045HH
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50588501 (CHEMBL5193538) Show SMILES Cn1c(cc2ccc(Oc3cnc(cn3)-c3nc(no3)-c3ccc(cc3)C(F)(F)F)cc12)C(=O)N1CCN(Cc2ccc(cc2)C(F)(F)F)CC1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	72	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c01554 BindingDB Entry DOI: 10.7270/Q2RB78J1
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50588506 (CHEMBL5201590) Show SMILES Cn1c(cc2ccc(Oc3cnc(cn3)-c3nc(no3)-c3ccc(cc3)C(F)(F)F)cc12)C(=O)N1CCN(Cc2ccc(OC(F)(F)F)cc2)CC1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	76	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c01554 BindingDB Entry DOI: 10.7270/Q2RB78J1
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50590920 (CHEMBL5171708) Show SMILES FC(F)(F)COc1ccc(CN2CCN(CC2)C(=O)c2ccc(cn2)-c2nc(no2)-c2ccc(cc2)C(F)(F)F)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	76	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00413 BindingDB Entry DOI: 10.7270/Q2RF6006
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 3 [702-738,740-752] (Homo sapiens (Human))	BDBM43604 (MLS000522376 | N-(4-chloranyl-2,5-dimethoxy-phenyl...) Show SMILES COc1cc(NC(=O)c2cc(on2)C2CC2)c(OC)cc1Cl Show InChI InChI=1S/C15H15ClN2O4/c1-20-13-6-10(14(21-2)5-9(13)16)17-15(19)11-7-12(22-18-11)8-3-4-8/h5-8H,3-4H2,1-2H3,(H,17,19)	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	>76	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay					Assay Description Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2S46QBK
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 3 [702-738,740-752] (Homo sapiens (Human))	BDBM43595 (MLS000104263 | N-(1-acetyl-2-chloro-3-indolyl)acet...) Show SMILES CC(=O)Nc1c(Cl)n(C(C)=O)c2ccccc12 Show InChI InChI=1S/C12H11ClN2O2/c1-7(16)14-11-9-5-3-4-6-10(9)15(8(2)17)12(11)13/h3-6H,1-2H3,(H,14,16)	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	PCBioAssay	n/a	n/a	>76	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay					Assay Description Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2S46QBK
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50335201 (5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...) Show SMILES C[C@H](Nc1ncc(Cl)c(Nc2cc(C)n[nH]2)n1)c1ncc(F)cn1 |r| Show InChI InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Inhibition of Stat3 phosphorylation in human HEL cells after 1 hr by Western blotting				J Med Chem 54: 262-76 (2011) Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50545650 (Delgocitinib | JTE-052 | JTE-052A | LEO 124249 | L...) Show SMILES C[C@H]1CN(C(=O)CC#N)[C@]11CCN(C1)c1ncnc2[nH]ccc12 |r| Show InChI InChI=1S/C16H18N6O/c1-11-8-22(13(23)2-5-17)16(11)4-7-21(9-16)15-12-3-6-18-14(12)19-10-20-15/h3,6,10-11H,2,4,7-9H2,1H3,(H,18,19,20)/t11-,16-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem		n/a	n/a	84	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50590889 (CHEMBL5177332) Show SMILES CC(C)(C)c1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)-c2nc(no2)-c2ccc(cc2)C(F)(F)F)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	88	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00413 BindingDB Entry DOI: 10.7270/Q2RF6006
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50590909 (CHEMBL5189774) Show SMILES FC(F)(F)COc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)-c2nc(no2)-c2ccc(Br)cc2)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	93	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00413 BindingDB Entry DOI: 10.7270/Q2RF6006
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50590916 (CHEMBL5183263) Show SMILES FC(F)(F)COc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)-c2nc(co2)-c2ccc(cc2)C(F)(F)F)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	94	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00413 BindingDB Entry DOI: 10.7270/Q2RF6006
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50300656 (4-(3-((S)-1-((cis)-2-((S)-5-amino-1-(benzyloxy)-5-...) Show SMILES CC(C)C[C@H](NC(=O)\C=C\c1ccc(OP(O)(O)=O)cc1)C(=O)N1C[C@H]2C[C@H]2[C@H]1C(=O)N[C@@H](CCC(N)=O)COCc1ccccc1 |r| Show InChI InChI=1S/C33H43N4O9P/c1-21(2)16-28(36-30(39)15-10-22-8-12-26(13-9-22)46-47(42,43)44)33(41)37-18-24-17-27(24)31(37)32(40)35-25(11-14-29(34)38)20-45-19-23-6-4-3-5-7-23/h3-10,12-13,15,21,24-25,27-28,31H,11,14,16-20H2,1-2H3,(H2,34,38)(H,35,40)(H,36,39)(H2,42,43,44)/b15-10+/t24-,25+,27-,28+,31+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	94	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas M. D. Anderson Cancer Center Curated by ChEMBL					Assay Description Inhibition of Stat3 SH2 domain by fluorescence polarization assay				J Med Chem 52: 6126-41 (2009) Article DOI: 10.1021/jm901105k BindingDB Entry DOI: 10.7270/Q2M045HH
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM420304 (LLL-12) Show SMILES NS(=O)(=O)c1cccc2C(=O)c3c(O)cccc3C(=O)c12 Show InChI InChI=1S/C14H9NO5S/c15-21(19,20)10-6-2-4-8-12(10)14(18)7-3-1-5-9(16)11(7)13(8)17/h1-6,16H,(H2,15,19,20)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE UniChem	Article PubMed	n/a	n/a	98	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of IL-6 induced STAT3 transcriptional activity in human HepG2 cells incubated for 1 hr followed by stimulation with IL-6 for 5.5 hrs by lu...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113333 BindingDB Entry DOI: 10.7270/Q2MP571B
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50588512 (CHEMBL5201252) Show SMILES Cn1c(cc2ccc(Oc3cnc(cn3)-c3nc(no3)-c3ccc(cc3)C(F)(F)F)cc12)C(=O)N1CCN(Cc2ccc(OCC(F)(F)F)c(F)c2)CC1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	101	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c01554 BindingDB Entry DOI: 10.7270/Q2RB78J1
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50213228 (2-(4-((S)-3-((S)-1-((S)-2-(((S)-5-amino-1-((2S,3R)...) Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OC(C(O)=O)C(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(O)=O Show InChI InChI=1S/C39H57N7O15/c1-18(2)16-26(43-33(51)25(41-21(6)48)17-22-9-11-23(12-10-22)61-31(38(57)58)39(59)60)36(54)46-15-7-8-27(46)34(52)42-24(13-14-28(40)49)32(50)45-30(20(5)47)35(53)44-29(19(3)4)37(55)56/h9-12,18-20,24-27,29-31,47H,7-8,13-17H2,1-6H3,(H2,40,49)(H,41,48)(H,42,52)(H,43,51)(H,44,53)(H,45,50)(H,55,56)(H,57,58)(H,59,60)/t20-,24+,25+,26+,27+,29+,30+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	108	n/a	n/a	n/a	n/a	n/a	n/a
Université Paris Descartes Curated by ChEMBL					Assay Description Inhibition of STAT3 dimer DNA binding activity by ELISA after 30 mins				Bioorg Med Chem Lett 17: 3943-6 (2007) Article DOI: 10.1016/j.bmcl.2007.04.107 BindingDB Entry DOI: 10.7270/Q2736QMV
					More data for this Ligand-Target Pair

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