Found 8 hits Enz. Inhib. hit(s) with all data for entry = 50016745 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Farnesyl pyrophosphate synthase
(Homo sapiens (Human)) | BDBM25298
((1-hydroxy-1-phosphonoheptyl)phosphonic acid | CHE...)Show InChI InChI=1S/C7H18O7P2/c1-2-3-4-5-6-7(8,15(9,10)11)16(12,13)14/h8H,2-6H2,1H3,(H2,9,10,11)(H2,12,13,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| 400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Buenos Aires
Curated by ChEMBL
| Assay Description Inhibition of trypanosoma cruzi farnesyl pyrophosphate synthase (TcFPPS) |
Bioorg Med Chem Lett 15: 4685-90 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.060 BindingDB Entry DOI: 10.7270/Q21Z43ZW |
More data for this Ligand-Target Pair | 3D Structure (docked) |
Farnesyl pyrophosphate synthase
(Homo sapiens (Human)) | BDBM50173056
((1-Amino-1-phosphono-hexyl)-phosphonic acid | CHEM...)Show InChI InChI=1S/C6H17NO6P2/c1-2-3-4-5-6(7,14(8,9)10)15(11,12)13/h2-5,7H2,1H3,(H2,8,9,10)(H2,11,12,13) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 382 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Buenos Aires
Curated by ChEMBL
| Assay Description Inhibitory concentration against trypanosoma cruzi farnesyl pyrophosphate synthase (TcFPPS) |
Bioorg Med Chem Lett 15: 4685-90 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.060 BindingDB Entry DOI: 10.7270/Q21Z43ZW |
More data for this Ligand-Target Pair | |
Farnesyl pyrophosphate synthase
(Homo sapiens (Human)) | BDBM25298
((1-hydroxy-1-phosphonoheptyl)phosphonic acid | CHE...)Show InChI InChI=1S/C7H18O7P2/c1-2-3-4-5-6-7(8,15(9,10)11)16(12,13)14/h8H,2-6H2,1H3,(H2,9,10,11)(H2,12,13,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.94E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Buenos Aires
Curated by ChEMBL
| Assay Description Inhibitory concentration against trypanosoma cruzi farnesyl pyrophosphate synthase (TcFPPS) |
Bioorg Med Chem Lett 15: 4685-90 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.060 BindingDB Entry DOI: 10.7270/Q21Z43ZW |
More data for this Ligand-Target Pair | 3D Structure (docked) |
Farnesyl pyrophosphate synthase
(Homo sapiens (Human)) | BDBM50173058
((1-Amino-1-phosphono-heptyl)-phosphonic acid | CHE...)Show InChI InChI=1S/C7H19NO6P2/c1-2-3-4-5-6-7(8,15(9,10)11)16(12,13)14/h2-6,8H2,1H3,(H2,9,10,11)(H2,12,13,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.57E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Buenos Aires
Curated by ChEMBL
| Assay Description Inhibitory concentration against trypanosoma cruzi farnesyl pyrophosphate synthase (TcFPPS) |
Bioorg Med Chem Lett 15: 4685-90 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.060 BindingDB Entry DOI: 10.7270/Q21Z43ZW |
More data for this Ligand-Target Pair | |
Farnesyl pyrophosphate synthase
(Homo sapiens (Human)) | BDBM50173055
((1-Amino-1-phosphono-pentyl)-phosphonic acid | CHE...)Show InChI InChI=1S/C5H15NO6P2/c1-2-3-4-5(6,13(7,8)9)14(10,11)12/h2-4,6H2,1H3,(H2,7,8,9)(H2,10,11,12) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3.91E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Buenos Aires
Curated by ChEMBL
| Assay Description Inhibitory concentration against trypanosoma cruzi farnesyl pyrophosphate synthase (TcFPPS) |
Bioorg Med Chem Lett 15: 4685-90 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.060 BindingDB Entry DOI: 10.7270/Q21Z43ZW |
More data for this Ligand-Target Pair | |
Farnesyl pyrophosphate synthase
(Homo sapiens (Human)) | BDBM50173053
((1-Amino-1-phosphono-butyl)-phosphonic acid | CHEM...)Show InChI InChI=1S/C4H13NO6P2/c1-2-3-4(5,12(6,7)8)13(9,10)11/h2-3,5H2,1H3,(H2,6,7,8)(H2,9,10,11) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3.08E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Buenos Aires
Curated by ChEMBL
| Assay Description Inhibitory concentration against trypanosoma cruzi farnesyl pyrophosphate synthase (TcFPPS) |
Bioorg Med Chem Lett 15: 4685-90 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.060 BindingDB Entry DOI: 10.7270/Q21Z43ZW |
More data for this Ligand-Target Pair | |
Farnesyl pyrophosphate synthase
(Homo sapiens (Human)) | BDBM50173054
((1-Amino-1-phosphono-ethyl)-phosphonic acid | CHEM...)Show InChI InChI=1S/C2H9NO6P2/c1-2(3,10(4,5)6)11(7,8)9/h3H2,1H3,(H2,4,5,6)(H2,7,8,9) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 6.67E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Buenos Aires
Curated by ChEMBL
| Assay Description Inhibitory concentration against trypanosoma cruzi farnesyl pyrophosphate synthase (TcFPPS) |
Bioorg Med Chem Lett 15: 4685-90 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.060 BindingDB Entry DOI: 10.7270/Q21Z43ZW |
More data for this Ligand-Target Pair | |
Farnesyl pyrophosphate synthase
(Homo sapiens (Human)) | BDBM50173057
((1-Amino-1-phosphono-propyl)-phosphonic acid | CHE...)Show InChI InChI=1S/C3H11NO6P2/c1-2-3(4,11(5,6)7)12(8,9)10/h2,4H2,1H3,(H2,5,6,7)(H2,8,9,10) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.50E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Buenos Aires
Curated by ChEMBL
| Assay Description Inhibitory concentration against trypanosoma cruzi farnesyl pyrophosphate synthase (TcFPPS) |
Bioorg Med Chem Lett 15: 4685-90 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.060 BindingDB Entry DOI: 10.7270/Q21Z43ZW |
More data for this Ligand-Target Pair | |