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Compile Data Set for Download or QSAR

Found 401 hits of ic50 data for polymerid = 9427,9428   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50539421
PNG
(CHEMBL4634355)
Show SMILES Oc1ccc2c(cc(=O)oc2c1O)-c1cc(O)c(O)c(O)c1
Show InChI InChI=1S/C15H10O7/c16-9-2-1-7-8(5-12(19)22-15(7)14(9)21)6-3-10(17)13(20)11(18)4-6/h1-5,16-18,20-21H
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n/an/a 0.25n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50405397
PNG
(CHEMBL2051983)
Show SMILES CO[C@H]1O[C@H](C)[C@@H](N[C@H]2C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C14H27NO9/c1-5-7(9(18)11(20)13(23-2)24-5)15-6-3-14(22,4-16)12(21)10(19)8(6)17/h5-13,15-22H,3-4H2,1-2H3/t5-,6+,7-,8+,9+,10-,11-,12+,13+,14+/m1/s1
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n/an/a 4.90n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against porcine maltase

J Med Chem 29: 1038-46 (1986)


BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50024137
PNG
(1-Hydroxymethyl-5-(2-hydroxy-2-phenyl-ethylamino)-...)
Show SMILES [H][C@](O)(CN[C@H]1C[C@](O)(CO)[C@H](O)[C@@H](O)[C@H]1O)c1ccccc1
Show InChI InChI=1S/C15H23NO6/c17-8-15(22)6-10(12(19)13(20)14(15)21)16-7-11(18)9-4-2-1-3-5-9/h1-5,10-14,16-22H,6-8H2/t10-,11-,12-,13-,14+,15-/m0/s1
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n/an/a 5.80n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against porcine maltase

J Med Chem 29: 1038-46 (1986)


BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50024119
PNG
(5-(2-Hydroxy-cyclohexylamino)-1-hydroxymethyl-cycl...)
Show SMILES OC[C@@]1(O)C[C@H](N[C@@H]2CCCC[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C13H25NO6/c15-6-13(20)5-8(10(17)11(18)12(13)19)14-7-3-1-2-4-9(7)16/h7-12,14-20H,1-6H2/t7-,8-,9-,10?,11-,12-,13?/m0/s1
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n/an/a 6.10n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against porcine maltase

J Med Chem 29: 1038-46 (1986)


BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50024124
PNG
(1-Hydroxymethyl-5-(2-hydroxy-1-phenyl-ethylamino)-...)
Show SMILES [H][C@@](CO)(N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O)c1ccccc1
Show InChI InChI=1S/C15H23NO6/c17-7-11(9-4-2-1-3-5-9)16-10-6-15(22,8-18)14(21)13(20)12(10)19/h1-5,10-14,16-22H,6-8H2/t10-,11-,12-,13+,14-,15-/m0/s1
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n/an/a 13n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against porcine maltase

J Med Chem 29: 1038-46 (1986)


BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50226273
PNG
(CHEMBL3349431)
Show SMILES OCN(CO)[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C9H19NO7/c11-2-9(17)1-5(10(3-12)4-13)6(14)7(15)8(9)16/h5-8,11-17H,1-4H2/t5-,6-,7+,8-,9-/m0/s1
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n/an/a 15n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against porcine maltase

J Med Chem 29: 1038-46 (1986)


BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50405395
PNG
(CHEMBL2051761)
Show SMILES C[C@H]1C[C@H](N)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C14H28N2O7/c1-5-2-6(15)9(18)11(20)8(5)16-7-3-14(23,4-17)13(22)12(21)10(7)19/h5-13,16-23H,2-4,15H2,1H3/t5-,6-,7-,8+,9-,10-,11-,12+,13-,14-/m0/s1
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n/an/a 28n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against porcine maltase

J Med Chem 29: 1038-46 (1986)


BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50259956
PNG
(2,6-Bis-hydroxymethyl-piperidine-3,4,5-triol | CHE...)
Show SMILES OC[C@H]1N[C@H](CO)[C@H](O)[C@@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C7H15NO5/c9-1-3-5(11)7(13)6(12)4(2-10)8-3/h3-13H,1-2H2/t3-,4-,5-,6+,7+/m1/s1
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n/an/a 40n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibitory activity measured against alpha-glucosidase of rice by colorimetric assay using the D-glucose oxidase-peroxidase method

J Med Chem 41: 2565-71 (1998)


Article DOI: 10.1021/jm970836l
BindingDB Entry DOI: 10.7270/Q25D8SHK
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM18351
PNG
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
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n/an/a 40n/an/an/an/an/an/a



Toyama Medical and Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibitory concentration against human alpha-glucosidase

J Med Chem 48: 2036-44 (2005)


Article DOI: 10.1021/jm0495881
BindingDB Entry DOI: 10.7270/Q2DF6S0M
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50024136
PNG
(5-(3,5-Di-tert-butyl-4-hydroxy-benzylamino)-1-hydr...)
Show SMILES CC(C)(C)c1cc(CN[C@H]2C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]2O)cc(c1O)C(C)(C)C |r|
Show InChI InChI=1S/C22H37NO6/c1-20(2,3)13-7-12(8-14(16(13)25)21(4,5)6)10-23-15-9-22(29,11-24)19(28)18(27)17(15)26/h7-8,15,17-19,23-29H,9-11H2,1-6H3/t15-,17?,18-,19-,22?/m0/s1
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n/an/a 43n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against porcine maltase

J Med Chem 29: 1038-46 (1986)


BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50405396
PNG
(CHEMBL2051762)
Show SMILES C[C@H]1C[C@H](O)[C@H](O)[C@@H](O)[C@H]1N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C14H27NO8/c1-5-2-7(17)10(19)11(20)8(5)15-6-3-14(23,4-16)13(22)12(21)9(6)18/h5-13,15-23H,2-4H2,1H3/t5-,6-,7-,8-,9-,10-,11-,12+,13-,14-/m0/s1
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n/an/a 68n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against porcine maltase

J Med Chem 29: 1038-46 (1986)


BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50405389
PNG
(CHEMBL2051982)
Show SMILES C[C@H]1C[C@@H](O)[C@H](O)[C@@H](O)[C@H]1N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C14H27NO8/c1-5-2-7(17)10(19)11(20)8(5)15-6-3-14(23,4-16)13(22)12(21)9(6)18/h5-13,15-23H,2-4H2,1H3/t5-,6-,7+,8-,9-,10-,11-,12+,13-,14-/m0/s1
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n/an/a 70n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against porcine maltase

J Med Chem 29: 1038-46 (1986)


BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50405393
PNG
(CHEMBL2051981)
Show SMILES CO[C@H]1O[C@H](CO)[C@@H](N[C@H]2C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C14H27NO10/c1-24-13-11(21)9(19)7(6(3-16)25-13)15-5-2-14(23,4-17)12(22)10(20)8(5)18/h5-13,15-23H,2-4H2,1H3/t5-,6+,7+,8-,9-,10+,11+,12-,13-,14-/m0/s1
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n/an/a 72n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against porcine maltase

J Med Chem 29: 1038-46 (1986)


BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50611854
PNG
(CHEMBL5271914)		PDB

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n/an/a 77n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50613821
PNG
(CHEMBL4854113)		PDB

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n/an/a 82n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50611832
PNG
(CHEMBL4856778)		PDB

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n/an/a 85n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50405387
PNG
(CHEMBL2051759)
Show SMILES CO[C@H]1O[C@H](CO)[C@H](N[C@H]2C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C14H27NO10/c1-24-13-11(21)9(19)7(6(3-16)25-13)15-5-2-14(23,4-17)12(22)10(20)8(5)18/h5-13,15-23H,2-4H2,1H3/t5-,6+,7-,8-,9-,10+,11+,12-,13-,14-/m0/s1
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n/an/a 100n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against porcine maltase

J Med Chem 29: 1038-46 (1986)


BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50024139
PNG
(1-Hydroxymethyl-5-phenethylamino-cyclohexane-1,2,3...)
Show SMILES OC[C@@]1(O)C[C@H](NCCc2ccccc2)[C@H](O)[C@@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C15H23NO5/c17-9-15(21)8-11(12(18)13(19)14(15)20)16-7-6-10-4-2-1-3-5-10/h1-5,11-14,16-21H,6-9H2/t11-,12?,13-,14-,15?/m0/s1
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n/an/a 100n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against porcine maltase

J Med Chem 29: 1038-46 (1986)


BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50613819
PNG
(CHEMBL3944972)		PDB

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n/an/a 120n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM18353
PNG
((2R,3R,4R,5S)-2-(hydroxymethyl)-1-methylpiperidine...)
Show SMILES CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C7H15NO4/c1-8-2-5(10)7(12)6(11)4(8)3-9/h4-7,9-12H,2-3H2,1H3/t4-,5+,6-,7-/m1/s1
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n/an/a 120n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of Glycosidases (maltase) in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method maltase

J Med Chem 38: 2349-56 (1995)


BindingDB Entry DOI: 10.7270/Q2N878T0
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50180584
PNG
(CHEMBL3814496)
Show SMILES [Cl-].OC[C@H](OCc1ccccc1[N+]([O-])=O)[C@H](O)C[S+]1C[C@@H](O)[C@H](O)[C@H]1CO |r|
Show InChI InChI=1S/C16H24NO8S.ClH/c18-5-14(25-7-10-3-1-2-4-11(10)17(23)24)12(20)8-26-9-13(21)16(22)15(26)6-19;/h1-4,12-16,18-22H,5-9H2;1H/q+1;/p-1/t12-,13-,14+,15-,16+,26?;/m1./s1
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n/an/a 150n/an/an/an/an/an/a



Kindai University

Curated by ChEMBL


Assay Description
Inhibition of human small intestine microsomal maltase using maltose as substrate incubated for 30 mins by glucose-oxidase method

Bioorg Med Chem 24: 3705-15 (2016)


Article DOI: 10.1016/j.bmc.2016.06.013
BindingDB Entry DOI: 10.7270/Q241700V
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM23406
PNG
((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...)
Show SMILES C[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@H](O[C@@H]3[C@@H](CO)OC(O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O |t:37|
Show InChI InChI=1S/C25H43NO18/c1-6-11(26-8-2-7(3-27)12(30)15(33)13(8)31)14(32)19(37)24(40-6)43-22-10(5-29)42-25(20(38)17(22)35)44-21-9(4-28)41-23(39)18(36)16(21)34/h2,6,8-39H,3-5H2,1H3/t6-,8+,9-,10-,11-,12-,13+,14+,15+,16-,17-,18-,19-,20-,21-,22-,23?,24-,25-/m1/s1
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n/an/a 172n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50613820
PNG
(CHEMBL4855744)		PDB

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n/an/a 186n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50024116
PNG
(1-Hydroxymethyl-5-(2-hydroxy-2-phenyl-ethylamino)-...)
Show SMILES [H][C@@](O)(CN[C@H]1C[C@](O)(CO)[C@H](O)[C@@H](O)[C@H]1O)c1ccccc1
Show InChI InChI=1S/C15H23NO6/c17-8-15(22)6-10(12(19)13(20)14(15)21)16-7-11(18)9-4-2-1-3-5-9/h1-5,10-14,16-22H,6-8H2/t10-,11+,12-,13-,14+,15-/m0/s1
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n/an/a 190n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against porcine maltase

J Med Chem 29: 1038-46 (1986)


BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50024120
PNG
(1-Hydroxymethyl-5-[(thiophen-2-ylmethyl)-amino]-cy...)
Show SMILES OC[C@@]1(O)C[C@H](NCc2cccs2)[C@H](O)[C@@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C12H19NO5S/c14-6-12(18)4-8(9(15)10(16)11(12)17)13-5-7-2-1-3-19-7/h1-3,8-11,13-18H,4-6H2/t8-,9?,10-,11-,12?/m0/s1
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n/an/a 200n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against porcine maltase

J Med Chem 29: 1038-46 (1986)


BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50024128
PNG
(5-(4-Bromo-benzylamino)-1-hydroxymethyl-cyclohexan...)
Show SMILES OC[C@@]1(O)C[C@H](NCc2ccc(Br)cc2)[C@H](O)[C@@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C14H20BrNO5/c15-9-3-1-8(2-4-9)6-16-10-5-14(21,7-17)13(20)12(19)11(10)18/h1-4,10-13,16-21H,5-7H2/t10-,11?,12-,13-,14?/m0/s1
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n/an/a 230n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against porcine maltase

J Med Chem 29: 1038-46 (1986)


BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50610724
PNG
(CHEMBL5280680)		PDB

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n/an/a 236n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50582512
PNG
(CHEMBL5082173)
Show SMILES COc1ccc(cc1)-c1oc2cc(OC)cc(OC)c2c(=O)c1OCCCCCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO |r|
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n/an/a 240n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alpha-glucosidase (unknown origin) preincubated for 5 mins followed by addition of pNPG substrate and measured after 30 mins by spectro...

Citation and Details

Article DOI: 10.1021/acs.jnatprod.1c00014
BindingDB Entry DOI: 10.7270/Q25M69K0
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50024114
PNG
(5-(Cyclohexylmethyl-amino)-1-hydroxymethyl-cyclohe...)
Show SMILES OC[C@@]1(O)C[C@H](NCC2CCCCC2)[C@H](O)[C@@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C14H27NO5/c16-8-14(20)6-10(11(17)12(18)13(14)19)15-7-9-4-2-1-3-5-9/h9-13,15-20H,1-8H2/t10-,11?,12-,13-,14?/m0/s1
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n/an/a 240n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against porcine maltase

J Med Chem 29: 1038-46 (1986)


BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50024133
PNG
(1-Hydroxymethyl-5-(3-phenyl-allylamino)-cyclohexan...)
Show SMILES OC[C@@]1(O)C[C@H](NC\C=C\c2ccccc2)[C@H](O)[C@@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C16H23NO5/c18-10-16(22)9-12(13(19)14(20)15(16)21)17-8-4-7-11-5-2-1-3-6-11/h1-7,12-15,17-22H,8-10H2/b7-4+/t12-,13?,14-,15-,16?/m0/s1
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n/an/a 270n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against porcine maltase

J Med Chem 29: 1038-46 (1986)


BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50024123
PNG
(1-Hydroxymethyl-5-(2-hydroxy-1-phenyl-ethylamino)-...)
Show SMILES [H][C@](CO)(N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O)c1ccccc1
Show InChI InChI=1S/C15H23NO6/c17-7-11(9-4-2-1-3-5-9)16-10-6-15(22,8-18)14(21)13(20)12(10)19/h1-5,10-14,16-22H,6-8H2/t10-,11+,12-,13+,14-,15-/m0/s1
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n/an/a 300n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against porcine maltase

J Med Chem 29: 1038-46 (1986)


BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50024126
PNG
(1-Hydroxymethyl-5-[(pyridin-3-ylmethyl)-amino]-cyc...)
Show SMILES OC[C@@]1(O)C[C@H](NCc2cccnc2)[C@H](O)[C@@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C13H20N2O5/c16-7-13(20)4-9(10(17)11(18)12(13)19)15-6-8-2-1-3-14-5-8/h1-3,5,9-12,15-20H,4,6-7H2/t9-,10?,11-,12-,13?/m0/s1
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n/an/a 330n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against porcine maltase

J Med Chem 29: 1038-46 (1986)


BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM18351
PNG
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
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n/an/a 360n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of Glycosidases (maltase) in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method

J Med Chem 38: 2349-56 (1995)


BindingDB Entry DOI: 10.7270/Q2N878T0
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50024117
PNG
(5-Cyclohexylamino-1-hydroxymethyl-cyclohexane-1,2,...)
Show SMILES OC[C@@]1(O)C[C@H](NC2CCCCC2)[C@H](O)[C@@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C13H25NO5/c15-7-13(19)6-9(10(16)11(17)12(13)18)14-8-4-2-1-3-5-8/h8-12,14-19H,1-7H2/t9-,10?,11-,12-,13?/m0/s1
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n/an/a 410n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against porcine maltase

J Med Chem 29: 1038-46 (1986)


BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50180583
PNG
(CHEMBL3815109)
Show SMILES [Cl-].CC(C)(C)CO[C@@H](CO)[C@H](O)C[S+]1C[C@@H](O)[C@H](O)[C@H]1CO |r|
Show InChI InChI=1S/C14H29O6S.ClH/c1-14(2,3)8-20-11(4-15)9(17)6-21-7-10(18)13(19)12(21)5-16;/h9-13,15-19H,4-8H2,1-3H3;1H/q+1;/p-1/t9-,10-,11+,12-,13+,21?;/m1./s1
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n/an/a 470n/an/an/an/an/an/a



Kindai University

Curated by ChEMBL


Assay Description
Inhibition of human small intestine microsomal maltase using maltose as substrate incubated for 30 mins by glucose-oxidase method

Bioorg Med Chem 24: 3705-15 (2016)


Article DOI: 10.1016/j.bmc.2016.06.013
BindingDB Entry DOI: 10.7270/Q241700V
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM223316
PNG
(YPYSCWVRH | piHA-Dm)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CS)N1SCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CO)C1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O |r|
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n/an/a 520n/an/an/an/a7.0n/a



The University of Tokyo



Assay Description
After kinetic analysis with HPA, piHA-Dm was tested as an inhibitor of ten additional enzymes. The conditions are listed as follows: Agrobacterium fa...

Cell Chem Biol 24: 381-390 (2017)


Article DOI: 10.1016/j.chembiol.2017.02.001
BindingDB Entry DOI: 10.7270/Q27D2T0M
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50024118
PNG
(5-(3,7-Dimethyl-octa-2,6-dienylamino)-1-hydroxymet...)
Show SMILES [#6]\[#6](-[#6])=[#6]/[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#7]-[#6@H]-1-[#6][C@]([#8])([#6]-[#8])[#6@@H](-[#8])-[#6@H](-[#8])-[#6@H]-1-[#8] |r|
Show InChI InChI=1S/C17H31NO5/c1-11(2)5-4-6-12(3)7-8-18-13-9-17(23,10-19)16(22)15(21)14(13)20/h5,7,13-16,18-23H,4,6,8-10H2,1-3H3/b12-7+/t13-,14?,15-,16-,17?/m0/s1
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n/an/a 520n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against porcine maltase

J Med Chem 29: 1038-46 (1986)


BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50024140
PNG
(5-(2-Hydroxy-1-hydroxymethyl-ethylamino)-1-hydroxy...)
Show SMILES OCC(CO)N[C@H]1C[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C10H21NO7/c12-2-5(3-13)11-6-1-10(18,4-14)9(17)8(16)7(6)15/h5-9,11-18H,1-4H2/t6-,7?,8-,9-,10?/m0/s1
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n/an/a 550n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against porcine maltase

J Med Chem 29: 1038-46 (1986)


BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50180580
PNG
(CHEMBL3814911)
Show SMILES [Cl-].CCCCCCCO[C@@H](CO)[C@H](O)C[S+]1C[C@@H](O)[C@H](O)[C@H]1CO |r|
Show InChI InChI=1S/C16H33O6S.ClH/c1-2-3-4-5-6-7-22-14(8-17)12(19)10-23-11-13(20)16(21)15(23)9-18;/h12-21H,2-11H2,1H3;1H/q+1;/p-1/t12-,13-,14+,15-,16+,23?;/m1./s1
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n/an/a 640n/an/an/an/an/an/a



Kindai University

Curated by ChEMBL


Assay Description
Inhibition of human small intestine microsomal maltase using maltose as substrate incubated for 30 mins by glucose-oxidase method

Bioorg Med Chem 24: 3705-15 (2016)


Article DOI: 10.1016/j.bmc.2016.06.013
BindingDB Entry DOI: 10.7270/Q241700V
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50613842
PNG
(CHEMBL5290630)		PDB

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n/an/a 645n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50405388
PNG
(CHEMBL2051760)
Show SMILES CO[C@H]1O[C@H](C)[C@H](N[C@H]2C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C14H27NO9/c1-5-7(9(18)11(20)13(23-2)24-5)15-6-3-14(22,4-16)12(21)10(19)8(6)17/h5-13,15-22H,3-4H2,1-2H3/t5-,6+,7+,8+,9+,10-,11-,12+,13+,14+/m1/s1
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n/an/a 650n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against porcine maltase

J Med Chem 29: 1038-46 (1986)


BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50180582
PNG
(CHEMBL3814988)
Show SMILES [Cl-].CC(C)CO[C@@H](CO)[C@H](O)C[S+]1C[C@@H](O)[C@H](O)[C@H]1CO |r|
Show InChI InChI=1S/C13H27O6S.ClH/c1-8(2)5-19-11(3-14)9(16)6-20-7-10(17)13(18)12(20)4-15;/h8-18H,3-7H2,1-2H3;1H/q+1;/p-1/t9-,10-,11+,12-,13+,20?;/m1./s1
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n/an/a 690n/an/an/an/an/an/a



Kindai University

Curated by ChEMBL


Assay Description
Inhibition of human small intestine microsomal maltase using maltose as substrate incubated for 30 mins by glucose-oxidase method

Bioorg Med Chem 24: 3705-15 (2016)


Article DOI: 10.1016/j.bmc.2016.06.013
BindingDB Entry DOI: 10.7270/Q241700V
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50614755
PNG
(CHEMBL5271502)		PDB

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n/an/a 700n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50065255
PNG
((R)-2,6-Bis-hydroxymethyl-piperidine-3,4,5-triol |...)
Show SMILES OCC1NC(CO)[C@@H](O)C(O)C1O
Show InChI InChI=1S/C7H15NO5/c9-1-3-5(11)7(13)6(12)4(2-10)8-3/h3-13H,1-2H2/t3?,4?,5-,6?,7?/m1/s1
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n/an/a 700n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibitory activity measured against alpha-glucosidase of rice by colorimetric assay using the D-glucose oxidase-peroxidase method

J Med Chem 41: 2565-71 (1998)


Article DOI: 10.1021/jm970836l
BindingDB Entry DOI: 10.7270/Q25D8SHK
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50598568
PNG
(CHEMBL5175772)
Show SMILES Cc1cc-2c(-c3c(O)c4cccc(O)c4c4oc(=O)c(c-2c34)-c2ccc(O)cc2)c(O)c1
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n/an/a 890n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c00626
BindingDB Entry DOI: 10.7270/Q2SJ1QP9
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM23406
PNG
((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...)
Show SMILES C[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@H](O[C@@H]3[C@@H](CO)OC(O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O |t:37|
Show InChI InChI=1S/C25H43NO18/c1-6-11(26-8-2-7(3-27)12(30)15(33)13(8)31)14(32)19(37)24(40-6)43-22-10(5-29)42-25(20(38)17(22)35)44-21-9(4-28)41-23(39)18(36)16(21)34/h2,6,8-39H,3-5H2,1H3/t6-,8+,9-,10-,11-,12-,13+,14+,15+,16-,17-,18-,19-,20-,21-,22-,23?,24-,25-/m1/s1
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n/an/a 900n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50180520
PNG
(CHEMBL3814838)
Show SMILES [Cl-].CCO[C@@H](CO)[C@H](O)C[S+]1C[C@@H](O)[C@H](O)[C@H]1CO |r|
Show InChI InChI=1S/C11H23O6S.ClH/c1-2-17-9(3-12)7(14)5-18-6-8(15)11(16)10(18)4-13;/h7-16H,2-6H2,1H3;1H/q+1;/p-1/t7-,8-,9+,10-,11+,18?;/m1./s1
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n/an/a 960n/an/an/an/an/an/a



Kindai University

Curated by ChEMBL


Assay Description
Inhibition of human small intestine microsomal maltase using maltose as substrate incubated for 30 mins by glucose-oxidase method

Bioorg Med Chem 24: 3705-15 (2016)


Article DOI: 10.1016/j.bmc.2016.06.013
BindingDB Entry DOI: 10.7270/Q241700V
More data for this
Ligand-Target Pair
Soluble maltase-glucoamylase


(Mus musculus (Mouse))		BDBM223316
PNG
(YPYSCWVRH | piHA-Dm)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CS)N1SCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CO)C1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O |r|
UniProtKB/TrEMBL

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n/an/a 990n/an/an/an/a7.0n/a



The University of Tokyo



Assay Description
After kinetic analysis with HPA, piHA-Dm was tested as an inhibitor of ten additional enzymes. The conditions are listed as follows: Agrobacterium fa...

Cell Chem Biol 24: 381-390 (2017)


Article DOI: 10.1016/j.chembiol.2017.02.001
BindingDB Entry DOI: 10.7270/Q27D2T0M
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50573734
PNG
(CHEMBL4856375)
Show SMILES Cl.C[C@]1(CO)NC[C@H](O)[C@@H](O)[C@@H]1O |r|
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human alpha-glucosidase

Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113716
BindingDB Entry DOI: 10.7270/Q27W6H1P
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))		BDBM50065252
PNG
(2,6-Bis-hydroxymethyl-1-methyl-piperidine-3,4,5-tr...)
Show SMILES CN1[C@H](CO)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1CO |r|
Show InChI InChI=1S/C8H17NO5/c1-9-4(2-10)6(12)8(14)7(13)5(9)3-11/h4-8,10-14H,2-3H2,1H3/t4-,5-,6-,7+,8+/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibitory activity measured against alpha-glucosidase of rice by colorimetric assay using the D-glucose oxidase-peroxidase method

J Med Chem 41: 2565-71 (1998)


Article DOI: 10.1021/jm970836l
BindingDB Entry DOI: 10.7270/Q25D8SHK
More data for this
Ligand-Target Pair
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