Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM552705 ((2S,4R)-l-((S)-2-(4-cyclopropyl-lH-l ,2,3-triazol-...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022103411 | n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WM1HMJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM552704 ((2S,4R)-l-((2S)-2-(adamantan-l-yl)-2-(4-cyclopropy...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022103411 | n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WM1HMJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM552703 ((2S,4R)-l-((S)-2-cyclohexyl-2-(4-cyclopropyl-lH-l,...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022103411 | n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WM1HMJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM552729 ((2S,4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-l...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022103411 | n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WM1HMJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM552708 ((2S,4R)-l-((S)-2-cyclohexyl-2-(4-cyclopropyl-lH-l,...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022103411 | n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WM1HMJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM552702 ((2S,4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-l...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022103411 | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WM1HMJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM552711 ((2S,4R)-l-((S)-3,3-dimethyl-2-(4-(l-methylcyclopro...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022103411 | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WM1HMJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM552706 ((2S,4R)-N-(l-(2-chloro-4-(4-methylthia7,ol-5-yl)ph...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022103411 | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WM1HMJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM552726 ((2S,4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-l...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022103411 | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WM1HMJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM552686 ((2S,4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-l...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022103411 | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WM1HMJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM552731 ((2S, 4R)-N-((S)-l-(2'-chloro-[l,r-biphenyl]-4-yl)e...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022103411 | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WM1HMJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM552686 ((2S,4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-l...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022103411 | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL / Elong... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WM1HMJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM454848 (US10730870, Example 11 | US11512083, Example 11) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | US Patent | n/a | n/a | 16.3 | n/a | n/a | n/a | n/a | n/a | n/a |
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY US Patent | Assay Description Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ... | US Patent US10730870 (2020) BindingDB Entry DOI: 10.7270/Q2WD43MN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM552687 ((2S,4R)-l-((S)-2-(4-benzyl-lH-l,2,3-triazol-l-yl)-...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022103411 | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WM1HMJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM552709 ((2S,4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-l...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022103411 | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WM1HMJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM552707 ((2S,4R)-l-((2S)-2-(adamantan-l-yl)-2-(4-cyclopropy...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022103411 | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WM1HMJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM552687 ((2S,4R)-l-((S)-2-(4-benzyl-lH-l,2,3-triazol-l-yl)-...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022103411 | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL / Elong... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WM1HMJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM552712 (WO2022103411, Compound 30 | WO2022103411, Example ...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022103411 | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WM1HMJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM50615679 (CHEMBL4449823) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | UniChem | n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM50615681 (CHEMBL5277721) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | UniChem | n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM552728 ((2S, 4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022103411 | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WM1HMJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM552710 ((2S,4R)-l-((S)-3,3-dimethyl-2-(4-(l-(trifluorometh...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022103411 | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WM1HMJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM536252 ((2S)-1-((2S,4R)-2-(5-(4-Bromophenyl)-5-methyl-4,5-...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 67.8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano... | Citation and Details BindingDB Entry DOI: 10.7270/Q2KW5K7X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM454972 (US10730870, Example 141 | US11512083, Example 141) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | US Patent | n/a | n/a | 70.9 | n/a | n/a | n/a | n/a | n/a | n/a |
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY US Patent | Assay Description Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ... | US Patent US10730870 (2020) BindingDB Entry DOI: 10.7270/Q2WD43MN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM50615683 (CHEMBL5274336) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | UniChem | n/a | n/a | 78 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM552725 ((2S, 4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022103411 | n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WM1HMJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM552685 ((2S,4R)-N-((R)-3-([l,l'-biphenyl]-4-yl)-l-amino-l-...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022103411 | n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL / Elong... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WM1HMJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM50459944 (CHEMBL4225537) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 88 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc. Curated by ChEMBL | Assay Description Inhibition of VHL (unknown origin) by fluorescence polarization assay | J Med Chem 63: 7957-7985 (2020) Article DOI: 10.1021/acs.jmedchem.9b01451 BindingDB Entry DOI: 10.7270/Q2QN6BBK | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM552691 ((2S,4R)-N-((R)-3-([l,l'-biphenyl]-4-yl)-l-amino-l-...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022103411 | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WM1HMJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM454969 (US10730870, Example 138 | US10730870, Example 145 ...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | US Patent | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY US Patent | Assay Description Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ... | US Patent US10730870 (2020) BindingDB Entry DOI: 10.7270/Q2WD43MN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM552683 ((2S,4R)-N-((R)-3-([1,1'-biphenyl]-4-yl)-l-amino-l-...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022103411 | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL / Elong... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WM1HMJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM552692 ((2S,4R)-N-((R)-3-([l,l'-biphenyl]-4-yl)-l-amino-l-...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022103411 | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WM1HMJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM552724 ((2S,4R)-N-((R)-3-([l,l'-biphenyl]-4-yl)-l-amino-l-...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022103411 | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WM1HMJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM552693 ((2S,4R)-N-((R)-3-([l,l'-biphenyl]-4-yl)-l-amino-l-...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022103411 | n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WM1HMJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM552690 ((2S,4R)-N-((R)-3-([l,l'-biphenyl]-4-yl)-l-amino-l-...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022103411 | n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WM1HMJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM50615678 (CHEMBL5285978) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | UniChem | n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM552684 ((2S,4R)-N-((R)-3-([l,l'-biphenyl]-4-yl)-l-amino-l-...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022103411 | n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL / Elong... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WM1HMJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM552684 ((2S,4R)-N-((R)-3-([l,l'-biphenyl]-4-yl)-l-amino-l-...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022103411 | n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WM1HMJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM552696 (WO2022103411, Example S11) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022103411 | n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WM1HMJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM50615684 (CHEMBL4565531) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | UniChem | n/a | n/a | 164 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM454909 (US10730870, Example 76 | US11512083, Example 76) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | US Patent | n/a | n/a | 169 | n/a | n/a | n/a | n/a | n/a | n/a |
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY US Patent | Assay Description Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ... | US Patent US10730870 (2020) BindingDB Entry DOI: 10.7270/Q2WD43MN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM454884 (US10730870, Example 47 | US11512083, Example 47) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | US Patent | n/a | n/a | 178 | n/a | n/a | n/a | n/a | n/a | n/a |
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY US Patent | Assay Description Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ... | US Patent US10730870 (2020) BindingDB Entry DOI: 10.7270/Q2WD43MN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM50615682 (CHEMBL5269644) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | UniChem | n/a | n/a | 179 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM171824 (US9085572, 34) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 180 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Bayer Intellectual Property GmbH US Patent | Assay Description Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i... | US Patent US9085572 (2015) BindingDB Entry DOI: 10.7270/Q2H70DMQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM50099062 (CHEMBL3344081 | US10730870, Example 3 | US11512083...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 185 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc. Curated by ChEMBL | Assay Description Inhibition of VHL (unknown origin) by fluorescence polarization assay | J Med Chem 63: 7957-7985 (2020) Article DOI: 10.1021/acs.jmedchem.9b01451 BindingDB Entry DOI: 10.7270/Q2QN6BBK | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM552723 ((2S,4R)-N-((R)-3-([l,l'-biphenyl]-4-yl)-l-amino-l-...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022103411 | n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WM1HMJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM50615680 (CHEMBL5283593) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PDB UniChem | PDB | n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM552689 ((2S,4R)-N-((R)-3-([l,l'-biphenyl]-4-yl)-l-amino-l-...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022103411 | n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WM1HMJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM552730 ((2S,4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-l...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022103411 | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WM1HMJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM552683 ((2S,4R)-N-((R)-3-([1,1'-biphenyl]-4-yl)-l-amino-l-...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022103411 | n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WM1HMJ | |||||||||||
More data for this Ligand-Target Pair |
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