Found 872 hits of ic50 for UniProtKB: Q16769 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581458
(CHEMBL5092802)Show SMILES COc1cc(ccc1OCCN1CCOCC1)N(CC1CCCC1)C(=O)NCCCn1cncc1C | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
PDB
UniChem
| PDB
Article
PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819
BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581397
(CHEMBL5085353)Show SMILES COc1cc(NC(=S)N(CCCn2cncc2C)C(C)C)ccc1OCCCCc1ccnc(N)c1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819
BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581442
(CHEMBL5086776)Show SMILES COc1cc(ccc1OCCN1CCNCC1)N(CC1CCCC1)C(=O)NCCCn1cncc1C | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.460 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819
BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581399
(CHEMBL5085226)Show SMILES COc1cc(ccc1OCCCCc1ccnc(N)c1)N(C1CCCC1)C(=S)NCCCn1cncc1C | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819
BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581400
(CHEMBL5075575)Show SMILES COc1cc(ccc1OCCCCc1ccnc(N)c1)N(C1CCCCC1)C(=S)NCCCn1cncc1C | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819
BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50237486
(CHEMBL4077433)Show InChI InChI=1S/C21H32N6O2S/c1-17-15-23-16-27(17)9-3-6-24-21(30)25-18-4-5-19(20(14-18)28-2)29-13-12-26-10-7-22-8-11-26/h4-5,14-16,22H,3,6-13H2,1-2H3,(H2,24,25,30) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Inhibition of human glutaminyl cyclase assessed as reduction in conversion of H-Gln-AMC hydrobromide to pGlu-AMC preincubated with substrate for 10 m... |
J Med Chem 60: 2573-2590 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00098
BindingDB Entry DOI: 10.7270/Q23X88X9 |
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581426
(CHEMBL5089771)Show SMILES COc1cc(ccc1OCCCCN(C)C)N(C1CCN(C)CC1)C(=O)NCCCn1cncc1C | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.710 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819
BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581398
(CHEMBL5083519)Show SMILES COc1cc(ccc1OCCCCc1ccnc(N)c1)N(C1CCC1)C(=S)NCCCn1cncc1C | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819
BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM652363
(US20240059675, Example 32) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM652305
(US20240059675, Example 8) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581450
(CHEMBL5085670)Show SMILES COc1cc(ccc1OCCN1CCN(C)CC1)N(CC1CCCC1)C(=O)NCCCn1cncc1C | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819
BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM652310
(US20240059675, Example 13) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM652312
(US20240059675, Example 15) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM652324
(US20240059675, Example 26) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581412
(CHEMBL5088732)Show SMILES COc1cc(ccc1OCCCCc1ccnc(N)c1)N(Cc1ccccc1)C(=O)NCCCn1cncc1C | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819
BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50519290
(CHEMBL4525926)Show SMILES COc1ccc(cc1OC)N(Cc1ccc(F)cc1)C(=S)NCCCn1cncc1C Show InChI InChI=1S/C23H27FN4O2S/c1-17-14-25-16-27(17)12-4-11-26-23(31)28(15-18-5-7-19(24)8-6-18)20-9-10-21(29-2)22(13-20)30-3/h5-10,13-14,16H,4,11-12,15H2,1-3H3,(H,26,31) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human N-terminal His6-tagged glutaminyl cyclase (Ala33 to Leu361 residues) expressed in baculovirus infected Sf21 insect ce... |
J Med Chem 62: 8011-8027 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00751
BindingDB Entry DOI: 10.7270/Q2W0999V |
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581445
(CHEMBL5089285)Show SMILES COc1cc(ccc1OCCN1CCNCC1)N(Cc1ccc(F)cc1)C(=O)NCCCn1cncc1C | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819
BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581441
(CHEMBL5081653)Show SMILES COc1cc(ccc1OCCN1CCNCC1)N(C1CCCCC1)C(=O)NCCCn1cncc1C | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819
BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581443
(CHEMBL5083687)Show SMILES COc1cc(ccc1OCCN1CCNCC1)N(C1CCN(C)CC1)C(=O)NCCCn1cncc1C | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819
BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581436
(CHEMBL5081891)Show SMILES COc1cc(ccc1OCCc1ccnc(N)c1)N(Cc1ccc(F)cc1)C(=O)NCCCn1cncc1C | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819
BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50519285
(CHEMBL4445407)Show SMILES COc1ccc(cc1OC)N(CCCCc1ccnc(NCCN)c1)C(=O)NCCCn1cncc1C Show InChI InChI=1S/C27H39N7O3/c1-21-19-29-20-33(21)15-6-12-32-27(35)34(23-8-9-24(36-2)25(18-23)37-3)16-5-4-7-22-10-13-30-26(17-22)31-14-11-28/h8-10,13,17-20H,4-7,11-12,14-16,28H2,1-3H3,(H,30,31)(H,32,35) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human N-terminal His6-tagged glutaminyl cyclase (Ala33 to Leu361 residues) expressed in baculovirus infected Sf21 insect ce... |
J Med Chem 62: 8011-8027 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00751
BindingDB Entry DOI: 10.7270/Q2W0999V |
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581434
(CHEMBL5081537)Show SMILES COc1cc(ccc1OCCc1ccnc(N)c1)N(C1CCCCC1)C(=O)NCCCn1cncc1C | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819
BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581451
(CHEMBL5092925)Show SMILES COc1cc(ccc1OCCN1CCN(C)CC1)N(C1CCN(C)CC1)C(=O)NCCCn1cncc1C | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819
BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50454733
(CHEMBL4204093)Show SMILES COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCCCc1ccnc(NCCN)c1 Show InChI InChI=1S/C26H37N7O2S/c1-20-18-28-19-33(20)14-5-11-31-26(36)32-22-7-8-23(24(17-22)34-2)35-15-4-3-6-21-9-12-29-25(16-21)30-13-10-27/h7-9,12,16-19H,3-6,10-11,13-15,27H2,1-2H3,(H,29,30)(H2,31,32,36) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Inhibition of human glutaminyl cyclase using Gln-AMC as substrate by pGAPase coupled fluorescence assay |
Bioorg Med Chem 26: 1035-1049 (2018)
Article DOI: 10.1016/j.bmc.2018.01.015
BindingDB Entry DOI: 10.7270/Q2SN0CKG |
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM652309
(US20240059675, Example 12) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM652328
(US20240059675, Example 30) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM652299
(US20240059675, Example 3) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50612645
(CHEMBL5279792) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50612631
(CHEMBL5266674) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581448
(CHEMBL5094369)Show SMILES COc1cc(ccc1OCCN1CCN(C)CC1)N(C(C)C)C(=O)NCCCn1cncc1C | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819
BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581460
(CHEMBL5084485)Show SMILES COc1cc(ccc1OCCN1CCOCC1)N(Cc1ccc(F)cc1)C(=O)NCCCn1cncc1C | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819
BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581422
(CHEMBL5079181)Show SMILES COc1cc(ccc1OCCCN(C)C)N(C1CCCCC1)C(=O)NCCCn1cncc1C | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819
BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50519280
(CHEMBL4464130)Show InChI InChI=1S/C19H28N4O2S/c1-14(2)23(16-7-8-17(24-4)18(11-16)25-5)19(26)21-9-6-10-22-13-20-12-15(22)3/h7-8,11-14H,6,9-10H2,1-5H3,(H,21,26) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human N-terminal His6-tagged glutaminyl cyclase (Ala33 to Leu361 residues) expressed in baculovirus infected Sf21 insect ce... |
J Med Chem 62: 8011-8027 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00751
BindingDB Entry DOI: 10.7270/Q2W0999V |
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581410
(CHEMBL5081843)Show SMILES COc1cc(ccc1OCCCCc1ccnc(N)c1)N(C1CCN(C)CC1)C(=O)NCCCn1cncc1C | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819
BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM652327
(US20240059675, Example 29) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM652330
(US20240059675, Example 31) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM652326
(US20240059675, Example 28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM652318
(US20240059675, Example 21) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50612648
(CHEMBL5266206) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM149365
(US8962860, 9)Show SMILES COc1ccc(cc1O)C1N(C(=O)NC1=O)c1ccc2[nH]cnc2c1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 3.24 | -11.8 | 3.08 | n/a | n/a | n/a | n/a | n/a | 30 |
Probiodrug AG
US Patent
| Assay Description
This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ... |
US Patent US8962860 (2015)
BindingDB Entry DOI: 10.7270/Q2B856V2 |
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50612627
(CHEMBL5282127) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581453
(CHEMBL5076836)Show SMILES COc1cc(ccc1OCCN1CCN(C)CC1)N(Cc1cccnc1)C(=O)NCCCn1cncc1C | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819
BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50519269
(CHEMBL4539841)Show SMILES COc1ccc(cc1OC)N(Cc1cccc(F)c1)C(=S)NCCCn1cncc1C Show InChI InChI=1S/C23H27FN4O2S/c1-17-14-25-16-27(17)11-5-10-26-23(31)28(15-18-6-4-7-19(24)12-18)20-8-9-21(29-2)22(13-20)30-3/h4,6-9,12-14,16H,5,10-11,15H2,1-3H3,(H,26,31) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human N-terminal His6-tagged glutaminyl cyclase (Ala33 to Leu361 residues) expressed in baculovirus infected Sf21 insect ce... |
J Med Chem 62: 8011-8027 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00751
BindingDB Entry DOI: 10.7270/Q2W0999V |
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581473
(CHEMBL5088100)Show SMILES COc1cc(ccc1OCCCCc1ccnc(N)c1)N(Cc1ccc(F)cc1)C(=O)NCc1ccc2[nH]cnc2c1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819
BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581409
(CHEMBL5088413)Show SMILES COc1cc(ccc1OCCCCc1ccnc(N)c1)N(CC1CCCC1)C(=O)NCCCn1cncc1C | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819
BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50612630
(CHEMBL5289328) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50519268
(CHEMBL4586501)Show SMILES COc1ccc(cc1OC)N(Cc1cccc(Cl)c1)C(=S)NCCCn1cncc1C Show InChI InChI=1S/C23H27ClN4O2S/c1-17-14-25-16-27(17)11-5-10-26-23(31)28(15-18-6-4-7-19(24)12-18)20-8-9-21(29-2)22(13-20)30-3/h4,6-9,12-14,16H,5,10-11,15H2,1-3H3,(H,26,31) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human N-terminal His6-tagged glutaminyl cyclase (Ala33 to Leu361 residues) expressed in baculovirus infected Sf21 insect ce... |
J Med Chem 62: 8011-8027 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00751
BindingDB Entry DOI: 10.7270/Q2W0999V |
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581452
(CHEMBL5092800)Show SMILES COc1cc(ccc1OCCN1CCN(C)CC1)N(Cc1ccc(F)cc1)C(=O)NCCCn1cncc1C | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819
BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581408
(CHEMBL5088872)Show SMILES COc1cc(ccc1OCCCCc1ccnc(N)c1)N(C1CCCCC1)C(=O)NCCCn1cncc1C | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819
BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this
Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50519240
(CHEMBL4547037)Show SMILES COc1ccc(cc1OC)N(CCCCc1ccnc(N)c1)C(=O)NCCCn1cncc1C Show InChI InChI=1S/C25H34N6O3/c1-19-17-27-18-30(19)13-6-11-29-25(32)31(21-8-9-22(33-2)23(16-21)34-3)14-5-4-7-20-10-12-28-24(26)15-20/h8-10,12,15-18H,4-7,11,13-14H2,1-3H3,(H2,26,28)(H,29,32) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human N-terminal His6-tagged glutaminyl cyclase (Ala33 to Leu361 residues) expressed in baculovirus infected Sf21 insect ce... |
J Med Chem 62: 8011-8027 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00751
BindingDB Entry DOI: 10.7270/Q2W0999V |
More data for this
Ligand-Target Pair | |
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