Found 59 hits Enz. Inhib. hit(s) with all data for entry = 50018233 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193204
(3-biphenyl-4-yl-1-((S)-2-pyrrolidin-1-ylmethyl-pyr...)Show SMILES O=C(\C=C\c1ccc(cc1)-c1ccccc1)N1CCC[C@H]1CN1CCCC1 Show InChI InChI=1S/C24H28N2O/c27-24(26-18-6-9-23(26)19-25-16-4-5-17-25)15-12-20-10-13-22(14-11-20)21-7-2-1-3-8-21/h1-3,7-8,10-15,23H,4-6,9,16-19H2/b15-12+/t23-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 3.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193199
((S)-1-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)-3...)Show SMILES FC(F)(F)c1ccc(\C=C\C(=O)N2CCC[C@H]2CN2CCCC2)cc1 |r| Show InChI InChI=1S/C19H23F3N2O/c20-19(21,22)16-8-5-15(6-9-16)7-10-18(25)24-13-3-4-17(24)14-23-11-1-2-12-23/h5-10,17H,1-4,11-14H2/b10-7+/t17-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 4.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193175
((S)-3-(4-chlorophenyl)-1-(2-(pyrrolidin-1-ylmethyl...)Show InChI InChI=1S/C18H23ClN2O/c19-16-8-5-15(6-9-16)7-10-18(22)21-13-3-4-17(21)14-20-11-1-2-12-20/h5-10,17H,1-4,11-14H2/b10-7+/t17-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 11.2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193185
((S)-1-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)-3...)Show SMILES FC(F)(F)Oc1ccc(\C=C\C(=O)N2CCC[C@H]2CN2CCCC2)cc1 Show InChI InChI=1S/C19H23F3N2O2/c20-19(21,22)26-17-8-5-15(6-9-17)7-10-18(25)24-13-3-4-16(24)14-23-11-1-2-12-23/h5-10,16H,1-4,11-14H2/b10-7+/t16-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| 13.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193209
((4-benzylpiperidin-1-yl)(4-isopropylpiperazin-1-yl...)Show InChI InChI=1S/C20H31N3O/c1-17(2)21-12-14-23(15-13-21)20(24)22-10-8-19(9-11-22)16-18-6-4-3-5-7-18/h3-7,17,19H,8-16H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193189
(CHEMBL218834 | [4-(3-Aza-bicyclo[3.2.2]nonane-3-ca...)Show SMILES CC(C)N1CCN(CC1)C(=O)N1CCC(CC1)C(=O)N1CC2CCC(CC2)C1 |(-10.27,-12.49,;-8.93,-13.25,;-8.92,-14.79,;-7.6,-12.47,;-7.61,-10.93,;-6.29,-10.15,;-4.94,-10.9,;-4.93,-12.44,;-6.26,-13.23,;-3.62,-10.12,;-3.64,-8.58,;-2.28,-10.87,;-2.27,-12.41,;-.93,-13.16,;.4,-12.38,;.38,-10.84,;-.96,-10.08,;1.74,-13.14,;1.75,-14.68,;3.07,-12.37,;4.64,-12.83,;5.99,-11.86,;7.33,-12.56,;6.6,-11.37,;4.98,-10.51,;5.01,-9.04,;6.04,-10.28,;4.29,-11.83,)| Show InChI InChI=1S/C22H38N4O2/c1-17(2)23-11-13-25(14-12-23)22(28)24-9-7-20(8-10-24)21(27)26-15-18-3-4-19(16-26)6-5-18/h17-20H,3-16H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193171
(CHEMBL218984 | N-(3,4-dichlorobenzyl)-4-cyclopenty...)Show InChI InChI=1S/C17H23Cl2N3O/c18-15-6-5-13(11-16(15)19)12-20-17(23)22-9-7-21(8-10-22)14-3-1-2-4-14/h5-6,11,14H,1-4,7-10,12H2,(H,20,23) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193208
((6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)(4-...)Show InChI InChI=1S/C19H29N3O3/c1-14(2)20-7-9-21(10-8-20)19(23)22-6-5-15-11-17(24-3)18(25-4)12-16(15)13-22/h11-12,14H,5-10,13H2,1-4H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193180
(CHEMBL220407 | N-(1-(1-isopropylpiperazine-4-carbo...)Show SMILES CC(C)N1CCN(CC1)C(=O)N1CCC(CC1)NC(=O)C1CCCC1 Show InChI InChI=1S/C19H34N4O2/c1-15(2)21-11-13-23(14-12-21)19(25)22-9-7-17(8-10-22)20-18(24)16-5-3-4-6-16/h15-17H,3-14H2,1-2H3,(H,20,24) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193203
(CHEMBL374023 | N-(3,4-dichlorobenzyl)-4-isopropylp...)Show InChI InChI=1S/C15H21Cl2N3O/c1-11(2)19-5-7-20(8-6-19)15(21)18-10-12-3-4-13(16)14(17)9-12/h3-4,9,11H,5-8,10H2,1-2H3,(H,18,21) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193210
((4-cyclopentylpiperazin-1-yl)(isoindolin-2-yl)meth...)Show InChI InChI=1S/C18H25N3O/c22-18(21-13-15-5-1-2-6-16(15)14-21)20-11-9-19(10-12-20)17-7-3-4-8-17/h1-2,5-6,17H,3-4,7-14H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193179
(CHEMBL218410 | tert-butyl 1-(1-isopropylpiperazine...)Show SMILES CC(C)N1CCN(CC1)C(=O)N1CCC(CC1)C(=O)OC(C)(C)C Show InChI InChI=1S/C18H33N3O3/c1-14(2)19-10-12-21(13-11-19)17(23)20-8-6-15(7-9-20)16(22)24-18(3,4)5/h14-15H,6-13H2,1-5H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193197
((4-isopropylpiperazin-1-yl)(4-phenyl-5,6-dihydropy...)Show SMILES CC(C)N1CCN(CC1)C(=O)N1CCC(=CC1)c1ccccc1 |c:15| Show InChI InChI=1S/C19H27N3O/c1-16(2)20-12-14-22(15-13-20)19(23)21-10-8-18(9-11-21)17-6-4-3-5-7-17/h3-8,16H,9-15H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 27 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193201
(4-cyclopentyl-N-(2,3-dihydro-1H-inden-2-yl)piperaz...)Show InChI InChI=1S/C19H27N3O/c23-19(20-17-13-15-5-1-2-6-16(15)14-17)22-11-9-21(10-12-22)18-7-3-4-8-18/h1-2,5-6,17-18H,3-4,7-14H2,(H,20,23) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193181
(CHEMBL219368 | N-(2,3-dihydro-1H-inden-2-yl)-4-iso...)Show InChI InChI=1S/C17H25N3O/c1-13(2)19-7-9-20(10-8-19)17(21)18-16-11-14-5-3-4-6-15(14)12-16/h3-6,13,16H,7-12H2,1-2H3,(H,18,21) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193196
((S)-N-(4-phenoxybenzyl)-2-(pyrrolidin-1-ylmethyl)p...)Show SMILES O=C(NCc1ccc(Oc2ccccc2)cc1)N1CCC[C@H]1CN1CCCC1 Show InChI InChI=1S/C23H29N3O2/c27-23(26-16-6-7-20(26)18-25-14-4-5-15-25)24-17-19-10-12-22(13-11-19)28-21-8-2-1-3-9-21/h1-3,8-13,20H,4-7,14-18H2,(H,24,27)/t20-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 34 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193178
(CHEMBL441708 | N-(4-phenoxybenzyl)-4-isopropylpipe...)Show InChI InChI=1S/C21H27N3O2/c1-17(2)23-12-14-24(15-13-23)21(25)22-16-18-8-10-20(11-9-18)26-19-6-4-3-5-7-19/h3-11,17H,12-16H2,1-2H3,(H,22,25) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 34 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193211
(4-isopropyl-piperazine-1-carboxylic acid biphenyl-...)Show SMILES CC(C)N1CCN(CC1)C(=O)N(C)Cc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C22H29N3O/c1-18(2)24-13-15-25(16-14-24)22(26)23(3)17-19-9-11-21(12-10-19)20-7-5-4-6-8-20/h4-12,18H,13-17H2,1-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 37 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193187
(CHEMBL218860 | N-(4-phenoxybenzyl)-4-cyclopentylpi...)Show SMILES O=C(NCc1ccc(Oc2ccccc2)cc1)N1CCN(CC1)C1CCCC1 Show InChI InChI=1S/C23H29N3O2/c27-23(26-16-14-25(15-17-26)20-6-4-5-7-20)24-18-19-10-12-22(13-11-19)28-21-8-2-1-3-9-21/h1-3,8-13,20H,4-7,14-18H2,(H,24,27) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 38 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193193
(4-ethyl-N-((1R,2S)-2-phenylcyclopropyl)piperazine-...)Show InChI InChI=1S/C16H23N3O/c1-2-18-8-10-19(11-9-18)16(20)17-15-12-14(15)13-6-4-3-5-7-13/h3-7,14-15H,2,8-12H2,1H3,(H,17,20)/t14-,15+/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50019293
(1-(1-{3-[Bis-(4-fluoro-phenyl)-amino]-propyl}-pipe...)Show SMILES Fc1ccc(cc1)N(CCCN1CCC(CC1)n1c2ccccc2[nH]c1=O)c1ccc(F)cc1 Show InChI InChI=1S/C27H28F2N4O/c28-20-6-10-22(11-7-20)32(23-12-8-21(29)9-13-23)17-3-16-31-18-14-24(15-19-31)33-26-5-2-1-4-25(26)30-27(33)34/h1-2,4-13,24H,3,14-19H2,(H,30,34) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| 42 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Displacement of [3H]Astemizole from hERG expressed in HEK293 cells at 10 uM |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193176
(CHEMBL373540 | N-(2,3-dihydro-1H-inden-2-yl)-4-eth...)Show InChI InChI=1S/C16H23N3O/c1-2-18-7-9-19(10-8-18)16(20)17-15-11-13-5-3-4-6-14(13)12-15/h3-6,15H,2,7-12H2,1H3,(H,17,20) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 44 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193198
((4-cyclopropylpiperazin-1-yl)(isoindolin-2-yl)meth...)Show InChI InChI=1S/C16H21N3O/c20-16(18-9-7-17(8-10-18)15-5-6-15)19-11-13-3-1-2-4-14(13)12-19/h1-4,15H,5-12H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 45 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193205
((S)-N-(3,4-dichlorobenzyl)-2-(pyrrolidin-1-ylmethy...)Show InChI InChI=1S/C17H23Cl2N3O/c18-15-6-5-13(10-16(15)19)11-20-17(23)22-9-3-4-14(22)12-21-7-1-2-8-21/h5-6,10,14H,1-4,7-9,11-12H2,(H,20,23)/t14-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 47 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193172
((4-tert-butylpiperidin-1-yl)(4-isopropylpiperazin-...)Show InChI InChI=1S/C17H33N3O/c1-14(2)18-10-12-20(13-11-18)16(21)19-8-6-15(7-9-19)17(3,4)5/h14-15H,6-13H2,1-5H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 47 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193213
((S)-N-(2,3-dihydro-1H-inden-2-yl)-2-(pyrrolidin-1-...)Show InChI InChI=1S/C19H27N3O/c23-19(20-17-12-15-6-1-2-7-16(15)13-17)22-11-5-8-18(22)14-21-9-3-4-10-21/h1-2,6-7,17-18H,3-5,8-14H2,(H,20,23)/t18-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 52 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193184
(CHEMBL219592 | isoindolin-2-yl(4-isopropylpiperazi...)Show InChI InChI=1S/C16H23N3O/c1-13(2)17-7-9-18(10-8-17)16(20)19-11-14-5-3-4-6-15(14)12-19/h3-6,13H,7-12H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 59 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193207
((3,4-dihydroisoquinolin-2(1H)-yl)(4-isopropylpiper...)Show InChI InChI=1S/C17H25N3O/c1-14(2)18-9-11-19(12-10-18)17(21)20-8-7-15-5-3-4-6-16(15)13-20/h3-6,14H,7-13H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 73 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193212
((S)-N-(3-(aminomethyl)benzyl)-2-(pyrrolidin-1-ylme...)Show InChI InChI=1S/C18H28N4O/c19-12-15-5-3-6-16(11-15)13-20-18(23)22-10-4-7-17(22)14-21-8-1-2-9-21/h3,5-6,11,17H,1-2,4,7-10,12-14,19H2,(H,20,23)/t17-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 78 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193195
((4-isopropylpiperazin-1-yl)(4-phenylpiperidin-1-yl...)Show InChI InChI=1S/C19H29N3O/c1-16(2)20-12-14-22(15-13-20)19(23)21-10-8-18(9-11-21)17-6-4-3-5-7-17/h3-7,16,18H,8-15H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 86 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193190
((S)-2-pyrrolidin-1-ylmethyl-pyrrolidine-1-carboxyl...)Show SMILES O=C(NCc1ccc(cc1)-c1ccccc1)N1CCC[C@H]1CN1CCCC1 Show InChI InChI=1S/C23H29N3O/c27-23(26-16-6-9-22(26)18-25-14-4-5-15-25)24-17-19-10-12-21(13-11-19)20-7-2-1-3-8-20/h1-3,7-8,10-13,22H,4-6,9,14-18H2,(H,24,27)/t22-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 87 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193214
(CHEMBL219757 | N-benzyl-4-cyclopentylpiperazine-1-...)Show InChI InChI=1S/C17H25N3O/c21-17(18-14-15-6-2-1-3-7-15)20-12-10-19(11-13-20)16-8-4-5-9-16/h1-3,6-7,16H,4-5,8-14H2,(H,18,21) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 94 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193200
((S)-isoindolin-2-yl(2-(pyrrolidin-1-ylmethyl)pyrro...)Show InChI InChI=1S/C18H25N3O/c22-18(20-12-15-6-1-2-7-16(15)13-20)21-11-5-8-17(21)14-19-9-3-4-10-19/h1-2,6-7,17H,3-5,8-14H2/t17-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 94 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193194
((S)-N-(4-(aminomethyl)benzyl)-2-(pyrrolidin-1-ylme...)Show InChI InChI=1S/C18H28N4O/c19-12-15-5-7-16(8-6-15)13-20-18(23)22-11-3-4-17(22)14-21-9-1-2-10-21/h5-8,17H,1-4,9-14,19H2,(H,20,23)/t17-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 109 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193202
((S)-N-(3-(trifluoromethyl)benzyl)-2-(pyrrolidin-1-...)Show SMILES FC(F)(F)c1cccc(CNC(=O)N2CCC[C@H]2CN2CCCC2)c1 Show InChI InChI=1S/C18H24F3N3O/c19-18(20,21)15-6-3-5-14(11-15)12-22-17(25)24-10-4-7-16(24)13-23-8-1-2-9-23/h3,5-6,11,16H,1-2,4,7-10,12-13H2,(H,22,25)/t16-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 117 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193174
((S)-N-(4-(trifluoromethoxy)benzyl)-2-(pyrrolidin-1...)Show SMILES FC(F)(F)Oc1ccc(CNC(=O)N2CCC[C@H]2CN2CCCC2)cc1 Show InChI InChI=1S/C18H24F3N3O2/c19-18(20,21)26-16-7-5-14(6-8-16)12-22-17(25)24-11-3-4-15(24)13-23-9-1-2-10-23/h5-8,15H,1-4,9-13H2,(H,22,25)/t15-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 121 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193188
((S)-N-(4-(trifluoromethyl)benzyl)-2-(pyrrolidin-1-...)Show SMILES FC(F)(F)c1ccc(CNC(=O)N2CCC[C@H]2CN2CCCC2)cc1 Show InChI InChI=1S/C18H24F3N3O/c19-18(20,21)15-7-5-14(6-8-15)12-22-17(25)24-11-3-4-16(24)13-23-9-1-2-10-23/h5-8,16H,1-4,9-13H2,(H,22,25)/t16-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 162 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193191
((S)-N-(4-chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)py...)Show InChI InChI=1S/C17H24ClN3O/c18-15-7-5-14(6-8-15)12-19-17(22)21-11-3-4-16(21)13-20-9-1-2-10-20/h5-8,16H,1-4,9-13H2,(H,19,22)/t16-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 165 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193177
((S)-N-(3-methoxybenzyl)-2-(pyrrolidin-1-ylmethyl)p...)Show InChI InChI=1S/C18H27N3O2/c1-23-17-8-4-6-15(12-17)13-19-18(22)21-11-5-7-16(21)14-20-9-2-3-10-20/h4,6,8,12,16H,2-3,5,7,9-11,13-14H2,1H3,(H,19,22)/t16-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 188 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193192
((S)-N-benzyl-2-(pyrrolidin-1-ylmethyl)pyrrolidine-...)Show InChI InChI=1S/C17H25N3O/c21-17(18-13-15-7-2-1-3-8-15)20-12-6-9-16(20)14-19-10-4-5-11-19/h1-3,7-8,16H,4-6,9-14H2,(H,18,21)/t16-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 196 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193183
((S)-N-phenethyl-2-(pyrrolidin-1-ylmethyl)pyrrolidi...)Show InChI InChI=1S/C18H27N3O/c22-18(19-11-10-16-7-2-1-3-8-16)21-14-6-9-17(21)15-20-12-4-5-13-20/h1-3,7-8,17H,4-6,9-15H2,(H,19,22)/t17-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
| Article PubMed
| 226 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193182
((S)-2-pyrrolidin-1-ylmethyl-pyrrolidine-1-carboxyl...)Show SMILES CN(Cc1ccc(cc1)-c1ccccc1)C(=O)N1CCC[C@H]1CN1CCCC1 Show InChI InChI=1S/C24H31N3O/c1-25(18-20-11-13-22(14-12-20)21-8-3-2-4-9-21)24(28)27-17-7-10-23(27)19-26-15-5-6-16-26/h2-4,8-9,11-14,23H,5-7,10,15-19H2,1H3/t23-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 281 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193173
((S)-N-(4-methoxybenzyl)-2-(pyrrolidin-1-ylmethyl)p...)Show InChI InChI=1S/C18H27N3O2/c1-23-17-8-6-15(7-9-17)13-19-18(22)21-12-4-5-16(21)14-20-10-2-3-11-20/h6-9,16H,2-5,10-14H2,1H3,(H,19,22)/t16-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 295 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM78577
(BEPRIDIL HYDROCHLORIDE | Bepridil | MLS000028456 |...)Show InChI InChI=1S/C24H34N2O/c1-21(2)19-27-20-24(25-15-9-10-16-25)18-26(23-13-7-4-8-14-23)17-22-11-5-3-6-12-22/h3-8,11-14,21,24H,9-10,15-20H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
DrugBank MCE KEGG PC cid PC sid PDB UniChem
Similars
| Article PubMed
| 444 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Displacement of [3H]Astemizole from hERG expressed in HEK293 cells at 10 uM |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50193206
((S)-N-(cyclohexylmethyl)-2-(pyrrolidin-1-ylmethyl)...)Show InChI InChI=1S/C17H31N3O/c21-17(18-13-15-7-2-1-3-8-15)20-12-6-9-16(20)14-19-10-4-5-11-19/h15-16H,1-14H2,(H,18,21)/t16-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 458 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor by hH3-[35S]GTPgamma[S] binding assay |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM21398
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| 512 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Displacement of [3H]Astemizole from hERG expressed in HEK293 cells at 10 uM |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50002338
((Thioridazine)10-[2-(1-Methyl-piperidin-2-yl)-ethy...)Show InChI InChI=1S/C21H26N2S2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank Article PubMed
| 869 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Displacement of [3H]Astemizole from hERG expressed in HEK293 cells at 10 uM |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Cytochrome P450 2D6
(Homo sapiens (Human)) | BDBM50193172
((4-tert-butylpiperidin-1-yl)(4-isopropylpiperazin-...)Show InChI InChI=1S/C17H33N3O/c1-14(2)18-10-12-20(13-11-18)16(21)19-8-6-15(7-9-19)17(3,4)5/h14-15H,6-13H2,1-5H3 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Inhibition of CYP2D6 in human liver microsomes |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Cytochrome P450 2D6
(Homo sapiens (Human)) | BDBM50193180
(CHEMBL220407 | N-(1-(1-isopropylpiperazine-4-carbo...)Show SMILES CC(C)N1CCN(CC1)C(=O)N1CCC(CC1)NC(=O)C1CCCC1 Show InChI InChI=1S/C19H34N4O2/c1-15(2)21-11-13-23(14-12-21)19(25)22-9-7-17(8-10-22)20-18(24)16-5-3-4-6-16/h15-17H,3-14H2,1-2H3,(H,20,24) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Inhibition of CYP2D6 in human liver microsomes |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |
Cytochrome P450 1A2
(Homo sapiens (Human)) | BDBM50193189
(CHEMBL218834 | [4-(3-Aza-bicyclo[3.2.2]nonane-3-ca...)Show SMILES CC(C)N1CCN(CC1)C(=O)N1CCC(CC1)C(=O)N1CC2CCC(CC2)C1 |(-10.27,-12.49,;-8.93,-13.25,;-8.92,-14.79,;-7.6,-12.47,;-7.61,-10.93,;-6.29,-10.15,;-4.94,-10.9,;-4.93,-12.44,;-6.26,-13.23,;-3.62,-10.12,;-3.64,-8.58,;-2.28,-10.87,;-2.27,-12.41,;-.93,-13.16,;.4,-12.38,;.38,-10.84,;-.96,-10.08,;1.74,-13.14,;1.75,-14.68,;3.07,-12.37,;4.64,-12.83,;5.99,-11.86,;7.33,-12.56,;6.6,-11.37,;4.98,-10.51,;5.01,-9.04,;6.04,-10.28,;4.29,-11.83,)| Show InChI InChI=1S/C22H38N4O2/c1-17(2)23-11-13-25(14-12-23)22(28)24-9-7-20(8-10-24)21(27)26-15-18-3-4-19(16-26)6-5-18/h17-20H,3-16H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Inhibition of CYP1A2 in human liver microsomes |
Bioorg Med Chem Lett 16: 5303-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.093 BindingDB Entry DOI: 10.7270/Q2RV0NBD |
More data for this Ligand-Target Pair | |