Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat)) | BDBM20971 (2-Arylamino-4-alkyloxypyridine, 13 | 3,6-dimethyl-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | 7.0 | 22 |
Pfizer | Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro. | J Med Chem 51: 1385-92 (2008) Article DOI: 10.1021/jm070579c BindingDB Entry DOI: 10.7270/Q29C6VQ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat)) | BDBM20966 (2-Aryloxy-4-alkylaminopyridine, 3a | 3,6-dimethyl-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 5.10 | n/a | n/a | n/a | n/a | 7.0 | 22 |
Pfizer | Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro. | J Med Chem 51: 1385-92 (2008) Article DOI: 10.1021/jm070579c BindingDB Entry DOI: 10.7270/Q29C6VQ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat)) | BDBM20968 (2-(4-bromo-2,6-dimethylphenoxy)-3,6-dimethyl-N-(pe...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.60 | n/a | n/a | n/a | n/a | 7.0 | 22 |
Pfizer | Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro. | J Med Chem 51: 1385-92 (2008) Article DOI: 10.1021/jm070579c BindingDB Entry DOI: 10.7270/Q29C6VQ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat)) | BDBM20969 (2-Aryloxy-4-alkylaminopyridine, 5a | methyl 2-(4-c...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6.40 | n/a | n/a | n/a | n/a | 7.0 | 22 |
Pfizer | Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro. | J Med Chem 51: 1385-92 (2008) Article DOI: 10.1021/jm070579c BindingDB Entry DOI: 10.7270/Q29C6VQ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat)) | BDBM20933 (3,6-dimethyl-4-(pentan-3-yloxy)-2-(2,4,6-trimethyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 6.80 | n/a | n/a | n/a | n/a | 7.0 | 22 |
Pfizer | Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro. | J Med Chem 51: 1385-92 (2008) Article DOI: 10.1021/jm070579c BindingDB Entry DOI: 10.7270/Q29C6VQ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat)) | BDBM20967 (2-(4-chloro-2,6-dimethylphenoxy)-3,6-dimethyl-N-(p...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.20 | n/a | n/a | n/a | n/a | 7.0 | 22 |
Pfizer | Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro. | J Med Chem 51: 1385-92 (2008) Article DOI: 10.1021/jm070579c BindingDB Entry DOI: 10.7270/Q29C6VQ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat)) | BDBM20970 (2-(4-chloro-2,6-dimethylphenoxy)-4-{[(2S)-1-hydrox...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 31 | n/a | n/a | n/a | n/a | 7.0 | 22 |
Pfizer | Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro. | J Med Chem 51: 1385-92 (2008) Article DOI: 10.1021/jm070579c BindingDB Entry DOI: 10.7270/Q29C6VQ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat)) | BDBM20972 (2,4-diaminopyridine, 16 | 3,6-dimethyl-4-N-(pentan...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 750 | n/a | n/a | n/a | n/a | 7.0 | 22 |
Pfizer | Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro. | J Med Chem 51: 1385-92 (2008) Article DOI: 10.1021/jm070579c BindingDB Entry DOI: 10.7270/Q29C6VQ7 | |||||||||||
More data for this Ligand-Target Pair |