Compile Data Set for Download or QSAR

Found 52 hits Enz. Inhib. hit(s) with all data for entry = 2355   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cathepsin S (Homo sapiens (Human))	BDBM19679 ((2S)-3-cyclohexyl-1-(morpholin-4-yl)-1-oxopropan-2...) Show SMILES Fc1ccc2N(C[C@H](COCc3ccccc3)NC(=O)O[C@@H](CC3CCCCC3)C(=O)N3CCOCC3)CCc2c1 |r| Show InChI InChI=1S/C32H42FN3O5/c33-27-11-12-29-26(20-27)13-14-36(29)21-28(23-40-22-25-9-5-2-6-10-25)34-32(38)41-30(19-24-7-3-1-4-8-24)31(37)35-15-17-39-18-16-35/h2,5-6,9-12,20,24,28,30H,1,3-4,7-8,13-19,21-23H2,(H,34,38)/t28-,30+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	8	-48.1	n/a	n/a	n/a	n/a	n/a	5.5	37
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Cathepsin S (Homo sapiens (Human))	BDBM19682 ((2S)-3-cyclohexyl-1-(morpholin-4-yl)-1-oxopropan-2...) Show SMILES CC(C)[C@@H](CNc1ccc(OC(F)(F)F)cc1)NC(=O)O[C@@H](CC1CCCCC1)C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C26H38F3N3O5/c1-18(2)22(17-30-20-8-10-21(11-9-20)37-26(27,28)29)31-25(34)36-23(16-19-6-4-3-5-7-19)24(33)32-12-14-35-15-13-32/h8-11,18-19,22-23,30H,3-7,12-17H2,1-2H3,(H,31,34)/t22-,23+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	8	-48.1	n/a	n/a	n/a	n/a	n/a	5.5	37
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Cathepsin S (Homo sapiens (Human))	BDBM19681 ((2S)-3-cyclohexyl-1-(morpholin-4-yl)-1-oxopropan-2...) Show SMILES CCC[C@@H](CNc1ccc(OC(F)(F)F)cc1)NC(=O)O[C@@H](CC1CCCCC1)C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C26H38F3N3O5/c1-2-6-21(18-30-20-9-11-22(12-10-20)37-26(27,28)29)31-25(34)36-23(17-19-7-4-3-5-8-19)24(33)32-13-15-35-16-14-32/h9-12,19,21,23,30H,2-8,13-18H2,1H3,(H,31,34)/t21-,23-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	16	-46.3	n/a	n/a	n/a	n/a	n/a	5.5	37
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Cathepsin S (Homo sapiens (Human))	BDBM19683 ((2S)-3-cyclohexyl-1-(morpholin-4-yl)-1-oxopropan-2...) Show SMILES FC(F)(F)Oc1ccc(NC[C@H](CCc2ccccc2)NC(=O)O[C@@H](CC2CCCCC2)C(=O)N2CCOCC2)cc1 |r| Show InChI InChI=1S/C31H40F3N3O5/c32-31(33,34)42-27-15-13-25(14-16-27)35-22-26(12-11-23-7-3-1-4-8-23)36-30(39)41-28(21-24-9-5-2-6-10-24)29(38)37-17-19-40-20-18-37/h1,3-4,7-8,13-16,24,26,28,35H,2,5-6,9-12,17-22H2,(H,36,39)/t26-,28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	18	-46.0	n/a	n/a	n/a	n/a	n/a	5.5	37
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Cathepsin S (Homo sapiens (Human))	BDBM19688 ((2S)-3-cyclohexyl-1-(morpholin-4-yl)-1-oxopropan-2...) Show SMILES CC1(C)CN(C[C@@H](NC(=O)O[C@@H](CC2CCCCC2)C(=O)N2CCOCC2)C2CC2)c2ccc(F)cc12 |r| Show InChI InChI=1S/C29H42FN3O4/c1-29(2)19-33(25-11-10-22(30)17-23(25)29)18-24(21-8-9-21)31-28(35)37-26(16-20-6-4-3-5-7-20)27(34)32-12-14-36-15-13-32/h10-11,17,20-21,24,26H,3-9,12-16,18-19H2,1-2H3,(H,31,35)/t24-,26+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	19	-45.8	n/a	n/a	n/a	n/a	n/a	5.5	37
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Cathepsin S (Homo sapiens (Human))	BDBM19687 ((2S)-3-cyclohexyl-1-(morpholin-4-yl)-1-oxopropan-2...) Show SMILES C[C@@H](CN1CC(C)(C)c2cc(F)ccc12)NC(=O)O[C@@H](CC1CCCCC1)C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C27H40FN3O4/c1-19(17-31-18-27(2,3)22-16-21(28)9-10-23(22)31)29-26(33)35-24(15-20-7-5-4-6-8-20)25(32)30-11-13-34-14-12-30/h9-10,16,19-20,24H,4-8,11-15,17-18H2,1-3H3,(H,29,33)/t19-,24-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	19	-45.8	n/a	n/a	n/a	n/a	n/a	5.5	37
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Cathepsin S (Homo sapiens (Human))	BDBM19696 ((2S)-3-cyclohexyl-1-oxo-1-(thiomorpholin-4-yl)prop...) Show SMILES C[C@@H](CN1CC(C)(C)c2cc(F)ccc12)NC(=O)O[C@@H](CC1CCCCC1)C(=O)N1CCSCC1 |r| Show InChI InChI=1S/C27H40FN3O3S/c1-19(17-31-18-27(2,3)22-16-21(28)9-10-23(22)31)29-26(33)34-24(15-20-7-5-4-6-8-20)25(32)30-11-13-35-14-12-30/h9-10,16,19-20,24H,4-8,11-15,17-18H2,1-3H3,(H,29,33)/t19-,24-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	23	-45.4	n/a	n/a	n/a	n/a	n/a	5.5	37
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Cathepsin S (Homo sapiens (Human))	BDBM19695 ((2S)-3-cyclohexyl-1-oxo-1-(piperidin-1-yl)propan-2...) Show SMILES C[C@@H](CN1CC(C)(C)c2cc(F)ccc12)NC(=O)O[C@@H](CC1CCCCC1)C(=O)N1CCCCC1 |r| Show InChI InChI=1S/C28H42FN3O3/c1-20(18-32-19-28(2,3)23-17-22(29)12-13-24(23)32)30-27(34)35-25(16-21-10-6-4-7-11-21)26(33)31-14-8-5-9-15-31/h12-13,17,20-21,25H,4-11,14-16,18-19H2,1-3H3,(H,30,34)/t20-,25-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	39	-44.0	n/a	n/a	n/a	n/a	n/a	5.5	37
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Cathepsin S (Homo sapiens (Human))	BDBM19694 ((2S)-3-cyclohexyl-1-oxo-1-(pyrrolidin-1-yl)propan-...) Show SMILES C[C@@H](CN1CC(C)(C)c2cc(F)ccc12)NC(=O)O[C@@H](CC1CCCCC1)C(=O)N1CCCC1 |r| Show InChI InChI=1S/C27H40FN3O3/c1-19(17-31-18-27(2,3)22-16-21(28)11-12-23(22)31)29-26(33)34-24(15-20-9-5-4-6-10-20)25(32)30-13-7-8-14-30/h11-12,16,19-20,24H,4-10,13-15,17-18H2,1-3H3,(H,29,33)/t19-,24-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	56	-43.1	n/a	n/a	n/a	n/a	n/a	5.5	37
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Cathepsin S (Homo sapiens (Human))	BDBM19686 ((2S)-3-cyclohexyl-1-(morpholin-4-yl)-1-oxopropan-2...) Show SMILES C[C@@H](CN1c2ccc(F)cc2CC1(C)C)NC(=O)O[C@@H](CC1CCCCC1)C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C27H40FN3O4/c1-19(18-31-23-10-9-22(28)16-21(23)17-27(31,2)3)29-26(33)35-24(15-20-7-5-4-6-8-20)25(32)30-11-13-34-14-12-30/h9-10,16,19-20,24H,4-8,11-15,17-18H2,1-3H3,(H,29,33)/t19-,24-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	80	-42.1	n/a	n/a	n/a	n/a	n/a	5.5	37
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Cathepsin S (Homo sapiens (Human))	BDBM19680 ((2S)-3-cyclohexyl-1-(morpholin-4-yl)-1-oxopropan-2...) Show SMILES C[C@@H](CNc1ccc(OC(F)(F)F)cc1)NC(=O)O[C@@H](CC1CCCCC1)C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C24H34F3N3O5/c1-17(16-28-19-7-9-20(10-8-19)35-24(25,26)27)29-23(32)34-21(15-18-5-3-2-4-6-18)22(31)30-11-13-33-14-12-30/h7-10,17-18,21,28H,2-6,11-16H2,1H3,(H,29,32)/t17-,21-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	100	-41.6	n/a	n/a	n/a	n/a	n/a	5.5	37
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Cathepsin S (Homo sapiens (Human))	BDBM19689 ((2S)-3-cyclohexyl-1-(morpholin-4-yl)-1-oxopropan-2...) Show SMILES C[C@@H](CN1CC2(CC2)c2cc(F)ccc12)NC(=O)O[C@@H](CC1CCCCC1)C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C27H38FN3O4/c1-19(17-31-18-27(9-10-27)22-16-21(28)7-8-23(22)31)29-26(33)35-24(15-20-5-3-2-4-6-20)25(32)30-11-13-34-14-12-30/h7-8,16,19-20,24H,2-6,9-15,17-18H2,1H3,(H,29,33)/t19-,24-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	122	-41.0	n/a	n/a	n/a	n/a	n/a	5.5	37
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Cathepsin S (Homo sapiens (Human))	BDBM19678 ((2S)-3-cyclohexyl-1-(morpholin-4-yl)-1-oxopropan-2...) Show SMILES OC[C@@H](CN1CCc2cc(F)ccc12)NC(=O)O[C@@H](CC1CCCCC1)C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C25H36FN3O5/c26-20-6-7-22-19(15-20)8-9-29(22)16-21(17-30)27-25(32)34-23(14-18-4-2-1-3-5-18)24(31)28-10-12-33-13-11-28/h6-7,15,18,21,23,30H,1-5,8-14,16-17H2,(H,27,32)/t21-,23+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	143	-40.6	n/a	n/a	n/a	n/a	n/a	5.5	37
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Cathepsin S (Homo sapiens (Human))	BDBM19691 ((1S)-2-cyclohexyl-1-[(2-methoxyethyl)(methyl)carba...) Show SMILES COCCN(C)C(=O)[C@H](CC1CCCCC1)OC(=O)N[C@@H](C)CN1CC(C)(C)c2cc(F)ccc12 |r| Show InChI InChI=1S/C27H42FN3O4/c1-19(17-31-18-27(2,3)22-16-21(28)11-12-23(22)31)29-26(33)35-24(15-20-9-7-6-8-10-20)25(32)30(4)13-14-34-5/h11-12,16,19-20,24H,6-10,13-15,17-18H2,1-5H3,(H,29,33)/t19-,24-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	172	-40.2	n/a	n/a	n/a	n/a	n/a	5.5	37
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Cathepsin S (Homo sapiens (Human))	BDBM19693 ((2S)-1-(azetidin-1-yl)-3-cyclohexyl-1-oxopropan-2-...) Show SMILES C[C@@H](CN1CC(C)(C)c2cc(F)ccc12)NC(=O)O[C@@H](CC1CCCCC1)C(=O)N1CCC1 |r| Show InChI InChI=1S/C26H38FN3O3/c1-18(16-30-17-26(2,3)21-15-20(27)10-11-22(21)30)28-25(32)33-23(24(31)29-12-7-13-29)14-19-8-5-4-6-9-19/h10-11,15,18-19,23H,4-9,12-14,16-17H2,1-3H3,(H,28,32)/t18-,23-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	217	-39.6	n/a	n/a	n/a	n/a	n/a	5.5	37
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Cathepsin S (Homo sapiens (Human))	BDBM19676 ((2S)-3-cyclohexyl-1-(morpholin-4-yl)-1-oxopropan-2...) Show SMILES C[C@@H](CN1CCc2cc(F)ccc12)NC(=O)O[C@@H](CC1CCCCC1)C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C25H36FN3O4/c1-18(17-29-10-9-20-16-21(26)7-8-22(20)29)27-25(31)33-23(15-19-5-3-2-4-6-19)24(30)28-11-13-32-14-12-28/h7-8,16,18-19,23H,2-6,9-15,17H2,1H3,(H,27,31)/t18-,23-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	226	-39.5	n/a	n/a	n/a	n/a	n/a	5.5	37
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Cathepsin S (Homo sapiens (Human))	BDBM19692 ((1S)-2-cyclohexyl-1-(dimethylcarbamoyl)ethyl N-[(2...) Show SMILES C[C@@H](CN1CC(C)(C)c2cc(F)ccc12)NC(=O)O[C@@H](CC1CCCCC1)C(=O)N(C)C |r| Show InChI InChI=1S/C25H38FN3O3/c1-17(15-29-16-25(2,3)20-14-19(26)11-12-21(20)29)27-24(31)32-22(23(30)28(4)5)13-18-9-7-6-8-10-18/h11-12,14,17-18,22H,6-10,13,15-16H2,1-5H3,(H,27,31)/t17-,22-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	227	-39.4	n/a	n/a	n/a	n/a	n/a	5.5	37
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Cathepsin S (Homo sapiens (Human))	BDBM19690 ((2S)-3-cyclohexyl-1-[(2R,6S)-2,6-dimethylmorpholin...) Show SMILES C[C@@H](CN1CC(C)(C)c2cc(F)ccc12)NC(=O)O[C@@H](CC1CCCCC1)C(=O)N1C[C@H](C)O[C@H](C)C1 |r| Show InChI InChI=1S/C29H44FN3O4/c1-19(15-33-18-29(4,5)24-14-23(30)11-12-25(24)33)31-28(35)37-26(13-22-9-7-6-8-10-22)27(34)32-16-20(2)36-21(3)17-32/h11-12,14,19-22,26H,6-10,13,15-18H2,1-5H3,(H,31,35)/t19-,20-,21+,26-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	297	-38.8	n/a	n/a	n/a	n/a	n/a	5.5	37
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Cathepsin K (Homo sapiens (Human))	BDBM19685 ((2S)-4,4-dimethyl-1-(morpholin-4-yl)-1-oxopentan-2...) Show SMILES C[C@@H](CNc1ccc(OC(F)(F)F)cc1)NC(=O)O[C@@H](CC(C)(C)C)C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C22H32F3N3O5/c1-15(14-26-16-5-7-17(8-6-16)33-22(23,24)25)27-20(30)32-18(13-21(2,3)4)19(29)28-9-11-31-12-10-28/h5-8,15,18,26H,9-14H2,1-4H3,(H,27,30)/t15-,18-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	355	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Cathepsin S (Homo sapiens (Human))	BDBM19697 ((2S)-3-cyclohexyl-1-(1,1-dioxo-1,4-thiomorpholin-4...) Show SMILES C[C@@H](CN1CC(C)(C)c2cc(F)ccc12)NC(=O)O[C@@H](CC1CCCCC1)C(=O)N1CCS(=O)(=O)CC1 |r| Show InChI InChI=1S/C27H40FN3O5S/c1-19(17-31-18-27(2,3)22-16-21(28)9-10-23(22)31)29-26(33)36-24(15-20-7-5-4-6-8-20)25(32)30-11-13-37(34,35)14-12-30/h9-10,16,19-20,24H,4-8,11-15,17-18H2,1-3H3,(H,29,33)/t19-,24-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	422	-37.8	n/a	n/a	n/a	n/a	n/a	5.5	37
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Cathepsin S (Homo sapiens (Human))	BDBM19698 ((2S)-3-cyclohexyl-1-(4-acetylpiperazin-1-yl)-1-oxo...) Show SMILES C[C@@H](CN1CC(C)(C)c2cc(F)ccc12)NC(=O)O[C@@H](CC1CCCCC1)C(=O)N1CCN(CC1)C(C)=O |r| Show InChI InChI=1S/C29H43FN4O4/c1-20(18-34-19-29(3,4)24-17-23(30)10-11-25(24)34)31-28(37)38-26(16-22-8-6-5-7-9-22)27(36)33-14-12-32(13-15-33)21(2)35/h10-11,17,20,22,26H,5-9,12-16,18-19H2,1-4H3,(H,31,37)/t20-,26-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	986	-35.7	n/a	n/a	n/a	n/a	n/a	5.5	37
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Cathepsin S (Homo sapiens (Human))	BDBM19685 ((2S)-4,4-dimethyl-1-(morpholin-4-yl)-1-oxopentan-2...) Show SMILES C[C@@H](CNc1ccc(OC(F)(F)F)cc1)NC(=O)O[C@@H](CC(C)(C)C)C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C22H32F3N3O5/c1-15(14-26-16-5-7-17(8-6-16)33-22(23,24)25)27-20(30)32-18(13-21(2,3)4)19(29)28-9-11-31-12-10-28/h5-8,15,18,26H,9-14H2,1-4H3,(H,27,30)/t15-,18-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	1.05E+3	-35.5	n/a	n/a	n/a	n/a	n/a	5.5	37
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Cathepsin S (Homo sapiens (Human))	BDBM19699 ((2S)-3-cyclohexyl-1-(4-methanesulfonylpiperazin-1-...) Show SMILES C[C@@H](CN1CC(C)(C)c2cc(F)ccc12)NC(=O)O[C@@H](CC1CCCCC1)C(=O)N1CCN(CC1)S(C)(=O)=O |r| Show InChI InChI=1S/C28H43FN4O5S/c1-20(18-32-19-28(2,3)23-17-22(29)10-11-24(23)32)30-27(35)38-25(16-21-8-6-5-7-9-21)26(34)31-12-14-33(15-13-31)39(4,36)37/h10-11,17,20-21,25H,5-9,12-16,18-19H2,1-4H3,(H,30,35)/t20-,25-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	1.08E+3	-35.4	n/a	n/a	n/a	n/a	n/a	5.5	37
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Cathepsin K (Homo sapiens (Human))	BDBM19682 ((2S)-3-cyclohexyl-1-(morpholin-4-yl)-1-oxopropan-2...) Show SMILES CC(C)[C@@H](CNc1ccc(OC(F)(F)F)cc1)NC(=O)O[C@@H](CC1CCCCC1)C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C26H38F3N3O5/c1-18(2)22(17-30-20-8-10-21(11-9-20)37-26(27,28)29)31-25(34)36-23(16-19-6-4-3-5-7-19)24(33)32-12-14-35-15-13-32/h8-11,18-19,22-23,30H,3-7,12-17H2,1-2H3,(H,31,34)/t22-,23+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	1.18E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Cathepsin K (Homo sapiens (Human))	BDBM19681 ((2S)-3-cyclohexyl-1-(morpholin-4-yl)-1-oxopropan-2...) Show SMILES CCC[C@@H](CNc1ccc(OC(F)(F)F)cc1)NC(=O)O[C@@H](CC1CCCCC1)C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C26H38F3N3O5/c1-2-6-21(18-30-20-9-11-22(12-10-20)37-26(27,28)29)31-25(34)36-23(17-19-7-4-3-5-8-19)24(33)32-13-15-35-16-14-32/h9-12,19,21,23,30H,2-8,13-18H2,1H3,(H,31,34)/t21-,23-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	1.39E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Cathepsin S (Homo sapiens (Human))	BDBM19677 ((2S)-3-cyclohexyl-1-(morpholin-4-yl)-1-oxopropan-2...) Show SMILES Fc1ccc2N(CCNC(=O)O[C@@H](CC3CCCCC3)C(=O)N3CCOCC3)CCc2c1 |r| Show InChI InChI=1S/C24H34FN3O4/c25-20-6-7-21-19(17-20)8-10-27(21)11-9-26-24(30)32-22(16-18-4-2-1-3-5-18)23(29)28-12-14-31-15-13-28/h6-7,17-18,22H,1-5,8-16H2,(H,26,30)/t22-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	2.95E+3	-32.8	n/a	n/a	n/a	n/a	n/a	5.5	37
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Cathepsin K (Homo sapiens (Human))	BDBM19683 ((2S)-3-cyclohexyl-1-(morpholin-4-yl)-1-oxopropan-2...) Show SMILES FC(F)(F)Oc1ccc(NC[C@H](CCc2ccccc2)NC(=O)O[C@@H](CC2CCCCC2)C(=O)N2CCOCC2)cc1 |r| Show InChI InChI=1S/C31H40F3N3O5/c32-31(33,34)42-27-15-13-25(14-16-27)35-22-26(12-11-23-7-3-1-4-8-23)36-30(39)41-28(21-24-9-5-2-6-10-24)29(38)37-17-19-40-20-18-37/h1,3-4,7-8,13-16,24,26,28,35H,2,5-6,9-12,17-22H2,(H,36,39)/t26-,28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	3.97E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM19681 ((2S)-3-cyclohexyl-1-(morpholin-4-yl)-1-oxopropan-2...) Show SMILES CCC[C@@H](CNc1ccc(OC(F)(F)F)cc1)NC(=O)O[C@@H](CC1CCCCC1)C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C26H38F3N3O5/c1-2-6-21(18-30-20-9-11-22(12-10-20)37-26(27,28)29)31-25(34)36-23(17-19-7-4-3-5-8-19)24(33)32-13-15-35-16-14-32/h9-12,19,21,23,30H,2-8,13-18H2,1H3,(H,31,34)/t21-,23-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	5.47E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM19682 ((2S)-3-cyclohexyl-1-(morpholin-4-yl)-1-oxopropan-2...) Show SMILES CC(C)[C@@H](CNc1ccc(OC(F)(F)F)cc1)NC(=O)O[C@@H](CC1CCCCC1)C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C26H38F3N3O5/c1-18(2)22(17-30-20-8-10-21(11-9-20)37-26(27,28)29)31-25(34)36-23(16-19-6-4-3-5-7-19)24(33)32-12-14-35-15-13-32/h8-11,18-19,22-23,30H,3-7,12-17H2,1-2H3,(H,31,34)/t22-,23+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	6.03E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Cathepsin K (Homo sapiens (Human))	BDBM19679 ((2S)-3-cyclohexyl-1-(morpholin-4-yl)-1-oxopropan-2...) Show SMILES Fc1ccc2N(C[C@H](COCc3ccccc3)NC(=O)O[C@@H](CC3CCCCC3)C(=O)N3CCOCC3)CCc2c1 |r| Show InChI InChI=1S/C32H42FN3O5/c33-27-11-12-29-26(20-27)13-14-36(29)21-28(23-40-22-25-9-5-2-6-10-25)34-32(38)41-30(19-24-7-3-1-4-8-24)31(37)35-15-17-39-18-16-35/h2,5-6,9-12,20,24,28,30H,1,3-4,7-8,13-19,21-23H2,(H,34,38)/t28-,30+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	8.71E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM19683 ((2S)-3-cyclohexyl-1-(morpholin-4-yl)-1-oxopropan-2...) Show SMILES FC(F)(F)Oc1ccc(NC[C@H](CCc2ccccc2)NC(=O)O[C@@H](CC2CCCCC2)C(=O)N2CCOCC2)cc1 |r| Show InChI InChI=1S/C31H40F3N3O5/c32-31(33,34)42-27-15-13-25(14-16-27)35-22-26(12-11-23-7-3-1-4-8-23)36-30(39)41-28(21-24-9-5-2-6-10-24)29(38)37-17-19-40-20-18-37/h1,3-4,7-8,13-16,24,26,28,35H,2,5-6,9-12,17-22H2,(H,36,39)/t26-,28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	9.79E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Cathepsin S (Homo sapiens (Human))	BDBM19684 ((2S)-1-(morpholin-4-yl)-1-oxo-3-phenylpropan-2-yl ...) Show SMILES C[C@@H](CNc1ccc(OC(F)(F)F)cc1)NC(=O)O[C@@H](Cc1ccccc1)C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C24H28F3N3O5/c1-17(16-28-19-7-9-20(10-8-19)35-24(25,26)27)29-23(32)34-21(15-18-5-3-2-4-6-18)22(31)30-11-13-33-14-12-30/h2-10,17,21,28H,11-16H2,1H3,(H,29,32)/t17-,21-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.26E+4	-29.1	n/a	n/a	n/a	n/a	n/a	5.5	37
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM19679 ((2S)-3-cyclohexyl-1-(morpholin-4-yl)-1-oxopropan-2...) Show SMILES Fc1ccc2N(C[C@H](COCc3ccccc3)NC(=O)O[C@@H](CC3CCCCC3)C(=O)N3CCOCC3)CCc2c1 |r| Show InChI InChI=1S/C32H42FN3O5/c33-27-11-12-29-26(20-27)13-14-36(29)21-28(23-40-22-25-9-5-2-6-10-25)34-32(38)41-30(19-24-7-3-1-4-8-24)31(37)35-15-17-39-18-16-35/h2,5-6,9-12,20,24,28,30H,1,3-4,7-8,13-19,21-23H2,(H,34,38)/t28-,30+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	1.77E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM19677 ((2S)-3-cyclohexyl-1-(morpholin-4-yl)-1-oxopropan-2...) Show SMILES Fc1ccc2N(CCNC(=O)O[C@@H](CC3CCCCC3)C(=O)N3CCOCC3)CCc2c1 |r| Show InChI InChI=1S/C24H34FN3O4/c25-20-6-7-21-19(17-20)8-10-27(21)11-9-26-24(30)32-22(16-18-4-2-1-3-5-18)23(29)28-12-14-31-15-13-28/h6-7,17-18,22H,1-5,8-16H2,(H,26,30)/t22-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM19676 ((2S)-3-cyclohexyl-1-(morpholin-4-yl)-1-oxopropan-2...) Show SMILES C[C@@H](CN1CCc2cc(F)ccc12)NC(=O)O[C@@H](CC1CCCCC1)C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C25H36FN3O4/c1-18(17-29-10-9-20-16-21(26)7-8-22(20)29)27-25(31)33-23(15-19-5-3-2-4-6-19)24(30)28-11-13-32-14-12-28/h7-8,16,18-19,23H,2-6,9-15,17H2,1H3,(H,27,31)/t18-,23-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Cathepsin K (Homo sapiens (Human))	BDBM19689 ((2S)-3-cyclohexyl-1-(morpholin-4-yl)-1-oxopropan-2...) Show SMILES C[C@@H](CN1CC2(CC2)c2cc(F)ccc12)NC(=O)O[C@@H](CC1CCCCC1)C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C27H38FN3O4/c1-19(17-31-18-27(9-10-27)22-16-21(28)7-8-23(22)31)29-26(33)35-24(15-20-5-3-2-4-6-20)25(32)30-11-13-34-14-12-30/h7-8,16,19-20,24H,2-6,9-15,17-18H2,1H3,(H,29,33)/t19-,24-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Cathepsin K (Homo sapiens (Human))	BDBM19688 ((2S)-3-cyclohexyl-1-(morpholin-4-yl)-1-oxopropan-2...) Show SMILES CC1(C)CN(C[C@@H](NC(=O)O[C@@H](CC2CCCCC2)C(=O)N2CCOCC2)C2CC2)c2ccc(F)cc12 |r| Show InChI InChI=1S/C29H42FN3O4/c1-29(2)19-33(25-11-10-22(30)17-23(25)29)18-24(21-8-9-21)31-28(35)37-26(16-20-6-4-3-5-7-20)27(34)32-12-14-36-15-13-32/h10-11,17,20-21,24,26H,3-9,12-16,18-19H2,1-2H3,(H,31,35)/t24-,26+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Cathepsin K (Homo sapiens (Human))	BDBM19680 ((2S)-3-cyclohexyl-1-(morpholin-4-yl)-1-oxopropan-2...) Show SMILES C[C@@H](CNc1ccc(OC(F)(F)F)cc1)NC(=O)O[C@@H](CC1CCCCC1)C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C24H34F3N3O5/c1-17(16-28-19-7-9-20(10-8-19)35-24(25,26)27)29-23(32)34-21(15-18-5-3-2-4-6-18)22(31)30-11-13-33-14-12-30/h7-10,17-18,21,28H,2-6,11-16H2,1H3,(H,29,32)/t17-,21-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Cathepsin K (Homo sapiens (Human))	BDBM19678 ((2S)-3-cyclohexyl-1-(morpholin-4-yl)-1-oxopropan-2...) Show SMILES OC[C@@H](CN1CCc2cc(F)ccc12)NC(=O)O[C@@H](CC1CCCCC1)C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C25H36FN3O5/c26-20-6-7-22-19(15-20)8-9-29(22)16-21(17-30)27-25(32)34-23(14-18-4-2-1-3-5-18)24(31)28-10-12-33-13-11-28/h6-7,15,18,21,23,30H,1-5,8-14,16-17H2,(H,27,32)/t21-,23+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM19689 ((2S)-3-cyclohexyl-1-(morpholin-4-yl)-1-oxopropan-2...) Show SMILES C[C@@H](CN1CC2(CC2)c2cc(F)ccc12)NC(=O)O[C@@H](CC1CCCCC1)C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C27H38FN3O4/c1-19(17-31-18-27(9-10-27)22-16-21(28)7-8-23(22)31)29-26(33)35-24(15-20-5-3-2-4-6-20)25(32)30-11-13-34-14-12-30/h7-8,16,19-20,24H,2-6,9-15,17-18H2,1H3,(H,29,33)/t19-,24-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Cathepsin K (Homo sapiens (Human))	BDBM19676 ((2S)-3-cyclohexyl-1-(morpholin-4-yl)-1-oxopropan-2...) Show SMILES C[C@@H](CN1CCc2cc(F)ccc12)NC(=O)O[C@@H](CC1CCCCC1)C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C25H36FN3O4/c1-18(17-29-10-9-20-16-21(26)7-8-22(20)29)27-25(31)33-23(15-19-5-3-2-4-6-19)24(30)28-11-13-32-14-12-28/h7-8,16,18-19,23H,2-6,9-15,17H2,1H3,(H,27,31)/t18-,23-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Cathepsin K (Homo sapiens (Human))	BDBM19677 ((2S)-3-cyclohexyl-1-(morpholin-4-yl)-1-oxopropan-2...) Show SMILES Fc1ccc2N(CCNC(=O)O[C@@H](CC3CCCCC3)C(=O)N3CCOCC3)CCc2c1 |r| Show InChI InChI=1S/C24H34FN3O4/c25-20-6-7-21-19(17-20)8-10-27(21)11-9-26-24(30)32-22(16-18-4-2-1-3-5-18)23(29)28-12-14-31-15-13-28/h6-7,17-18,22H,1-5,8-16H2,(H,26,30)/t22-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM19688 ((2S)-3-cyclohexyl-1-(morpholin-4-yl)-1-oxopropan-2...) Show SMILES CC1(C)CN(C[C@@H](NC(=O)O[C@@H](CC2CCCCC2)C(=O)N2CCOCC2)C2CC2)c2ccc(F)cc12 |r| Show InChI InChI=1S/C29H42FN3O4/c1-29(2)19-33(25-11-10-22(30)17-23(25)29)18-24(21-8-9-21)31-28(35)37-26(16-20-6-4-3-5-7-20)27(34)32-12-14-36-15-13-32/h10-11,17,20-21,24,26H,3-9,12-16,18-19H2,1-2H3,(H,31,35)/t24-,26+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Cathepsin K (Homo sapiens (Human))	BDBM19687 ((2S)-3-cyclohexyl-1-(morpholin-4-yl)-1-oxopropan-2...) Show SMILES C[C@@H](CN1CC(C)(C)c2cc(F)ccc12)NC(=O)O[C@@H](CC1CCCCC1)C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C27H40FN3O4/c1-19(17-31-18-27(2,3)22-16-21(28)9-10-23(22)31)29-26(33)35-24(15-20-7-5-4-6-8-20)25(32)30-11-13-34-14-12-30/h9-10,16,19-20,24H,4-8,11-15,17-18H2,1-3H3,(H,29,33)/t19-,24-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Cathepsin K (Homo sapiens (Human))	BDBM19686 ((2S)-3-cyclohexyl-1-(morpholin-4-yl)-1-oxopropan-2...) Show SMILES C[C@@H](CN1c2ccc(F)cc2CC1(C)C)NC(=O)O[C@@H](CC1CCCCC1)C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C27H40FN3O4/c1-19(18-31-23-10-9-22(28)16-21(23)17-27(31,2)3)29-26(33)35-24(15-20-7-5-4-6-8-20)25(32)30-11-13-34-14-12-30/h9-10,16,19-20,24H,4-8,11-15,17-18H2,1-3H3,(H,29,33)/t19-,24-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Cathepsin K (Homo sapiens (Human))	BDBM19684 ((2S)-1-(morpholin-4-yl)-1-oxo-3-phenylpropan-2-yl ...) Show SMILES C[C@@H](CNc1ccc(OC(F)(F)F)cc1)NC(=O)O[C@@H](Cc1ccccc1)C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C24H28F3N3O5/c1-17(16-28-19-7-9-20(10-8-19)35-24(25,26)27)29-23(32)34-21(15-18-5-3-2-4-6-18)22(31)30-11-13-33-14-12-30/h2-10,17,21,28H,11-16H2,1H3,(H,29,32)/t17-,21-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM19684 ((2S)-1-(morpholin-4-yl)-1-oxo-3-phenylpropan-2-yl ...) Show SMILES C[C@@H](CNc1ccc(OC(F)(F)F)cc1)NC(=O)O[C@@H](Cc1ccccc1)C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C24H28F3N3O5/c1-17(16-28-19-7-9-20(10-8-19)35-24(25,26)27)29-23(32)34-21(15-18-5-3-2-4-6-18)22(31)30-11-13-33-14-12-30/h2-10,17,21,28H,11-16H2,1H3,(H,29,32)/t17-,21-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM19678 ((2S)-3-cyclohexyl-1-(morpholin-4-yl)-1-oxopropan-2...) Show SMILES OC[C@@H](CN1CCc2cc(F)ccc12)NC(=O)O[C@@H](CC1CCCCC1)C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C25H36FN3O5/c26-20-6-7-22-19(15-20)8-9-29(22)16-21(17-30)27-25(32)34-23(14-18-4-2-1-3-5-18)24(31)28-10-12-33-13-11-28/h6-7,15,18,21,23,30H,1-5,8-14,16-17H2,(H,27,32)/t21-,23+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM19686 ((2S)-3-cyclohexyl-1-(morpholin-4-yl)-1-oxopropan-2...) Show SMILES C[C@@H](CN1c2ccc(F)cc2CC1(C)C)NC(=O)O[C@@H](CC1CCCCC1)C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C27H40FN3O4/c1-19(18-31-23-10-9-22(28)16-21(23)17-27(31,2)3)29-26(33)35-24(15-20-7-5-4-6-8-20)25(32)30-11-13-34-14-12-30/h9-10,16,19-20,24H,4-8,11-15,17-18H2,1-3H3,(H,29,33)/t19-,24-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM19687 ((2S)-3-cyclohexyl-1-(morpholin-4-yl)-1-oxopropan-2...) Show SMILES C[C@@H](CN1CC(C)(C)c2cc(F)ccc12)NC(=O)O[C@@H](CC1CCCCC1)C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C27H40FN3O4/c1-19(17-31-18-27(2,3)22-16-21(28)9-10-23(22)31)29-26(33)35-24(15-20-7-5-4-6-8-20)25(32)30-11-13-34-14-12-30/h9-10,16,19-20,24H,4-8,11-15,17-18H2,1-3H3,(H,29,33)/t19-,24-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5107-11 (2006) Article DOI: 10.1016/j.bmcl.2006.07.032 BindingDB Entry DOI: 10.7270/Q2FF3QM1
					More data for this Ligand-Target Pair

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