Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50143464 (3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (3R,...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibitory activity against hepatitis C virus NS3.4A protease | Bioorg Med Chem Lett 14: 1939-42 (2004) Article DOI: 10.1016/j.bmcl.2004.01.078 BindingDB Entry DOI: 10.7270/Q2862FVH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50143458 ((4S,5R)-1-((R)-2-{2-Cyclohexyl-2-[(hydroxy-pyrazin...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibitory activity against hepatitis C virus NS3.4A protease | Bioorg Med Chem Lett 14: 1939-42 (2004) Article DOI: 10.1016/j.bmcl.2004.01.078 BindingDB Entry DOI: 10.7270/Q2862FVH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50143459 ((4S,5R)-3-Cyclohexyl-1-((R)-2-{2-cyclohexyl-2-[(hy...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibitory activity against hepatitis C virus NS3.4A protease | Bioorg Med Chem Lett 14: 1939-42 (2004) Article DOI: 10.1016/j.bmcl.2004.01.078 BindingDB Entry DOI: 10.7270/Q2862FVH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50143472 ((4S,5R)-3-sec-Butyl-1-((R)-2-{2-cyclohexyl-2-[(hyd...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibitory activity against hepatitis C virus NS3.4A protease | Bioorg Med Chem Lett 14: 1939-42 (2004) Article DOI: 10.1016/j.bmcl.2004.01.078 BindingDB Entry DOI: 10.7270/Q2862FVH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50143470 (2-((S)-3-{[(4S,5R)-3-sec-Butyl-1-((R)-3-methyl-2-{...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibitory activity against hepatitis C virus NS3.4A protease | Bioorg Med Chem Lett 14: 1939-42 (2004) Article DOI: 10.1016/j.bmcl.2004.01.078 BindingDB Entry DOI: 10.7270/Q2862FVH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50143469 ((4S,5S)-1-((R)-2-{2-Cyclohexyl-2-[(hydroxy-pyrazin...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibitory activity against hepatitis C virus NS3.4A protease | Bioorg Med Chem Lett 14: 1939-42 (2004) Article DOI: 10.1016/j.bmcl.2004.01.078 BindingDB Entry DOI: 10.7270/Q2862FVH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50143471 ((4S,5S)-2-[1-((S)-(S)-1-Carboxy-2-phenyl-ethylamin...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibitory activity against hepatitis C virus NS3.4A protease | Bioorg Med Chem Lett 14: 1939-42 (2004) Article DOI: 10.1016/j.bmcl.2004.01.078 BindingDB Entry DOI: 10.7270/Q2862FVH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50143473 (2-((S)-3-{[(4S,5S)-3-Allyl-1-((R)-3-methyl-2-{(R)-...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 210 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibitory activity against hepatitis C virus NS3.4A protease | Bioorg Med Chem Lett 14: 1939-42 (2004) Article DOI: 10.1016/j.bmcl.2004.01.078 BindingDB Entry DOI: 10.7270/Q2862FVH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50143462 (2-((S)-3-{[(4S,5S)-3-Ethyl-1-((R)-3-methyl-2-{(R)-...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibitory activity against hepatitis C virus NS3.4A protease | Bioorg Med Chem Lett 14: 1939-42 (2004) Article DOI: 10.1016/j.bmcl.2004.01.078 BindingDB Entry DOI: 10.7270/Q2862FVH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50143467 ((4S,5R)-1-((R)-2-{2-Cyclohexyl-2-[(hydroxy-pyrazin...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 250 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibitory activity against hepatitis C virus NS3.4A protease | Bioorg Med Chem Lett 14: 1939-42 (2004) Article DOI: 10.1016/j.bmcl.2004.01.078 BindingDB Entry DOI: 10.7270/Q2862FVH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50143466 ((4S,5S)-3-Benzyl-1-((R)-2-{2-cyclohexyl-2-[(hydrox...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 310 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibitory activity against hepatitis C virus NS3.4A protease | Bioorg Med Chem Lett 14: 1939-42 (2004) Article DOI: 10.1016/j.bmcl.2004.01.078 BindingDB Entry DOI: 10.7270/Q2862FVH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50143468 ((4S,5R)-1-((R)-2-{2-Cyclohexyl-2-[(hydroxy-pyrazin...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 330 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibitory activity against hepatitis C virus NS3.4A protease | Bioorg Med Chem Lett 14: 1939-42 (2004) Article DOI: 10.1016/j.bmcl.2004.01.078 BindingDB Entry DOI: 10.7270/Q2862FVH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50143460 ((2S,3R)-3-tert-Butyl-1-((R)-2-{(R)-2-cyclohexyl-2-...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 460 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibitory activity against hepatitis C virus NS3.4A protease | Bioorg Med Chem Lett 14: 1939-42 (2004) Article DOI: 10.1016/j.bmcl.2004.01.078 BindingDB Entry DOI: 10.7270/Q2862FVH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50141219 (CHEMBL407433 | Pyrazine-2-carboxylic acid [(R)-1-(...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 920 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibitory activity against hepatitis C virus NS3.4A protease | Bioorg Med Chem Lett 14: 1939-42 (2004) Article DOI: 10.1016/j.bmcl.2004.01.078 BindingDB Entry DOI: 10.7270/Q2862FVH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50143461 ((S)-1-((R)-2-{2-Cyclohexyl-2-[(hydroxy-pyrazin-2-y...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibitory activity against hepatitis C virus NS3.4A protease | Bioorg Med Chem Lett 14: 1939-42 (2004) Article DOI: 10.1016/j.bmcl.2004.01.078 BindingDB Entry DOI: 10.7270/Q2862FVH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50143465 (2-((S)-3-{[(4S,5S)-1-((R)-3-Methyl-2-{(R)-3-methyl...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibitory activity against hepatitis C virus NS3.4A protease | Bioorg Med Chem Lett 14: 1939-42 (2004) Article DOI: 10.1016/j.bmcl.2004.01.078 BindingDB Entry DOI: 10.7270/Q2862FVH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50143463 (CHEMBL177235 | Pyrazine-2-carboxylic acid [(R)-2-m...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibitory activity against hepatitis C virus NS3.4A protease | Bioorg Med Chem Lett 14: 1939-42 (2004) Article DOI: 10.1016/j.bmcl.2004.01.078 BindingDB Entry DOI: 10.7270/Q2862FVH | |||||||||||
More data for this Ligand-Target Pair |