Compile Data Set for Download or QSAR

Found 360 hits of ec50 for UniProtKB: P29597   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Non-receptor tyrosine-protein kinase TYK2 [575-869] (Homo sapiens (Human))	BDBM500309 (US11021475, Example 147) Show SMILES CNC(=O)c1nnc(Nc2ccccn2)cc1Nc1cccc(-c2nnn(C)n2)c1OC Show InChI InChI=1S/C20H20N10O2/c1-21-20(31)17-14(11-16(25-26-17)24-15-9-4-5-10-22-15)23-13-8-6-7-12(18(13)32-3)19-27-29-30(2)28-19/h4-11H,1-3H3,(H,21,31)(H2,22,23,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.877	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The probe displacement assay is conducted as follows: In a 385 well plate, test compounds along with recombinantly expressed His-tagged protein corre...				US Patent US11021475 (2021) BindingDB Entry DOI: 10.7270/Q2S75KGC
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [575-869] (Homo sapiens (Human))	BDBM500296 (US11021475, Example 84) Show SMILES CNC(=O)c1nnc(Nc2cc(ccn2)C(C)O)cc1Nc1cccc(-c2ncn(C)n2)c1OC Show InChI InChI=1S/C23H25N9O3/c1-13(33)14-8-9-25-18(10-14)28-19-11-17(20(30-29-19)23(34)24-2)27-16-7-5-6-15(21(16)35-4)22-26-12-32(3)31-22/h5-13,33H,1-4H3,(H,24,34)(H2,25,27,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.28	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The probe displacement assay is conducted as follows: In a 385 well plate, test compounds along with recombinantly expressed His-tagged protein corre...				US Patent US11021475 (2021) BindingDB Entry DOI: 10.7270/Q2S75KGC
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [575-869] (Homo sapiens (Human))	BDBM500301 (US11021475, Example 108) Show SMILES CNC(=O)c1nnc(Nc2cc(C)nc(C)n2)cc1Nc1cccc(-c2ncn(C)n2)c1OC Show InChI InChI=1S/C22H24N10O2/c1-12-9-17(26-13(2)25-12)28-18-10-16(19(30-29-18)22(33)23-3)27-15-8-6-7-14(20(15)34-5)21-24-11-32(4)31-21/h6-11H,1-5H3,(H,23,33)(H2,25,26,27,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.46	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The probe displacement assay is conducted as follows: In a 385 well plate, test compounds along with recombinantly expressed His-tagged protein corre...				US Patent US11021475 (2021) BindingDB Entry DOI: 10.7270/Q2S75KGC
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [575-869] (Homo sapiens (Human))	BDBM500300 (US11021475, Example 102) Show SMILES CNC(=O)c1nnc(Nc2ccc(CO)cn2)cc1Nc1cccc(-c2ncn(C)n2)c1OC Show InChI InChI=1S/C22H23N9O3/c1-23-22(33)19-16(9-18(28-29-19)27-17-8-7-13(11-32)10-24-17)26-15-6-4-5-14(20(15)34-3)21-25-12-31(2)30-21/h4-10,12,32H,11H2,1-3H3,(H,23,33)(H2,24,26,27,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.59	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The probe displacement assay is conducted as follows: In a 385 well plate, test compounds along with recombinantly expressed His-tagged protein corre...				US Patent US11021475 (2021) BindingDB Entry DOI: 10.7270/Q2S75KGC
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [575-869] (Homo sapiens (Human))	BDBM500289 (US11021475, Example 61 | US11021475, Example 76) Show SMILES CNC(=O)c1nnc(Nc2ccccn2)cc1Nc1cccc(-c2ncn(C)n2)c1OC Show InChI InChI=1S/C21H21N9O2/c1-22-21(31)18-15(11-17(27-28-18)26-16-9-4-5-10-23-16)25-14-8-6-7-13(19(14)32-3)20-24-12-30(2)29-20/h4-12H,1-3H3,(H,22,31)(H2,23,25,26,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.66	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The probe displacement assay is conducted as follows: In a 385 well plate, test compounds along with recombinantly expressed His-tagged protein corre...				US Patent US11021475 (2021) BindingDB Entry DOI: 10.7270/Q2S75KGC
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [575-869] (Homo sapiens (Human))	BDBM500308 (US11021475, Example 146) Show SMILES CNC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2nnn(C)n2)c1OC Show InChI InChI=1S/C19H21N9O3/c1-20-19(30)15-13(9-14(23-24-15)22-18(29)10-7-8-10)21-12-6-4-5-11(16(12)31-3)17-25-27-28(2)26-17/h4-6,9-10H,7-8H2,1-3H3,(H,20,30)(H2,21,22,23,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.70	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The probe displacement assay is conducted as follows: In a 385 well plate, test compounds along with recombinantly expressed His-tagged protein corre...				US Patent US11021475 (2021) BindingDB Entry DOI: 10.7270/Q2S75KGC
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [575-869] (Homo sapiens (Human))	BDBM500299 (US11021475, Example 94) Show SMILES CNC(=O)c1nnc(Nc2ccncn2)cc1Nc1cccc(-c2ncn(C)n2)c1OC Show InChI InChI=1S/C20H20N10O2/c1-21-20(31)17-14(9-16(27-28-17)26-15-7-8-22-10-23-15)25-13-6-4-5-12(18(13)32-3)19-24-11-30(2)29-19/h4-11H,1-3H3,(H,21,31)(H2,22,23,25,26,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.72	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The probe displacement assay is conducted as follows: In a 385 well plate, test compounds along with recombinantly expressed His-tagged protein corre...				US Patent US11021475 (2021) BindingDB Entry DOI: 10.7270/Q2S75KGC
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [575-869] (Homo sapiens (Human))	BDBM500303 (US11021475, Example 114) Show SMILES CNC(=O)c1nnc(Nc2cc(C)nc(COC)n2)cc1Nc1cccc(-c2ncn(C)n2)c1OC Show InChI InChI=1S/C23H26N10O3/c1-13-9-17(29-19(26-13)11-35-4)28-18-10-16(20(31-30-18)23(34)24-2)27-15-8-6-7-14(21(15)36-5)22-25-12-33(3)32-22/h6-10,12H,11H2,1-5H3,(H,24,34)(H2,26,27,28,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.89	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The probe displacement assay is conducted as follows: In a 385 well plate, test compounds along with recombinantly expressed His-tagged protein corre...				US Patent US11021475 (2021) BindingDB Entry DOI: 10.7270/Q2S75KGC
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [575-869] (Homo sapiens (Human))	BDBM500302 (US11021475, Example 112) Show SMILES CNC(=O)c1nnc(Nc2cnccn2)cc1Nc1cccc(-c2ncccn2)c1OC Show InChI InChI=1S/C21H19N9O2/c1-22-21(31)18-15(11-16(29-30-18)28-17-12-23-9-10-24-17)27-14-6-3-5-13(19(14)32-2)20-25-7-4-8-26-20/h3-12H,1-2H3,(H,22,31)(H2,24,27,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.94	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The probe displacement assay is conducted as follows: In a 385 well plate, test compounds along with recombinantly expressed His-tagged protein corre...				US Patent US11021475 (2021) BindingDB Entry DOI: 10.7270/Q2S75KGC
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [575-869] (Homo sapiens (Human))	BDBM500298 (US11021475, Example 87) Show SMILES CNC(=O)c1nnc(Nc2cc(OC)nc(C)n2)cc1Nc1cccc(-c2ncn(C)n2)c1OC Show InChI InChI=1S/C22H24N10O3/c1-12-25-16(10-18(26-12)34-4)28-17-9-15(19(30-29-17)22(33)23-2)27-14-8-6-7-13(20(14)35-5)21-24-11-32(3)31-21/h6-11H,1-5H3,(H,23,33)(H2,25,26,27,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.02	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The probe displacement assay is conducted as follows: In a 385 well plate, test compounds along with recombinantly expressed His-tagged protein corre...				US Patent US11021475 (2021) BindingDB Entry DOI: 10.7270/Q2S75KGC
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM50434787 (CHEMBL2386635 | US10487083, Example C | US10703751...) Show SMILES C[C@@H](O)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 |r,wU:18.21,wD:15.17,1.1,(49.07,-5.95,;48.31,-7.29,;46.77,-7.3,;49.09,-8.62,;48.48,-10.02,;49.62,-11.04,;49.62,-12.58,;50.95,-13.35,;52.28,-12.58,;53.75,-13.05,;54.65,-11.81,;53.75,-10.56,;52.28,-11.04,;50.94,-10.26,;50.61,-8.77,;51.68,-7.66,;53.17,-8.05,;54.24,-6.95,;53.83,-5.47,;54.9,-4.37,;56.39,-4.75,;57.88,-5.12,;52.34,-5.09,;51.26,-6.19,)| Show InChI InChI=1S/C18H21N5O/c1-11(24)18-22-15-10-21-17-14(7-9-20-17)16(15)23(18)13-4-2-12(3-5-13)6-8-19/h7,9-13,24H,2-6H2,1H3,(H,20,21)/t11-,12-,13-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	US Patent	n/a	n/a	n/a	n/a	3.32	n/a	n/a	n/a	n/a
Leo Pharma A/S US Patent					Assay Description Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...				US Patent US10703751 (2020) BindingDB Entry DOI: 10.7270/Q2DN4832
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM466496 (US10799507, Example 162 | [3-(Hydroxymethyl)-1,1-D...) Show SMILES OCC1(COC(=O)[C@H]2CCN(CC22CC2)c2ncnc3[nH]ccc23)CS(=O)(=O)C1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.60	n/a	n/a	n/a	n/a
Leo Pharma A/S US Patent					Assay Description Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...				US Patent US10799507 (2020) BindingDB Entry DOI: 10.7270/Q2VM4GBC
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM466343 ((8S)-N-[(2S)-2- cyclopentyl-2- hydroxy-ethyl]-5- (...) Show SMILES O[C@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)C1CCCC1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.60	n/a	n/a	n/a	n/a
Leo Pharma A/S US Patent					Assay Description Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...				US Patent US10799507 (2020) BindingDB Entry DOI: 10.7270/Q2VM4GBC
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM466494 (US10799507, Example 160 | [3,3-Difluoro-1-(Hydroxy...) Show SMILES OCC1(COC(=O)[C@H]2CCN(CC22CC2)c2ncnc3[nH]ccc23)CC(F)(F)C1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.70	n/a	n/a	n/a	n/a
Leo Pharma A/S US Patent					Assay Description Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...				US Patent US10799507 (2020) BindingDB Entry DOI: 10.7270/Q2VM4GBC
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM50530404 (CHEMBL4279883) Show SMILES CNc1cc(Nc2cc(F)cc(F)c2OC)nn2c(cnc12)C(=O)NC[C@](C)(O)CO |r| Show InChI InChI=1S/C19H22F2N6O4/c1-19(30,9-28)8-24-18(29)14-7-23-17-13(22-2)6-15(26-27(14)17)25-12-5-10(20)4-11(21)16(12)31-3/h4-7,22,28,30H,8-9H2,1-3H3,(H,24,29)(H,25,26)/t19-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	3.80	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of TYK2 JH2 (unknown origin) by Scintillation proximity assay				J Med Chem 62: 8953-8972 (2019) Article DOI: 10.1021/acs.jmedchem.9b00443 BindingDB Entry DOI: 10.7270/Q2W95DMQ
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM50530404 (CHEMBL4279883) Show SMILES CNc1cc(Nc2cc(F)cc(F)c2OC)nn2c(cnc12)C(=O)NC[C@](C)(O)CO |r| Show InChI InChI=1S/C19H22F2N6O4/c1-19(30,9-28)8-24-18(29)14-7-23-17-13(22-2)6-15(26-27(14)17)25-12-5-10(20)4-11(21)16(12)31-3/h4-7,22,28,30H,8-9H2,1-3H3,(H,24,29)(H,25,26)/t19-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	3.80	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of TYK2 JH2 (unknown origin) by Scintillation proximity assay				J Med Chem 62: 8953-8972 (2019) Article DOI: 10.1021/acs.jmedchem.9b00443 BindingDB Entry DOI: 10.7270/Q2W95DMQ
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM466346 ((8S)-N-[(2S)-2- cyclohexyl-2- hydroxy-ethyl]-5- (7...) Show SMILES O[C@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)C1CCCCC1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	4	n/a	n/a	n/a	n/a
Leo Pharma A/S US Patent					Assay Description Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...				US Patent US10799507 (2020) BindingDB Entry DOI: 10.7270/Q2VM4GBC
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM466484 ((8S)-N-[(1S,2S)-2- (3,4- difluorophenyl)-2- hydrox...) Show SMILES C[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)[C@@H](O)c1ccc(F)c(F)c1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	4.20	n/a	n/a	n/a	n/a
Leo Pharma A/S US Patent					Assay Description Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...				US Patent US10799507 (2020) BindingDB Entry DOI: 10.7270/Q2VM4GBC
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM466344 ((8S)-N-(2- cyclohexyl-2- hydroxy-ethyl)-5- (7H-pyr...) Show SMILES OC(CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)C1CCCCC1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	4.60	n/a	n/a	n/a	n/a
Leo Pharma A/S US Patent					Assay Description Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...				US Patent US10799507 (2020) BindingDB Entry DOI: 10.7270/Q2VM4GBC
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM466349 ((8S)-N-[(2S)-2-(4- fluorophenyl)-2- hydroxy-ethyl]...) Show SMILES O[C@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)c1ccc(F)cc1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	4.90	n/a	n/a	n/a	n/a
Leo Pharma A/S US Patent					Assay Description Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...				US Patent US10799507 (2020) BindingDB Entry DOI: 10.7270/Q2VM4GBC
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM633338 (US20190276450, Example 17.5) Show SMILES CO[C@]1(CCOC1)c1cc(C)cc(n1)-c1cn([C@@H]2C[C@@H](C2)C#N)c2cnc(NC(C)=O)cc12 |r,wU:17.18,19.23,wD:2.1,(2.69,7.81,;2.29,6.32,;.8,5.92,;1.28,7.39,;.03,8.29,;-1.22,7.39,;-.74,5.92,;1.89,4.83,;3.38,5.23,;4.47,4.14,;5.95,4.54,;4.07,2.65,;2.58,2.26,;1.49,3.34,;2.18,.77,;3.09,-.48,;2.18,-1.72,;2.58,-3.21,;1.81,-4.55,;3.14,-5.32,;3.91,-3.98,;3.54,-6.8,;3.94,-8.29,;.72,-1.25,;-.62,-2.02,;-1.95,-1.25,;-1.95,.29,;-3.29,1.06,;-4.62,.29,;-5.95,1.06,;-4.62,-1.25,;-.62,1.06,;.72,.29,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5	n/a	n/a	n/a	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent									US Patent US9616059 (2017) BindingDB Entry DOI: 10.7270/Q2TT4T0S
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM50193995 (3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...) Show SMILES C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N |r| Show InChI InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	n/a	n/a	<5	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00335 BindingDB Entry DOI: 10.7270/Q2RF601N
					More data for this Ligand-Target Pair				3D Structure (crystal)
Non-receptor tyrosine-protein kinase TYK2 [575-869] (Homo sapiens (Human))	BDBM500318 (US11021475, Example 188) Show SMILES CNC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2cnn(CC(F)F)c2)c1OC Show InChI InChI=1S/C22H23F2N7O3/c1-25-22(33)19-16(8-18(29-30-19)28-21(32)12-6-7-12)27-15-5-3-4-14(20(15)34-2)13-9-26-31(10-13)11-17(23)24/h3-5,8-10,12,17H,6-7,11H2,1-2H3,(H,25,33)(H2,27,28,29,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5.10	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The probe displacement assay is conducted as follows: In a 385 well plate, test compounds along with recombinantly expressed His-tagged protein corre...				US Patent US11021475 (2021) BindingDB Entry DOI: 10.7270/Q2S75KGC
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM466493 (US10799507, Example 159 | [1-(Hydroxymethyl)Cyclop...) Show SMILES OCC1(COC(=O)[C@H]2CCN(CC22CC2)c2ncnc3[nH]ccc23)CCCC1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5.10	n/a	n/a	n/a	n/a
Leo Pharma A/S US Patent					Assay Description Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...				US Patent US10799507 (2020) BindingDB Entry DOI: 10.7270/Q2VM4GBC
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [575-869] (Homo sapiens (Human))	BDBM500288 (US11021475, Example 52 | US11021475, Example 67 | ...) Show SMILES CNC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ncn(C)n2)c1OC Show InChI InChI=1S/C20H22N8O3/c1-21-20(30)16-14(9-15(25-26-16)24-19(29)11-7-8-11)23-13-6-4-5-12(17(13)31-3)18-22-10-28(2)27-18/h4-6,9-11H,7-8H2,1-3H3,(H,21,30)(H2,23,24,25,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	n/a	n/a	5.13	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The probe displacement assay is conducted as follows: In a 385 well plate, test compounds along with recombinantly expressed His-tagged protein corre...				US Patent US11021475 (2021) BindingDB Entry DOI: 10.7270/Q2S75KGC
					More data for this Ligand-Target Pair				3D Structure (crystal)
Non-receptor tyrosine-protein kinase TYK2 [575-869] (Homo sapiens (Human))	BDBM500293 (US11021475, Example 73) Show SMILES CNC(=O)c1nnc(Nc2ccccn2)cc1Nc1cccc(-c2nc(C)cs2)c1OC Show InChI InChI=1S/C22H21N7O2S/c1-13-12-32-22(25-13)14-7-6-8-15(20(14)31-3)26-16-11-18(27-17-9-4-5-10-24-17)28-29-19(16)21(30)23-2/h4-12H,1-3H3,(H,23,30)(H2,24,26,27,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5.21	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The probe displacement assay is conducted as follows: In a 385 well plate, test compounds along with recombinantly expressed His-tagged protein corre...				US Patent US11021475 (2021) BindingDB Entry DOI: 10.7270/Q2S75KGC
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [575-869] (Homo sapiens (Human))	BDBM500292 (US11021475, Example 70) Show SMILES CNC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ncccn2)c1OC Show InChI InChI=1S/C21H21N7O3/c1-22-21(30)17-15(11-16(27-28-17)26-20(29)12-7-8-12)25-14-6-3-5-13(18(14)31-2)19-23-9-4-10-24-19/h3-6,9-12H,7-8H2,1-2H3,(H,22,30)(H2,25,26,27,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	n/a	n/a	5.22	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The probe displacement assay is conducted as follows: In a 385 well plate, test compounds along with recombinantly expressed His-tagged protein corre...				US Patent US11021475 (2021) BindingDB Entry DOI: 10.7270/Q2S75KGC
					More data for this Ligand-Target Pair				3D Structure (crystal)
Non-receptor tyrosine-protein kinase TYK2 [575-869] (Homo sapiens (Human))	BDBM500305 (US11021475, Example 134) Show SMILES CNC(=O)c1nnc(Nc2cc(NC(=O)C3CC3)nc(C)n2)cc1Nc1cccc(-c2ncn(C)n2)c1OC Show InChI InChI=1S/C25H27N11O3/c1-13-28-18(11-19(29-13)32-24(37)14-8-9-14)31-20-10-17(21(34-33-20)25(38)26-2)30-16-7-5-6-15(22(16)39-4)23-27-12-36(3)35-23/h5-7,10-12,14H,8-9H2,1-4H3,(H,26,38)(H3,28,29,30,31,32,33,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5.64	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The probe displacement assay is conducted as follows: In a 385 well plate, test compounds along with recombinantly expressed His-tagged protein corre...				US Patent US11021475 (2021) BindingDB Entry DOI: 10.7270/Q2S75KGC
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [575-869] (Homo sapiens (Human))	BDBM500316 (US11021475, Example 183) Show SMILES CNC(=O)c1nnc(Nc2cc(C)nc(C)n2)cc1Nc1cccc(-c2nc(C)n(C)n2)c1OC Show InChI InChI=1S/C23H26N10O2/c1-12-10-18(26-13(2)25-12)29-19-11-17(20(31-30-19)23(34)24-4)28-16-9-7-8-15(21(16)35-6)22-27-14(3)33(5)32-22/h7-11H,1-6H3,(H,24,34)(H2,25,26,28,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5.72	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The probe displacement assay is conducted as follows: In a 385 well plate, test compounds along with recombinantly expressed His-tagged protein corre...				US Patent US11021475 (2021) BindingDB Entry DOI: 10.7270/Q2S75KGC
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM475700 ((4aR,8aS)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimidin-4...) Show SMILES CC[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a
LEO Pharma A/S US Patent					Assay Description Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...				US Patent US10851116 (2020) BindingDB Entry DOI: 10.7270/Q24B34DG
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [575-869] (Homo sapiens (Human))	BDBM500289 (US11021475, Example 61 | US11021475, Example 76) Show SMILES CNC(=O)c1nnc(Nc2ccccn2)cc1Nc1cccc(-c2ncn(C)n2)c1OC Show InChI InChI=1S/C21H21N9O2/c1-22-21(31)18-15(11-17(27-28-18)26-16-9-4-5-10-23-16)25-14-8-6-7-13(19(14)32-3)20-24-12-30(2)29-20/h4-12H,1-3H3,(H,22,31)(H2,23,25,26,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6.17	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The probe displacement assay is conducted as follows: In a 385 well plate, test compounds along with recombinantly expressed His-tagged protein corre...				US Patent US11021475 (2021) BindingDB Entry DOI: 10.7270/Q2S75KGC
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [575-869] (Homo sapiens (Human))	BDBM500294 (US11021475, Example 75) Show SMILES CNC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2cnccn2)c1OC Show InChI InChI=1S/C21H21N7O3/c1-22-21(30)18-15(10-17(27-28-18)26-20(29)12-6-7-12)25-14-5-3-4-13(19(14)31-2)16-11-23-8-9-24-16/h3-5,8-12H,6-7H2,1-2H3,(H,22,30)(H2,25,26,27,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6.18	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The probe displacement assay is conducted as follows: In a 385 well plate, test compounds along with recombinantly expressed His-tagged protein corre...				US Patent US11021475 (2021) BindingDB Entry DOI: 10.7270/Q2S75KGC
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM466345 ((8S)-N-[(1S,2S)-2- cyclohexyl-2- hydroxy-1- methyl...) Show SMILES C[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)[C@@H](O)C1CCCCC1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6.20	n/a	n/a	n/a	n/a
Leo Pharma A/S US Patent					Assay Description Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...				US Patent US10799507 (2020) BindingDB Entry DOI: 10.7270/Q2VM4GBC
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM466347 ((8S)—N-[(1S,2S)-2-Cyclopentyl-2-Hydroxy-1-Methyl-E...) Show SMILES C[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)[C@@H](O)C1CCCC1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6.30	n/a	n/a	n/a	n/a
Leo Pharma A/S US Patent					Assay Description Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...				US Patent US10799507 (2020) BindingDB Entry DOI: 10.7270/Q2VM4GBC
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [575-869] (Homo sapiens (Human))	BDBM500314 (US11021475, Example 176) Show SMILES CNC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ncn(CC(F)F)n2)c1OC Show InChI InChI=1S/C21H22F2N8O3/c1-24-21(33)17-14(8-16(28-29-17)27-20(32)11-6-7-11)26-13-5-3-4-12(18(13)34-2)19-25-10-31(30-19)9-15(22)23/h3-5,8,10-11,15H,6-7,9H2,1-2H3,(H,24,33)(H2,26,27,28,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6.35	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The probe displacement assay is conducted as follows: In a 385 well plate, test compounds along with recombinantly expressed His-tagged protein corre...				US Patent US11021475 (2021) BindingDB Entry DOI: 10.7270/Q2S75KGC
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM466495 (US10799507, Example 161 | [1-(Hydroxymethyl)Cycloh...) Show SMILES OCC1(COC(=O)[C@H]2CCN(CC22CC2)c2ncnc3[nH]ccc23)CCCCC1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6.40	n/a	n/a	n/a	n/a
Leo Pharma A/S US Patent					Assay Description Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...				US Patent US10799507 (2020) BindingDB Entry DOI: 10.7270/Q2VM4GBC
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [575-869] (Homo sapiens (Human))	BDBM500288 (US11021475, Example 52 | US11021475, Example 67 | ...) Show SMILES CNC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ncn(C)n2)c1OC Show InChI InChI=1S/C20H22N8O3/c1-21-20(30)16-14(9-15(25-26-16)24-19(29)11-7-8-11)23-13-6-4-5-12(17(13)31-3)18-22-10-28(2)27-18/h4-6,9-11H,7-8H2,1-3H3,(H,21,30)(H2,23,24,25,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	n/a	n/a	6.53	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The probe displacement assay is conducted as follows: In a 385 well plate, test compounds along with recombinantly expressed His-tagged protein corre...				US Patent US11021475 (2021) BindingDB Entry DOI: 10.7270/Q2S75KGC
					More data for this Ligand-Target Pair				3D Structure (crystal)
Non-receptor tyrosine-protein kinase TYK2 [575-869] (Homo sapiens (Human))	BDBM500286 (US11021475, Example 16) Show SMILES CNC(=O)c1nnc(Nc2ccccn2)cc1Nc1ccccc1S(C)(=O)=O Show InChI InChI=1S/C18H18N6O3S/c1-19-18(25)17-13(21-12-7-3-4-8-14(12)28(2,26)27)11-16(23-24-17)22-15-9-5-6-10-20-15/h3-11H,1-2H3,(H,19,25)(H2,20,21,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	n/a	n/a	6.57	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The probe displacement assay is conducted as follows: In a 385 well plate, test compounds along with recombinantly expressed His-tagged protein corre...				US Patent US11021475 (2021) BindingDB Entry DOI: 10.7270/Q2S75KGC
					More data for this Ligand-Target Pair				3D Structure (crystal)
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM50530394 (CHEMBL4561663) Show SMILES NC(=O)c1ccccc1Nc1cc(Nc2ccc(F)cn2)ncc1C(N)=O Show InChI InChI=1S/C18H15FN6O2/c19-10-5-6-15(22-8-10)25-16-7-14(12(9-23-16)18(21)27)24-13-4-2-1-3-11(13)17(20)26/h1-9H,(H2,20,26)(H2,21,27)(H2,22,23,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	6.60	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of TYK2 JH2 (unknown origin) by Scintillation proximity assay				J Med Chem 62: 8953-8972 (2019) Article DOI: 10.1021/acs.jmedchem.9b00443 BindingDB Entry DOI: 10.7270/Q2W95DMQ
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM50530394 (CHEMBL4561663) Show SMILES NC(=O)c1ccccc1Nc1cc(Nc2ccc(F)cn2)ncc1C(N)=O Show InChI InChI=1S/C18H15FN6O2/c19-10-5-6-15(22-8-10)25-16-7-14(12(9-23-16)18(21)27)24-13-4-2-1-3-11(13)17(20)26/h1-9H,(H2,20,26)(H2,21,27)(H2,22,23,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	6.60	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of TYK2 JH2 (unknown origin) by Scintillation proximity assay				J Med Chem 62: 8953-8972 (2019) Article DOI: 10.1021/acs.jmedchem.9b00443 BindingDB Entry DOI: 10.7270/Q2W95DMQ
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [575-869] (Homo sapiens (Human))	BDBM500307 (US11021475, Example 142) Show SMILES CNC(=O)c1nnc(Nc2cc(C)c(F)cn2)cc1Nc1cccc(-c2n[nH]c(C)n2)c1OC Show InChI InChI=1S/C22H22FN9O2/c1-11-8-17(25-10-14(11)23)28-18-9-16(19(31-30-18)22(33)24-3)27-15-7-5-6-13(20(15)34-4)21-26-12(2)29-32-21/h5-10H,1-4H3,(H,24,33)(H,26,29,32)(H2,25,27,28,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6.95	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The probe displacement assay is conducted as follows: In a 385 well plate, test compounds along with recombinantly expressed His-tagged protein corre...				US Patent US11021475 (2021) BindingDB Entry DOI: 10.7270/Q2S75KGC
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [575-869] (Homo sapiens (Human))	BDBM500315 (US11021475, Example 181) Show SMILES CNC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2nc(C)n(C)n2)c1OC Show InChI InChI=1S/C21H24N8O3/c1-11-23-19(28-29(11)3)13-6-5-7-14(18(13)32-4)24-15-10-16(25-20(30)12-8-9-12)26-27-17(15)21(31)22-2/h5-7,10,12H,8-9H2,1-4H3,(H,22,31)(H2,24,25,26,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6.97	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The probe displacement assay is conducted as follows: In a 385 well plate, test compounds along with recombinantly expressed His-tagged protein corre...				US Patent US11021475 (2021) BindingDB Entry DOI: 10.7270/Q2S75KGC
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM466348 ((8S)-N-[(1S,2S)-2- (4-fluorophenyl)- 2-hydroxy-1- ...) Show SMILES C[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)[C@@H](O)c1ccc(F)cc1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	7	n/a	n/a	n/a	n/a
Leo Pharma A/S US Patent					Assay Description Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...				US Patent US10799507 (2020) BindingDB Entry DOI: 10.7270/Q2VM4GBC
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [575-869] (Homo sapiens (Human))	BDBM500312 (US11021475, Example 155) Show SMILES CNC(=O)c1nnc(Nc2ccccn2)cc1Nc1cccc(-c2nnc(C)s2)c1OC Show InChI InChI=1S/C21H20N8O2S/c1-12-26-29-21(32-12)13-7-6-8-14(19(13)31-3)24-15-11-17(25-16-9-4-5-10-23-16)27-28-18(15)20(30)22-2/h4-11H,1-3H3,(H,22,30)(H2,23,24,25,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	7.13	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The probe displacement assay is conducted as follows: In a 385 well plate, test compounds along with recombinantly expressed His-tagged protein corre...				US Patent US11021475 (2021) BindingDB Entry DOI: 10.7270/Q2S75KGC
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [575-869] (Homo sapiens (Human))	BDBM500287 (US11021475, Example 51) Show SMILES CNC(=O)c1nnc(Nc2cc(COC)ccn2)cc1Nc1ccccc1S(C)(=O)=O Show InChI InChI=1S/C20H22N6O4S/c1-21-20(27)19-15(23-14-6-4-5-7-16(14)31(3,28)29)11-18(25-26-19)24-17-10-13(12-30-2)8-9-22-17/h4-11H,12H2,1-3H3,(H,21,27)(H2,22,23,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	7.19	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The probe displacement assay is conducted as follows: In a 385 well plate, test compounds along with recombinantly expressed His-tagged protein corre...				US Patent US11021475 (2021) BindingDB Entry DOI: 10.7270/Q2S75KGC
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [575-869] (Homo sapiens (Human))	BDBM500310 (US11021475, Example 151) Show SMILES CNC(=O)c1nnc(Nc2ccccn2)cc1Nc1cccc(-c2nnc(C)o2)c1OC Show InChI InChI=1S/C21H20N8O3/c1-12-26-29-21(32-12)13-7-6-8-14(19(13)31-3)24-15-11-17(25-16-9-4-5-10-23-16)27-28-18(15)20(30)22-2/h4-11H,1-3H3,(H,22,30)(H2,23,24,25,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	7.22	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The probe displacement assay is conducted as follows: In a 385 well plate, test compounds along with recombinantly expressed His-tagged protein corre...				US Patent US11021475 (2021) BindingDB Entry DOI: 10.7270/Q2S75KGC
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [575-869] (Homo sapiens (Human))	BDBM500297 (US11021475, Example 85) Show SMILES CNC(=O)c1nnc(Nc2cc(C)n(C)n2)cc1Nc1cccc(-c2cnn(C)c2)c1OC Show InChI InChI=1S/C22H25N9O2/c1-13-9-19(29-31(13)4)26-18-10-17(20(28-27-18)22(32)23-2)25-16-8-6-7-15(21(16)33-5)14-11-24-30(3)12-14/h6-12H,1-5H3,(H,23,32)(H2,25,26,27,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	7.36	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The probe displacement assay is conducted as follows: In a 385 well plate, test compounds along with recombinantly expressed His-tagged protein corre...				US Patent US11021475 (2021) BindingDB Entry DOI: 10.7270/Q2S75KGC
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM466357 ((8S)-N-[(2R)-2- cyclohexyl-2- hydroxy-ethyl]-5- (7...) Show SMILES O[C@@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)C1CCCCC1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	7.40	n/a	n/a	n/a	n/a
Leo Pharma A/S US Patent					Assay Description Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...				US Patent US10799507 (2020) BindingDB Entry DOI: 10.7270/Q2VM4GBC
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM466351 ((8S)-N-[(1S,2S)-2- (4-fluorophenyl)- 2-hydroxy-1- ...) Show SMILES OC[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)[C@@H](O)c1ccc(F)cc1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	7.70	n/a	n/a	n/a	n/a
Leo Pharma A/S US Patent					Assay Description Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...				US Patent US10799507 (2020) BindingDB Entry DOI: 10.7270/Q2VM4GBC
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM633336 (US20190276450, Example 17.3) Show SMILES CO[C@]1(CCOC1)c1cc(cc(n1)-c1cn([C@@H]2C[C@@H](C2)C#N)c2cnc(NC(C)=O)cc12)C(F)F |r,wU:16.17,18.22,wD:2.1,(2.14,7.81,;1.74,6.32,;.26,5.92,;.73,7.39,;-.51,8.29,;-1.76,7.39,;-1.28,5.92,;1.34,4.83,;2.83,5.23,;3.92,4.14,;3.52,2.65,;2.03,2.26,;.95,3.34,;1.64,.77,;2.54,-.48,;1.64,-1.72,;2.03,-3.21,;1.26,-4.55,;2.6,-5.32,;3.37,-3.98,;3,-6.8,;3.4,-8.29,;.17,-1.25,;-1.16,-2.02,;-2.5,-1.25,;-2.5,.29,;-3.83,1.06,;-5.16,.29,;-6.5,1.06,;-5.16,-1.25,;-1.16,1.06,;.17,.29,;5.41,4.54,;6.5,3.45,;5.81,6.03,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent									US Patent US9616059 (2017) BindingDB Entry DOI: 10.7270/Q2TT4T0S
					More data for this Ligand-Target Pair

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