Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Rhomboid protease GluP (Bacillus subtilis (strain 168)) | BDBM50460516 (CHEMBL4227539) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 470 | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven Curated by ChEMBL | Assay Description Competitive inhibition of Bacillus subtilis rhomboid YqgP preincubated for 30 mins followed by FP-Rh addition measured after 1 hr by gel-based ABPP m... | Bioorg Med Chem Lett 28: 1423-1427 (2018) Article DOI: 10.1016/j.bmcl.2017.12.056 BindingDB Entry DOI: 10.7270/Q2WH2SM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rhomboid protease GluP (Bacillus subtilis (strain 168)) | BDBM50460510 (CHEMBL4225584) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven Curated by ChEMBL | Assay Description Competitive inhibition of Bacillus subtilis rhomboid YqgP preincubated for 30 mins followed by FP-Rh addition measured after 1 hr by gel-based ABPP m... | Bioorg Med Chem Lett 28: 1423-1427 (2018) Article DOI: 10.1016/j.bmcl.2017.12.056 BindingDB Entry DOI: 10.7270/Q2WH2SM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rhomboid protease GluP (Bacillus subtilis (strain 168)) | BDBM50460511 (CHEMBL4225103) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven Curated by ChEMBL | Assay Description Competitive inhibition of Bacillus subtilis rhomboid YqgP preincubated for 30 mins followed by FP-Rh addition measured after 1 hr by gel-based ABPP m... | Bioorg Med Chem Lett 28: 1423-1427 (2018) Article DOI: 10.1016/j.bmcl.2017.12.056 BindingDB Entry DOI: 10.7270/Q2WH2SM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rhomboid protease GluP (Bacillus subtilis (strain 168)) | BDBM50406296 (CHEMBL145012) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven Curated by ChEMBL | Assay Description Competitive inhibition of Bacillus subtilis rhomboid YqgP preincubated for 30 mins followed by FP-Rh addition measured after 1 hr by gel-based ABPP m... | Bioorg Med Chem Lett 28: 1423-1427 (2018) Article DOI: 10.1016/j.bmcl.2017.12.056 BindingDB Entry DOI: 10.7270/Q2WH2SM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rhomboid protease GluP [F193S,L370F,L379S,R499W] (Bacillus subtilis (Firmicutes)) | BDBM50199883 (3,4‐Dichloroisocoumarin (2) | 3,4-Dichloro-i...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | 4.10E+3 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Technische Universität München | Assay Description We selected several inhibitor structures and determined their apparent IC50 by competitive ABPP. | ACS Chem Biol 10: 2325-33 (2015) Article DOI: 10.1021/acschembio.5b00514 BindingDB Entry DOI: 10.7270/Q2668BZ8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rhomboid protease GluP (Bacillus subtilis (strain 168)) | BDBM50460512 (CHEMBL4225312) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven Curated by ChEMBL | Assay Description Competitive inhibition of Bacillus subtilis rhomboid YqgP preincubated for 30 mins followed by FP-Rh addition measured after 1 hr by gel-based ABPP m... | Bioorg Med Chem Lett 28: 1423-1427 (2018) Article DOI: 10.1016/j.bmcl.2017.12.056 BindingDB Entry DOI: 10.7270/Q2WH2SM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rhomboid protease GluP (Bacillus subtilis (strain 168)) | BDBM50460514 (CHEMBL4229256) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven Curated by ChEMBL | Assay Description Competitive inhibition of Bacillus subtilis rhomboid YqgP preincubated for 30 mins followed by FP-Rh addition measured after 1 hr by gel-based ABPP m... | Bioorg Med Chem Lett 28: 1423-1427 (2018) Article DOI: 10.1016/j.bmcl.2017.12.056 BindingDB Entry DOI: 10.7270/Q2WH2SM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rhomboid protease GluP (Bacillus subtilis (strain 168)) | BDBM50288096 (5-Chloro-2-ethoxy-benzo[d][1,3]oxazin-4-one | CHEM...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven Curated by ChEMBL | Assay Description Competitive inhibition of Bacillus subtilis rhomboid YqgP preincubated for 30 mins followed by FP-Rh addition measured after 1 hr by gel-based ABPP m... | Bioorg Med Chem Lett 28: 1423-1427 (2018) Article DOI: 10.1016/j.bmcl.2017.12.056 BindingDB Entry DOI: 10.7270/Q2WH2SM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rhomboid protease GluP (Bacillus subtilis (strain 168)) | BDBM50460513 (CHEMBL4228380) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 7.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven Curated by ChEMBL | Assay Description Competitive inhibition of Bacillus subtilis rhomboid YqgP preincubated for 30 mins followed by FP-Rh addition measured after 1 hr by gel-based ABPP m... | Bioorg Med Chem Lett 28: 1423-1427 (2018) Article DOI: 10.1016/j.bmcl.2017.12.056 BindingDB Entry DOI: 10.7270/Q2WH2SM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rhomboid protease GluP (Bacillus subtilis (strain 168)) | BDBM50460515 (CHEMBL4229280) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven Curated by ChEMBL | Assay Description Competitive inhibition of Bacillus subtilis rhomboid YqgP preincubated for 30 mins followed by FP-Rh addition measured after 1 hr by gel-based ABPP m... | Bioorg Med Chem Lett 28: 1423-1427 (2018) Article DOI: 10.1016/j.bmcl.2017.12.056 BindingDB Entry DOI: 10.7270/Q2WH2SM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rhomboid protease GluP [F193S,L370F,L379S,R499W] (Bacillus subtilis (Firmicutes)) | BDBM165194 (4‐Chloro‐7‐nitro‐3‐[...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Technische Universität München | Assay Description We selected several inhibitor structures and determined their apparent IC50 by competitive ABPP. | ACS Chem Biol 10: 2325-33 (2015) Article DOI: 10.1021/acschembio.5b00514 BindingDB Entry DOI: 10.7270/Q2668BZ8 | |||||||||||
More data for this Ligand-Target Pair |