Compile Data Set for Download or QSAR

Found 218 hits of kd for UniProtKB: P29597   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399558 (US10323036, Compound I-1 | US10323036, Compound I-...) Show SMILES COc1c(Nc2cc(NC(=O)C3CC3)nc3[nH]n(C)c(=O)c23)cccc1-c1nnn(C)n1 Show InChI InChI=1S/C20H21N9O3/c1-28-20(31)15-13(9-14(22-18(15)25-28)23-19(30)10-7-8-10)21-12-6-4-5-11(16(12)32-3)17-24-27-29(2)26-17/h4-6,9-10H,7-8H2,1-3H3,(H3,21,22,23,25,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399773 (US10323036, Compound XVI-4 | US10793574, Compound ...) Show SMILES CCc1nn(-c2cccc(-c3nnn(C)n3)c2OC)c2cc(NC(=O)C3CC3)ncc12 Show InChI InChI=1S/C21H22N8O2/c1-4-15-14-11-22-18(23-21(30)12-8-9-12)10-17(14)29(25-15)16-7-5-6-13(19(16)31-3)20-24-27-28(2)26-20/h5-7,10-12H,4,8-9H2,1-3H3,(H,22,23,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399566 (US10323036, Compound I-9 | US10793574, Compound I-...) Show SMILES COc1c(Nc2cc(Nc3cc(C)nc(C)n3)nc3[nH]n(C)c(=O)c23)cccc1-c1nnn(C)n1 Show InChI InChI=1S/C22H23N11O2/c1-11-9-16(24-12(2)23-11)26-17-10-15(18-21(27-17)29-32(3)22(18)34)25-14-8-6-7-13(19(14)35-5)20-28-31-33(4)30-20/h6-10H,1-5H3,(H3,23,24,25,26,27,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399567 (US10323036, Compound I-10 | US10793574, Compound I...) Show SMILES COc1c(Nc2cc(Nc3ccc(C)nn3)nc3[nH]n(C)c(=O)c23)cccc1-c1nnn(C)n1 Show InChI InChI=1S/C21H21N11O2/c1-11-8-9-15(26-25-11)23-16-10-14(17-20(24-16)28-31(2)21(17)33)22-13-7-5-6-12(18(13)34-4)19-27-30-32(3)29-19/h5-10H,1-4H3,(H3,22,23,24,26,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399569 (US10323036, Compound I-12 | US10793574, Compound I...) Show SMILES COc1c(Nc2cc(Nc3ccc(cn3)C#N)nc3[nH]n(C)c(=O)c23)cccc1-c1nnn(C)n1 Show InChI InChI=1S/C22H19N11O2/c1-32-22(34)18-15(9-17(27-21(18)29-32)26-16-8-7-12(10-23)11-24-16)25-14-6-4-5-13(19(14)35-3)20-28-31-33(2)30-20/h4-9,11H,1-3H3,(H3,24,25,26,27,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399570 (US10323036, Compound I-13 | US10793574, Compound I...) Show SMILES COc1c(Nc2cc(Nc3ccn(C)n3)nc3[nH]n(C)c(=O)c23)cccc1-c1nnn(C)n1 Show InChI InChI=1S/C20H21N11O2/c1-29-9-8-14(25-29)22-15-10-13(16-19(23-15)26-30(2)20(16)32)21-12-7-5-6-11(17(12)33-4)18-24-28-31(3)27-18/h5-10H,1-4H3,(H3,21,22,23,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399574 (US10323036, Compound I-17 | US10793574, Compound I...) Show SMILES COc1c(Nc2cc(Nc3ccccn3)nc3[nH]n(C)c(=O)c23)cccc1-c1ncn(C)n1 Show InChI InChI=1S/C22H21N9O2/c1-30-12-24-20(28-30)13-7-6-8-14(19(13)33-3)25-15-11-17(26-16-9-4-5-10-23-16)27-21-18(15)22(32)31(2)29-21/h4-12H,1-3H3,(H3,23,25,26,27,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399587 (US10323036, Compound I-31 | US10793574, Compound I...) Show SMILES COc1c(Nc2cc(Nc3cc(ncn3)C#N)nc3[nH]n(C)c(=O)c23)cccc1-c1ncn(C)n1 Show InChI InChI=1S/C22H19N11O2/c1-32-11-26-20(30-32)13-5-4-6-14(19(13)35-3)27-15-8-17(28-16-7-12(9-23)24-10-25-16)29-21-18(15)22(34)33(2)31-21/h4-8,10-11H,1-3H3,(H3,24,25,27,28,29,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399613 (US10323036, Compound I-57 | US10793574, Compound I...) Show SMILES COc1c(Nc2cc(NC(=O)C3CC3)nc3[nH]n(C)c(=O)c23)cccc1-c1ccn(C)n1 Show InChI InChI=1S/C22H23N7O3/c1-28-10-9-14(26-28)13-5-4-6-15(19(13)32-3)23-16-11-17(25-21(30)12-7-8-12)24-20-18(16)22(31)29(2)27-20/h4-6,9-12H,7-8H2,1-3H3,(H3,23,24,25,27,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399618 (US10323036, Compound I-62 | US10793574, Compound I...) Show SMILES COc1c(Nc2cc(NC(=O)C3CC3)nc3[nH]n(C)c(=O)c23)cccc1-c1n[nH]c(C)n1 Show InChI InChI=1S/C21H22N8O3/c1-10-22-18(27-26-10)12-5-4-6-13(17(12)32-3)23-14-9-15(25-20(30)11-7-8-11)24-19-16(14)21(31)29(2)28-19/h4-6,9,11H,7-8H2,1-3H3,(H,22,26,27)(H3,23,24,25,28,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399620 (US10323036, Compound I-64 | US10793574, Compound I...) Show SMILES COc1c(Nc2cc(Nc3cncc(n3)C#N)nc3[nH]n(C)c(=O)c23)cccc1-c1nnn(C)n1 Show InChI InChI=1S/C21H18N12O2/c1-32-21(34)17-14(7-15(27-20(17)29-32)26-16-10-23-9-11(8-22)24-16)25-13-6-4-5-12(18(13)35-3)19-28-31-33(2)30-19/h4-7,9-10H,1-3H3,(H3,24,25,26,27,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399558 (US10323036, Compound I-1 | US10323036, Compound I-...) Show SMILES COc1c(Nc2cc(NC(=O)C3CC3)nc3[nH]n(C)c(=O)c23)cccc1-c1nnn(C)n1 Show InChI InChI=1S/C20H21N9O3/c1-28-20(31)15-13(9-14(22-18(15)25-28)23-19(30)10-7-8-10)21-12-6-4-5-11(16(12)32-3)17-24-27-29(2)26-17/h4-6,9-10H,7-8H2,1-3H3,(H3,21,22,23,25,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399668 (US10323036, Compound I-112 | US10793574, Compound ...) Show SMILES Cn1[nH]c2nc(Nc3cccc(n3)C#N)cc(Nc3ccccc3S(C)(=O)=O)c2c1=O Show InChI InChI=1S/C20H17N7O3S/c1-27-20(28)18-14(23-13-7-3-4-8-15(13)31(2,29)30)10-17(25-19(18)26-27)24-16-9-5-6-12(11-21)22-16/h3-10H,1-2H3,(H3,22,23,24,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399717 (US10323036, Compound I-201 | US10793574, Compound ...) Show SMILES Cn1[nH]c2nc(NC(=O)C3CC3)cc(Nc3ccc(cc3S(C)(=O)=O)C3CC3)c2c1=O Show InChI InChI=1S/C21H23N5O4S/c1-26-21(28)18-15(10-17(23-19(18)25-26)24-20(27)12-5-6-12)22-14-8-7-13(11-3-4-11)9-16(14)31(2,29)30/h7-12H,3-6H2,1-2H3,(H3,22,23,24,25,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399730 (US10323036, Compound I-217 | US10793574, Compound ...) Show SMILES CCc1ccc(Nc2cc(NC(=O)C3CC3)nc3[nH]n(C)c(=O)c23)c(c1)N(C)S(C)(=O)=O Show InChI InChI=1S/C21H26N6O4S/c1-5-12-6-9-14(16(10-12)27(3)32(4,30)31)22-15-11-17(24-20(28)13-7-8-13)23-19-18(15)21(29)26(2)25-19/h6,9-11,13H,5,7-8H2,1-4H3,(H3,22,23,24,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399731 (US10323036, Compound I-218 | US10793574, Compound ...) Show SMILES COCc1ccc(Nc2cc(NC(=O)C3CC3)nc3[nH]n(C)c(=O)c23)c(c1)N(C)S(C)(=O)=O Show InChI InChI=1S/C21H26N6O5S/c1-26-21(29)18-15(10-17(23-19(18)25-26)24-20(28)13-6-7-13)22-14-8-5-12(11-32-3)9-16(14)27(2)33(4,30)31/h5,8-10,13H,6-7,11H2,1-4H3,(H3,22,23,24,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399737 (US10323036, Compound I-225 | US10793574, Compound ...) Show SMILES CN(c1ccccc1Nc1cc(Nc2cnc3CCCc3n2)nc2[nH]n(C)c(=O)c12)S(C)(=O)=O Show InChI InChI=1S/C22H24N8O3S/c1-29-22(31)20-16(24-15-7-4-5-10-17(15)30(2)34(3,32)33)11-18(27-21(20)28-29)26-19-12-23-13-8-6-9-14(13)25-19/h4-5,7,10-12H,6,8-9H2,1-3H3,(H3,24,25,26,27,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399739 (US10323036, Compound I-227 | US10793574, Compound ...) Show SMILES CN(c1ccccc1Nc1cc(Nc2cc3COCc3cn2)nc2[nH]n(C)c(=O)c12)S(C)(=O)=O Show InChI InChI=1S/C22H23N7O4S/c1-28-22(30)20-16(24-15-6-4-5-7-17(15)29(2)34(3,31)32)9-19(26-21(20)27-28)25-18-8-13-11-33-12-14(13)10-23-18/h4-10H,11-12H2,1-3H3,(H3,23,24,25,26,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399741 (US10323036, Compound I-229 | US10793574, Compound ...) Show SMILES CN(c1cc(C)ccc1Nc1cc(NC(=O)C2CC2)nc2[nH]n(C)c(=O)c12)S(C)(=O)=O Show InChI InChI=1S/C20H24N6O4S/c1-11-5-8-13(15(9-11)26(3)31(4,29)30)21-14-10-16(23-19(27)12-6-7-12)22-18-17(14)20(28)25(2)24-18/h5,8-10,12H,6-7H2,1-4H3,(H3,21,22,23,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399744 (US10323036, Compound I-232 | US10793574, Compound ...) Show SMILES CN(c1cc(ccc1Nc1cc(NC(=O)C2CC2)nc2[nH]n(C)c(=O)c12)C1CC1)S(C)(=O)=O Show InChI InChI=1S/C22H26N6O4S/c1-27-22(30)19-16(11-18(24-20(19)26-27)25-21(29)13-6-7-13)23-15-9-8-14(12-4-5-12)10-17(15)28(2)33(3,31)32/h8-13H,4-7H2,1-3H3,(H3,23,24,25,26,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399764 (US10323036, Compound VIII-12 | US10793574, Compoun...) Show SMILES COc1c(Nc2cc(Nc3ccc(C)nn3)ncc2-c2nnc(CO)o2)cccc1-c1ncn(C)n1 Show InChI InChI=1S/C23H22N10O3/c1-13-7-8-18(29-28-13)27-19-9-17(15(10-24-19)23-31-30-20(11-34)36-23)26-16-6-4-5-14(21(16)35-3)22-25-12-33(2)32-22/h4-10,12,34H,11H2,1-3H3,(H2,24,26,27,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399765 (US10323036, Compound VIII-13 | US10793574, Compoun...) Show SMILES COc1c(Nc2cc(Nc3cccc(n3)C#N)ncc2-c2nnc(CO)o2)cccc1-c1ncn(C)n1 Show InChI InChI=1S/C24H20N10O3/c1-34-13-27-23(33-34)15-6-4-7-17(22(15)36-2)29-18-9-20(30-19-8-3-5-14(10-25)28-19)26-11-16(18)24-32-31-21(12-35)37-24/h3-9,11,13,35H,12H2,1-2H3,(H2,26,28,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399766 (US10323036, Compound VIII-14 | US10793574, Compoun...) Show SMILES COc1c(Nc2cc(Nc3cc(C)nc(C)n3)ncc2-c2nnc(CO)o2)cccc1-c1ncn(C)n1 Show InChI InChI=1S/C24H24N10O3/c1-13-8-20(28-14(2)27-13)30-19-9-18(16(10-25-19)24-32-31-21(11-35)37-24)29-17-7-5-6-15(22(17)36-4)23-26-12-34(3)33-23/h5-10,12,35H,11H2,1-4H3,(H2,25,27,28,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399768 (US10323036, Compound VIII-16 | US10793574, Compoun...) Show SMILES COc1c(Nc2cc(Nc3ccc(C)nn3)ncc2-c2ncc(Cl)s2)cccc1-c1nnn(C)n1 Show InChI InChI=1S/C22H19ClN10OS/c1-12-7-8-18(29-28-12)27-19-9-16(14(10-24-19)22-25-11-17(23)35-22)26-15-6-4-5-13(20(15)34-3)21-30-32-33(2)31-21/h4-11H,1-3H3,(H2,24,26,27,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399769 (US10323036, Compound VIII-17 | US10793574, Compoun...) Show SMILES COCc1ccnc(Nc2cc(Nc3cccc(-c4nnn(C)n4)c3OC)c(cn2)-c2ncc(Cl)s2)c1 Show InChI InChI=1S/C24H22ClN9O2S/c1-34-32-23(31-33-34)15-5-4-6-17(22(15)36-3)29-18-10-21(27-11-16(18)24-28-12-19(25)37-24)30-20-9-14(13-35-2)7-8-26-20/h4-12H,13H2,1-3H3,(H2,26,27,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399565 (US10323036, Compound I-8 | US10793574, Compound I-...) Show SMILES COc1c(Nc2cc(Nc3cc(C)c(F)cn3)nc3[nH]n(C)c(=O)c23)cccc1-c1nnn(C)n1 Show InChI InChI=1S/C22H21FN10O2/c1-11-8-16(24-10-13(11)23)26-17-9-15(18-21(27-17)29-32(2)22(18)34)25-14-7-5-6-12(19(14)35-4)20-28-31-33(3)30-20/h5-10H,1-4H3,(H3,24,25,26,27,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399757 (US10323036, Compound VIII-5 | US10793574, Compound...) Show SMILES COc1c(Nc2cc(NC(=O)C3CC3)ncc2-c2nnc(CO)o2)cccc1-c1ncn(C)n1 Show InChI InChI=1S/C22H22N8O4/c1-30-11-24-20(29-30)13-4-3-5-15(19(13)33-2)25-16-8-17(26-21(32)12-6-7-12)23-9-14(16)22-28-27-18(10-31)34-22/h3-5,8-9,11-12,31H,6-7,10H2,1-2H3,(H2,23,25,26,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399759 (US10323036, Compound VIII-7 | US10793574, Compound...) Show SMILES COc1c(Nc2cc(NC(=O)C3CC3)ncc2-c2nnc(C)s2)cccc1-c1ncn(C)n1 Show InChI InChI=1S/C22H22N8O2S/c1-12-27-28-22(33-12)15-10-23-18(26-21(31)13-7-8-13)9-17(15)25-16-6-4-5-14(19(16)32-3)20-24-11-30(2)29-20/h4-6,9-11,13H,7-8H2,1-3H3,(H2,23,25,26,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399767 (US10323036, Compound VIII-15 | US10793574, Compoun...) Show SMILES COc1c(Nc2cc(Nc3cccc(n3)C#N)ncc2-c2ncc(Cl)s2)cccc1-c1nnn(C)n1 Show InChI InChI=1S/C23H17ClN10OS/c1-34-32-22(31-33-34)14-6-4-7-16(21(14)35-2)29-17-9-20(30-19-8-3-5-13(10-25)28-19)26-11-15(17)23-27-12-18(24)36-23/h3-9,11-12H,1-2H3,(H2,26,28,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399559 (US10323036, Compound I-2 | US10793574, Compound I-...) Show SMILES COCc1ccnc(Nc2cc(Nc3cccc(-c4nnn(C)n4)c3OC)c3c(n2)[nH]n(C)c3=O)c1 Show InChI InChI=1S/C23H24N10O3/c1-32-23(34)19-16(25-15-7-5-6-14(20(15)36-4)21-28-31-33(2)30-21)11-18(27-22(19)29-32)26-17-10-13(12-35-3)8-9-24-17/h5-11H,12H2,1-4H3,(H3,24,25,26,27,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399560 (US10323036, Compound I-3 | US10793574, Compound I-...) Show SMILES COc1c(Nc2cc(Nc3ccc(C)cn3)nc3[nH]n(C)c(=O)c23)cccc1-c1nnn(C)n1 Show InChI InChI=1S/C22H22N10O2/c1-12-8-9-16(23-11-12)25-17-10-15(18-21(26-17)28-31(2)22(18)33)24-14-7-5-6-13(19(14)34-4)20-27-30-32(3)29-20/h5-11H,1-4H3,(H3,23,24,25,26,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399561 (US10323036, Compound I-4 | US10793574, Compound I-...) Show SMILES COc1c(Nc2cc(Nc3ccccn3)nc3[nH]n(C)c(=O)c23)cccc1-c1nnn(C)n1 Show InChI InChI=1S/C21H20N10O2/c1-30-21(32)17-14(11-16(25-20(17)27-30)24-15-9-4-5-10-22-15)23-13-8-6-7-12(18(13)33-3)19-26-29-31(2)28-19/h4-11H,1-3H3,(H3,22,23,24,25,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399571 (US10323036, Compound I-14 | US10793574, Compound I...) Show SMILES COc1c(Nc2cc(NC(=O)C3CC3)nc3[nH]n(C)c(=O)c23)cccc1-c1ncn(C)n1 Show InChI InChI=1S/C21H22N8O3/c1-28-10-22-18(26-28)12-5-4-6-13(17(12)32-3)23-14-9-15(25-20(30)11-7-8-11)24-19-16(14)21(31)29(2)27-19/h4-6,9-11H,7-8H2,1-3H3,(H3,23,24,25,27,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399572 (US10323036, Compound I-15 | US10793574, Compound I...) Show SMILES COCc1ccnc(Nc2cc(Nc3cccc(-c4ncn(C)n4)c3OC)c3c(n2)[nH]n(C)c3=O)c1 Show InChI InChI=1S/C24H25N9O3/c1-32-13-26-22(30-32)15-6-5-7-16(21(15)36-4)27-17-11-19(29-23-20(17)24(34)33(2)31-23)28-18-10-14(12-35-3)8-9-25-18/h5-11,13H,12H2,1-4H3,(H3,25,27,28,29,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399573 (US10323036, Compound I-16 | US10793574, Compound I...) Show SMILES COc1c(Nc2cc(Nc3ccc(C)cn3)nc3[nH]n(C)c(=O)c23)cccc1-c1ncn(C)n1 Show InChI InChI=1S/C23H23N9O2/c1-13-8-9-17(24-11-13)27-18-10-16(19-22(28-18)30-32(3)23(19)33)26-15-7-5-6-14(20(15)34-4)21-25-12-31(2)29-21/h5-12H,1-4H3,(H3,24,26,27,28,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399575 (US10323036, Compound I-18 | US10793574, Compound I...) Show SMILES COc1c(Nc2cc(Nc3cc(C)ccn3)nc3[nH]n(C)c(=O)c23)cccc1-c1ncn(C)n1 Show InChI InChI=1S/C23H23N9O2/c1-13-8-9-24-17(10-13)27-18-11-16(19-22(28-18)30-32(3)23(19)33)26-15-7-5-6-14(20(15)34-4)21-25-12-31(2)29-21/h5-12H,1-4H3,(H3,24,26,27,28,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399577 (US10323036, Compound I-20 | US10793574, Compound I...) Show SMILES COc1c(Nc2cc(Nc3ccc(cn3)N3CCOCC3)nc3[nH]n(C)c(=O)c23)cccc1-c1ncn(C)n1 Show InChI InChI=1S/C26H28N10O3/c1-34-15-28-24(32-34)17-5-4-6-18(23(17)38-3)29-19-13-21(31-25-22(19)26(37)35(2)33-25)30-20-8-7-16(14-27-20)36-9-11-39-12-10-36/h4-8,13-15H,9-12H2,1-3H3,(H3,27,29,30,31,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399578 (US10323036, Compound I-21 | US10793574, Compound I...) Show SMILES COc1c(Nc2cc(Nc3cc(C)c(F)cn3)nc3[nH]n(C)c(=O)c23)cccc1-c1ncn(C)n1 Show InChI InChI=1S/C23H22FN9O2/c1-12-8-17(25-10-14(12)24)28-18-9-16(19-22(29-18)31-33(3)23(19)34)27-15-7-5-6-13(20(15)35-4)21-26-11-32(2)30-21/h5-11H,1-4H3,(H3,25,27,28,29,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399581 (US10323036, Compound I-24 | US10793574, Compound I...) Show SMILES COc1c(Nc2cc(Nc3ccc(cn3)N3CCCCC3)nc3[nH]n(C)c(=O)c23)cccc1-c1ncn(C)n1 Show InChI InChI=1S/C27H30N10O2/c1-35-16-29-25(33-35)18-8-7-9-19(24(18)39-3)30-20-14-22(32-26-23(20)27(38)36(2)34-26)31-21-11-10-17(15-28-21)37-12-5-4-6-13-37/h7-11,14-16H,4-6,12-13H2,1-3H3,(H3,28,30,31,32,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399582 (US10323036, Compound I-25 | US10793574, Compound I...) Show SMILES COc1c(Nc2cc(Nc3ccc(cn3)C#N)nc3[nH]n(C)c(=O)c23)cccc1-c1ncn(C)n1 Show InChI InChI=1S/C23H20N10O2/c1-32-12-26-21(30-32)14-5-4-6-15(20(14)35-3)27-16-9-18(28-17-8-7-13(10-24)11-25-17)29-22-19(16)23(34)33(2)31-22/h4-9,11-12H,1-3H3,(H3,25,27,28,29,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399585 (US10323036, Compound I-29 | US10793574, Compound I...) Show SMILES COc1c(Nc2cc(Nc3cc(ncn3)C#N)nc3[nH]n(C)c(=O)c23)cccc1-c1nnn(C)n1 Show InChI InChI=1S/C21H18N12O2/c1-32-21(34)17-14(8-16(27-20(17)29-32)26-15-7-11(9-22)23-10-24-15)25-13-6-4-5-12(18(13)35-3)19-28-31-33(2)30-19/h4-8,10H,1-3H3,(H3,23,24,25,26,27,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399609 (US10323036, Compound I-53 | US10793574, Compound I...) Show SMILES COc1c(Nc2cc(NC(=O)C3CC3)nc3[nH]n(C)c(=O)c23)cccc1-c1nc(C)n(C)n1 Show InChI InChI=1S/C22H24N8O3/c1-11-23-19(27-29(11)2)13-6-5-7-14(18(13)33-4)24-15-10-16(26-21(31)12-8-9-12)25-20-17(15)22(32)30(3)28-20/h5-7,10,12H,8-9H2,1-4H3,(H3,24,25,26,28,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399615 (US10323036, Compound I-59 | US10793574, Compound I...) Show SMILES COc1c(Nc2cc(Nc3ccc(cn3)C3CC3)nc3[nH]n(C)c(=O)c23)cccc1-c1nnn(C)n1 Show InChI InChI=1S/C24H24N10O2/c1-33-24(35)20-17(26-16-6-4-5-15(21(16)36-3)22-29-32-34(2)31-22)11-19(28-23(20)30-33)27-18-10-9-14(12-25-18)13-7-8-13/h4-6,9-13H,7-8H2,1-3H3,(H3,25,26,27,28,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399616 (US10323036, Compound I-60 | US10793574, Compound I...) Show SMILES COc1c(Nc2cc(Nc3cccc(n3)C(F)(F)F)nc3[nH]n(C)c(=O)c23)cccc1-c1nnn(C)n1 Show InChI InChI=1S/C22H19F3N10O2/c1-34-21(36)17-13(26-12-7-4-6-11(18(12)37-3)19-30-33-35(2)32-19)10-16(29-20(17)31-34)28-15-9-5-8-14(27-15)22(23,24)25/h4-10H,1-3H3,(H3,26,27,28,29,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399619 (US10323036, Compound I-63 | US10793574, Compound I...) Show SMILES COC1CN(C1)c1cccc(Nc2cc(Nc3cccc(-c4nnn(C)n4)c3OC)c3c(n2)[nH]n(C)c3=O)n1 Show InChI InChI=1S/C25H27N11O3/c1-34-25(37)21-17(26-16-8-5-7-15(22(16)39-4)23-30-33-35(2)32-23)11-19(29-24(21)31-34)27-18-9-6-10-20(28-18)36-12-14(13-36)38-3/h5-11,14H,12-13H2,1-4H3,(H3,26,27,28,29,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399621 (US10323036, Compound I-65 | US10793574, Compound I...) Show SMILES COc1c(Nc2cc(Nc3cccc(n3)C3CC3)nc3[nH]n(C)c(=O)c23)cccc1-c1nnn(C)n1 Show InChI InChI=1S/C24H24N10O2/c1-33-24(35)20-17(25-16-8-4-6-14(21(16)36-3)22-29-32-34(2)31-22)12-19(28-23(20)30-33)27-18-9-5-7-15(26-18)13-10-11-13/h4-9,12-13H,10-11H2,1-3H3,(H3,25,26,27,28,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399624 (US10323036, Compound I-68 | US10793574, Compound I...) Show SMILES COCc1ccc(Nc2cc(Nc3cccc(n3)C#N)nc3[nH]n(C)c(=O)c23)c(OC)c1 Show InChI InChI=1S/C22H21N7O3/c1-29-22(30)20-16(25-15-8-7-13(12-31-2)9-17(15)32-3)10-19(27-21(20)28-29)26-18-6-4-5-14(11-23)24-18/h4-10H,12H2,1-3H3,(H3,24,25,26,27,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399626 (US10323036, Compound I-70 | US10793574, Compound I...) Show SMILES COc1cc(ccc1Nc1cc(NC(=O)C2CC2)nc2[nH]n(C)c(=O)c12)C(=O)N1CCCC1 Show InChI InChI=1S/C23H26N6O4/c1-28-23(32)19-16(12-18(25-20(19)27-28)26-21(30)13-5-6-13)24-15-8-7-14(11-17(15)33-2)22(31)29-9-3-4-10-29/h7-8,11-13H,3-6,9-10H2,1-2H3,(H3,24,25,26,27,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399630 (US10323036, Compound I-74 | US10793574, Compound I...) Show SMILES COc1c(F)cccc1Nc1cc(Nc2cc(C)nc(C)n2)nc2[nH]n(C)c(=O)c12 Show InChI InChI=1S/C20H20FN7O2/c1-10-8-15(23-11(2)22-10)25-16-9-14(17-19(26-16)27-28(3)20(17)29)24-13-7-5-6-12(21)18(13)30-4/h5-9H,1-4H3,(H3,22,23,24,25,26,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human))	BDBM399631 (US10323036, Compound I-75 | US10793574, Compound I...) Show SMILES COc1c(F)cccc1Nc1cc(Nc2ccc(C)nn2)nc2[nH]n(C)c(=O)c12 Show InChI InChI=1S/C19H18FN7O2/c1-10-7-8-14(25-24-10)22-15-9-13(16-18(23-15)26-27(2)19(16)28)21-12-6-4-5-11(20)17(12)29-3/h4-9H,1-3H3,(H3,21,22,23,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair

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