Compile Data Set for Download or QSAR

Found 72 hits of ic50 for UniProtKB: P16234   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM472775 (US10829493, Example 1) Show SMILES CC(C)(O)Cn1cc(cn1)-c1cc2c(N)ncnn2c1 Show InChI InChI=1S/C13H16N6O/c1-13(2,20)7-18-5-10(4-16-18)9-3-11-12(14)15-8-17-19(11)6-9/h3-6,8,20H,7H2,1-2H3,(H2,14,15,17)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.300	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM469288 (US10807985, Compound 63 | US10829493, Example 63 o...) Show SMILES CCn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(N)c1ccc(F)cc1 |r| Show InChI InChI=1S/C27H29FN10/c1-3-37-16-20(13-33-37)19-12-24-25(32-18-34-38(24)17-19)35-8-10-36(11-9-35)26-30-14-22(15-31-26)27(2,29)21-4-6-23(28)7-5-21/h4-7,12-18H,3,8-11,29H2,1-2H3/t27-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.300	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM472777 (US10829493, Example 3) Show SMILES C[C@@H](O)Cn1cc(cn1)-c1cc2c(N)ncnn2c1 |r| Show InChI InChI=1S/C12H14N6O/c1-8(19)4-17-5-10(3-15-17)9-2-11-12(13)14-7-16-18(11)6-9/h2-3,5-8,19H,4H2,1H3,(H2,13,14,16)/t8-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.300	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM472778 (US10829493, Example 4) Show SMILES Nc1ncnn2cc(cc12)-c1cnn(CCO)c1 Show InChI InChI=1S/C11H12N6O/c12-11-10-3-8(6-17(10)15-7-13-11)9-4-14-16(5-9)1-2-18/h3-7,18H,1-2H2,(H2,12,13,15)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.300	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM472779 (US10829493, Example 5) Show SMILES C[C@H](CO)n1cc(cn1)-c1cc2c(N)ncnn2c1 |r| Show InChI InChI=1S/C12H14N6O/c1-8(6-19)17-5-10(3-15-17)9-2-11-12(13)14-7-16-18(11)4-9/h2-5,7-8,19H,6H2,1H3,(H2,13,14,16)/t8-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.300	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM472780 (US10829493, Example 6) Show SMILES C[C@@H](CO)n1cc(cn1)-c1cc2c(N)ncnn2c1 |r| Show InChI InChI=1S/C12H14N6O/c1-8(6-19)17-5-10(3-15-17)9-2-11-12(13)14-7-16-18(11)4-9/h2-5,7-8,19H,6H2,1H3,(H2,13,14,16)/t8-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.300	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM472781 (US10829493, Example 7) Show SMILES Nc1ncnn2cc(cc12)-c1cnn(c1)C1COC1 Show InChI InChI=1S/C12H12N6O/c13-12-11-1-8(3-18(11)16-7-14-12)9-2-15-17(4-9)10-5-19-6-10/h1-4,7,10H,5-6H2,(H2,13,14,16)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.300	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM472782 (US10829493, Example 8) Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(CC2COC2)c1 |r| Show InChI InChI=1S/C29H31FN10O/c1-29(31,23-2-4-25(30)5-3-23)24-12-32-28(33-13-24)38-8-6-37(7-9-38)27-26-10-21(16-40(26)36-19-34-27)22-11-35-39(15-22)14-20-17-41-18-20/h2-5,10-13,15-16,19-20H,6-9,14,17-18,31H2,1H3/t29-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.300	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM472783 (US10829493, Example 9) Show SMILES C[C@H](O)Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(N)c1ccc(F)cc1 |r| Show InChI InChI=1S/C28H31FN10O/c1-19(40)15-38-16-21(12-34-38)20-11-25-26(33-18-35-39(25)17-20)36-7-9-37(10-8-36)27-31-13-23(14-32-27)28(2,30)22-3-5-24(29)6-4-22/h3-6,11-14,16-19,40H,7-10,15,30H2,1-2H3/t19-,28-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.300	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM472784 (US10829493, Example 10) Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)C1C[C@H](O)C1 |r,wU:1.0,38.44,wD:1.1,(2.18,-6.48,;3.27,-5.39,;1.78,-4.99,;4.6,-6.16,;4.6,-7.7,;5.93,-8.47,;7.27,-7.7,;8.6,-8.47,;7.27,-6.16,;5.93,-5.39,;3.27,-3.85,;1.93,-3.08,;1.93,-1.54,;3.27,-.77,;4.6,-1.54,;4.6,-3.08,;3.27,.77,;1.93,1.54,;1.93,3.08,;3.27,3.85,;4.6,3.08,;4.6,1.54,;3.27,5.39,;4.6,6.16,;4.6,7.7,;3.27,8.47,;1.93,7.7,;.47,8.18,;-.44,6.93,;.47,5.68,;1.93,6.16,;-1.98,6.93,;-2.88,8.18,;-4.35,7.7,;-4.35,6.16,;-2.88,5.68,;-5.59,5.25,;-7.11,5.5,;-7.36,3.97,;-8.6,3.07,;-5.83,3.73,)| Show InChI InChI=1S/C29H31FN10O/c1-29(31,21-2-4-23(30)5-3-21)22-14-32-28(33-15-22)38-8-6-37(7-9-38)27-26-10-19(16-40(26)36-18-34-27)20-13-35-39(17-20)24-11-25(41)12-24/h2-5,10,13-18,24-25,41H,6-9,11-12,31H2,1H3/t24?,25-,29-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.300	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM472785 (US10829493, Example 11) Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)C1C[C@H](O)C1 |r,wU:1.0,wD:1.1,38.44,(2.18,-6.48,;3.27,-5.39,;1.78,-4.99,;4.6,-6.16,;4.6,-7.7,;5.93,-8.47,;7.27,-7.7,;8.6,-8.47,;7.27,-6.16,;5.93,-5.39,;3.27,-3.85,;1.93,-3.08,;1.93,-1.54,;3.27,-.77,;4.6,-1.54,;4.6,-3.08,;3.27,.77,;1.93,1.54,;1.93,3.08,;3.27,3.85,;4.6,3.08,;4.6,1.54,;3.27,5.39,;4.6,6.16,;4.6,7.7,;3.27,8.47,;1.93,7.7,;.47,8.18,;-.44,6.93,;.47,5.68,;1.93,6.16,;-1.98,6.93,;-2.88,8.18,;-4.35,7.7,;-4.35,6.16,;-2.88,5.68,;-5.59,5.25,;-5.83,3.73,;-7.36,3.97,;-8.6,3.07,;-7.11,5.5,)| Show InChI InChI=1S/C29H31FN10O/c1-29(31,21-2-4-23(30)5-3-21)22-14-32-28(33-15-22)38-8-6-37(7-9-38)27-26-10-19(16-40(26)36-18-34-27)20-13-35-39(17-20)24-11-25(41)12-24/h2-5,10,13-18,24-25,41H,6-9,11-12,31H2,1H3/t24?,25-,29-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.300	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM472786 (US10829493, Example 12) Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(CC2(O)CC2)c1 |r| Show InChI InChI=1S/C29H31FN10O/c1-28(31,22-2-4-24(30)5-3-22)23-14-32-27(33-15-23)38-10-8-37(9-11-38)26-25-12-20(17-40(25)36-19-34-26)21-13-35-39(16-21)18-29(41)6-7-29/h2-5,12-17,19,41H,6-11,18,31H2,1H3/t28-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.300	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM472787 (US10829493, Example 13) Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)C1(CO)CC1 |r| Show InChI InChI=1S/C29H31FN10O/c1-28(31,22-2-4-24(30)5-3-22)23-14-32-27(33-15-23)38-10-8-37(9-11-38)26-25-12-20(16-39(25)36-19-34-26)21-13-35-40(17-21)29(18-41)6-7-29/h2-5,12-17,19,41H,6-11,18,31H2,1H3/t28-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.300	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM472788 (US10829493, Example 14) Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@@H]1CCOC1 |r| Show InChI InChI=1S/C29H31FN10O/c1-29(31,22-2-4-24(30)5-3-22)23-14-32-28(33-15-23)38-9-7-37(8-10-38)27-26-12-20(16-40(26)36-19-34-27)21-13-35-39(17-21)25-6-11-41-18-25/h2-5,12-17,19,25H,6-11,18,31H2,1H3/t25-,29+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.300	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM472789 (US10829493, Example 15) Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@H]1CCOC1 |r| Show InChI InChI=1S/C29H31FN10O/c1-29(31,22-2-4-24(30)5-3-22)23-14-32-28(33-15-23)38-9-7-37(8-10-38)27-26-12-20(16-40(26)36-19-34-27)21-13-35-39(17-21)25-6-11-41-18-25/h2-5,12-17,19,25H,6-11,18,31H2,1H3/t25-,29-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.300	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM472790 (US10829493, Example 16) Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)C1CCOCC1 |r| Show InChI InChI=1S/C30H33FN10O/c1-30(32,23-2-4-25(31)5-3-23)24-16-33-29(34-17-24)39-10-8-38(9-11-39)28-27-14-21(18-41(27)37-20-35-28)22-15-36-40(19-22)26-6-12-42-13-7-26/h2-5,14-20,26H,6-13,32H2,1H3/t30-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.300	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM472791 (US10829493, Example 17) Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@@H]1COC[C@@H]1O |r| Show InChI InChI=1S/C29H31FN10O2/c1-29(31,21-2-4-23(30)5-3-21)22-12-32-28(33-13-22)38-8-6-37(7-9-38)27-24-10-19(14-39(24)36-18-34-27)20-11-35-40(15-20)25-16-42-17-26(25)41/h2-5,10-15,18,25-26,41H,6-9,16-17,31H2,1H3/t25-,26+,29+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.300	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM472792 (US10829493, Example 18) Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@H]1COC[C@@H]1O |r| Show InChI InChI=1S/C29H31FN10O2/c1-29(31,21-2-4-23(30)5-3-21)22-12-32-28(33-13-22)38-8-6-37(7-9-38)27-24-10-19(14-39(24)36-18-34-27)20-11-35-40(15-20)25-16-42-17-26(25)41/h2-5,10-15,18,25-26,41H,6-9,16-17,31H2,1H3/t25-,26-,29-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.300	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM472793 (US10829493, Example 19) Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@@H]1COC[C@H]1O |r| Show InChI InChI=1S/C29H31FN10O2/c1-29(31,21-2-4-23(30)5-3-21)22-12-32-28(33-13-22)38-8-6-37(7-9-38)27-24-10-19(14-39(24)36-18-34-27)20-11-35-40(15-20)25-16-42-17-26(25)41/h2-5,10-15,18,25-26,41H,6-9,16-17,31H2,1H3/t25-,26-,29+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.300	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM472794 (US10829493, Example 20) Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@H]1COC[C@H]1O |r| Show InChI InChI=1S/C29H31FN10O2/c1-29(31,21-2-4-23(30)5-3-21)22-12-32-28(33-13-22)38-8-6-37(7-9-38)27-24-10-19(14-39(24)36-18-34-27)20-11-35-40(15-20)25-16-42-17-26(25)41/h2-5,10-15,18,25-26,41H,6-9,16-17,31H2,1H3/t25-,26+,29-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.300	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM472795 (US10829493, Example 21) Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@H]1CC[C@@H]1O |r| Show InChI InChI=1S/C29H31FN10O/c1-29(31,21-2-4-23(30)5-3-21)22-14-32-28(33-15-22)38-10-8-37(9-11-38)27-25-12-19(16-40(25)36-18-34-27)20-13-35-39(17-20)24-6-7-26(24)41/h2-5,12-18,24,26,41H,6-11,31H2,1H3/t24-,26-,29-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.300	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM472796 (US10829493, Example 22) Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(c1)[C@@H]1CC[C@H]1O |r| Show InChI InChI=1S/C29H31FN10O/c1-29(31,21-2-4-23(30)5-3-21)22-14-32-28(33-15-22)38-10-8-37(9-11-38)27-25-12-19(16-40(25)36-18-34-27)20-13-35-39(17-20)24-6-7-26(24)41/h2-5,12-18,24,26,41H,6-11,31H2,1H3/t24-,26-,29+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.300	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM472776 (US10829493, Example 2) Show SMILES CC(C)(CO)n1cc(cn1)-c1cc2c(N)ncnn2c1 Show InChI InChI=1S/C13H16N6O/c1-13(2,7-20)19-6-10(4-16-19)9-3-11-12(14)15-8-17-18(11)5-9/h3-6,8,20H,7H2,1-2H3,(H2,14,15,17)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.300	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...				US Patent US10829493 (2020) BindingDB Entry DOI: 10.7270/Q2MP56BZ
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM469232 (US10807985, Compound 7) Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(Cc2ccccc2)cn1 Show InChI InChI=1S/C25H25N9/c1-31-16-22(15-29-31)21-12-23-24(28-18-30-34(23)17-21)32-7-9-33(10-8-32)25-26-13-20(14-27-25)11-19-5-3-2-4-6-19/h2-6,12-18H,7-11H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...				US Patent US10807985 (2020) BindingDB Entry DOI: 10.7270/Q2F76GNN
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM469235 (US10807985, Compound 10) Show SMILES C[C@@H](c1ccccc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(C)c1 |r| Show InChI InChI=1S/C26H27N9/c1-19(20-6-4-3-5-7-20)22-13-27-26(28-14-22)34-10-8-33(9-11-34)25-24-12-21(17-35(24)31-18-29-25)23-15-30-32(2)16-23/h3-7,12-19H,8-11H2,1-2H3/t19-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...				US Patent US10807985 (2020) BindingDB Entry DOI: 10.7270/Q2F76GNN
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM469246 (US10807985, Compound 21) Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@](C)(N)c1ccccc1 |r| Show InChI InChI=1S/C26H28N10/c1-26(27,21-6-4-3-5-7-21)22-14-28-25(29-15-22)35-10-8-34(9-11-35)24-23-12-19(17-36(23)32-18-30-24)20-13-31-33(2)16-20/h3-7,12-18H,8-11,27H2,1-2H3/t26-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...				US Patent US10807985 (2020) BindingDB Entry DOI: 10.7270/Q2F76GNN
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM469247 (US10807985, Compound 22) Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(N)c1ccccc1 |r| Show InChI InChI=1S/C26H28N10/c1-26(27,21-6-4-3-5-7-21)22-14-28-25(29-15-22)35-10-8-34(9-11-35)24-23-12-19(17-36(23)32-18-30-24)20-13-31-33(2)16-20/h3-7,12-18H,8-11,27H2,1-2H3/t26-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...				US Patent US10807985 (2020) BindingDB Entry DOI: 10.7270/Q2F76GNN
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM469251 (US10807985, Compound 26) Show SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cn[nH]c1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...				US Patent US10807985 (2020) BindingDB Entry DOI: 10.7270/Q2F76GNN
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM469255 (US10807985, Compound 30) Show SMILES C[C@](O)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cn[nH]c1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...				US Patent US10807985 (2020) BindingDB Entry DOI: 10.7270/Q2F76GNN
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM469259 (US10807985, Compound 34) Show SMILES C[C@](N)(c1ccccc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1ccc(F)cc1 |r| Show InChI InChI=1S/C28H27FN8/c1-28(30,22-5-3-2-4-6-22)23-16-31-27(32-17-23)36-13-11-35(12-14-36)26-25-15-21(18-37(25)34-19-33-26)20-7-9-24(29)10-8-20/h2-10,15-19H,11-14,30H2,1H3/t28-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...				US Patent US10807985 (2020) BindingDB Entry DOI: 10.7270/Q2F76GNN
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM469260 (US10807985, Compound 35) Show SMILES CCn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(N)c1ccccc1 |r| Show InChI InChI=1S/C27H30N10/c1-3-36-17-21(14-32-36)20-13-24-25(31-19-33-37(24)18-20)34-9-11-35(12-10-34)26-29-15-23(16-30-26)27(2,28)22-7-5-4-6-8-22/h4-8,13-19H,3,9-12,28H2,1-2H3/t27-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...				US Patent US10807985 (2020) BindingDB Entry DOI: 10.7270/Q2F76GNN
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM469264 (US10807985, Compound 39) Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)C(C)(C)c1ccc(F)cc1 Show InChI InChI=1S/C27H28FN9/c1-27(2,21-4-6-23(28)7-5-21)22-14-29-26(30-15-22)36-10-8-35(9-11-36)25-24-12-19(17-37(24)33-18-31-25)20-13-32-34(3)16-20/h4-7,12-18H,8-11H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...				US Patent US10807985 (2020) BindingDB Entry DOI: 10.7270/Q2F76GNN
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM469269 (US10807985, Compound 44) Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(N)c1ccc(F)cc1 |r| Show InChI InChI=1S/C26H27FN10/c1-26(28,20-3-5-22(27)6-4-20)21-13-29-25(30-14-21)36-9-7-35(8-10-36)24-23-11-18(16-37(23)33-17-31-24)19-12-32-34(2)15-19/h3-6,11-17H,7-10,28H2,1-2H3/t26-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...				US Patent US10807985 (2020) BindingDB Entry DOI: 10.7270/Q2F76GNN
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM469270 (US10807985, Compound 45) Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@](C)(O)c1ccc(F)cc1 |r| Show InChI InChI=1S/C26H26FN9O/c1-26(37,20-3-5-22(27)6-4-20)21-13-28-25(29-14-21)35-9-7-34(8-10-35)24-23-11-18(16-36(23)32-17-30-24)19-12-31-33(2)15-19/h3-6,11-17,37H,7-10H2,1-2H3/t26-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...				US Patent US10807985 (2020) BindingDB Entry DOI: 10.7270/Q2F76GNN
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM469271 (US10807985, Compound 46) Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(O)c1ccc(F)cc1 |r| Show InChI InChI=1S/C26H26FN9O/c1-26(37,20-3-5-22(27)6-4-20)21-13-28-25(29-14-21)35-9-7-34(8-10-35)24-23-11-18(16-36(23)32-17-30-24)19-12-31-33(2)15-19/h3-6,11-17,37H,7-10H2,1-2H3/t26-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...				US Patent US10807985 (2020) BindingDB Entry DOI: 10.7270/Q2F76GNN
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM469283 (US10807985, Compound 58) Show SMILES C[C@@](O)(c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cn[nH]c1)c1ccc(F)cc1F |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...				US Patent US10807985 (2020) BindingDB Entry DOI: 10.7270/Q2F76GNN
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM469302 (US10807985, Compound 77) Show SMILES C[C@@H]1CN(CCN1c1ncc(cn1)[C@@](C)(O)c1ccc(F)cc1)c1ncnn2cc(cc12)-c1cnn(C)c1 |r| Show InChI InChI=1S/C27H28FN9O/c1-18-14-35(25-24-10-19(16-37(24)33-17-31-25)20-11-32-34(3)15-20)8-9-36(18)26-29-12-22(13-30-26)27(2,38)21-4-6-23(28)7-5-21/h4-7,10-13,15-18,38H,8-9,14H2,1-3H3/t18-,27+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...				US Patent US10807985 (2020) BindingDB Entry DOI: 10.7270/Q2F76GNN
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM469303 (US10807985, Compound 78) Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(CO)c1ccc(F)cc1 |r| Show InChI InChI=1S/C27H28FN9O/c1-27(17-38,21-3-5-23(28)6-4-21)22-13-29-26(30-14-22)36-9-7-35(8-10-36)25-24-11-19(16-37(24)33-18-31-25)20-12-32-34(2)15-20/h3-6,11-16,18,38H,7-10,17H2,1-2H3/t27-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...				US Patent US10807985 (2020) BindingDB Entry DOI: 10.7270/Q2F76GNN
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM469304 (US10807985, Compound 79) Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@](C)(CO)c1ccc(F)cc1 |r| Show InChI InChI=1S/C27H28FN9O/c1-27(17-38,21-3-5-23(28)6-4-21)22-13-29-26(30-14-22)36-9-7-35(8-10-36)25-24-11-19(16-37(24)33-18-31-25)20-12-32-34(2)15-20/h3-6,11-16,18,38H,7-10,17H2,1-2H3/t27-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...				US Patent US10807985 (2020) BindingDB Entry DOI: 10.7270/Q2F76GNN
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM469311 (US10807985, Compound 86) Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@](C)(N)c1ccc(F)cc1F |r| Show InChI InChI=1S/C26H26F2N10/c1-26(29,21-4-3-20(27)10-22(21)28)19-12-30-25(31-13-19)37-7-5-36(6-8-37)24-23-9-17(15-38(23)34-16-32-24)18-11-33-35(2)14-18/h3-4,9-16H,5-8,29H2,1-2H3/t26-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...				US Patent US10807985 (2020) BindingDB Entry DOI: 10.7270/Q2F76GNN
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM469318 (US10807985, Compound 93) Show SMILES C[C@@H]1CN(CCN1c1ncc(cn1)[C@](C)(O)c1ccc(F)cc1F)c1ncnn2cc(cc12)-c1cnn(C)c1 |r| Show InChI InChI=1S/C27H27F2N9O/c1-17-13-36(25-24-8-18(15-38(24)34-16-32-25)19-10-33-35(3)14-19)6-7-37(17)26-30-11-20(12-31-26)27(2,39)22-5-4-21(28)9-23(22)29/h4-5,8-12,14-17,39H,6-7,13H2,1-3H3/t17-,27+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...				US Patent US10807985 (2020) BindingDB Entry DOI: 10.7270/Q2F76GNN
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM469319 (US10807985, Compound 94) Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(O)c1ccc(F)cc1F |r| Show InChI InChI=1S/C26H25F2N9O/c1-26(38,21-4-3-20(27)10-22(21)28)19-12-29-25(30-13-19)36-7-5-35(6-8-36)24-23-9-17(15-37(23)33-16-31-24)18-11-32-34(2)14-18/h3-4,9-16,38H,5-8H2,1-2H3/t26-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...				US Patent US10807985 (2020) BindingDB Entry DOI: 10.7270/Q2F76GNN
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM469321 (US10807985, Compound 96) Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@](O)(CF)c1ccc(F)cc1 |r| Show InChI InChI=1S/C26H25F2N9O/c1-34-14-19(11-32-34)18-10-23-24(31-17-33-37(23)15-18)35-6-8-36(9-7-35)25-29-12-21(13-30-25)26(38,16-27)20-2-4-22(28)5-3-20/h2-5,10-15,17,38H,6-9,16H2,1H3/t26-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...				US Patent US10807985 (2020) BindingDB Entry DOI: 10.7270/Q2F76GNN
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM469323 (US10807985, Compound 98) Show SMILES CN(C)C(=O)c1ccc(cc1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(Cc2ccccc2)cn1 Show InChI InChI=1S/C30H30N8O/c1-35(2)29(39)25-10-8-24(9-11-25)26-17-27-28(33-21-34-38(27)20-26)36-12-14-37(15-13-36)30-31-18-23(19-32-30)16-22-6-4-3-5-7-22/h3-11,17-21H,12-16H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...				US Patent US10807985 (2020) BindingDB Entry DOI: 10.7270/Q2F76GNN
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM469325 (US10807985, Compound 100) Show SMILES O[C@@](C(F)F)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cn[nH]c1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...				US Patent US10807985 (2020) BindingDB Entry DOI: 10.7270/Q2F76GNN
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM469336 (US10807985, Compound 111) Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@](N)(C(F)F)c1ccc(F)cc1 |r| Show InChI InChI=1S/C26H25F3N10/c1-36-14-18(11-34-36)17-10-22-23(33-16-35-39(22)15-17)37-6-8-38(9-7-37)25-31-12-20(13-32-25)26(30,24(28)29)19-2-4-21(27)5-3-19/h2-5,10-16,24H,6-9,30H2,1H3/t26-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...				US Patent US10807985 (2020) BindingDB Entry DOI: 10.7270/Q2F76GNN
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM469340 (US10807985, Compound 115) Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@](C)(O)c1c(F)cc(F)cc1F |r| Show InChI InChI=1S/C26H24F3N9O/c1-26(39,23-20(28)8-19(27)9-21(23)29)18-11-30-25(31-12-18)37-5-3-36(4-6-37)24-22-7-16(14-38(22)34-15-32-24)17-10-33-35(2)13-17/h7-15,39H,3-6H2,1-2H3/t26-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...				US Patent US10807985 (2020) BindingDB Entry DOI: 10.7270/Q2F76GNN
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM469341 (US10807985, Compound 116) Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(O)c1c(F)cc(F)cc1F |r| Show InChI InChI=1S/C26H24F3N9O/c1-26(39,23-20(28)8-19(27)9-21(23)29)18-11-30-25(31-12-18)37-5-3-36(4-6-37)24-22-7-16(14-38(22)34-15-32-24)17-10-33-35(2)13-17/h7-15,39H,3-6H2,1-2H3/t26-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...				US Patent US10807985 (2020) BindingDB Entry DOI: 10.7270/Q2F76GNN
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM469346 (US10807985, Compound 121) Show SMILES C[C@](O)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)C1=NC=N[N]2=CC(C=C12)c1cnn(c1)C1COC1 |r,c:27,t:25,29,32| Show InChI InChI=1S/C28H29FN9O2/c1-28(39,21-2-4-23(29)5-3-21)22-12-30-27(31-13-22)36-8-6-35(7-9-36)26-25-10-19(14-38(25)34-18-32-26)20-11-33-37(15-20)24-16-40-17-24/h2-5,10-15,18-19,24,39H,6-9,16-17H2,1H3/t19?,28-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Blueprint Medicines Corporation US Patent					Assay Description In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...				US Patent US10807985 (2020) BindingDB Entry DOI: 10.7270/Q2F76GNN
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [D842V] (Homo sapiens (Human))	BDBM504397 ((S)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyr...) Show SMILES Cn1cc(cn1)-c1cc2c(ccnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(N)c1ccc(F)cc1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description KIT, KIT mutant, and PDGFRα mutant kinase profiling was performed with recombinant enzymes including wild-type KIT, KIT V560G, KIT V559D/T670I, ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2Q52SR0
					More data for this Ligand-Target Pair

Displayed 1 to 50 (of 72 total )  |  Next  |  Last  >>

Jump to: