Compile Data Set for Download or QSAR

Found 20 hits of ic50 for UniProtKB: P00523   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase Src [251-533] (Gallus gallus (Chicken))	BDBM234848 (US9353116, 5) Show SMILES CC(C)n1nc(-c2ccc(NS(=O)(=O)C=C)cc2)c2c(N)ncnc12 Show InChI InChI=1S/C16H18N6O2S/c1-4-25(23,24)21-12-7-5-11(6-8-12)14-13-15(17)18-9-19-16(13)22(20-14)10(2)3/h4-10,21H,1H2,2-3H3,(H2,17,18,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	899	n/a	n/a	n/a	n/a	8.0	n/a
The Regents of the University of California US Patent					Assay Description In vitro kinase assays for c-Src variants were performed in 50 mM Tris (pH 8.0), 10 mM MgCl2 and 1 mg/mL BSA. When obtaining kinetic parameters (kcat...				US Patent US9353116 (2016) BindingDB Entry DOI: 10.7270/Q2V123N7
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src [251-533] (Gallus gallus (Chicken))	BDBM234843 (US9353116, 3) Show SMILES CC(C)n1nc(-c2cccc(NS(=O)(=O)C=C)c2)c2c(N)ncnc12 Show InChI InChI=1S/C16H18N6O2S/c1-4-25(23,24)21-12-7-5-6-11(8-12)14-13-15(17)18-9-19-16(13)22(20-14)10(2)3/h4-10,21H,1H2,2-3H3,(H2,17,18,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	8.0	n/a
The Regents of the University of California US Patent					Assay Description In vitro kinase assays for c-Src variants were performed in 50 mM Tris (pH 8.0), 10 mM MgCl2 and 1 mg/mL BSA. When obtaining kinetic parameters (kcat...				US Patent US9353116 (2016) BindingDB Entry DOI: 10.7270/Q2V123N7
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src [251-533] (Gallus gallus (Chicken))	BDBM234861 (US9353116, 20) Show SMILES COc1cc2ncnc(Nc3ccc(NS(=O)(=O)C=C)cc3)c2cc1OC Show InChI InChI=1S/C18H18N4O4S/c1-4-27(23,24)22-13-7-5-12(6-8-13)21-18-14-9-16(25-2)17(26-3)10-15(14)19-11-20-18/h4-11,22H,1H2,2-3H3,(H,19,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.17E+3	n/a	n/a	n/a	n/a	8.0	n/a
The Regents of the University of California US Patent					Assay Description In vitro kinase assays for c-Src variants were performed in 50 mM Tris (pH 8.0), 10 mM MgCl2 and 1 mg/mL BSA. When obtaining kinetic parameters (kcat...				US Patent US9353116 (2016) BindingDB Entry DOI: 10.7270/Q2V123N7
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src [251-533] (Gallus gallus (Chicken))	BDBM234845 (US9353116, 1) Show SMILES CC(C)n1nc(-c2cccc(NC(=O)C=C)c2)c2c(N)ncnc12 Show InChI InChI=1S/C17H18N6O/c1-4-13(24)21-12-7-5-6-11(8-12)15-14-16(18)19-9-20-17(14)23(22-15)10(2)3/h4-10H,1H2,2-3H3,(H,21,24)(H2,18,19,20)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.32E+3	n/a	n/a	n/a	n/a	8.0	n/a
The Regents of the University of California US Patent					Assay Description In vitro kinase assays for c-Src variants were performed in 50 mM Tris (pH 8.0), 10 mM MgCl2 and 1 mg/mL BSA. When obtaining kinetic parameters (kcat...				US Patent US9353116 (2016) BindingDB Entry DOI: 10.7270/Q2V123N7
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src [251-533] (Gallus gallus (Chicken))	BDBM234852 (US9353116, 10) Show SMILES CC(C)n1nc(Cc2ccc(NS(=O)(=O)C=C)cc2)c2c(N)ncnc12 Show InChI InChI=1S/C17H20N6O2S/c1-4-26(24,25)22-13-7-5-12(6-8-13)9-14-15-16(18)19-10-20-17(15)23(21-14)11(2)3/h4-8,10-11,22H,1,9H2,2-3H3,(H2,18,19,20)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.08E+3	n/a	n/a	n/a	n/a	8.0	n/a
The Regents of the University of California US Patent					Assay Description In vitro kinase assays for c-Src variants were performed in 50 mM Tris (pH 8.0), 10 mM MgCl2 and 1 mg/mL BSA. When obtaining kinetic parameters (kcat...				US Patent US9353116 (2016) BindingDB Entry DOI: 10.7270/Q2V123N7
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src [251-533] (Gallus gallus (Chicken))	BDBM234853 (US9353116, 11) Show SMILES CCS(=O)(=O)Nc1cccc(Cc2nn(C(C)C)c3ncnc(N)c23)c1 Show InChI InChI=1S/C17H22N6O2S/c1-4-26(24,25)22-13-7-5-6-12(8-13)9-14-15-16(18)19-10-20-17(15)23(21-14)11(2)3/h5-8,10-11,22H,4,9H2,1-3H3,(H2,18,19,20)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	8.0	n/a
The Regents of the University of California US Patent					Assay Description In vitro kinase assays for c-Src variants were performed in 50 mM Tris (pH 8.0), 10 mM MgCl2 and 1 mg/mL BSA. When obtaining kinetic parameters (kcat...				US Patent US9353116 (2016) BindingDB Entry DOI: 10.7270/Q2V123N7
					More data for this Ligand-Target Pair				3D Structure (crystal)
Proto-oncogene tyrosine-protein kinase Src [251-533] (Gallus gallus (Chicken))	BDBM234854 (US9353116, 12) Show SMILES CC(C)n1nc(Cc2cccc(NC(=O)CCl)c2)c2c(N)ncnc12 Show InChI InChI=1S/C17H19ClN6O/c1-10(2)24-17-15(16(19)20-9-21-17)13(23-24)7-11-4-3-5-12(6-11)22-14(25)8-18/h3-6,9-10H,7-8H2,1-2H3,(H,22,25)(H2,19,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	8.0	n/a
The Regents of the University of California US Patent					Assay Description In vitro kinase assays for c-Src variants were performed in 50 mM Tris (pH 8.0), 10 mM MgCl2 and 1 mg/mL BSA. When obtaining kinetic parameters (kcat...				US Patent US9353116 (2016) BindingDB Entry DOI: 10.7270/Q2V123N7
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src [251-533] (Gallus gallus (Chicken))	BDBM234844 (US9353116, 13) Show SMILES CC(C)n1nc(Cc2cccc(c2)C(=O)CF)c2c(N)ncnc12 Show InChI InChI=1S/C17H18FN5O/c1-10(2)23-17-15(16(19)20-9-21-17)13(22-23)7-11-4-3-5-12(6-11)14(24)8-18/h3-6,9-10H,7-8H2,1-2H3,(H2,19,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	8.0	n/a
The Regents of the University of California US Patent					Assay Description In vitro kinase assays for c-Src variants were performed in 50 mM Tris (pH 8.0), 10 mM MgCl2 and 1 mg/mL BSA. When obtaining kinetic parameters (kcat...				US Patent US9353116 (2016) BindingDB Entry DOI: 10.7270/Q2V123N7
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src [251-533] (Gallus gallus (Chicken))	BDBM234855 (US9353116, 14) Show SMILES CC(C)n1nc(Cc2cccc(c2)C(C)=O)c2c(N)ncnc12 Show InChI InChI=1S/C17H19N5O/c1-10(2)22-17-15(16(18)19-9-20-17)14(21-22)8-12-5-4-6-13(7-12)11(3)23/h4-7,9-10H,8H2,1-3H3,(H2,18,19,20)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	8.0	n/a
The Regents of the University of California US Patent					Assay Description In vitro kinase assays for c-Src variants were performed in 50 mM Tris (pH 8.0), 10 mM MgCl2 and 1 mg/mL BSA. When obtaining kinetic parameters (kcat...				US Patent US9353116 (2016) BindingDB Entry DOI: 10.7270/Q2V123N7
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src [251-533] (Gallus gallus (Chicken))	BDBM234856 (US9353116, 15) Show SMILES Cn1nc(Cc2cccc(NS(=O)(=O)C=C)c2)c2c(N)ncnc12 Show InChI InChI=1S/C15H16N6O2S/c1-3-24(22,23)20-11-6-4-5-10(7-11)8-12-13-14(16)17-9-18-15(13)21(2)19-12/h3-7,9,20H,1,8H2,2H3,(H2,16,17,18)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	8.0	n/a
The Regents of the University of California US Patent					Assay Description In vitro kinase assays for c-Src variants were performed in 50 mM Tris (pH 8.0), 10 mM MgCl2 and 1 mg/mL BSA. When obtaining kinetic parameters (kcat...				US Patent US9353116 (2016) BindingDB Entry DOI: 10.7270/Q2V123N7
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src [251-533] (Gallus gallus (Chicken))	BDBM234857 (US9353116, 16) Show SMILES CC(C)(C)n1nc(Cc2cccc(NS(=O)(=O)C=C)c2)c2c(N)ncnc12 Show InChI InChI=1S/C18H22N6O2S/c1-5-27(25,26)23-13-8-6-7-12(9-13)10-14-15-16(19)20-11-21-17(15)24(22-14)18(2,3)4/h5-9,11,23H,1,10H2,2-4H3,(H2,19,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	8.0	n/a
The Regents of the University of California US Patent					Assay Description In vitro kinase assays for c-Src variants were performed in 50 mM Tris (pH 8.0), 10 mM MgCl2 and 1 mg/mL BSA. When obtaining kinetic parameters (kcat...				US Patent US9353116 (2016) BindingDB Entry DOI: 10.7270/Q2V123N7
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src [251-533] (Gallus gallus (Chicken))	BDBM234858 (US9353116, 17) Show SMILES Nc1ncnc2n(nc(Cc3cccc(NS(=O)(=O)C=C)c3)c12)C1CCCC1 Show InChI InChI=1S/C19H22N6O2S/c1-2-28(26,27)24-14-7-5-6-13(10-14)11-16-17-18(20)21-12-22-19(17)25(23-16)15-8-3-4-9-15/h2,5-7,10,12,15,24H,1,3-4,8-9,11H2,(H2,20,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	8.0	n/a
The Regents of the University of California US Patent					Assay Description In vitro kinase assays for c-Src variants were performed in 50 mM Tris (pH 8.0), 10 mM MgCl2 and 1 mg/mL BSA. When obtaining kinetic parameters (kcat...				US Patent US9353116 (2016) BindingDB Entry DOI: 10.7270/Q2V123N7
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src [251-533] (Gallus gallus (Chicken))	BDBM234859 (US9353116, 18) Show SMILES COc1cc2ncnc(Nc3cccc(NC(=O)C=C)c3)c2cc1OC Show InChI InChI=1S/C19H18N4O3/c1-4-18(24)22-12-6-5-7-13(8-12)23-19-14-9-16(25-2)17(26-3)10-15(14)20-11-21-19/h4-11H,1H2,2-3H3,(H,22,24)(H,20,21,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	8.0	n/a
The Regents of the University of California US Patent					Assay Description In vitro kinase assays for c-Src variants were performed in 50 mM Tris (pH 8.0), 10 mM MgCl2 and 1 mg/mL BSA. When obtaining kinetic parameters (kcat...				US Patent US9353116 (2016) BindingDB Entry DOI: 10.7270/Q2V123N7
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src [251-533] (Gallus gallus (Chicken))	BDBM234860 (US9353116, 19 | US9353116, Fig. 16, Compound 1) Show SMILES COc1cc2ncnc(Nc3cccc(NS(=O)(=O)C=C)c3)c2cc1OC Show InChI InChI=1S/C18H18N4O4S/c1-4-27(23,24)22-13-7-5-6-12(8-13)21-18-14-9-16(25-2)17(26-3)10-15(14)19-11-20-18/h4-11,22H,1H2,2-3H3,(H,19,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	8.0	n/a
The Regents of the University of California US Patent					Assay Description In vitro kinase assays for c-Src variants were performed in 50 mM Tris (pH 8.0), 10 mM MgCl2 and 1 mg/mL BSA. When obtaining kinetic parameters (kcat...				US Patent US9353116 (2016) BindingDB Entry DOI: 10.7270/Q2V123N7
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src [251-533] (Gallus gallus (Chicken))	BDBM50403061 (CHEMBL2216823 | US9353116, 9) Show SMILES CC(C)n1nc(Cc2cccc(NS(=O)(=O)C=C)c2)c2c(N)ncnc12 Show InChI InChI=1S/C17H20N6O2S/c1-4-26(24,25)22-13-7-5-6-12(8-13)9-14-15-16(18)19-10-20-17(15)23(21-14)11(2)3/h4-8,10-11,22H,1,9H2,2-3H3,(H2,18,19,20)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	US Patent	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	8.0	n/a
The Regents of the University of California US Patent					Assay Description In vitro kinase assays for c-Src variants were performed in 50 mM Tris (pH 8.0), 10 mM MgCl2 and 1 mg/mL BSA. When obtaining kinetic parameters (kcat...				US Patent US9353116 (2016) BindingDB Entry DOI: 10.7270/Q2V123N7
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src [251-533] (Gallus gallus (Chicken))	BDBM234851 (US9353116, 8) Show SMILES CC(C)n1nc(Cc2ccc(NC(=O)C=C)cc2)c2c(N)ncnc12 Show InChI InChI=1S/C18H20N6O/c1-4-15(25)22-13-7-5-12(6-8-13)9-14-16-17(19)20-10-21-18(16)24(23-14)11(2)3/h4-8,10-11H,1,9H2,2-3H3,(H,22,25)(H2,19,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	8.0	n/a
The Regents of the University of California US Patent					Assay Description In vitro kinase assays for c-Src variants were performed in 50 mM Tris (pH 8.0), 10 mM MgCl2 and 1 mg/mL BSA. When obtaining kinetic parameters (kcat...				US Patent US9353116 (2016) BindingDB Entry DOI: 10.7270/Q2V123N7
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src [251-533] (Gallus gallus (Chicken))	BDBM234850 (US9353116, 7) Show SMILES CC(C)n1nc(Cc2cccc(NC(=O)C=C)c2)c2c(N)ncnc12 Show InChI InChI=1S/C18H20N6O/c1-4-15(25)22-13-7-5-6-12(8-13)9-14-16-17(19)20-10-21-18(16)24(23-14)11(2)3/h4-8,10-11H,1,9H2,2-3H3,(H,22,25)(H2,19,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	8.0	n/a
The Regents of the University of California US Patent					Assay Description In vitro kinase assays for c-Src variants were performed in 50 mM Tris (pH 8.0), 10 mM MgCl2 and 1 mg/mL BSA. When obtaining kinetic parameters (kcat...				US Patent US9353116 (2016) BindingDB Entry DOI: 10.7270/Q2V123N7
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src [251-533] (Gallus gallus (Chicken))	BDBM234849 (US9353116, 6) Show SMILES CC(C)n1nc(-c2cccc(NC(=O)CCl)c2)c2c(N)ncnc12 Show InChI InChI=1S/C16H17ClN6O/c1-9(2)23-16-13(15(18)19-8-20-16)14(22-23)10-4-3-5-11(6-10)21-12(24)7-17/h3-6,8-9H,7H2,1-2H3,(H,21,24)(H2,18,19,20)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	8.0	n/a
The Regents of the University of California US Patent					Assay Description In vitro kinase assays for c-Src variants were performed in 50 mM Tris (pH 8.0), 10 mM MgCl2 and 1 mg/mL BSA. When obtaining kinetic parameters (kcat...				US Patent US9353116 (2016) BindingDB Entry DOI: 10.7270/Q2V123N7
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src [251-533] (Gallus gallus (Chicken))	BDBM234847 (US9353116, 4) Show SMILES CC(C)n1nc(-c2cccc(NS(=O)(=O)C=C)c2)c2cncnc12 Show InChI InChI=1S/C16H17N5O2S/c1-4-24(22,23)20-13-7-5-6-12(8-13)15-14-9-17-10-18-16(14)21(19-15)11(2)3/h4-11,20H,1H2,2-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	8.0	n/a
The Regents of the University of California US Patent					Assay Description In vitro kinase assays for c-Src variants were performed in 50 mM Tris (pH 8.0), 10 mM MgCl2 and 1 mg/mL BSA. When obtaining kinetic parameters (kcat...				US Patent US9353116 (2016) BindingDB Entry DOI: 10.7270/Q2V123N7
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src [251-533] (Gallus gallus (Chicken))	BDBM234846 (US9353116, 2) Show SMILES CC(C)n1nc(-c2cccc(NC(=O)C=C)c2)c2cncnc12 Show InChI InChI=1S/C17H17N5O/c1-4-15(23)20-13-7-5-6-12(8-13)16-14-9-18-10-19-17(14)22(21-16)11(2)3/h4-11H,1H2,2-3H3,(H,20,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	8.0	n/a
The Regents of the University of California US Patent					Assay Description In vitro kinase assays for c-Src variants were performed in 50 mM Tris (pH 8.0), 10 mM MgCl2 and 1 mg/mL BSA. When obtaining kinetic parameters (kcat...				US Patent US9353116 (2016) BindingDB Entry DOI: 10.7270/Q2V123N7
					More data for this Ligand-Target Pair