BindingDB PrimarySearch

Found 5 hits Enz. Inhib. hit(s) with all data for entry = 50046777
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Nuclear receptor subfamily 1 group I member 2 (Homo sapiens (Human))	BDBM50130734 (CHEMBL3632931) Show SMILES Cc1cc(no1)-c1onc(C)c1C(=O)Sc1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	850	n/a	n/a	n/a	n/a	n/a	n/a
University of Ljubljana Curated by ChEMBL					Assay Description Antagonist activity at PXR (unknown origin)				Eur J Med Chem 103: 551-62 (2015) Article DOI: 10.1016/j.ejmech.2015.09.005 BindingDB Entry DOI: 10.7270/Q2N87CMJ
University of Ljubljana Curated by ChEMBL					More data for this Ligand-Target Pair
Nuclear receptor subfamily 1 group I member 2 (Homo sapiens (Human))	BDBM20625 (4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol \| ...) Show SMILES CC\C(=C(\CC)c1ccc(O)cc1)c1ccc(O)cc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.46E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Ljubljana Curated by ChEMBL					Assay Description Antagonist activity at full length human PXR transfected in human HepG2 cells assessed as reduction in rifaximin-induced receptor transactivation aft...				Eur J Med Chem 103: 551-62 (2015) Article DOI: 10.1016/j.ejmech.2015.09.005 BindingDB Entry DOI: 10.7270/Q2N87CMJ
University of Ljubljana Curated by ChEMBL					More data for this Ligand-Target Pair
Nuclear receptor subfamily 1 group I member 2 (Homo sapiens (Human))	BDBM50130718 (CHEMBL3632924) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.74E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Ljubljana Curated by ChEMBL					Assay Description Antagonist activity at full length human PXR transfected in human HepG2 cells assessed as reduction in rifaximin-induced receptor transactivation aft...				Eur J Med Chem 103: 551-62 (2015) Article DOI: 10.1016/j.ejmech.2015.09.005 BindingDB Entry DOI: 10.7270/Q2N87CMJ
University of Ljubljana Curated by ChEMBL					More data for this Ligand-Target Pair
Nuclear receptor subfamily 1 group I member 2 (Homo sapiens (Human))	BDBM50130717 (CHEBI:34701 \| CHEMBL113650) Show SMILES CC\C(=C(\CC)c1ccc(OC)cc1)c1ccc(OC)cc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.05E+4	n/a	n/a	n/a	n/a
University of Ljubljana Curated by ChEMBL					Assay Description Transactivation of full length human PXR transfected in human HepG2 cells after 18 hrs by luciferase reporter assay relative to rifaximin				Eur J Med Chem 103: 551-62 (2015) Article DOI: 10.1016/j.ejmech.2015.09.005 BindingDB Entry DOI: 10.7270/Q2N87CMJ
University of Ljubljana Curated by ChEMBL					More data for this Ligand-Target Pair
Nuclear receptor subfamily 1 group I member 2 (Homo sapiens (Human))	BDBM50347620 (RIFAXIMIN \| Rifacol \| Rifaxidin) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	1.12E+4	n/a	n/a	n/a	n/a
University of Ljubljana Curated by ChEMBL					Assay Description Transactivation of full length human PXR transfected in human HepG2 cells after 18 hrs by luciferase reporter assay relative to rifaximin				Eur J Med Chem 103: 551-62 (2015) Article DOI: 10.1016/j.ejmech.2015.09.005 BindingDB Entry DOI: 10.7270/Q2N87CMJ
University of Ljubljana Curated by ChEMBL					More data for this Ligand-Target Pair