Compile Data Set for Download or QSAR

Found 123 hits Enz. Inhib. hit(s) with all data for entry = 8505   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Complement factor D (Homo sapiens (Human))	BDBM254483 (US9468661, 61) Show SMILES C[C@@H](NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(C)=O)c2cc(OCc3ncn(C)n3)ccc12)[C@H]1CC1(Cl)Cl |r| Show InChI InChI=1S/C26H29Cl2N7O4/c1-13(18-9-26(18,27)28)30-25(38)21-7-15-6-20(15)35(21)23(37)10-34-19-5-4-16(8-17(19)24(32-34)14(2)36)39-11-22-29-12-33(3)31-22/h4-5,8,12-13,15,18,20-21H,6-7,9-11H2,1-3H3,(H,30,38)/t13-,15-,18-,20-,21+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254498 (US9468661, 109 | US9468661, 76) Show SMILES CC1[C@@H](CNC(=O)[C@@H]2C[C@H]3C[C@H]3N2C(=O)Cn2nc(C(C)=O)c3cc(OCc4ncccn4)ccc23)C1(Cl)Cl |r| Show InChI InChI=1S/C27H28Cl2N6O4/c1-14-19(27(14,28)29)11-32-26(38)22-9-16-8-21(16)35(22)24(37)12-34-20-5-4-17(10-18(20)25(33-34)15(2)36)39-13-23-30-6-3-7-31-23/h3-7,10,14,16,19,21-22H,8-9,11-13H2,1-2H3,(H,32,38)/t14?,16-,19-,21-,22+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254486 (US9468661, 64) Show SMILES C[C@@H](NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(C)=O)c2cc(OCc3cc(C)[nH]n3)ccc12)[C@H]1CC1(Cl)Cl |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254471 (US9468661, 49) Show SMILES C[C@@H](NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccc(Cl)cc12)[C@H]1CC1(Cl)Cl |r| Show InChI InChI=1S/C21H22Cl3N5O3/c1-9(13-7-21(13,23)24)26-20(32)16-5-10-4-14(10)29(16)17(30)8-28-15-6-11(22)2-3-12(15)18(27-28)19(25)31/h2-3,6,9-10,13-14,16H,4-5,7-8H2,1H3,(H2,25,31)(H,26,32)/t9-,10-,13-,14-,16+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254475 (US9468661, 53) Show SMILES C[C@@H](NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(C)=O)c2cc(OCc3ncccn3)c(C)cc12)[C@H]1CC1(Cl)Cl |r| Show InChI InChI=1S/C28H30Cl2N6O4/c1-14-7-21-18(10-23(14)40-13-24-31-5-4-6-32-24)26(16(3)37)34-35(21)12-25(38)36-20-8-17(20)9-22(36)27(39)33-15(2)19-11-28(19,29)30/h4-7,10,15,17,19-20,22H,8-9,11-13H2,1-3H3,(H,33,39)/t15-,17-,19-,20-,22+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254488 (US9468661, 66) Show SMILES C[C@@H](NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(C)=O)c2cc(OCc3ccn(C)n3)ccc12)[C@H]1CC1(Cl)Cl |r| Show InChI InChI=1S/C27H30Cl2N6O4/c1-14(20-11-27(20,28)29)30-26(38)23-9-16-8-22(16)35(23)24(37)12-34-21-5-4-18(10-19(21)25(32-34)15(2)36)39-13-17-6-7-33(3)31-17/h4-7,10,14,16,20,22-23H,8-9,11-13H2,1-3H3,(H,30,38)/t14-,16-,20-,22-,23+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254528 (US9468661, 106) Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC[C@H]2CC2(Cl)Cl)c2ccc(OCc3nccs3)cc12 |r| Show InChI InChI=1S/C25H25Cl2N5O4S/c1-13(33)23-17-8-16(36-12-21-28-4-5-37-21)2-3-18(17)31(30-23)11-22(34)32-19-6-14(19)7-20(32)24(35)29-10-15-9-25(15,26)27/h2-5,8,14-15,19-20H,6-7,9-12H2,1H3,(H,29,35)/t14-,15-,19-,20+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254454 (US9468661, 32) Show SMILES C[C@@H](NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(C)=O)c2cc(OCc3ncccn3)ccc12)C1CC1(Cl)Cl |r| Show InChI InChI=1S/C27H28Cl2N6O4/c1-14(19-11-27(19,28)29)32-26(38)22-9-16-8-21(16)35(22)24(37)12-34-20-5-4-17(10-18(20)25(33-34)15(2)36)39-13-23-30-6-3-7-31-23/h3-7,10,14,16,19,21-22H,8-9,11-13H2,1-2H3,(H,32,38)/t14-,16-,19?,21-,22+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254485 (US9468661, 63) Show SMILES C[C@@H](NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(C)=O)c2cc(OCc3cc(C)n(C)n3)ccc12)[C@H]1CC1(Cl)Cl |r| Show InChI InChI=1S/C28H32Cl2N6O4/c1-14-7-18(32-34(14)4)13-40-19-5-6-22-20(10-19)26(16(3)37)33-35(22)12-25(38)36-23-8-17(23)9-24(36)27(39)31-15(2)21-11-28(21,29)30/h5-7,10,15,17,21,23-24H,8-9,11-13H2,1-4H3,(H,31,39)/t15-,17-,21-,23-,24+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254497 (US9468661, 108 | US9468661, 75) Show SMILES CC1[C@H](CNC(=O)[C@@H]2C[C@H]3C[C@H]3N2C(=O)Cn2nc(C(C)=O)c3cc(OCc4ncccn4)ccc23)C1(Cl)Cl |r| Show InChI InChI=1S/C27H28Cl2N6O4/c1-14-19(27(14,28)29)11-32-26(38)22-9-16-8-21(16)35(22)24(37)12-34-20-5-4-17(10-18(20)25(33-34)15(2)36)39-13-23-30-6-3-7-31-23/h3-7,10,14,16,19,21-22H,8-9,11-13H2,1-2H3,(H,32,38)/t14?,16-,19+,21-,22+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254462 (US9468661, 40) Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC[C@H]2CC2(Cl)Cl)c2ccc(OCc3nccs3)cc12 |r| Show InChI InChI=1S/C24H24Cl2N6O4S/c25-24(26)8-13(24)9-29-23(35)18-6-12-5-17(12)32(18)20(33)10-31-16-2-1-14(36-11-19-28-3-4-37-19)7-15(16)21(30-31)22(27)34/h1-4,7,12-13,17-18H,5-6,8-11H2,(H2,27,34)(H,29,35)/t12-,13-,17-,18+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254478 (US9468661, 56) Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC[C@H]2CC2(Cl)Cl)c2ccc(OCc3nccc(C)n3)cc12 |r| Show InChI InChI=1S/C27H28Cl2N6O4/c1-14-5-6-30-23(32-14)13-39-18-3-4-20-19(9-18)25(15(2)36)33-34(20)12-24(37)35-21-7-16(21)8-22(35)26(38)31-11-17-10-27(17,28)29/h3-6,9,16-17,21-22H,7-8,10-13H2,1-2H3,(H,31,38)/t16-,17-,21-,22+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254459 (US9468661, 37) Show SMILES C[C@@H](NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccncc12)[C@H]1CC1(Cl)Cl |r| Show InChI InChI=1S/C20H22Cl2N6O3/c1-9(12-6-20(12,21)22)25-19(31)14-5-10-4-13(10)28(14)16(29)8-27-15-7-24-3-2-11(15)17(26-27)18(23)30/h2-3,7,9-10,12-14H,4-6,8H2,1H3,(H2,23,30)(H,25,31)/t9-,10-,12-,13-,14+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254468 (US9468661, 46) Show SMILES C[C@@H](NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(C)=O)c2ccccc12)[C@H]1CC1(Cl)Cl |r| Show InChI InChI=1S/C22H24Cl2N4O3/c1-11(15-9-22(15,23)24)25-21(31)18-8-13-7-17(13)28(18)19(30)10-27-16-6-4-3-5-14(16)20(26-27)12(2)29/h3-6,11,13,15,17-18H,7-10H2,1-2H3,(H,25,31)/t11-,13-,15-,17-,18+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254496 (US9468661, 74 | US9468661, 78) Show SMILES CC1[C@@H](CNC(=O)[C@@H]2C[C@H]3C[C@H]3N2C(=O)Cn2nc(C(N)=O)c3ccccc23)C1(Cl)Cl |r| Show InChI InChI=1S/C21H23Cl2N5O3/c1-10-13(21(10,22)23)8-25-20(31)16-7-11-6-15(11)28(16)17(29)9-27-14-5-3-2-4-12(14)18(26-27)19(24)30/h2-5,10-11,13,15-16H,6-9H2,1H3,(H2,24,30)(H,25,31)/t10?,11-,13-,15-,16+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254458 (US9468661, 121 | US9468661, 36) Show SMILES C[C@@H](NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccccc12)[C@H]1CC1(Cl)Cl |r| Show InChI InChI=1S/C21H23Cl2N5O3/c1-10(13-8-21(13,22)23)25-20(31)16-7-11-6-15(11)28(16)17(29)9-27-14-5-3-2-4-12(14)18(26-27)19(24)30/h2-5,10-11,13,15-16H,6-9H2,1H3,(H2,24,30)(H,25,31)/t10-,11-,13-,15-,16+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254527 (US9468661, 105) Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC[C@H]2CC2(Cl)Cl)c2ccc(OCc3cscn3)cc12 |r| Show InChI InChI=1S/C25H25Cl2N5O4S/c1-13(33)23-18-6-17(36-10-16-11-37-12-29-16)2-3-19(18)31(30-23)9-22(34)32-20-4-14(20)5-21(32)24(35)28-8-15-7-25(15,26)27/h2-3,6,11-12,14-15,20-21H,4-5,7-10H2,1H3,(H,28,35)/t14-,15-,20-,21+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254481 (US9468661, 59) Show SMILES CO[C@@H]1[C@@H](F)CN([C@@H]1C(=O)N[C@H](C)[C@H]1CC1(Cl)Cl)C(=O)Cn1nc(C(N)=O)c2ccccc12 |r| Show InChI InChI=1S/C21H24Cl2FN5O4/c1-10(12-7-21(12,22)23)26-20(32)17-18(33-2)13(24)8-28(17)15(30)9-29-14-6-4-3-5-11(14)16(27-29)19(25)31/h3-6,10,12-13,17-18H,7-9H2,1-2H3,(H2,25,31)(H,26,32)/t10-,12-,13+,17+,18-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254452 (US9468661, 30) Show SMILES C[C@@H](NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Nc1cn(C(N)=O)c2ccccc12)[C@H]1CC1(Cl)Cl |r| Show InChI InChI=1S/C21H23Cl2N5O3/c1-10(13-8-21(13,22)23)25-18(29)17-7-11-6-16(11)28(17)20(31)26-14-9-27(19(24)30)15-5-3-2-4-12(14)15/h2-5,9-11,13,16-17H,6-8H2,1H3,(H2,24,30)(H,25,29)(H,26,31)/t10-,11-,13-,16-,17+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254526 (US9468661, 104) Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC[C@H]2C(C)(C)C2(Cl)Cl)c2ccc(OCc3ncccn3)cc12 |r| Show InChI InChI=1S/C28H30Cl2N6O4/c1-15(37)25-18-11-17(40-14-23-31-7-4-8-32-23)5-6-19(18)35(34-25)13-24(38)36-20-9-16(20)10-21(36)26(39)33-12-22-27(2,3)28(22,29)30/h4-8,11,16,20-22H,9-10,12-14H2,1-3H3,(H,33,39)/t16-,20-,21+,22+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254516 (US9468661, 94) Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC[C@H]2CC2(Cl)Cl)c2ccc(OCc3ncccn3)cc12 |r| Show InChI InChI=1S/C26H26Cl2N6O4/c1-14(35)24-18-9-17(38-13-22-29-5-2-6-30-22)3-4-19(18)33(32-24)12-23(36)34-20-7-15(20)8-21(34)25(37)31-11-16-10-26(16,27)28/h2-6,9,15-16,20-21H,7-8,10-13H2,1H3,(H,31,37)/t15-,16-,20-,21+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254479 (US9468661, 57) Show SMILES C[C@@H](NC(=O)[C@@H]1C[C@@]2(CO)C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccccc12)[C@H]1CC1(Cl)Cl |r| Show InChI InChI=1S/C22H25Cl2N5O4/c1-11(13-6-22(13,23)24)26-20(33)15-7-21(10-30)8-16(21)29(15)17(31)9-28-14-5-3-2-4-12(14)18(27-28)19(25)32/h2-5,11,13,15-16,30H,6-10H2,1H3,(H2,25,32)(H,26,33)/t11-,13-,15+,16-,21+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254515 (US9468661, 93) Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC[C@@H]2CC2(Cl)Cl)c2ccc(OCc3ncccn3)cc12 |r| Show InChI InChI=1S/C26H26Cl2N6O4/c1-14(35)24-18-9-17(38-13-22-29-5-2-6-30-22)3-4-19(18)33(32-24)12-23(36)34-20-7-15(20)8-21(34)25(37)31-11-16-10-26(16,27)28/h2-6,9,15-16,20-21H,7-8,10-13H2,1H3,(H,31,37)/t15-,16+,20-,21+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254449 (US9468661, 27) Show SMILES CC1(C)[C@H](CNC(=O)[C@@H]2C[C@H]3C[C@H]3N2C(=O)Nc2cn(C(N)=O)c3ccccc23)C1(Cl)Cl |r| Show InChI InChI=1S/C22H25Cl2N5O3/c1-21(2)17(22(21,23)24)9-26-18(30)16-8-11-7-15(11)29(16)20(32)27-13-10-28(19(25)31)14-6-4-3-5-12(13)14/h3-6,10-11,15-17H,7-9H2,1-2H3,(H2,25,31)(H,26,30)(H,27,32)/t11-,15-,16+,17+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254487 (US9468661, 65) Show SMILES CC1CC(CNC(=O)[C@@H]2C[C@H]3C[C@H]3N2C(=O)Cn2nc(C(C)=O)c3cc(OCc4ncccn4)ccc23)C1 |r,wU:8.7,wD:10.10,12.11,(6.72,8.16,;5.63,7.07,;5.63,5.53,;4.09,5.53,;3,4.44,;1.52,4.84,;.43,3.75,;.82,2.26,;-1.06,4.15,;-1.54,5.61,;-3.08,5.61,;-4.58,5.29,;-3.55,4.15,;-2.31,3.24,;-2.31,1.7,;-.97,.93,;-3.64,.93,;-3.64,-.61,;-4.89,-1.51,;-4.41,-2.98,;-5.18,-4.31,;-4.41,-5.64,;-6.72,-4.31,;-2.87,-2.98,;-1.84,-4.12,;-.33,-3.8,;.76,-4.89,;2.24,-4.49,;3.33,-5.58,;2.93,-7.07,;4.02,-8.16,;5.51,-7.76,;5.91,-6.27,;4.82,-5.18,;.14,-2.34,;-.89,-1.19,;-2.39,-1.51,;4.09,7.07,)| Show InChI InChI=1S/C28H32N6O4/c1-16-8-18(9-16)13-31-28(37)24-11-19-10-23(19)34(24)26(36)14-33-22-5-4-20(12-21(22)27(32-33)17(2)35)38-15-25-29-6-3-7-30-25/h3-7,12,16,18-19,23-24H,8-11,13-15H2,1-2H3,(H,31,37)/t16?,18?,19-,23-,24+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254501 (US9468661, 79 | US9468661, 81) Show SMILES CC1[C@H](CNC(=O)[C@@H]2C[C@H]3C[C@H]3N2C(=O)Cn2nc(C(N)=O)c3ccncc23)C1(Cl)Cl |r| Show InChI InChI=1S/C20H22Cl2N6O3/c1-9-12(20(9,21)22)6-25-19(31)14-5-10-4-13(10)28(14)16(29)8-27-15-7-24-3-2-11(15)17(26-27)18(23)30/h2-3,7,9-10,12-14H,4-6,8H2,1H3,(H2,23,30)(H,25,31)/t9?,10-,12+,13-,14+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254514 (US9468661, 92) Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC[C@H]2CC2(Cl)Cl)c2cnccc12 |r| Show InChI InChI=1S/C20H21Cl2N5O3/c1-10(28)18-13-2-3-23-8-16(13)26(25-18)9-17(29)27-14-4-11(14)5-15(27)19(30)24-7-12-6-20(12,21)22/h2-3,8,11-12,14-15H,4-7,9H2,1H3,(H,24,30)/t11-,12-,14-,15+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	24	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254458 (US9468661, 121 | US9468661, 36) Show SMILES C[C@@H](NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccccc12)[C@H]1CC1(Cl)Cl |r| Show InChI InChI=1S/C21H23Cl2N5O3/c1-10(13-8-21(13,22)23)25-20(31)16-7-11-6-15(11)28(16)17(29)9-27-14-5-3-2-4-12(14)18(26-27)19(24)30/h2-5,10-11,13,15-16H,6-9H2,1H3,(H2,24,30)(H,25,31)/t10-,11-,13-,15-,16+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254470 (US9468661, 48) Show SMILES CO[C@@H]1[C@@H](F)CN([C@@H]1C(=O)NC[C@H]1CC1(Cl)Cl)C(=O)Cn1nc(C(N)=O)c2ccc(C)cc12 |r| Show InChI InChI=1S/C21H24Cl2FN5O4/c1-10-3-4-12-14(5-10)29(27-16(12)19(25)31)9-15(30)28-8-13(24)18(33-2)17(28)20(32)26-7-11-6-21(11,22)23/h3-5,11,13,17-18H,6-9H2,1-2H3,(H2,25,31)(H,26,32)/t11-,13+,17+,18-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254461 (US9468661, 39) Show SMILES CCc1cc2c(nn(CC(=O)N3[C@@H]4C[C@@H]4C[C@H]3C(=O)N[C@H](C)[C@H]3CC3(Cl)Cl)c2cn1)C(N)=O |r| Show InChI InChI=1S/C22H26Cl2N6O3/c1-3-12-6-13-17(8-26-12)29(28-19(13)20(25)32)9-18(31)30-15-4-11(15)5-16(30)21(33)27-10(2)14-7-22(14,23)24/h6,8,10-11,14-16H,3-5,7,9H2,1-2H3,(H2,25,32)(H,27,33)/t10-,11-,14-,15-,16+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254497 (US9468661, 108 | US9468661, 75) Show SMILES CC1[C@H](CNC(=O)[C@@H]2C[C@H]3C[C@H]3N2C(=O)Cn2nc(C(C)=O)c3cc(OCc4ncccn4)ccc23)C1(Cl)Cl |r| Show InChI InChI=1S/C27H28Cl2N6O4/c1-14-19(27(14,28)29)11-32-26(38)22-9-16-8-21(16)35(22)24(37)12-34-20-5-4-17(10-18(20)25(33-34)15(2)36)39-13-23-30-6-3-7-31-23/h3-7,10,14,16,19,21-22H,8-9,11-13H2,1-2H3,(H,32,38)/t14?,16-,19+,21-,22+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254521 (US9468661, 99) Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC[C@H]2CC2(Cl)Cl)c2ccc(OCc3ncccc3F)cc12 |r| Show InChI InChI=1S/C27H26Cl2FN5O4/c1-14(36)25-18-9-17(39-13-20-19(30)3-2-6-31-20)4-5-21(18)34(33-25)12-24(37)35-22-7-15(22)8-23(35)26(38)32-11-16-10-27(16,28)29/h2-6,9,15-16,22-23H,7-8,10-13H2,1H3,(H,32,38)/t15-,16-,22-,23+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	32	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254453 (US9468661, 31) Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC[C@H]2CC2(Cl)Cl)c2ccccc12 |r| Show InChI InChI=1S/C20H21Cl2N5O3/c21-20(22)7-11(20)8-24-19(30)15-6-10-5-14(10)27(15)16(28)9-26-13-4-2-1-3-12(13)17(25-26)18(23)29/h1-4,10-11,14-15H,5-9H2,(H2,23,29)(H,24,30)/t10-,11-,14-,15+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	32	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254469 (US9468661, 47) Show SMILES C[C@@H](NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(C)=O)c2ccncc12)[C@H]1CC1(Cl)Cl |r| Show InChI InChI=1S/C21H23Cl2N5O3/c1-10(14-7-21(14,22)23)25-20(31)16-6-12-5-15(12)28(16)18(30)9-27-17-8-24-4-3-13(17)19(26-27)11(2)29/h3-4,8,10,12,14-16H,5-7,9H2,1-2H3,(H,25,31)/t10-,12-,14-,15-,16+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	35	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254495 (US9468661, 73 | US9468661, 77) Show SMILES CC1[C@H](CNC(=O)[C@@H]2C[C@H]3C[C@H]3N2C(=O)Cn2nc(C(N)=O)c3ccccc23)C1(Cl)Cl |r| Show InChI InChI=1S/C21H23Cl2N5O3/c1-10-13(21(10,22)23)8-25-20(31)16-7-11-6-15(11)28(16)17(29)9-27-14-5-3-2-4-12(14)18(26-27)19(24)30/h2-5,10-11,13,15-16H,6-9H2,1H3,(H2,24,30)(H,25,31)/t10?,11-,13+,15-,16+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	35	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254494 (US9468661, 72) Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC[C@H]2CC2(Cl)Cl)c2cnccc12 |r| Show InChI InChI=1S/C19H20Cl2N6O3/c20-19(21)5-10(19)6-24-18(30)13-4-9-3-12(9)27(13)15(28)8-26-14-7-23-2-1-11(14)16(25-26)17(22)29/h1-2,7,9-10,12-13H,3-6,8H2,(H2,22,29)(H,24,30)/t9-,10-,12-,13+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	36	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254480 (US9468661, 58) Show SMILES C[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1nc(C(N)=O)c2ccccc12)[C@H]1CC1(Cl)Cl |r| Show InChI InChI=1S/C20H22Cl2FN5O3/c1-10(13-7-20(13,21)22)25-19(31)15-6-11(23)8-27(15)16(29)9-28-14-5-3-2-4-12(14)17(26-28)18(24)30/h2-5,10-11,13,15H,6-9H2,1H3,(H2,24,30)(H,25,31)/t10-,11-,13-,15+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	39	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254536 (US9468661, 114) Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC[C@H]2CC2(Cl)Cl)c2cc(Cl)ccc12 |r| Show InChI InChI=1S/C20H20Cl3N5O3/c21-11-1-2-12-14(5-11)27(26-17(12)18(24)30)8-16(29)28-13-3-9(13)4-15(28)19(31)25-7-10-6-20(10,22)23/h1-2,5,9-10,13,15H,3-4,6-8H2,(H2,24,30)(H,25,31)/t9-,10-,13-,15+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	40	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254460 (US9468661, 38) Show SMILES C[C@@H](NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2cc(C)ncc12)[C@H]1CC1(Cl)Cl |r| Show InChI InChI=1S/C21H24Cl2N6O3/c1-9-3-12-16(7-25-9)28(27-18(12)19(24)31)8-17(30)29-14-4-11(14)5-15(29)20(32)26-10(2)13-6-21(13,22)23/h3,7,10-11,13-15H,4-6,8H2,1-2H3,(H2,24,31)(H,26,32)/t10-,11-,13-,14-,15+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	40	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254532 (US9468661, 110) Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC[C@H]2CC2(Cl)Cl)c2ccc(OCc3ncccn3)cc12 |r| Show InChI InChI=1S/C25H25Cl2N7O4/c26-25(27)9-14(25)10-31-24(37)19-7-13-6-18(13)34(19)21(35)11-33-17-3-2-15(8-16(17)22(32-33)23(28)36)38-12-20-29-4-1-5-30-20/h1-5,8,13-14,18-19H,6-7,9-12H2,(H2,28,36)(H,31,37)/t13-,14-,18-,19+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	41	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254466 (US9468661, 44) Show SMILES C[C@@H](NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccnc(C)c12)[C@H]1CC1(Cl)Cl |r| Show InChI InChI=1S/C21H24Cl2N6O3/c1-9(13-7-21(13,22)23)26-20(32)15-6-11-5-14(11)29(15)16(30)8-28-18-10(2)25-4-3-12(18)17(27-28)19(24)31/h3-4,9,11,13-15H,5-8H2,1-2H3,(H2,24,31)(H,26,32)/t9-,11-,13-,14-,15+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	41	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254467 (US9468661, 45) Show SMILES C[C@@H](NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2cc(C)nc(C)c12)[C@H]1CC1(Cl)Cl |r| Show InChI InChI=1S/C22H26Cl2N6O3/c1-9-4-13-18(20(25)32)28-29(19(13)11(3)26-9)8-17(31)30-15-5-12(15)6-16(30)21(33)27-10(2)14-7-22(14,23)24/h4,10,12,14-16H,5-8H2,1-3H3,(H2,25,32)(H,27,33)/t10-,12-,14-,15-,16+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	43	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254513 (US9468661, 91) Show SMILES C[C@@H]1CC[C@H](CNC(=O)[C@@H]2C[C@H]3C[C@H]3N2C(=O)Cn2nc(C(N)=O)c3ccccc23)C1 |r| Show InChI InChI=1S/C23H29N5O3/c1-13-6-7-14(8-13)11-25-23(31)19-10-15-9-18(15)28(19)20(29)12-27-17-5-3-2-4-16(17)21(26-27)22(24)30/h2-5,13-15,18-19H,6-12H2,1H3,(H2,24,30)(H,25,31)/t13-,14+,15-,18-,19+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	46	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254451 (US9468661, 29) Show SMILES CC1CCCC(CNC(=O)[C@@H]2C[C@H]3C[C@H]3N2C(=O)Nc2cn(C(N)=O)c3ccccc23)C1 |r| Show InChI InChI=1S/C24H31N5O3/c1-14-5-4-6-15(9-14)12-26-22(30)21-11-16-10-20(16)29(21)24(32)27-18-13-28(23(25)31)19-8-3-2-7-17(18)19/h2-3,7-8,13-16,20-21H,4-6,9-12H2,1H3,(H2,25,31)(H,26,30)(H,27,32)/t14?,15?,16-,20-,21+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	46	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254498 (US9468661, 109 | US9468661, 76) Show SMILES CC1[C@@H](CNC(=O)[C@@H]2C[C@H]3C[C@H]3N2C(=O)Cn2nc(C(C)=O)c3cc(OCc4ncccn4)ccc23)C1(Cl)Cl |r| Show InChI InChI=1S/C27H28Cl2N6O4/c1-14-19(27(14,28)29)11-32-26(38)22-9-16-8-21(16)35(22)24(37)12-34-20-5-4-17(10-18(20)25(33-34)15(2)36)39-13-23-30-6-3-7-31-23/h3-7,10,14,16,19,21-22H,8-9,11-13H2,1-2H3,(H,32,38)/t14?,16-,19-,21-,22+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	49	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254463 (US9468661, 41) Show SMILES CO[C@@H]1[C@@H](F)CN([C@@H]1C(=O)NC[C@H]1CC1(Cl)Cl)C(=O)Cn1nc(C(N)=O)c2ccc(Cl)cc12 |r| Show InChI InChI=1S/C20H21Cl3FN5O4/c1-33-17-12(24)7-28(16(17)19(32)26-6-9-5-20(9,22)23)14(30)8-29-13-4-10(21)2-3-11(13)15(27-29)18(25)31/h2-4,9,12,16-17H,5-8H2,1H3,(H2,25,31)(H,26,32)/t9-,12+,16+,17-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	51	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254529 (US9468661, 107) Show SMILES CC1(C)[C@H](CNC(=O)[C@@H]2C[C@H]3C[C@H]3N2C(=O)Cn2nc(C(N)=O)c3ccccc23)C1(Cl)Cl |r| Show InChI InChI=1S/C22H25Cl2N5O3/c1-21(2)16(22(21,23)24)9-26-20(32)15-8-11-7-14(11)29(15)17(30)10-28-13-6-4-3-5-12(13)18(27-28)19(25)31/h3-6,11,14-16H,7-10H2,1-2H3,(H2,25,31)(H,26,32)/t11-,14-,15+,16+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	52	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254512 (US9468661, 90) Show SMILES CC1CCC(CNC(=O)[C@@H]2C[C@H]3C[C@H]3N2C(=O)Cn2nc(C(N)=O)c3ccccc23)C1 |r| Show InChI InChI=1S/C23H29N5O3/c1-13-6-7-14(8-13)11-25-23(31)19-10-15-9-18(15)28(19)20(29)12-27-17-5-3-2-4-16(17)21(26-27)22(24)30/h2-5,13-15,18-19H,6-12H2,1H3,(H2,24,30)(H,25,31)/t13?,14?,15-,18-,19+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	53	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254491 (US9468661, 69) Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC[C@H]2CC2(Cl)Cl)c2ncccc12 |r| Show InChI InChI=1S/C20H21Cl2N5O3/c1-10(28)17-13-3-2-4-23-18(13)26(25-17)9-16(29)27-14-5-11(14)6-15(27)19(30)24-8-12-7-20(12,21)22/h2-4,11-12,14-15H,5-9H2,1H3,(H,24,30)/t11-,12-,14-,15+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	53	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM254474 (US9468661, 52) Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@]3(CO)C[C@H]2C(=O)NC[C@H]2CC2(Cl)Cl)c2ccccc12 |r| Show InChI InChI=1S/C21H23Cl2N5O4/c22-21(23)5-11(21)8-25-19(32)14-6-20(10-29)7-15(20)28(14)16(30)9-27-13-4-2-1-3-12(13)17(26-27)18(24)31/h1-4,11,14-15,29H,5-10H2,(H2,24,31)(H,25,32)/t11-,14+,15-,20+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	56	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9468661 (2016) BindingDB Entry DOI: 10.7270/Q23N22B5
					More data for this Ligand-Target Pair

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