Compile Data Set for Download or QSAR

Found 31 hits of ic50 for UniProtKB: P51531   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] (Homo sapiens (Human))	BDBM394585 (2-(6-amino-5-(1-(1- | US10308614, Example 188) Show SMILES CC(c1ccccc1)n1cc(cn1)-c1cc(nnc1N)-c1ccccc1O Show InChI InChI=1S/C21H19N5O/c1-14(15-7-3-2-4-8-15)26-13-16(12-23-26)18-11-19(24-25-21(18)22)17-9-5-6-10-20(17)27/h2-14,27H,1H3,(H2,22,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.70	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research					Assay Description Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...				J Med Chem 52: 2255-64 (2009) BindingDB Entry DOI: 10.7270/Q26112NJ
					More data for this Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] (Homo sapiens (Human))	BDBM394575 (2-(6-amino-5-(2- | US10308614, Example 178) Show SMILES CC(COc1cc(nnc1N)-c1ccccc1O)c1ccccc1 Show InChI InChI=1S/C19H19N3O2/c1-13(14-7-3-2-4-8-14)12-24-18-11-16(21-22-19(18)20)15-9-5-6-10-17(15)23/h2-11,13,23H,12H2,1H3,(H2,20,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.20	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research					Assay Description Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...				J Med Chem 52: 2255-64 (2009) BindingDB Entry DOI: 10.7270/Q26112NJ
					More data for this Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] (Homo sapiens (Human))	BDBM394605 (2-(6-amino-5-cyclohexylpyridazin-3-yl)phenol | US1...) Show SMILES Nc1nnc(cc1C1CCCCC1)-c1ccccc1O Show InChI InChI=1S/C16H19N3O/c17-16-13(11-6-2-1-3-7-11)10-14(18-19-16)12-8-4-5-9-15(12)20/h4-5,8-11,20H,1-3,6-7H2,(H2,17,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.80	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research					Assay Description Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...				J Med Chem 52: 2255-64 (2009) BindingDB Entry DOI: 10.7270/Q26112NJ
					More data for this Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] (Homo sapiens (Human))	BDBM394584 (2-(6-amino-5-(1-methyl- | US10308614, Example 187) Show SMILES Cn1cc(cn1)-c1cc(nnc1N)-c1ccccc1O Show InChI InChI=1S/C14H13N5O/c1-19-8-9(7-16-19)11-6-12(17-18-14(11)15)10-4-2-3-5-13(10)20/h2-8,20H,1H3,(H2,15,18)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research					Assay Description Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...				J Med Chem 52: 2255-64 (2009) BindingDB Entry DOI: 10.7270/Q26112NJ
					More data for this Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] (Homo sapiens (Human))	BDBM394567 ((S)-2-(6-amino-5-(1- | US10308614, Example 170) Show SMILES C[C@H](Oc1cc(nnc1N)-c1ccccc1O)c1ccccc1 |r| Show InChI InChI=1S/C18H17N3O2/c1-12(13-7-3-2-4-8-13)23-17-11-15(20-21-18(17)19)14-9-5-6-10-16(14)22/h2-12,22H,1H3,(H2,19,21)/t12-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14.9	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research					Assay Description Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...				J Med Chem 52: 2255-64 (2009) BindingDB Entry DOI: 10.7270/Q26112NJ
					More data for this Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] (Homo sapiens (Human))	BDBM394528 (1-(4-(3-amino-6-(2- | US10308614, Example 129) Show SMILES CC1CN(CCN1C(=O)C(C)(C)C)c1cc(nnc1N)-c1ccccc1O Show InChI InChI=1S/C20H27N5O2/c1-13-12-24(9-10-25(13)19(27)20(2,3)4)16-11-15(22-23-18(16)21)14-7-5-6-8-17(14)26/h5-8,11,13,26H,9-10,12H2,1-4H3,(H2,21,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	18.4	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research					Assay Description Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...				J Med Chem 52: 2255-64 (2009) BindingDB Entry DOI: 10.7270/Q26112NJ
					More data for this Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] (Homo sapiens (Human))	BDBM394571 (2-(6-amino-5- | US10308614, Example 174) Show SMILES Nc1nnc(cc1OCCc1ccccc1)-c1ccccc1O Show InChI InChI=1S/C18H17N3O2/c19-18-17(23-11-10-13-6-2-1-3-7-13)12-15(20-21-18)14-8-4-5-9-16(14)22/h1-9,12,22H,10-11H2,(H2,19,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research					Assay Description Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...				J Med Chem 52: 2255-64 (2009) BindingDB Entry DOI: 10.7270/Q26112NJ
					More data for this Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] (Homo sapiens (Human))	BDBM394403 (2-(6-amino-5-(4-((dimethylami- | US10308614, Examp...) Show SMILES CN(C)CC1CCN(CC1)c1cc(nnc1N)-c1ccccc1O Show InChI InChI=1S/C18H25N5O/c1-22(2)12-13-7-9-23(10-8-13)16-11-15(20-21-18(16)19)14-5-3-4-6-17(14)24/h3-6,11,13,24H,7-10,12H2,1-2H3,(H2,19,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	22.5	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research					Assay Description Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...				J Med Chem 52: 2255-64 (2009) BindingDB Entry DOI: 10.7270/Q26112NJ
					More data for this Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] (Homo sapiens (Human))	BDBM394606 (2-(6-amino-5- | US10308614, Example 210) Show SMILES Nc1nnc(cc1C1CCCC1)-c1ccccc1O Show InChI InChI=1S/C15H17N3O/c16-15-12(10-5-1-2-6-10)9-13(17-18-15)11-7-3-4-8-14(11)19/h3-4,7-10,19H,1-2,5-6H2,(H2,16,18)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research					Assay Description Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...				J Med Chem 52: 2255-64 (2009) BindingDB Entry DOI: 10.7270/Q26112NJ
					More data for this Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] (Homo sapiens (Human))	BDBM394456 (2-(6-amino-5-(3- | US10308614, Example 57) Show SMILES Nc1nnc(cc1N1CC(C1)Oc1ccccc1)-c1ccccc1O Show InChI InChI=1S/C19H18N4O2/c20-19-17(10-16(21-22-19)15-8-4-5-9-18(15)24)23-11-14(12-23)25-13-6-2-1-3-7-13/h1-10,14,24H,11-12H2,(H2,20,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	35.6	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research					Assay Description Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...				J Med Chem 52: 2255-64 (2009) BindingDB Entry DOI: 10.7270/Q26112NJ
					More data for this Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] (Homo sapiens (Human))	BDBM394507 (2-(6-amino-5-(3-methyl-4-(methylsulfonyl)piperazin...) Show SMILES CC1CN(CCN1S(C)(=O)=O)c1cc(nnc1N)-c1ccccc1O Show InChI InChI=1S/C16H21N5O3S/c1-11-10-20(7-8-21(11)25(2,23)24)14-9-13(18-19-16(14)17)12-5-3-4-6-15(12)22/h3-6,9,11,22H,7-8,10H2,1-2H3,(H2,17,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	35.8	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research					Assay Description Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...				J Med Chem 52: 2255-64 (2009) BindingDB Entry DOI: 10.7270/Q26112NJ
					More data for this Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] (Homo sapiens (Human))	BDBM394414 (2-(6-amino-5-(4-(1- | US10308614, Example 15) Show SMILES CC(N1CCN(CC1)c1cc(nnc1N)-c1ccccc1O)c1ccccc1 Show InChI InChI=1S/C22H25N5O/c1-16(17-7-3-2-4-8-17)26-11-13-27(14-12-26)20-15-19(24-25-22(20)23)18-9-5-6-10-21(18)28/h2-10,15-16,28H,11-14H2,1H3,(H2,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	36.1	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research					Assay Description Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...				J Med Chem 52: 2255-64 (2009) BindingDB Entry DOI: 10.7270/Q26112NJ
					More data for this Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] (Homo sapiens (Human))	BDBM394583 (2-(6-amino-5-phenylpyridazin-3-yl)phenol | US10308...) Show SMILES Nc1nnc(cc1-c1ccccc1)-c1ccccc1O Show InChI InChI=1S/C16H13N3O/c17-16-13(11-6-2-1-3-7-11)10-14(18-19-16)12-8-4-5-9-15(12)20/h1-10,20H,(H2,17,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	37.3	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research					Assay Description Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...				J Med Chem 52: 2255-64 (2009) BindingDB Entry DOI: 10.7270/Q26112NJ
					More data for this Ligand-Target Pair				3D Structure (crystal)
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] (Homo sapiens (Human))	BDBM394521 (1-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-2...) Show SMILES CC1CN(CCN1C(C)=O)c1cc(nnc1N)-c1ccccc1O Show InChI InChI=1S/C17H21N5O2/c1-11-10-21(7-8-22(11)12(2)23)15-9-14(19-20-17(15)18)13-5-3-4-6-16(13)24/h3-6,9,11,24H,7-8,10H2,1-2H3,(H2,18,20)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research					Assay Description Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...				J Med Chem 52: 2255-64 (2009) BindingDB Entry DOI: 10.7270/Q26112NJ
					More data for this Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] (Homo sapiens (Human))	BDBM394614 (2-(6-amino-5-(1-benzylpiperidin-4-yl)pyridazin-3-y...) Show SMILES Nc1nnc(cc1C1CCN(Cc2ccccc2)CC1)-c1ccccc1O Show InChI InChI=1S/C22H24N4O/c23-22-19(14-20(24-25-22)18-8-4-5-9-21(18)27)17-10-12-26(13-11-17)15-16-6-2-1-3-7-16/h1-9,14,17,27H,10-13,15H2,(H2,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	39.3	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research					Assay Description Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...				J Med Chem 52: 2255-64 (2009) BindingDB Entry DOI: 10.7270/Q26112NJ
					More data for this Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] (Homo sapiens (Human))	BDBM394490 (2-(6-amino-5-(piperidin-1-yl)pyridazin-3-yl)phenol...) Show SMILES Nc1nnc(cc1N1CCCCC1)-c1ccccc1O Show InChI InChI=1S/C15H18N4O/c16-15-13(19-8-4-1-5-9-19)10-12(17-18-15)11-6-2-3-7-14(11)20/h2-3,6-7,10,20H,1,4-5,8-9H2,(H2,16,18)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	45.9	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research					Assay Description Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...				J Med Chem 52: 2255-64 (2009) BindingDB Entry DOI: 10.7270/Q26112NJ
					More data for this Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] (Homo sapiens (Human))	BDBM394518 (2-(6-amino-5-(3-benzyl- | US10308614, Example 119) Show SMILES CS(=O)(=O)N1CCN(CC1Cc1ccccc1)c1cc(nnc1N)-c1ccccc1O Show InChI InChI=1S/C22H25N5O3S/c1-31(29,30)27-12-11-26(15-17(27)13-16-7-3-2-4-8-16)20-14-19(24-25-22(20)23)18-9-5-6-10-21(18)28/h2-10,14,17,28H,11-13,15H2,1H3,(H2,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	46.8	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research					Assay Description Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...				J Med Chem 52: 2255-64 (2009) BindingDB Entry DOI: 10.7270/Q26112NJ
					More data for this Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] (Homo sapiens (Human))	BDBM394408 (2-(6-amino-5-((3aR,6aS)-5- | US10308614, Example 9) Show SMILES Nc1nnc(cc1N1C[C@@H]2CN(Cc3ccccc3)C[C@@H]2C1)-c1ccccc1O |r| Show InChI InChI=1S/C23H25N5O/c24-23-21(10-20(25-26-23)19-8-4-5-9-22(19)29)28-14-17-12-27(13-18(17)15-28)11-16-6-2-1-3-7-16/h1-10,17-18,29H,11-15H2,(H2,24,26)/t17-,18+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	47.6	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research					Assay Description Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...				J Med Chem 52: 2255-64 (2009) BindingDB Entry DOI: 10.7270/Q26112NJ
					More data for this Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] (Homo sapiens (Human))	BDBM394586 (2-(6-amino-5-(4- | US10308614, Example 189) Show SMILES CN(C)Cc1ccc(cc1)-c1cc(nnc1N)-c1ccccc1O Show InChI InChI=1S/C19H20N4O/c1-23(2)12-13-7-9-14(10-8-13)16-11-17(21-22-19(16)20)15-5-3-4-6-18(15)24/h3-11,24H,12H2,1-2H3,(H2,20,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	49.3	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research					Assay Description Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...				J Med Chem 52: 2255-64 (2009) BindingDB Entry DOI: 10.7270/Q26112NJ
					More data for this Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] (Homo sapiens (Human))	BDBM394577 (2-(6-amino-5-((1- | US10308614, Example 180) Show SMILES Nc1nnc(cc1OC1CCN(Cc2ccccc2)C1)-c1ccccc1O Show InChI InChI=1S/C21H22N4O2/c22-21-20(12-18(23-24-21)17-8-4-5-9-19(17)26)27-16-10-11-25(14-16)13-15-6-2-1-3-7-15/h1-9,12,16,26H,10-11,13-14H2,(H2,22,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	59.7	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research					Assay Description Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...				J Med Chem 52: 2255-64 (2009) BindingDB Entry DOI: 10.7270/Q26112NJ
					More data for this Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] (Homo sapiens (Human))	BDBM394401 (2-(6-amino-5-(4-(pyridin- | US10308614, Example 3) Show SMILES Nc1nnc(cc1N1CCN(Cc2cccnc2)CC1)-c1ccccc1O Show InChI InChI=1S/C20H22N6O/c21-20-18(12-17(23-24-20)16-5-1-2-6-19(16)27)26-10-8-25(9-11-26)14-15-4-3-7-22-13-15/h1-7,12-13,27H,8-11,14H2,(H2,21,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	60.7	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research					Assay Description Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...				J Med Chem 52: 2255-64 (2009) BindingDB Entry DOI: 10.7270/Q26112NJ
					More data for this Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] (Homo sapiens (Human))	BDBM394432 (2-(6-amino-5-(2,6- | US10308614, Example 33) Show SMILES CC1CN(CC(C)O1)c1cc(nnc1N)-c1ccccc1O Show InChI InChI=1S/C16H20N4O2/c1-10-8-20(9-11(2)22-10)14-7-13(18-19-16(14)17)12-5-3-4-6-15(12)21/h3-7,10-11,21H,8-9H2,1-2H3,(H2,17,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	69.6	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research					Assay Description Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...				J Med Chem 52: 2255-64 (2009) BindingDB Entry DOI: 10.7270/Q26112NJ
					More data for this Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] (Homo sapiens (Human))	BDBM394444 (2-(6-amino-5- | US10308614, Example 45) Show SMILES Nc1nnc(cc1N1CCOCC1)-c1ccccc1O Show InChI InChI=1S/C14H16N4O2/c15-14-12(18-5-7-20-8-6-18)9-11(16-17-14)10-3-1-2-4-13(10)19/h1-4,9,19H,5-8H2,(H2,15,17)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	71.5	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research					Assay Description Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...				J Med Chem 52: 2255-64 (2009) BindingDB Entry DOI: 10.7270/Q26112NJ
					More data for this Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] (Homo sapiens (Human))	BDBM394402 (1-(4-(3-amino-6-(2- | US10308614, Example 4) Show SMILES CC(=O)N1CCN(CC1)c1cc(nnc1N)-c1ccccc1O Show InChI InChI=1S/C16H19N5O2/c1-11(22)20-6-8-21(9-7-20)14-10-13(18-19-16(14)17)12-4-2-3-5-15(12)23/h2-5,10,23H,6-9H2,1H3,(H2,17,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	71.7	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research					Assay Description Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...				J Med Chem 52: 2255-64 (2009) BindingDB Entry DOI: 10.7270/Q26112NJ
					More data for this Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] (Homo sapiens (Human))	BDBM394415 (2-(6-amino-5-(8-benzyl-3,8- | US10308614, Example ...) Show SMILES Nc1nnc(cc1N1CC2CCC(C1)N2Cc1ccccc1)-c1ccccc1O Show InChI InChI=1S/C23H25N5O/c24-23-21(12-20(25-26-23)19-8-4-5-9-22(19)29)27-14-17-10-11-18(15-27)28(17)13-16-6-2-1-3-7-16/h1-9,12,17-18,29H,10-11,13-15H2,(H2,24,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	79	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research					Assay Description Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...				J Med Chem 52: 2255-64 (2009) BindingDB Entry DOI: 10.7270/Q26112NJ
					More data for this Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] (Homo sapiens (Human))	BDBM394574 (2-(6-amino-5-((1- | US10308614, Example 177) Show SMILES CC(Cc1ccccc1)Oc1cc(nnc1N)-c1ccccc1O Show InChI InChI=1S/C19H19N3O2/c1-13(11-14-7-3-2-4-8-14)24-18-12-16(21-22-19(18)20)15-9-5-6-10-17(15)23/h2-10,12-13,23H,11H2,1H3,(H2,20,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	92.5	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research					Assay Description Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...				J Med Chem 52: 2255-64 (2009) BindingDB Entry DOI: 10.7270/Q26112NJ
					More data for this Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] (Homo sapiens (Human))	BDBM394565 (2-(6-amino-5-(1- | US10308614, Example 168) Show SMILES CC(Oc1cc(nnc1N)-c1ccccc1O)C1CCOCC1 Show InChI InChI=1S/C17H21N3O3/c1-11(12-6-8-22-9-7-12)23-16-10-14(19-20-17(16)18)13-4-2-3-5-15(13)21/h2-5,10-12,21H,6-9H2,1H3,(H2,18,20)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	197	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research					Assay Description Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...				J Med Chem 52: 2255-64 (2009) BindingDB Entry DOI: 10.7270/Q26112NJ
					More data for this Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] (Homo sapiens (Human))	BDBM394570 (2-(6-amino-5-(2- | US10308614, Example 173) Show SMILES CN(C)CCOc1cc(nnc1N)-c1ccccc1O Show InChI InChI=1S/C14H18N4O2/c1-18(2)7-8-20-13-9-11(16-17-14(13)15)10-5-3-4-6-12(10)19/h3-6,9,19H,7-8H2,1-2H3,(H2,15,17)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	276	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research					Assay Description Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...				J Med Chem 52: 2255-64 (2009) BindingDB Entry DOI: 10.7270/Q26112NJ
					More data for this Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] (Homo sapiens (Human))	BDBM394602 (2-(6-amino-5-phenylpyridazin-3-yl)-6-fluorophenol ...) Show SMILES Nc1nnc(cc1-c1ccccc1)-c1cccc(F)c1O Show InChI InChI=1S/C16H12FN3O/c17-13-8-4-7-11(15(13)21)14-9-12(16(18)20-19-14)10-5-2-1-3-6-10/h1-9,21H,(H2,18,20)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research					Assay Description Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...				J Med Chem 52: 2255-64 (2009) BindingDB Entry DOI: 10.7270/Q26112NJ
					More data for this Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] (Homo sapiens (Human))	BDBM394613 (2-(6-amino-5-(1-(phenylsulfonyl)pyrrolidin-3-yl)py...) Show SMILES Nc1nnc(cc1C1CCN(C1)S(=O)(=O)c1ccccc1)-c1ccccc1O Show InChI InChI=1S/C20H20N4O3S/c21-20-17(12-18(22-23-20)16-8-4-5-9-19(16)25)14-10-11-24(13-14)28(26,27)15-6-2-1-3-7-15/h1-9,12,14,25H,10-11,13H2,(H2,21,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	466	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research					Assay Description Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...				J Med Chem 52: 2255-64 (2009) BindingDB Entry DOI: 10.7270/Q26112NJ
					More data for this Ligand-Target Pair
Isoform Short of Probable global transcription activator SNF2L2 (Short) 377-1486] (Homo sapiens (Human))	BDBM394600 (2-(6-(methylamino)pyridazin-3-yl)phenol | US103086...) Show SMILES CNc1ccc(nn1)-c1ccccc1O Show InChI InChI=1S/C11H11N3O/c1-12-11-7-6-9(13-14-11)8-4-2-3-5-10(8)15/h2-7,15H,1H3,(H,12,14)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.04E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research					Assay Description Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...				J Med Chem 52: 2255-64 (2009) BindingDB Entry DOI: 10.7270/Q26112NJ
					More data for this Ligand-Target Pair