Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase SYK (Homo sapiens (Human)) | BDBM50400047 (BIIB-057 | CHEMBL2177736 | US9579320, Example 87) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc. US Patent | Assay Description Employing the Milipore panel of purified kinases EXAMPLE 87 (IC50=1 nM) inhibited 98% of purified Syk kinase activity at 50 nM. IC50 values were dete... | US Patent US8952027 (2015) BindingDB Entry DOI: 10.7270/Q2CF9NV0 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase SYK (Homo sapiens (Human)) | BDBM50396073 (CHEMBL1235110) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Similars | DrugBank MMDB PDB US Patent | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc. US Patent | Assay Description SYK tyrosine phosphorylation activity is measured using the LANCE Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.). ... | US Patent US8952027 (2015) BindingDB Entry DOI: 10.7270/Q2CF9NV0 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase SYK (Homo sapiens (Human)) | BDBM50400047 (BIIB-057 | CHEMBL2177736 | US9579320, Example 87) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc. US Patent | Assay Description SYK tyrosine phosphorylation activity is measured using the LANCE Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.). ... | US Patent US8952027 (2015) BindingDB Entry DOI: 10.7270/Q2CF9NV0 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase SYK (Homo sapiens (Human)) | BDBM144635 (US8952027, 596) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc. US Patent | Assay Description SYK tyrosine phosphorylation activity is measured using the LANCE Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.). ... | US Patent US8952027 (2015) BindingDB Entry DOI: 10.7270/Q2CF9NV0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase 9 (Homo sapiens (Human)) | BDBM50400047 (BIIB-057 | CHEMBL2177736 | US9579320, Example 87) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc. US Patent | Assay Description Employing the Milipore panel of purified kinases EXAMPLE 87 (IC50=1 nM) inhibited 98% of purified Syk kinase activity at 50 nM. IC50 values were dete... | US Patent US8952027 (2015) BindingDB Entry DOI: 10.7270/Q2CF9NV0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase Fgr (Homo sapiens (Human)) | BDBM50400047 (BIIB-057 | CHEMBL2177736 | US9579320, Example 87) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 81 | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc. US Patent | Assay Description Employing the Milipore panel of purified kinases EXAMPLE 87 (IC50=1 nM) inhibited 98% of purified Syk kinase activity at 50 nM. IC50 values were dete... | US Patent US8952027 (2015) BindingDB Entry DOI: 10.7270/Q2CF9NV0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase Yes (Homo sapiens (Human)) | BDBM50400047 (BIIB-057 | CHEMBL2177736 | US9579320, Example 87) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 123 | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc. US Patent | Assay Description Employing the Milipore panel of purified kinases EXAMPLE 87 (IC50=1 nM) inhibited 98% of purified Syk kinase activity at 50 nM. IC50 values were dete... | US Patent US8952027 (2015) BindingDB Entry DOI: 10.7270/Q2CF9NV0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human)) | BDBM50400047 (BIIB-057 | CHEMBL2177736 | US9579320, Example 87) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 139 | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc. US Patent | Assay Description Employing the Milipore panel of purified kinases EXAMPLE 87 (IC50=1 nM) inhibited 98% of purified Syk kinase activity at 50 nM. IC50 values were dete... | US Patent US8952027 (2015) BindingDB Entry DOI: 10.7270/Q2CF9NV0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase PAK 5 (Homo sapiens (Human)) | BDBM50400047 (BIIB-057 | CHEMBL2177736 | US9579320, Example 87) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 166 | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc. US Patent | Assay Description Employing the Milipore panel of purified kinases EXAMPLE 87 (IC50=1 nM) inhibited 98% of purified Syk kinase activity at 50 nM. IC50 values were dete... | US Patent US8952027 (2015) BindingDB Entry DOI: 10.7270/Q2CF9NV0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase Lyn (Homo sapiens (Human)) | BDBM50400047 (BIIB-057 | CHEMBL2177736 | US9579320, Example 87) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 199 | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc. US Patent | Assay Description Employing the Milipore panel of purified kinases EXAMPLE 87 (IC50=1 nM) inhibited 98% of purified Syk kinase activity at 50 nM. IC50 values were dete... | US Patent US8952027 (2015) BindingDB Entry DOI: 10.7270/Q2CF9NV0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM50400047 (BIIB-057 | CHEMBL2177736 | US9579320, Example 87) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 244 | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc. US Patent | Assay Description Employing the Milipore panel of purified kinases EXAMPLE 87 (IC50=1 nM) inhibited 98% of purified Syk kinase activity at 50 nM. IC50 values were dete... | US Patent US8952027 (2015) BindingDB Entry DOI: 10.7270/Q2CF9NV0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase Lck (Homo sapiens (Human)) | BDBM50400047 (BIIB-057 | CHEMBL2177736 | US9579320, Example 87) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc. US Patent | Assay Description Employing the Milipore panel of purified kinases EXAMPLE 87 (IC50=1 nM) inhibited 98% of purified Syk kinase activity at 50 nM. IC50 values were dete... | US Patent US8952027 (2015) BindingDB Entry DOI: 10.7270/Q2CF9NV0 | |||||||||||
More data for this Ligand-Target Pair |